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breast cancer antigen
相关语句
  乳腺癌抗原
     Breast Cancer Antigen Immunosensor Based on the Functional Sol-gel Film
     基于功能化溶胶-凝胶膜的乳腺癌抗原免疫传感器
短句来源
     1. The breast cancer antigen specifically combined with M4G3 McAb has 48,000 dalton molecule weight.
     1.与M4G3单抗结合的乳腺癌抗原分子量约为48,000 dalton。
短句来源
     Conclusion:The breast cancer antigen specifically combined with M4G3McAb has48000dalton molecule weight.
     结论 :与M4G3单抗结合的乳腺癌抗原分子量约为48000dalton。
短句来源
     AIM: To investigate the effects of interleukin 6(IL-6) on t he expression of breast cancer antigen (CA15-3) and carcinoembryonic antigen (CEA ) in the breast cancer cells.
     目的 :探索白细胞介素 6 (interleukin 6 ,IL 6 )增强乳腺癌细胞表达乳腺癌抗原 (CA15 3)和癌胚抗原 (CEA)的作用。
短句来源
     A new type of non labeled immunosensor for the determination of breast cancer antigen(CA15 3) was made by combining sol gel with cross link techniques and utilizing glutaraldehyde(GA) to link CA15 3 antibody(Ab) on the functional sol gel film, so the sol gel/GA/Ab layer was immobilized on the surface of platinum disk electrode.
     结合溶胶 -凝胶 ( sol-gel)和交联技术 ,将乳腺癌抗体固定在铂盘电极表面的氨基化 sol-gel功能膜上 ,制备出用于检测乳腺癌抗原 ( CA1 5 -3 )的免疫传感器 .
短句来源
  “breast cancer antigen”译为未确定词的双语例句
     These proteins are st ratifin , symplekin , B7-1 , TPMsk1 t ropomyosin isoforms , serologically defined breast cancer antigen N Y2BR220 etc. Intriguingly , most identified candidate proteins have been shown to be somehow associated with distinct aspects of tumor metastasis such as cell communication protein , motility , adhesion , invasion and tumor immunity associated protein , etc.
     对其中10个差异较明显的蛋白质点,进一步进行基质辅助激光解吸电离飞行时间质谱测定肽质量指纹图谱,查找SWISS PROT数据库,结果显示,多个蛋白如Stratifin、Symplekin、B7和乳腺癌相关抗原NY-BR-20等在两个细胞系中表达有差异。
短句来源
  相似匹配句对
     Fas antigen expression in breast cancer
     Fas抗原在乳腺癌组织中的表达
短句来源
     Adipocytokines and breast cancer
     脂肪细胞因子与乳腺癌
短句来源
     Pregnancy and breast cancer
     妊娠与乳腺癌
短句来源
     TUMOR-ASSOCIATED MUCINOUS ANTIGEN IN HUMAN BREAST CANCER DIAGNOSIS
     乳腺癌相关性抗原对乳腺癌的诊断
短句来源
     Factor 8 Related Antigen and Cathepsin D in Human Breast Cancer
     乳腺癌组织中第Ⅷ因子相关抗原和组织蛋白酶D与癌转移及预后的关系
短句来源
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  breast cancer antigen
These results suggest that KASIFLK or its cross-reactive epitope is a breast cancer antigen and is immunogenic in humans.
      
Recognition of an epitope of a breast cancer antigen by human antibody
      
This article summarizes our approach of antigen identification and evaluation giving the example of the recently cloned breast cancer antigen NY-BR-1.
      
The detection of a breast cancer antigen on MCF-7 cells reactive with the TCR(α) of a specific killer T cell line
      


A new type of non labeled immunosensor for the determination of breast cancer antigen(CA15 3) was made by combining sol gel with cross link techniques and utilizing glutaraldehyde(GA) to link CA15 3 antibody(Ab) on the functional sol gel film, so the sol gel/GA/Ab layer was immobilized on the surface of platinum disk electrode. Infrared spectrum(IR) and cyclic voltammetry(CV) were employed to investigate the structure and the electrochemical characteristics of the immunosensor, respectively. The...

