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mice
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  小鼠
    Studies on Intraocular Allogenic Melanomas and Associated Immune Deviation in Mice
    小鼠眼内移植性黑色素瘤及其相关免疫偏离的研究
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    Regulation of Somatostatin Receptor on Small Cell Lung Cancer Cells and Imaging of Radiolabeled RC-160 in Mice Bearing Tumors
    小细胞肺癌的生长抑素受体调变及核素标记RC-160的荷瘤小鼠显像研究
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    Experiment on Activation of Omental Milky Spots and Peritoneal Macrophages in Mice and Cytotoxicity Against the Gastric Cancer Cell SGC-7901
    激活小鼠网膜乳斑及腹腔巨噬细胞杀伤胃癌SGC-7901的实验研究
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    Establishment of the Human Bile Duct Carcinoma Model in Nude Mice and Its Application
    人胆管癌裸小鼠移植瘤模型的建立及其应用
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    Establishment and Characterization of a Human Acute Monocytic Leukemic Cell Line, SHI-1, Carrying t(6;11)(q27;q23) and Having High Tumorigenicity in Nude Mice
    伴有t(6;11)(q27;q23)易位的裸小鼠高致瘤性人单核细胞白血病细胞系SHI-1的建立和鉴定
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    A Study on Suppressive Effect and Its Molecular Mechanisms of Genistein on Growth and Invasion of Human Ovarian Carcinoma Cell Line SKOV_3 and Its Xenograft in Nude Mice
    Genistein对人卵巢癌细胞系SKOV_3及其裸移植瘤生长和侵袭的抑制作用与分子机理的研究
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    Study on Radiommunoimaging and Radiommunotherapy with ~(131)Ⅰ-Anti-CEA, TPS Monclonal Antibody in Nude Mice Bearing Human Breast Carcinoma
    ~(131)Ⅰ标记的抗CEA、TPS单克隆抗体在荷人乳腺癌裸体内的放射免疫显像及治疗的研究
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    Inhibitory Effect of p27kip1 Gene Transfere on Esophageal Carcinoma Cells and Its Transplantable Models in Nude Mice
    p27kip1基因转移对食管癌细胞及裸移植瘤生长的抑制作用
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    Gene Therapy Mediated by Angiostatin and aHIF for C6 Subcutaneous Glioma in Nude Mice
    Angiostatin和aHIF基因治疗裸胶质瘤的实验研究
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    Experimental Study of Treating Impanted Human Primary Hepatic Carcinoma of Nude Mice by Angiostatin Gene and Antisense HIF-1α Gene In-Vivo
    Angiostatin基因联合反义HIF-1α基因治疗人肝癌裸移植瘤的实验研究
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    Antitumor Effect and Pharmacokinetic Properties of F951, a Novel Antisense Phosphorothioate Oligodeoxynucleotide to Bcl-2, on Human Lymphoma Cell in Vitro and in Mice
    一种新的Bcl-2反义硫代磷酸寡脱氧核苷酸(F951)治疗人恶性淋巴瘤的药效学和药代动力学实验研究
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    Prevent and Therapeutic Antitumor Response to Cervical Cancer in Mice Immunized with U14 Cell Vaccines Transfected with Costimulatory B7 Gene and HPV16E6/B7 DNA Recombinant Vaccines
    B7修饰的U14细胞疫苗和HPV16E6/B7重组基因疫苗预防及治疗宫颈癌实验研究
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    The Experiment Study on Chlorophyllin Preventing Colorectal Tumors Induced by DMH in Mice and Inhibiting HT29 Cells in Vitro
    叶绿酸铜钠预防化学诱导大肠肿瘤的实验研究及对HT29肠癌细胞的体外抑制作用研究
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    The Immunotherapeutic Effect of Dendritic Cell Vaccine Modified with IFN-γ Inducible Protein-10 Gene and Tumor Cell Lysate on Mice with Prostate Cancer
    干扰素γ诱导蛋白10基因与肿瘤抗原修饰树突状细胞抗前列腺癌实验研究
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    Antitumor Effect of F951, a Novel Antisense Phosphorothioate Oligodeoxynucleotide to Bcl-2, on Human Small Cell Lung Cancer in Vitro and in Mice
    新型Bcl-2反义寡核苷酸(F951)治疗人小细胞肺癌的药效学实验研究
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  mice
Investigations of their biodistribution in mice showed all five pseudo-peptide chelators (MGQ, MGGQ, MAGQ, MVGQ, MFGQ) are rapidly cleared from blood, mainly through renal clearance.
      
