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mutant mice
相关语句
  突变型小鼠
     STUDY ON LEARNING AND MEMORY OF MUTANT MICE
     突变型小鼠在学习记忆研究中的应用
短句来源
     Objective To observe the difference in lung injury between toll-like receptor 4(TLR4) mutant mice and wild type mice in a model of hypovolemic shock resuscitation plus lipopolysaccharide(LPS) attack induced acute lung injury(ALI).
     目的观察Toll样受体4(toll-like receptor 4,TLR4)基因突变型小鼠与野生型小鼠急性肺损伤(acute lung injury,ALI)模型中肺组织损伤差异,分析不同TLR4遗传性状对ALI发生的影响及机制。
短句来源
  突变小鼠
     The STAT3 mutant mice were highly susceptible to ES with increased serum concentration of inflammatory cytokines such as tumor necrosis factor-a(TNF-a), interleukin-lp (IL-13) and interleukin-6 (IL-6).
     已有报道缺乏STAT3的突变小鼠对ES高度敏感,血清炎性细胞因子如肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白介素-1β(interleukin-1β,IL-1β) 和白介素-6(nterleukin6,IL*)浓度增加。
短句来源
     Early T Cell Development in Gene Targeted Mutant Mice
     基因打靶突变小鼠的早期T细胞发育
短句来源
     The mutant mice exhibited cardiac hypertrophy at 1-month-old, with the increased ratio of Heart Weight/Body Weight(HW/BW), Heart Weight/Tibia Length(HW/TL) and upregulation of the hypertrophic marker genes, such as MHCp, ANF and BNP.
     Smad4基因剔除小鼠在1月龄开始出现心肌肥厚,其心脏与体重(HW/BW)、心脏与胫骨长度(HW/TL)的比值较对照小鼠明显升高,MHCβ,ANF,BNP等心肌肥厚的标志性分子在突变小鼠心肌中的表达水平也显著上调。
短句来源
     Eya1 knock-out mutant mice were used to dig the functions of Eya1 in eye development.
     以Eya1基因的敲除突变小鼠为实验对象,初步研究了Eya1基因在小鼠眼发育中的作用.
短句来源
     2) Positional cloning of host-resistance genes in mutant mice;
     (2 )在突变小鼠中 ,宿主抗性基因位置克隆 ;
短句来源
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  基因突变小鼠
     Methods: Bcl-2 over-expression transgenic mice were mated with GFAP/Vimentin double gene knock out mice (GFAP-/-/Vim-/-) to produce Bcl-2 tg/GFAP-/-/Vim-/- triple mutant mice (3M).
     方法:将Bcl-2高表达转基因小鼠(Bcl-2tg)和GFAP/Vimentin双基因敲除小鼠(GFAP-/-/Vim-/-)交配获得三基因突变小鼠(Bcl-2tg/GFAP-/-/Vim-/-,3M)。
短句来源
     The expression of TLR4 mRNA and activation of NF-κB were increased following hemorrhagic shock in wild type mice,while there was no significant change in TLR4 mutant mice.
     基因突变小鼠肺组织TLR4 mRNA表达及NF-κB活性变化不明显,而野生型小鼠TLR4 mRNA在2、4和6h表达增加,NF-κB在失血性休克后1和2 h活性显著增加。
短句来源
     Study on differentially expressed gene of the liver of treble fatty metabolism genes mutant mice using cDNA microarray
     脂代谢相关三基因突变小鼠肝组织基因表达差异研究
短句来源
     Pax6 heterozygous mutant mice displayed islet dysfunction and homozygous mutant mice showed absent of a cells.
     第一部分 ENu诱变和筛选得到Pax6基因突变小鼠
短句来源
     Results:The lung neutrophil infiltration and erythrocyte effusion in toll-like receptor 4 mutant mice were milder than those in wild type mice.
     结果:失血性休克刺激后,基因突变小鼠肺组织中性粒细胞浸润、红细胞渗出较野生型小鼠明显减轻;
短句来源
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  “mutant mice”译为未确定词的双语例句
     Methods 5 wild-type mice(100% Cu/ZnSOD activity,Sod1+/+)and 15Cu/ZnSOD gene (Cu/Zn superoxide dismutase gene,Sod1)knockout mice including 5 homozygous mutant mice (no measurable Cu/ZnSOD activity,Sod1-/-)and 10 heterozygous mutant mice (50% reduction of Cu/ZnSOD activity,Sod1+/-)were detected by nested polymerase chain reaction (PCR).
     方法 对 5只Cu/ZnSOD基因敲除纯合突变 (Cu/ZnSOD无活性 ,Sod1- / - )小鼠和 10只Cu/ZnSOD杂合突变 (5 0 %Cu/ZnSOD失活 ,Sod1+/ - )小鼠及 5只野生小鼠 (Cu/Zn SOD活性正常 ,Sod1+/ +)进行ABR检测及内、外毛细胞计数。
短句来源
     Location and distribution of the Smad4 gene in wild-type and mutant mice
     Smad4基因在野生型和基因缺陷小鼠耳蜗内的定位和分布
短句来源
     To investigate the roles of TGF β1 mediated by SMAD3 in proliferation and differentiation of murine chondrocytes,chondrocytes were isolated from rib cartilage of wild type and Smad3 targeted disruption ( Smad3 ex8/ex8 ) mutant mice and cultured in vitro .
     为研究TGF β1 SMAD3信号对小鼠软骨细胞增殖和分化的影响 ,分离了野生型与Smad3基因剔除 (Smad3ex8 ex8)突变纯合子小鼠肋骨软骨细胞并进行了体外培养 .
短句来源
     Notably NKX3.1 mutant mice display the pathologic changes of prostatic intraepithelial neoplasia (PIN) that is the presumed precursor to prostate cancer in human, which implies that loss of NKX3.1 expression correlates with the initiation of prostate carcinogenesis.
     更重要的是Nkx3.1基因敲除鼠随着年龄的增长,出现了类似于人前列腺上皮内瘤(intraepithelial neoplasia,PIN)的病理变化,表明Nkx3.1缺失可能与前列腺癌的起始有关。
短句来源
     The characteristic of eEF1A-1 expression in mutant mice is consistent with the wild mice.
     突变型(eEF1A-2(?)
短句来源
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  mutant mice
Abnormal hair growth and structure in the we/we mutant mice results from defective cell differentiation in the inner root sheath of a hair follicle.
      
