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mice
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  小鼠
    Studies of the Impairing Effects and Mechanism of Action of Selective Estrogen Receptor Modulators on Learning and Memory Function in Mice
    选择性雌激素受体调节剂对小鼠学习记忆功能的损伤作用及机理研究
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    Impact of Itraconazole/IFN-gamma on Immune Function of Mice Infected with Fungi
    伊曲康唑γ-干扰素对真菌感染小鼠免疫功能的影响
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    STUDIES ON ANTIBILHARZIAL DRUGS ⅩⅩⅦ.SCREENING OF 377 COMPOUNDS ON SCHISTOSOMIASIS JAPONICA IN MICE
    防治血吸虫病药物的研究 ⅩⅩⅦ.377种药物对小鼠日本血吸虫病的治疗
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    THE ANABOLIC AND ANDROGENIC ACTIVITIES OF 17α-METHYLTESTOSTERONE AND RELATED STEROIDS IN CASTRATED RATS AND MICE
    17α-甲基睾丸素及其某些衍生物对去势大鼠和小鼠同化作用的观察
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    LABORATORY STUDIES ON A TRANSPLANTABLE MOUSE LEUKEMIA (L615) Ⅴ. THE USE OF L615 LEUKEMIC MICE IN THE SCEEENING OF ANTI-TUMOK AGENTS
    可移植性小鼠白血病(L615)的实验研究——Ⅴ.L615在筛选抗癌药物中的应用
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    Protection Functions and Mechanisms of IFN-PDS on Virus Pneumonia in Mice Infected with a Type Influenza Virus
    IFN-PDS合剂对甲型流感病毒噬肺强毒株所致病毒性肺炎的保护作用及机制研究
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    EXPERIMENTAL THERAPY OF SCHISTOSOMIASIS JAPONICA,Ⅻ.EFFECTIVENESS OF 8-HYDROXYQUINOLINE-ANTIMONY COMPLEX IN THE ORAL TREATMENT OF EXPERIMENTAL SCHISTOSOMIASIS IN MICE
    口服8-羟喹啉锑实验治疗小白血吸虫病的研究(血吸虫病实验治疗研究之十二)
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    STUDIES ON HEMEROCALLIS THUNBERGII BAKER Ⅱ.EFFECTIVENESS OF HEMEROCALLIS THUNBERGII IN ORAL TREATMENT OF EXPERIMENTAL SCHISTOSOMIASIS IN MICE
    萱草根的研究 Ⅱ.萱草根实验治疗小白血吸虫病的研究
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    STUDIES ON ANTITUMOR DRUGS ⅩⅥ. THE EFFECT OF COMBINATION THERAPY OF Sb-71 WITH SOME METAL SALTS ON EHRLICH ASCITES CARCINOMA IN MICE
    抗肿瘤药物的研究 ⅩⅥ.Sb-71与几种金属盐合并治疗小白Ehrlich腹水癌的作用
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    METABOLISM OF QUATERNARY SALT OF ~(14)C-SiNOMENINE A BISMETHYLIODIDE IN MICE
    ~(14)C-汉防己甲素双碘甲烷季铵盐在小白体内的代谢
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  “mice”译为未确定词的双语例句
    Study on the Antitumor Effect and Toxicity of F951, a Novel Antisense Phosphorothioate Oligodeoxynucleotide to Bcl-2, on AML, Both in Vitro and in Mice
    新型Bcl-2反义寡核苷酸(F951)治疗急性髓性白血病药效学和毒理学实验研究
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    STUDIES ON ANTITUMOR DRUGS——ⅩⅦ.INFLUENCE OF Sb-71 ON INCORPORATION OF Zn~(65)INTO TUMOR CELLS IN MICE BEARING EHRLICH ASCITES CARCINOMA
    抗肿瘤药物的研究 ⅩⅦ.Sb-71对Zn~(65)渗入Ehrlich腹水瘤细胞的影响
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    THE STUDY ON THE DNA BIOSYNTHESIS OF VARIOUS SEGMENT OF INTESTINAL MUCOSA IN MICE BY INCORPORATING ~3H-TdR INTO DNA
    应用~3H-TdR掺入试验观察不同肠段粘膜DNA生物合成
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    PRELIMINARY STUDIES OF THE RADIOPROTECTIVE MECHANISM OF WR-2721 ON THE INTESTINAL EPITHELIUM IN IRRADIATED MICE
    WR-2721防护肠上皮辐射损伤机理的初步探讨
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    Experiment study on the treating effects of diazepam on mice poisoned by isoniazid
    安定治疗异烟肼急性中毒的实验研究
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  mice
Investigations of their biodistribution in mice showed all five pseudo-peptide chelators (MGQ, MGGQ, MAGQ, MVGQ, MFGQ) are rapidly cleared from blood, mainly through renal clearance.
      