The multiple antioxidant activity of the polysaccharides was evidenced by significant reducing power, superoxide scavenging ability, inhibition of mice erythrocyte hemolysis mediated by peroxyl free radicals, and also ferrous ion chelating potency.
      
Compounds Ia-Ih were hydrogenated with Pd-C to give IIa-IIh, and their hypoglycemic activity was evaluated with a glucose oxidase kit and insulin load test on normal mice.
      
The purified product was found to be biologically active and to reduce the food intake and body weight of mice during tests.
      
The effects of hematopoietic stem/progenitor cells (HSPCs) expanded in the two step coculture with human bone marrow mesenchymal stem cells (hMSCs) on the hematopoietic reconstruction of irradiated NOD/SCID mice were studied.
      
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1. Changes in some enzymatic activities and content of -SH group of the skin of mice during carcinogenesis induced by methylcholanthrene were investigated.

(一)对表皮LDH、ATP酶、組織蛋白酶的某些性貭作了初步研究。(二)在甲基胆蒽誘发皮肤癌过程中,观察到:(1)組織提取液的蛋白貭含量有所增高;(2)GDH、GOT、谷氨酰胺酶的活性显著降低;(3)LDH的活性显著增高;(4)組織蛋白酶与二肽酶活性在增生期有所增高;在乳头瘤及皮肤癌則略有降低;(5)ATP酶活性无显著变化;(6)在增生期蛋白—SH基增多,非蛋白—SH基減少;乳头瘤与皮肤癌的蛋白—SH基接近正常,非蛋白—SH基增多。(三)在皮肤引癌早期,如滴甲基胆蒽一次后2斗小时,GDH活性即显著下降,而LDH活性仍接近正常。(四)滴非致癌物,蒽对表皮GDH及LDH活性无显著影响。(五)結合形态学的观察,对上述酶活性及—SH基变化在皮肤癌变中的可能意义,作了簡短討論。

Mice inoculated with Ehrlich ascites carcinoma cells were intraperitoneally injected on the 8th day with actinomycin K. The animals were killed 6 hours after injection.

小白鼠接种Ehrlich腹水癌細胞后第8天,腹腔注射生理盐水(对照組)或放线菌素K,6小时后解剖,研究放綫菌素K对癌細胞核酸等含量的影响。当放綫菌素K的剂量为50微克/公斤体重(治疗剂量)时,6小时后每毫克干重癌細胞中酸溶磷、脂溶磷、RNA和DNA的含量都沒有变化。增高剂量为400微克/公斤时,每毫克干重癌細胞中酸溶磷、无机磷、脂溶磷、核蛋白氮以及DNA的含量仍沒有明显改变,但RNA含量則降低。以細胞为单位作比較,結果也一致。若于接种后第3天开始給药,剂量为50微克/公斤/天,共5天,停药后6小时解剖。每单位細胞的干重稍有減低,但經t测驗比較,相差不显著。每单位癌細胞中酸溶磷、脂溶磷和DNA沒有明显影响,RNA則下降更甚而核蛋白氮也开始減少。若以干重为单位比較,RNA仍有很大降低,核蛋白氮相差不明显而DNA反有显著升高。于一次注射药物后2小时,皮下注射Na_2HP~(32)O_41微居里/克体重,再隔4小时后解剖,比較对照組和給药組癌細胞中酸溶磷、无机磷和RNA的比放射強度(脉冲数/分钟/微克磷)。发現給药組酸溶磷和无机磷的比放射強度,不論剂量为50或400微克/公斤,都不变。RNA的比放射強度則下降:50微...