Myelin-deficient (mld) mutant mice were treated with phenobarbital between 60 and 90 d of age.
      
The relatively late occurrence of the palmitic acid deficiency compared with that of the VLCFAG and the normal palmitate synthetase activity observed in young mutant mice indicates that the former is an indirect consequence of the Trembler mutation.
      
These biochemical changes were observed prior to the appearance of clinical motor dysfunctions in theMnd mutant mice.
      
Intracellular distribution of hepatic copper in macular mutant mice
      
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A reccesive mutant mouse which first appeared among the colony of the inbred mice-Tian-jin Albino 3 (TA3) was discovered in Tianjin Medical College by T. Y. Chen in 1982. It was a male, showing juvenile body proportion when reached adulthood, vigorous but fertile. Now it had ken propagated in line. Studies of body weight and body dimension were conducted to monitor the growth of mutant and normal mice. A total of 59 pairs of the same sex of dwarf mice and TA3 sibs of different age...

A reccesive mutant mouse which first appeared among the colony of the inbred mice-Tian-jin Albino 3 (TA3) was discovered in Tianjin Medical College by T. Y. Chen in 1982. It was a male, showing juvenile body proportion when reached adulthood, vigorous but fertile. Now it had ken propagated in line. Studies of body weight and body dimension were conducted to monitor the growth of mutant and normal mice. A total of 59 pairs of the same sex of dwarf mice and TA3 sibs of different age groups(30,50 and 90 days) were accumulated. Body weight, bone dimension, body length and tail length were measured. All of the p values when comparing between dwarf and TA3 were less than 0.01 or 0.05 for humerus, radius, femur, and tibia length, skull width and length. There were 88 pairs of different ages groups of 30-, 50, and 90 days and same sex of dwarf and sibs. The ratio of average body weight of TA3 to dwarf was about 2.5:1. The body length and tail length of TA3 at different ages were all greater than those of the dwarf through t test (p<0.01 or 0.05). The ratios of TA3 to dwarf for body length and tail length at different ages through correlation analysis showed no significant difference (p>0.05). The mutant-dwarf mice, though small, were well proportioned.

