To observe the protective effect of selenium enriched yeast(SEY)with different ig dose(30,60,90 mg/kg)for 7d on chemical liver injury produced by CCl 4 and D-Gal-N.
The projective effects of J - 911 on the acute liver injury in mice and the chronic liver in jury in rats were observed and studied by establishing animal models.
Hepatic SOD and GSH decreased, MDA and TG increased as liver injury and fibrosis developed.
随着肝脏损伤与肝纤维化的发展,肝脏SOD与GSH水平下降,MDA与TG水平上升。
The expression of CD19+CD25+ cells in peripheral blood in patients would reflect degree of liver injury and status of humoral immunity, that may be helpful to instruct clinical therapy and judge the prognosis.
Conclusions Ischemia preconditioning relieves the liver injury after reduced-size liver transplantation during early period,and facilitates the expression of Ref-1 protein in hepatic tissue after transplantation, implying the protection mechanism is at least partially relevant to the promotion of Ref-1 protein expression.
Changes in sphingomyelinase activity, tumor necrosis factor α expression, and level of lipid peroxidation products in the course of development of cholestatic liver injury have been studied.
In conclusion, induction of HO-1 provides protection against liver injury during cold ischemia preservation and improves the preservation of liver graft.
Effectiveness of pectin extracted from the eelgrass Zostera marina for alleviating lead-induced liver injury
The effects of pectin from the eelgrass Zostera marina on toxic liver injury induced by enteral administration of lead acetate are examined in experiments on rats.
The hepatoprotective potential of earthworm extract (EE) (Lampito mauritii, Kinberg) was evaluated against paracetamol-induced liver injury in Wistar albino rat, in comparison with silymarin, the standard hepatoprotective drug.
Toxic hepatitis was induced with carbon tetrachloride in mice. L-4-oxalysine (I-677) l00mg/kg injected daily has been proved to be effective in lowering the serum glutamic-pyruvate transaminase (SGPT) level in both aoute and subacute liver injuries. Pathological examinations also showed that the degeneration and necrosis of liver cells were protected by the administration of I-677. In the course of inducing experimental liver oirrhosis with CCl_4, I-677 administered for 8 weeks affected neither...
Toxic hepatitis was induced with carbon tetrachloride in mice. L-4-oxalysine (I-677) l00mg/kg injected daily has been proved to be effective in lowering the serum glutamic-pyruvate transaminase (SGPT) level in both aoute and subacute liver injuries. Pathological examinations also showed that the degeneration and necrosis of liver cells were protected by the administration of I-677. In the course of inducing experimental liver oirrhosis with CCl_4, I-677 administered for 8 weeks affected neither liver function besides a lowering of serum bilirubin, nor liver collagen content and histological appearance. The mechanism of serum GPT-lowering was found to be a lowering of hepatic enzyme activity. No direct inhibition on the activity of both liver and serum GPT was observed in vitro. The transaminase-lowering effect of I-677 could not be antagonized by simultaneous administrations of L-lysine. Amino-oxyacetic acid, a GPT inhibitor, showed potent inhibition on the GPT activity in vitro, but not in vivo. Large doses of I-677 (8-32 times the clinical dose) for 11 weeks in rats induced a lowering of serum albumin, a decrease of incorporation of ~3H-lysine into serum protein, and an increase of the lipid of liver. This revealed that albumin synthesis and lipid transport function of liver were inhibited by I-677, but this effect could be antagonized by L-lysine.
Schizandrin B, one of the components isolated from Fructus Schizandrae, was found to have protective action on liver injury and to increase the weight of liver in mice. In order to elucidate the cause and implications of the liver enlargement by Schizandrirn B, some studies were carried out in mice. The results indicate that the content of water, protein, RNA, glycogen and total lipid per gram liver of the group given Schizandrin B was almost the same as those of the control group, but...
Schizandrin B, one of the components isolated from Fructus Schizandrae, was found to have protective action on liver injury and to increase the weight of liver in mice. In order to elucidate the cause and implications of the liver enlargement by Schizandrirn B, some studies were carried out in mice. The results indicate that the content of water, protein, RNA, glycogen and total lipid per gram liver of the group given Schizandrin B was almost the same as those of the control group, but the amount of all these biochemical constituents markedly increased. The DNA content per gram liver decreased, although the total amount of DNA in whole liver was the same as that of the control.In partially hepatectomized mice, Schizandrin B was also shown to increase the protein, RNA and DNA contents as well as, mitosis of liver cells. In addition, Schizandrin B Was found to enhance-the incorporation of ~(14)G-phenylalanine into liver protein, and to increase hepatic microsomal cytochrome P-450 and protein contents significantly. From these results, it may be concluded that Schizandrin B is'an inducing agent of drug metabolizing enzyme, and the enlargement of the liver caused by Schizandrin B is mainly, due to hypertrophy and to a lesser degree, hyperplasia. However, Schizandrin B is different from phenobarbital in the respectof inducing drug metabolizing enzyme. The difference is that phenobarbital also induced an increase of liver cell microsomal RNA and phospholipid contents. Besides, phenobarbital wasshown to be able to shorten the survival time of CC14-intoxicated mice, while Schizandrin B did not.
The isolation, purification and identification of liver-specific membrane lipo-protein (LSP) is briefly presented. Human fetal liver was homogenized and submitted to 105,000 g for 1 hour. The supernatent was detected with presence of LSP. It was then fractioned by chromatography through Sephadex G-100 and Sephadex G-200. LSP revealed in the first peak.Nine rabbits of both sexes, weighing about 3 kg, were immunized with LSP to prepare antiserum. 80 sera of various liver disease patients were detected. Evidence...
The isolation, purification and identification of liver-specific membrane lipo-protein (LSP) is briefly presented. Human fetal liver was homogenized and submitted to 105,000 g for 1 hour. The supernatent was detected with presence of LSP. It was then fractioned by chromatography through Sephadex G-100 and Sephadex G-200. LSP revealed in the first peak.Nine rabbits of both sexes, weighing about 3 kg, were immunized with LSP to prepare antiserum. 80 sera of various liver disease patients were detected. Evidence of an immune response to the LSP was present in 18 of 23 cases (78.2%) of chronic active hepatitis. This observation suggests that the LSP may play an important role in the pathogenesis of liver injury.
liver injury
肝损伤
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