小白鼠接种Ehrlich腹水癌細胞后第8天,腹腔注射生理盐水(对照組)或放线菌素K,6小时后解剖,研究放綫菌素K对癌細胞核酸等含量的影响。当放綫菌素K的剂量为50微克/公斤体重(治疗剂量)时,6小时后每毫克干重癌細胞中酸溶磷、脂溶磷、RNA和DNA的含量都沒有变化。增高剂量为400微克/公斤时,每毫克干重癌細胞中酸溶磷、无机磷、脂溶磷、核蛋白氮以及DNA的含量仍沒有明显改变,但RNA含量則降低。以細胞为单位作比較,結果也一致。若于接种后第3天开始給药,剂量为50微克/公斤/天,共5天,停药后6小时解剖。每单位細胞的干重稍有減低,但經t测驗比較,相差不显著。每单位癌細胞中酸溶磷、脂溶磷和DNA沒有明显影响,RNA則下降更甚而核蛋白氮也开始減少。若以干重为单位比較,RNA仍有很大降低,核蛋白氮相差不明显而DNA反有显著升高。于一次注射药物后2小时,皮下注射Na_2HP~(32)O_41微居里/克体重,再隔4小时后解剖,比較对照組和給药組癌細胞中酸溶磷、无机磷和RNA的比放射強度(脉冲数/分钟/微克磷)。发現給药組酸溶磷和无机磷的比放射強度,不論剂量为50或400微克/公斤,都不变。RNA的比放射強度則下降:50微克/公斤組降低40%,400微克/公斤組降低52%。

Six principles were extracted from the Chinese traditional drug Schisandra sphenanthera Rehd et Wils., and their chemical structures were characterized. Schisantherin A, B, C and D have been shown to be effective in lowering the serum glutamic-pyruvic transaminase (GPT) of hepatitis in experimental animals and in patients, while deoxyschisandrin and schisantherin E were not.Ultrastructural modifications of hepatic cells were observed by electron microscopy after carbon tetrachloride intoxication in mice....

Six principles were extracted from the Chinese traditional drug Schisandra sphenanthera Rehd et Wils., and their chemical structures were characterized. Schisantherin A, B, C and D have been shown to be effective in lowering the serum glutamic-pyruvic transaminase (GPT) of hepatitis in experimental animals and in patients, while deoxyschisandrin and schisantherin E were not.Ultrastructural modifications of hepatic cells were observed by electron microscopy after carbon tetrachloride intoxication in mice. The hepatic cellular injuries were protected by schisantherin A. This drug has no direct toxic action on the liver cells.Tritium labeled schisantherinol A is absorbed quickly after oral administration in mice. It is transformed from lipid-soluble to water-soluble metabolites in the liver, and excreted mainly by the kidney.The transaminase of rat liver was purified and immunized to rabbits. By means of antigen-antibody reactions, lowering of the activity of serum GPT was found to be due to inhibition of the activity of the liver enzyme by the drug.

从华中五味子中分离得6种结晶成分,并确定了它们的化学结构。其中酯甲、乙、丙及丁经药理和临床试验证明有降低血清GPT作用,去氧五味子素及酯戊无效。用电子显微镜观察酯甲对小鼠四氯化碳中毒后肝细胞亚微结构的影响,认为肝细胞的损伤受到保护,酯甲对肝细胞无直接损害作用。氚标记醇甲口服后很快吸收,在肝内从脂溶性迅速转化为水溶性代谢物,主要经肾排泄。提纯大鼠肝GPT酶蛋白,免疫家兔后,用抗原抗体反应证明酯甲的降酶机理可能与抑制肝内GPT活力有关。

 
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