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mice
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  小鼠
    Screening and Cloning the Genes Related to Heterogeneity of Traumatic Responses in the Interstrain Mice
    小鼠创伤反应异质性相关基因的筛选与克隆
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    Study on the Mechanism of Urinary Trypsin Inhibitor Attenuates Hepatic Cold Ischemia-reperfusion Injury in Mice
    尿胰蛋白酶抑制剂减轻小鼠肝脏冷缺血再灌注损伤的作用机制研究
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    Wound Healing in CD36 Knock-out Mice
    CD36基因敲除小鼠的皮肤伤口愈合
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    Evaluation of Polymorphism in Hsp90 Functional Region and Its Effect on the Stress Competence of Mice
    Hsp90功能域多态性的鉴定及其对小鼠应激反应的影响
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    Mechanisms of Cyclosporine A and Tacrolimus Inhibiting the Expression of Costimulatory Molecule 4-1BB in Alloimmune Response after Heart Transplantation in Mice
    环孢霉素A和他克莫司抑制小鼠心脏移植免疫反应中4-1BB分子的表达及其机制研究
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    The Induction of Transplantation Tolerance and Prevention of Autoimmune Disease by Grafting with Mixed Fetal Thymus in Nude Mice
    混合胸腺移植诱导移植耐受及预防自身免疫损害的研究
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    Study on the Induction of Islet Transplantation Tolerance in Mice by Allogeneic Antigen-specific CD4~+CD25~+ Regulatory T Cells and Its Mechanisms
    抗原特异性CD4~+CD25~+调节性T细胞诱导胰岛移植耐受及其机制的初步研究
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    Studies of the direct contact inhibition of macrophages on T-cells aftertrauma in mice
    创伤后巨噬细胞对T淋巴细胞的直接接触免疫抑制作用
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    Transplantation of cultured human fetal pituitary cells in nude mice
    人胎脑垂体细胞移植于裸鼠的研究
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    Study of the gene expression changes of interleukin 2 and its receptor after burn injury and the modulation effects of ginsenoside in mice
    烧伤后白介素2与白介素2受体基因表达的变化及人参茎叶皂甙的调节作用
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  mice
Investigations of their biodistribution in mice showed all five pseudo-peptide chelators (MGQ, MGGQ, MAGQ, MVGQ, MFGQ) are rapidly cleared from blood, mainly through renal clearance.
      
The multiple antioxidant activity of the polysaccharides was evidenced by significant reducing power, superoxide scavenging ability, inhibition of mice erythrocyte hemolysis mediated by peroxyl free radicals, and also ferrous ion chelating potency.
      
Compounds Ia-Ih were hydrogenated with Pd-C to give IIa-IIh, and their hypoglycemic activity was evaluated with a glucose oxidase kit and insulin load test on normal mice.
      
The purified product was found to be biologically active and to reduce the food intake and body weight of mice during tests.
      
The effects of hematopoietic stem/progenitor cells (HSPCs) expanded in the two step coculture with human bone marrow mesenchymal stem cells (hMSCs) on the hematopoietic reconstruction of irradiated NOD/SCID mice were studied.
      
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As reported by us previously, FA pretreated grafts can prolong the mean survival time (MST) of both allo-and xenogenic skin grafts. On the basis that the 2nd set graft will be rejected earlier than the 1st one, the present 2 experiments were designed with the intension of exploring the role of FA in prolonging the survival time of skin grafts.Exp. Ⅰ: In the 1st set grafting, mice were divided into 2 groups, namely, non-pretreated skin grafting (control group) and FA-treated skin grafting(FA group). As...

As reported by us previously, FA pretreated grafts can prolong the mean survival time (MST) of both allo-and xenogenic skin grafts. On the basis that the 2nd set graft will be rejected earlier than the 1st one, the present 2 experiments were designed with the intension of exploring the role of FA in prolonging the survival time of skin grafts.Exp. Ⅰ: In the 1st set grafting, mice were divided into 2 groups, namely, non-pretreated skin grafting (control group) and FA-treated skin grafting(FA group). As soon as 2/3 of the control grafts were rejected, the still living grafts of the FA group were peeled off. Twenty days after the transplantation of the 1st set, the 2nd grafting were performed with non-pretreated skin on both groups of animals. No acceleration of rejection of FA-pretreated allografts was observed, and its MST was as long as that of grafting of control group in the 1st set. It denotes that FA has shown some effect in retarding the development of rejection response of the host. But the result is different in xenografting. There was accelerated rejection in both control and FA groups, indicating that in the 1st set grafting the host has also been sensitized by FA treated grafts, although the grafts themselves were protected by FA and showed no sign of rejection before they were peeled off.Exp. Ⅱ: In the 1st set grafting, all mice were grafted with non-pretreated skin to sensitize the hosts. Twenty days later, non-pretreated or FA treated skin grafts were transplanted. There was not only no accelerated rejection but also prolongation of MST of treated grafts in either allo-or xenografts. It suggests that FA protects the treated grafts against the rejective of the already sensitized hosts.Therefore, the preliminary impression of the role of FA in prolonging allo-or xenografts is mainly a temporary local protective effect against the host's rejection reaction. In allografting, in addition to local protection, there seems to be some effect of FA in retarding the establishment of immune response of the host.