侏儒小鼠与津白3体重的比值为1:2.5。它们的骨骼、休重、休长及尾长的测量均具非常显著或显著意义。经均衡性检验,不同日龄、不同性别间TA3/dw~t小鼠的不同骨骼、体重、体长及尾长的比值变化是均匀一致的。证明侏儒小鼠骨骼、体重、体长及尾长均系均匀缩小,是身体各部分匀称的侏儒小鼠。

A pair of mutant mice with a first sparse coat appeared spontaneousely in the production stock of normal BALB / c mice. After being sibmated, they produced three phenotypes in their progenies f mice with normal hair(H), mice with a first sparse coat and then fuzzy coat (S), and bald mice(B) with thicker skin. Genetic studies revealed that the mutants had inherited an autosomal monogene that was semidominant. The genotypes of the mice were + / +(H), b / b(B), and b /...

A pair of mutant mice with a first sparse coat appeared spontaneousely in the production stock of normal BALB / c mice. After being sibmated, they produced three phenotypes in their progenies f mice with normal hair(H), mice with a first sparse coat and then fuzzy coat (S), and bald mice(B) with thicker skin. Genetic studies revealed that the mutants had inherited an autosomal monogene that was semidominant. The genotypes of the mice were + / +(H), b / b(B), and b / +(S). These mice all had thymus and could be maintained in the open system with a one to two-year life span. While both sexes of homozygotes were fertile and the females could nurse their young, the litters were smaller than those of the other two types of mice (P<0.05). Also, their body weights at 10, 20, and 30 days were significantly lighter. Because of their unique characteristics, the bald mice are of potential value as mouse models in the studies of dermatosis, immunology and some related areas of research.

在BALB/c小鼠生产群中,1罐(:=1:1交配)繁殖鼠生下2 .7被毛稀疏的仔鼠。该对仔鼠成年后进行兄妹交配,后代出现三种表型:被毛紧披,生长快,繁殖力强的正常全毛小鼠;完全无毛,有胸腺,生长慢,性成熟晚,雄性隐睾率高,雌性窝产仔数少的无毛鼠;被毛稀疏,生长较快,繁殖率较高的中间态稀毛鼠。三种小鼠皆能在开放系统中生存,寿命 1.5~2年。对这些小鼠进行交配试验,结果表明:此种突变由位于常染色体上的单对基因控制,呈半显性。三种表型小鼠的基因型为全毛+/+、无毛 b/b、稀毛 b/+。该突变既影响小鼠的上皮组织,又影响小鼠的繁殖、生长等性能。该小鼠可望成为皮肤、免疫、化妆品等研究领域的动物模型。

Inheritance 19 gene marks ,normal karyotypes and G-bands of choromo- somes in the new mutant mice with three phenotypes (Haired,H;Sparse-coat,S;Bald- coat,B)were investigated.Mating studies showed that the mutation was caused by an autosomal semidominant gene.Among the three phenotypes,no difference was ob- served in the normal karyotypes,G bands as well as 19 gene markers examined,which were similar to those of nomal BALB/c mice.The mutation did not cause marked change in these characteristics.The...

Inheritance 19 gene marks ,normal karyotypes and G-bands of choromo- somes in the new mutant mice with three phenotypes (Haired,H;Sparse-coat,S;Bald- coat,B)were investigated.Mating studies showed that the mutation was caused by an autosomal semidominant gene.Among the three phenotypes,no difference was ob- served in the normal karyotypes,G bands as well as 19 gene markers examined,which were similar to those of nomal BALB/c mice.The mutation did not cause marked change in these characteristics.The location of the mutant loci should be further stud- ied.

对所发现的一种新的BALB/c突变小鼠的遗传特性,包括遗传规律、染色体组型和G带核型以及19个生化基因部位进行了研究。该突变小鼠是由1对基因突变所致,该基因位于常染色体上,呈半显性遗传。3种表型小鼠的正常核型、G带核型以及所测定的所有生化基因部位间无明显差异,且与正常BALB/c小鼠的一致。

 
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