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regulation region
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  调控区
    The gene sequences of α 2A-adrenergic receptor (α 2A-AR) in 39 Chinese and 1 Englishman showed 13 differences of g or c insertion or deletion in its regulation region, coding region and 3′ untranslated region, compared with that reported in GenBank.
    对 39名中国人和 1名英国白人α2A 肾上腺素能受体 (α2A AR)全长基因序列分析显示 ,其序列与GenBank中人α2A AR基因序列在调控区、编码区和 3′非编码区存在 13处 g或C插入或缺失的不同 ,但所有人的α2A AR基因序列则完全一致 ,包括该基因不同批次PCR产物正义链和反义链测序结果。
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  regulation region
A site-directed mutant DNA fragment was synthesized and transfected into clinical Neisseria Gonorrhoeae (NG) stains to construct the transformants that contained the corresponding mutagenesis of regulation region of mtrR gene.
      
In vitro recombination and identification of mutated fragment corresponding to regulation region of mtrR gene of Neisseria Gonor
      
The mutation (C→T) in the 5' regulation region of chicken MC4R gene results in one more NF-E2 and cap transcription factor binding sites in the mutation allele than in the wild allele.
      
Unusual structure in the regulation region of the Bacillus subtilis riboflavin biosynthesis operon.
      
The genes of most of the structural muscle proteins have a MyoD-binding regulation region.
      
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The gene sequences of α 2A-adrenergic receptor (α 2A-AR) in 39 Chinese and 1 Englishman showed 13 differences of g or c insertion or deletion in its regulation region, coding region and 3′ untranslated region, compared with that reported in GenBank. The gene sequences from all the samples respectively were identical except for 2 single nucleotide polymorphisms, including the sequence of sense and antisense strand sequenced. It was found that: (1) the frequency of gg genotype...

The gene sequences of α 2A-adrenergic receptor (α 2A-AR) in 39 Chinese and 1 Englishman showed 13 differences of g or c insertion or deletion in its regulation region, coding region and 3′ untranslated region, compared with that reported in GenBank. The gene sequences from all the samples respectively were identical except for 2 single nucleotide polymorphisms, including the sequence of sense and antisense strand sequenced. It was found that: (1) the frequency of gg genotype in Chinese and Japanese, who are high susceptible to motion sickness, were 5.8 and 7.8 fold higher than that in Englishmen; (2) g allele frequencies in Chinese and Japanese were higher than latter ( P<0.01 ); (3) gg genotype frequency in population susceptible to motion sickness was 1.6 fold higher than that in population unsusceptible to motion sickness, and g allele frequency was higher than latter (P<0.01). All the populations were in Hardy-Weinberg equilibrium. The results suggested that gg genotype and g allele at site -1296 in α 2A-AR gene could associate with the susceptibility to motion sickness.

对 39名中国人和 1名英国白人α2A 肾上腺素能受体 (α2A AR)全长基因序列分析显示 ,其序列与GenBank中人α2A AR基因序列在调控区、编码区和 3′非编码区存在 13处 g或C插入或缺失的不同 ,但所有人的α2A AR基因序列则完全一致 ,包括该基因不同批次PCR产物正义链和反义链测序结果。得到的人α2A AR基因序列已在GenBank登录 (AY0 32 736 )。对α2A AR基因调控区第 - 12 96位基因型在晕动病易感性不同人群中分布情况的分析结果显示 ,晕动病易感性较高的中国和日本人群分别与易感性较低的英国人群相比 ,前两者该位点 gg基因型分别是后者的 6 .8倍和 8.8倍 ,g等位基因频率均明显高于后者 (P <0 .0 1) ;中国汉族无亲缘关系的晕动病易感人群与不易感人群 (歼击机飞行员 )相比 ,前者该位点 gg基因型是后者的 2 .6倍 ,g等位基因频率亦明显高于后者(P <0 .0 1)。各组人群等位基因分布均符合Hardy Weinberg平衡。提示 ,α2A AR基因第 - 12 96位 gg基因型和g等位基因可能与晕动病易感性有关

Objective The present study was to investigate whether a polymorphism in the promoter region of the serotonin 2C (5 HT 2C ) receptor gene was associated with tardive dyskinesia (TD) in schizophrenic patients Methods Forty two male schizophrenic patients with TD and 50 without TD were entered the study The diagnosis of TD was made according to the Abnormal Involuntary Movement Scale (AIMS) score, with the AIMS score≥3 as having TD Psychiatric symptoms were rated using the Brief Psychiatric Rating...