A new type of non labeled immunosensor for the determination of breast cancer antigen(CA15 3) was made by combining sol gel with cross link techniques and utilizing glutaraldehyde(GA) to link CA15 3 antibody(Ab) on the functional sol gel film, so the sol gel/GA/Ab layer was immobilized on the surface of platinum disk electrode. Infrared spectrum(IR) and cyclic voltammetry(CV) were employed to investigate the structure and the electrochemical characteristics of the immunosensor, respectively. The linearity of CA15 3 in the range of 8—240 U/mL with a detection limit of 5 U/mL and the correlation coefficient of 0 998 are obtained. The experimental results show that the activity of the immobilized CA15 3 antibody is maintained better by this method, and the stability of the immunosensor is improved. The dependences of the potential response on pH, incubation time, sensitivity and reproducibility were studied, and the stability of the sensor was also evaluated. The immunosensor was found to be stable for about 30 days when stored in a dry state at 4 ℃. Satisfactory determination results of CA15 3 in serum samples were obtained by this method.

结合溶胶 -凝胶 ( sol-gel)和交联技术 ,将乳腺癌抗体固定在铂盘电极表面的氨基化 sol-gel功能膜上 ,制备出用于检测乳腺癌抗原 ( CA1 5 -3 )的免疫传感器 .用红外光谱验证了该传感器功能膜的形成过程和组成结构 ,采用循环伏安法对传感器逐层修饰过程进行了表征 ,并对传感器功能膜的作用机理进行了探讨 .该法检测 CA1 5 -3的线性范围为 8~ 2 40 U/m L,线性回归方程为ΔE=75 .75 lgc-5 6.3 6,r=0 .998.结果表明 ,该方法很好地保持了被固定抗体的活性 ,增强了传感器的稳定性 ,所制备的传感器于 4℃干态保存 3 0 d,其响应信号基本不变 .且该传感器响应迅速、灵敏度高、选择性好 ,血清中常见抗原不干扰测定

The molecular genesis of a tumor is a multi-step and complex process in which many factors are involved such as oncogenes, tumor suppressor genes and MHC-Ⅰ etc. Metastasis is the essential character causing mortality from such tumors and little is currently known about mechanisms underlying cancer metastasis. As a step toward understanding the complex differences between high metastatic and low metastatic cells, metastasis-associated gene expression patterns and proteomes were separated and identified by suppression...

The molecular genesis of a tumor is a multi-step and complex process in which many factors are involved such as oncogenes, tumor suppressor genes and MHC-Ⅰ etc. Metastasis is the essential character causing mortality from such tumors and little is currently known about mechanisms underlying cancer metastasis. As a step toward understanding the complex differences between high metastatic and low metastatic cells, metastasis-associated gene expression patterns and proteomes were separated and identified by suppression subtraction hybridization and comparative proteomics analysis between high metastatic cell AccM and low metastatic cell Acc2. Although extensive similarity was noted between the expression profiles of the two cell lines, twenty-eight genes highly expressed were obtained in tester, low metastatic cells, compared with their low expression in driver, high metastatic cells while six genes in reverse hybridization. These function of genes are related to cell proliferation, differentiation or cell metabolism while several novel EST sequences which function are unknown. Two novel genes were ACC metastasis-associated RNH ACC metastasis-associated suspected protein. Meanwhile, ten proteins were randomly selected which are expressed different qualitatively or quantitatively and identified by mass fingerprinting (MALDI-TOF-MS).These proteins are stratifin, symplekin, B7, TPMsk1 tropomyosin isoforms, serologically defined breast cancer antigen NY-BR-20 etc. Intriguingly, most identified candidate proteins have been shown to be somehow associated with distinct aspects of tumor metastasis such as cell communication protein, motility, adhesion, invasion and tumor immunity associated protein, etc. These results suggest that attaining the ability to metastasize is related to the changed expression of these genes or protein. These data provide insight into the extent of expression differences underlying metastasis-related genes that may prove useful as diagnostic or prognostic markers.

转移性和侵袭性是恶性肿瘤的重要特征 ,与基因和蛋白质水平上一系列改变密切相关 .应用mRNA抑制性消减杂交技术和双向电泳结合肽质量指纹分析技术 ,对涎腺腺样囊性癌高、低转移细胞系的mRNA和蛋白质表达谱的差异性进行比较研究 .实验结果显示 ,在抑制性消减杂交中 ,分别以两个细胞系为测试子 ,共获得差异片段 34个 ,其中高转移株细胞中高表达的基因序列有 6个 ,低转移细胞系中有 2 8个 ,其中包括两个新的表达序列标签 (EST) .对这些基因序列 ,进一步以RNA斑点杂交对这些基因的表达状况进行验证并排除假阳性结果 ,结果发现 ,32个基因在mRNA水平上有不同程度的表达量改变 ,改变趋势与消减杂交结果一致 .以蛋白质等电聚焦结合SDS 聚丙烯酰胺凝胶电泳的双向电泳技术获得的总蛋白质分离 ,经PDQuest2DE软件分析结果表明 ,高转移细胞系表达谱的平均蛋白质点数为 (978± 38) ,低转移细胞系的平均蛋白质点数为 (996± 2 7) .其中高转移细胞与低转移细胞相比 ,其蛋白质点有 35 5个未被匹配 ,低转移细胞相比高转移细胞有 2 2 2个未被匹配 .对其中 10个差异较明显的蛋白质点 ,进一...