The multiple antioxidant activity of the polysaccharides was evidenced by significant reducing power, superoxide scavenging ability, inhibition of mice erythrocyte hemolysis mediated by peroxyl free radicals, and also ferrous ion chelating potency.
      
Compounds Ia-Ih were hydrogenated with Pd-C to give IIa-IIh, and their hypoglycemic activity was evaluated with a glucose oxidase kit and insulin load test on normal mice.
      
The purified product was found to be biologically active and to reduce the food intake and body weight of mice during tests.
      
The effects of hematopoietic stem/progenitor cells (HSPCs) expanded in the two step coculture with human bone marrow mesenchymal stem cells (hMSCs) on the hematopoietic reconstruction of irradiated NOD/SCID mice were studied.
      
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Acute toxicity experiment consisted of one single intraperitoneal injection, while subacute toxicity experiment consisted of one injection daily for 14 days, of tartar emetic and a subsequent 3-day holding period. The mortality of mice from tartar emetic was observed after concomitant injections of 5 testing drugs (procaine-HCl, sodium phenyl acetate, sodium α α'-dimercaptoadipate, sodium mercaptosuccinate and sodium thiosulfate). The effective detoxicants were mixed up with tartar emetic and then injected...

Acute toxicity experiment consisted of one single intraperitoneal injection, while subacute toxicity experiment consisted of one injection daily for 14 days, of tartar emetic and a subsequent 3-day holding period. The mortality of mice from tartar emetic was observed after concomitant injections of 5 testing drugs (procaine-HCl, sodium phenyl acetate, sodium α α'-dimercaptoadipate, sodium mercaptosuccinate and sodium thiosulfate). The effective detoxicants were mixed up with tartar emetic and then injected intraperitoneally, once daily for 14 days, to infected mice. The mice were killed after a holding period of another 14 days. Basing on the average number of worms remained in each mouse, the effects of detoxicants on the antibilharzial activity of tartar emetic were compared. The results were as follows: (1) In mice the acute and subacute LD_(50) after intraperitoneal injection of tartar emetic were found to be 38 and 35 mg/kg/day respectively. (2) The mortality of mice from tartar emetic could be markedly reduced by simultaneous injection of procaine, sodium phenyl acetate, sodium α α'-dimercaptoadipate and sodium mercaptosuccinate, while sodium thiosulfate did not afford any protection. (3) Procaine, sodium phenyl acetate, sodium α α'-dimercaptoadipate and sodium mercaptosuccinate did not decrease the therapeutic. activity of tartar emetic, and, moreover, procaine could significantly augment its therapeutic activity against schistosomiasis japonica.

本文叙述了5种药物(盐酸普鲁卡因、苯乙酸钠、aa′-二巯基己二酸钠、巯基丁二酸钠及硫代硫酸钠)对小白鼠腹腔注射吐酒石急性(注射1次,观察3天)及亚急性(注射14天,观察3天)中毒死亡的影响;并将其中有效解毒药分别和吐酒石混合後腹腔注射小鼠14天以治疗日本血吸虫病,然後停药14天解剖,根据平均每鼠余存虫数比较各药对於吐酒石疗效的影响。结果如下: (一)小白鼠腹腔注射吐酒石急性及亚急性LD_(50)分别为38及35毫克/千克/天。 (二)普鲁卡因、苯乙酸钠、aa′-二巯基己二酸钠及巯基丁二酸钠能使小鼠腹腔注射吐酒石急性及亚急性中毒死亡率明显地减低,而硫代硫酸钠则无效。 (三)普鲁卡因、苯乙酸钠、aa′-二巯基己二酸钠及巯基丁二酸钠4种解毒药并不减低吐酒石之疗效,其中普鲁卡因尚能提高吐酒石治疗日本血吸虫病之疗效。

(1) White mice were exposed to 40 cercariae of Schistosoma japonicum on the abdomen for 3, 5, 10, 15 and 20 minutes. Five weeks later, mice were killed and searched for worms. The percentage of worms recovered in the 5-minute group was found to be low (33%), whereas the differences between those in the 10-minute (45%), 15-minute (51%) and 20-minute (54%) groups were non-significant. (2) Infected mice were treated with tartar emetic given by mouth for 2 weeks. After a holding period of 1, 2,...