Objective The present study was to investigate whether a polymorphism in the promoter region of the serotonin 2C (5 HT 2C ) receptor gene was associated with tardive dyskinesia (TD) in schizophrenic patients Methods Forty two male schizophrenic patients with TD and 50 without TD were entered the study The diagnosis of TD was made according to the Abnormal Involuntary Movement Scale (AIMS) score, with the AIMS score≥3 as having TD Psychiatric symptoms were rated using the Brief Psychiatric Rating Scale The 5 HT 2C receptor gene polymorphism was analyzed with the polymerase chain reaction restriction fragment length polymorphism Results A significant excess of -697C (mutant) (χ 2=4 7, P =0 03, OR =2 8) and a trend excess of -759T (χ 2=2 9, P =0 09) was in patients with TD compared to those without However, neither of the alleles -697C and -759T nor any clinical demographic characteristics were associated with the AIMS total scores in patients with TD There were no significant differences in clinical demographic characteristics and scores of clinical assessment between two allelic types of -759, or -697, in all schizophrenic patients or only patients with TD ( P >0 05) Conclusion The -697 mutant in the promoter regulation region of the 5 HT 2C receptor gene may be a risk factor for the susceptibility of TD in schizophrenic patients

目的 探讨 5 羟色胺 2C(5 HT2C)受体基因启动区 - 759C/T和 - 697G/C单碱基置换多态性与精神分裂症伴迟发性运动障碍 (TD)的相关性。方法 先用异常不自主运动量表 (AIMS)评定精神分裂症男性患者有无TD及其严重程度 ,再对 42例符合TD(AIMS总分≥ 3分 )者和与TD组严格相匹配的 50例非TD者 ,采用简明精神病评定量表 (BPRS)评定精神症状 ,并应用聚合酶链反应 限制性片段长度多态性方法分析 5 HT2C受体基因的分布频率。结果  (1 )TD组的 - 697C(突变型 )半合子型频率 (38% )高于非TD组 (1 8% ;χ2 =4 7,P =0 0 3 ,OR =2 8)。TD组 - 759T(突变型 )半合子型频率和 - 759T/ - 697C突变型单倍体频率虽高于非TD组 ,但差异均无显著性 (χ2 值分别为 2 9和 4 9,P =0 0 9)。 (2 )TD组的AIMS和BPRS评分分别为 (6 5± 1 8)分和 (51 2± 7 8)分 ,非TD组分别为 0分和(50 0± 7 3)分 ,差异无显著性 (P >0 0 5)。结论 ...

目的 探讨 5 羟色胺 2C(5 HT2C)受体基因启动区 - 759C/T和 - 697G/C单碱基置换多态性与精神分裂症伴迟发性运动障碍 (TD)的相关性。方法 先用异常不自主运动量表 (AIMS)评定精神分裂症男性患者有无TD及其严重程度 ,再对 42例符合TD(AIMS总分≥ 3分 )者和与TD组严格相匹配的 50例非TD者 ,采用简明精神病评定量表 (BPRS)评定精神症状 ,并应用聚合酶链反应 限制性片段长度多态性方法分析 5 HT2C受体基因的分布频率。结果  (1 )TD组的 - 697C(突变型 )半合子型频率 (38% )高于非TD组 (1 8% ;χ2 =4 7,P =0 0 3 ,OR =2 8)。TD组 - 759T(突变型 )半合子型频率和 - 759T/ - 697C突变型单倍体频率虽高于非TD组 ,但差异均无显著性 (χ2 值分别为 2 9和 4 9,P =0 0 9)。 (2 )TD组的AIMS和BPRS评分分别为 (6 5± 1 8)分和 (51 2± 7 8)分 ,非TD组分别为 0分和(50 0± 7 3)分 ,差异无显著性 (P >0 0 5)。结论  5 HT2C受体基因启动控制区的 - 697G/T单碱基置换突变可能是精神分裂症患者发生TD的易感因素之一

 
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