实验一:在第1次植皮时,受皮小鼠分两组,对照组植以新鲜皮片,氟氢松醋酸酯(FA)组植FA处理的皮片。当2/3对照组皮片排斥时,将仍生长良好的FA组皮片撕去。于第1次植皮后20天给予第2次植皮,两组均植以新鲜皮片。在同种移植,FA组的第2次所植皮片未见加速排斥,其平均存活时间与对照组的第1次植皮相近,说明FA对宿主排斥反应的建立有一定的推迟作用。但在异种移植则不同,对照和FA组的第2次所植皮片均呈现加速排斥,说明在第1次植皮时,经FA处理的皮片在被撕去前已使宿主致敏,而皮片本身由于FA的保护作用仍生长良好,无被排斥的征兆。实验二:在第1次植皮时,所有小鼠均植以新鲜皮片,使宿主致敏。20天后分为两组分别植以新鲜皮片及经FA处理皮片。不论在同种或异种移植,经FA处理的皮片不仅未见加速排斥,且其存活期还有所延长。说明FA可以保护被处理皮片对抗已被致敏宿主的排斥反应。总之,关于FA的作用机理,可能是暂时性的局部保护作用,以对抗宿主的排斥。而在同种移植,还有一定的推迟宿主免疫反应建立的作用。

Human and horse polyvalent immune serum and immune globulin were used to control experimental pseudomonas aeruginosa sepsis in burned and unburned mice. The results indicated that the survival rates for the human immune preparations ranged from 70-85.7%; and that for the horse immunoglobulin ranged from 71.4-90% Furthermore, surviving mice showed a shortening of clinical course with rapid abatement of symptoms and signs. The,survival rate was 14.8-20% in untreated control groups, and most of the...

Human and horse polyvalent immune serum and immune globulin were used to control experimental pseudomonas aeruginosa sepsis in burned and unburned mice. The results indicated that the survival rates for the human immune preparations ranged from 70-85.7%; and that for the horse immunoglobulin ranged from 71.4-90% Furthermore, surviving mice showed a shortening of clinical course with rapid abatement of symptoms and signs. The,survival rate was 14.8-20% in untreated control groups, and most of the mice died in 1-4 days after, infection.It is therefore believed that this immunological approach is an efficacious adjunctive measure in controlling life-threatening infection caused by pseudo-monas aeruginosa.

本文报道应用人抗绿脓杆菌免疫血浆和免疫球蛋白,以及马抗绿脓杆菌免疫球蛋白治疗正常和烧伤小白鼠绿脓杆菌脓毒症的实验研究,均获得较好的特异性疗效。表现在:免疫治疗组动物活存率比对照组显著提高,人免疫血浆和免疫球蛋白治疗组为70~85.7%;马免疫球蛋白治疗组为71.4~90%;而且这些活存小白鼠接受治疗后症状迅速改善,脓毒症很快得到控制。相反,未经免疫治疗的对照动物,绝大部分在感染后1~4天内死于绿脓杆菌脓毒症,其活存率仅为14.3~20%。两者差异非常显著。因此,认为这类制剂的被动免疫,是治疗绿脓杆菌严重感染病人的一项有效措施。

Seven hundred and forty-six mice, weighing 30-35 grams, were divided into four groups randomly. The animals of the first three groups were inflicted with radiation injury (12 Gy total body irradiation from a Co60 source) , burn injury (15% of third degree burns), and combined injury of radiation and burns(12 Gy total body irradiation and 15% of third degree burns) respectively. The fourth group worked as normal control.The mortality and the dynamic changes of the intestinal epithelium of the experimental...

Seven hundred and forty-six mice, weighing 30-35 grams, were divided into four groups randomly. The animals of the first three groups were inflicted with radiation injury (12 Gy total body irradiation from a Co60 source) , burn injury (15% of third degree burns), and combined injury of radiation and burns(12 Gy total body irradiation and 15% of third degree burns) respectively. The fourth group worked as normal control.The mortality and the dynamic changes of the intestinal epithelium of the experimental animals were studied. It was found that the clinical course of the combined injury group was quite different from other two. The mortality of the combined injury group was higher and the damage on the intestinal epithelium was more severe than those of the radiation injury group in the first 48 hours after injury. In the second 48 hours, the mortality of the combined injury group became lower and the recovery of the intestinal epithelium faster.The reactions of the experimental animals to the combined injury of radiation and burn were-very complicate. Further investigation is essential to elucidate the mechanism and to formulate appropriate therapeutic measures.

体重30~35g杂种健康雄性小鼠746只,分设四组:单放(~(60)Co 12 Gy)、单烧(15%Ⅲ度)、放烧(两伤复合)和正常对照组。对比研究放烧复合后的死亡效应和肠上皮损伤效应的动态变化。结果表明复合效应有明显的病程阶段性差异:伤后48小时内放烧组死亡率较单放组为高,肠上皮损伤亦较重,其原因可能与早期休克有关。而伤后49~96小时,放烧组的死亡率却较单放组为低,肠上皮恢复亦较好。由此可见,机体对复合伤的反应十分复杂,必须对其作具体分析,有针对性地进行防治。

 
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