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acidic drug
相关语句
  酸性药物
     Study of Protein Binding of Acidic Drug, Nateglinide, in Human Plasma Albumin Solution by High Performance Capillary Electrophoresis/Frontal Analysis
     高效毛细管电泳前沿分析法研究酸性药物那格列奈与人血浆白蛋白的结合
短句来源
     CE/FA is used to to determine the binding parameters of the acidic drug nateglinide and amlodipine enantiomers to protein.
     实验中建立了用CE/FA测定以那格列奈为代表的酸性药物以及氨氯地平异构体与蛋白的结合参数。
短句来源
     The protein binding constants, binding sites and binding rate of acidic drug, Nateglinide, in human plasma albumin solution was studied by high performance capillary electrophoresis frontal analysis (HPCE/FA).
     用高效毛细管电泳前沿分析法研究了酸性药物那格列奈与人血浆白蛋白的结合常数、结合位点和结合率。
短句来源
     The characteristics of bias caused by split-flow electrokinetic injection (SEKI), a new sample injection method applied in coupled flow injection-capillary electrophoretic system(FI-CE), was investigated using pseudoephedrine hydrochloride, a basic drug and ibuprofen, an acidic drug, as model analytes.
     以碱性药物盐酸伪麻黄碱和酸性药物布洛芬为对象研究了分流式电动进样 (一种用于流动注射 毛细管电泳(FI CE)联用系统的新进样方法)歧视效应的特性。
短句来源
  相似匹配句对
     antibody drug
     抗体药物
     Drug and Leukemia
     药物与白血病
短句来源
     Four different adding drug ways were used to discuss the mechanism of acidic peptide.
     采用不同的加药方式作用于TA98菌株 ,探讨酸性肽的抗突变机理。
短句来源
     The acidic isomerization was studied.
     并详细研究了在酸性条件下2—亚戊基环戊酮异构成2—正戊基环戊—2—烯酮的异构化反应。
短句来源
     Processing of Acidic Crudes
     含酸原油的加工
短句来源
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  acidic drug
Supported by the product distribution studies, the stabilization is proposed to involve the neutralization of the acidic drug by the basic excipients.
      
The induced ellipticities of the acidic drug-α1-AGP system decreased with increasing pH, while the ellipticities for the basic drugs increased with pH.
      
Effect of Buffer Species on the Inclusion Complexation of Acidic Drug Celecoxib with Cyclodextrin in Solution
      
The plasma protein binding of a representative acidic drug, salicylate, and a representative basic drug, quinidine, has been studied in patients with several diseases that are sometimes associated with uraemia or a change in serum albumin level.
      
F-AAG) is the most pronounced for methadone and the lowest for thioridazine, while it is absent for the acidic drug mephenytoin.
      
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Twenty weak acidic organic drugs (eleven sulfanilamide derivatives and nine other weak acidic drugs)were determined with 0.1 N tetra-n-butylammonium hydroxide and sodium methoxide. Strong base catalyzing acrylonitrile anionic polymerization was used to indi- cate the end-point of titration. Hydrochlothiazide and fluorouracil in tablets were determined by direct titration without extraction and separation. Satisfactory results of the titration were obtained with a Twin-stirrer thermo- metric...

Twenty weak acidic organic drugs (eleven sulfanilamide derivatives and nine other weak acidic drugs)were determined with 0.1 N tetra-n-butylammonium hydroxide and sodium methoxide. Strong base catalyzing acrylonitrile anionic polymerization was used to indi- cate the end-point of titration. Hydrochlothiazide and fluorouracil in tablets were determined by direct titration without extraction and separation. Satisfactory results of the titration were obtained with a Twin-stirrer thermo- metric recorder. The emphasis of this paper is placed on selecting titrants, solvents and ther- mometric indicators in order to obtain the good titration curves, in which the end-point may be directly located by observing inflection of the curves.

本文利用在非水溶液中碱滴定剂催化丙烯腈阴离子聚合放热反应指示终点,使用双磁搅拌温度记录仪记录滴定曲线,测定了20种弱酸性有机原料药物;并且不经事先分离提取直接测定了氟脲嘧啶、氢氯噻嗪片剂的含量,精密度和准确度较好。还从选择滴定剂、溶剂、指示剂系统看手,研究了如何获得转折敏锐的滴定曲线,使反应当量比接近理论值。

A novel titrimetry in aqueous solution to weak acidic drug Chlopromazine is developed in this paper. There is no necessary to ascertain the equivalence point and to standardize the concentration of the titrant. The present methode is simple, rapid and good results were obtained.

本文研究成功一种水溶液中测定弱酸性药物盐酸氯丙嗪的新型滴定分析方法——固定PH滴定法。该法基于在某固定PH值,水溶液中弱酸(碱)各种存在形式的分布系数为一常数,与弱酸(碱)含量无关。滴定时不需要确定化学计量点,也不需要已知滴定剂浓度,而是用单标准比较、标准曲线或线性回归对试样定量分析。测定盐酸氯丙嗪原料药和片剂,结果与中国药典法无显著性差异。操作简单、方便、快速。

In present study, amylopectin tris(phenylcarbamate) was synthesized, and used as chiral stationary phase on silica gel. This stationary phase offered a practically useful chiral column with high enantiomer separability. Amylopectin was allowed to react with an excess of phenylisocyanate in pyridine for 48 h. The obtained carbamates were dissolved in THF and adsorbed on silica gel which has been treated with 3 aminopropyltriethoxysilane. The weight ratio of the carbamate to the silica gel was 0.45/2.55. One...

In present study, amylopectin tris(phenylcarbamate) was synthesized, and used as chiral stationary phase on silica gel. This stationary phase offered a practically useful chiral column with high enantiomer separability. Amylopectin was allowed to react with an excess of phenylisocyanate in pyridine for 48 h. The obtained carbamates were dissolved in THF and adsorbed on silica gel which has been treated with 3 aminopropyltriethoxysilane. The weight ratio of the carbamate to the silica gel was 0.45/2.55. One cyclic ketone, one cyclic alcohol and two acidic drugs were resoluted on amylopectin tris(phenylcarbamate) chiral stationary phase. Separation was carried out with a hexane/2 propanol mixture at a flow rate of 0.5 mL/min at room temperature. The effects of 2 propanol concentration on the retention and resolution had been investigated.

支链淀粉-三(苯基氨基甲酸酯)手性固定相的制备及对外消旋化合物的直接拆分1)周志强候经国陈立仁2)(中国科学院兰州化学物理研究所兰州730000)关键词高效液相色谱支链淀粉-三(苯基氨基甲酸酯)外消旋化合物手性拆分分类号O657.7在大量的手性固定相...

 
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