转移性和侵袭性是恶性肿瘤的重要特征 ,与基因和蛋白质水平上一系列改变密切相关 .应用mRNA抑制性消减杂交技术和双向电泳结合肽质量指纹分析技术 ,对涎腺腺样囊性癌高、低转移细胞系的mRNA和蛋白质表达谱的差异性进行比较研究 .实验结果显示 ,在抑制性消减杂交中 ,分别以两个细胞系为测试子 ,共获得差异片段 34个 ,其中高转移株细胞中高表达的基因序列有 6个 ,低转移细胞系中有 2 8个 ,其中包括两个新的表达序列标签 (EST) .对这些基因序列 ,进一步以RNA斑点杂交对这些基因的表达状况进行验证并排除假阳性结果 ,结果发现 ,32个基因在mRNA水平上有不同程度的表达量改变 ,改变趋势与消减杂交结果一致 .以蛋白质等电聚焦结合SDS 聚丙烯酰胺凝胶电泳的双向电泳技术获得的总蛋白质分离 ,经PDQuest2DE软件分析结果表明 ,高转移细胞系表达谱的平均蛋白质点数为 (978± 38) ,低转移细胞系的平均蛋白质点数为 (996± 2 7) .其中高转移细胞与低转移细胞相比 ,其蛋白质点有 35 5个未被匹配 ,低转移细胞相比高转移细胞有 2 2 2个未被匹配 .对其中 10个差异较明显的蛋白质点 ,进一步进行基质辅助激光解吸电离飞行时间质谱 (MALDI TOF MS)测定肽质量指纹图谱 ,用Peptident软件对SWISSPROT数据库比较分析 ,结果显示 ,S

A new type of non-labeled immunosensor was prepared for the determination of breast cancer antigen CA15-3(Ag). The breast cancer antibody(Ab) was first encapsulated in a tetraethylorthosilicate(TEOS) sol-gel film, and the sol-gel-Ab layer was then coated onto the surface of a platinum-disk electrode. The electrochemical characteristics of the modified electrode at different stages of modi-fication was studied by cyclic voltammetry(CV) in a solution of K3Fe(CN)6(5 mmol/L)-KNO3(0.1mol/L)-PBS(0.1...

A new type of non-labeled immunosensor was prepared for the determination of breast cancer antigen CA15-3(Ag). The breast cancer antibody(Ab) was first encapsulated in a tetraethylorthosilicate(TEOS) sol-gel film, and the sol-gel-Ab layer was then coated onto the surface of a platinum-disk electrode. The electrochemical characteristics of the modified electrode at different stages of modi-fication was studied by cyclic voltammetry(CV) in a solution of K3Fe(CN)6(5 mmol/L)-KNO3(0.1mol/L)-PBS(0.1 mol/L). With the progress of the antibody-antigen reaction, the immune com-plex of Ab-Ag brings about a change of the membrane potential ΔV. The magnitude of this changeis pertinent to the extent of the immune reaction. This correlation has been applied to the quantitativedetermination of antigen CA15-3. ΔV and lg c show a good linear correlation in the range of 5~240U/mL with a correlation coefficient of 0.998. The effects of pH and incubation time have been studied.The sensor has a fast response, high sensitivity, good reproducibility and prolonged stability for 30 daysat 4 ℃.

采用溶胶 -凝胶技术将乳腺癌抗体固定于电极表面 ,研制成用于检测乳腺癌抗原的非标记型溶胶 -凝胶 -抗体膜免疫传感器 ;用循环伏安法对电极的修饰过程进行表征 ,同时对乳腺癌抗原定量检测的可行性进行了探讨 ;随着抗体与抗原特异性反应的进行 ,形成的抗体 -抗原免疫复合物使膜电位发生变化 (ΔV) ,该变化的大小与溶胶 -凝胶 -抗体膜表面免疫反应进行的程度相关 ;本文以此为依据对CA15_3进行检测 ,在5~240U/mL范围内 ,ΔV与lgcCA15_3 呈良好的线性关系 ,线性相关系数r=0.998;该传感器响应迅速 ,灵敏度高 ,稳定性好 ,于4℃干态保存30d ,其响应信号基本不变。

 
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