(1) White mice were exposed to 40 cercariae of Schistosoma japonicum on the abdomen for 3, 5, 10, 15 and 20 minutes. Five weeks later, mice were killed and searched for worms. The percentage of worms recovered in the 5-minute group was found to be low (33%), whereas the differences between those in the 10-minute (45%), 15-minute (51%) and 20-minute (54%) groups were non-significant. (2) Infected mice were treated with tartar emetic given by mouth for 2 weeks. After a holding period of 1, 2, 3 or 4 weeks, mice were sacrificed. The differences between the number of worms remained in the 4 groups of mice were non-significant. Therefore, one week may be adopted as the holding period in the screening test for antimonials. (3) In the control group and in the treated group with tartar emetic 270 mg/kg/day, there was no significant difference between the number of worms remained in male and in female mice. But in the treated group with tartar emetic 170 mg/kg/day, the number of worms remained in female mice was less than that in male mice. Hence it is advisable to use equal number of both sexes of mice in experimental therapy. (4) After the treatment with tartar emetic, mice were divided into 2 grades according to the body weights. The number of worms remained in mice of the 2 grades revealed a significent difference only in the group with holding period of 3 weeks, but not in other groups.

(一)小白鼠腹部皮肤感染40条日本血吸虫尾蚴,感染时间自3至20分钟不等,5周後解剖,检查成虫数,发现感染尾蚴5分钟的成虫发育率较低(33%),而感染10分钟(45%),15分钟(51%)及20分钟(54%)之差别不显著。 (二)病员经口服吐酒石治疗2周後停药1,2,3或4周解剖,发现余存虫数之差别并不显著。所以可用1周作为比较锑剂疗效试验的停药时间。 (三)对照组及吐酒石270毫克/千克/天剂量组内,雌雄鼠体内余存虫数相差不显著,但在吐酒石1700毫克/千克/天治疗组内,雌鼠体内的余存虫数少於雄鼠体内的虫数。所以实验治疗所用的小白鼠最好是雌雄各半。 (四)吐酒石治疗後大小两级体重鼠体内余存虫数,仅在停药3周组内有显著的差别:其他组内则未见显著差别。

Four water soluble organic trivalent antimony compounds such as sodium antimony gluconate, potassium antimony saccharate, sodium antimony citrate and sodium antimony mannitol have been prepared by the reaction of polyhydroxyl acids or polyhydroxyl alcohols with antimony trichloride, antimonyoxychloride or antimonous oxide in the presence of alkali. The aqueous solution of sodium antimony gluconate is not stable and can be stablized by adjusting its pH value with the addition of gluconic acid. The sodium antimony...

Four water soluble organic trivalent antimony compounds such as sodium antimony gluconate, potassium antimony saccharate, sodium antimony citrate and sodium antimony mannitol have been prepared by the reaction of polyhydroxyl acids or polyhydroxyl alcohols with antimony trichloride, antimonyoxychloride or antimonous oxide in the presence of alkali. The aqueous solution of sodium antimony gluconate is not stable and can be stablized by adjusting its pH value with the addition of gluconic acid. The sodium antimony mannitol, prepared from 2 moles of mannitol and 1 mole of antimonous oxide, is also not stable. Its stability can be increased by changing the mole ratio of the reactants, mannitol and antimonous oxide, to 3:1. This product is probably a complex compound of sodium antimony mannitol and mannitol. All of them have been proved to possess the therapeutic action in the treatment of experimental infections of Schistosoma japonicum in mice.

水溶性多羟酸或多元醇的三价銻化合物,如葡萄糖酸銻鈉,糖酸锑鉀,檸檬酸锑鈉及甘露醇锑鈉,可由多羟酸或多元醇与三氯化锑,氯氧化锑或三氧化二锑在鹼性溶液中制取。葡萄糖酸锑鈉水溶液性不稳定,可用葡萄糖酸調节其pH值,以增其稳定性。由二分子甘露醇和一分子三氧化二锑作用而成的甘露醇锑鈉的水溶液,亦不稳定.我們改由三分子甘露醇及一分子三氧化二锑作用,則所得产物的水溶液稳定。由其锑含量推測,此产物可能为一分子甘露醇锑鈉及一分子甘露醇的复合物。

 
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