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liver target
相关语句
  肝靶向
    Synthesis and stability of bile acid conjugate lamivudine as a liver target prodrug
    肝靶向前药胆酸拉米夫定酰胺的合成及其稳定性初步研究
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  肝靶向
    Synthesis and stability of bile acid conjugate lamivudine as a liver target prodrug
    肝靶向前药胆酸拉米夫定酰胺的合成及其稳定性初步研究
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OBJECTIVE To design and synthesize a liver target lamivudine prodrug that would utilizes the human apical sodium dependent bile acid transporter and enhance lamivudine oral bioavailability METHODS Using deoxy cholate and lamivudine,the new prodrug was designed and synthesized,and the structure of the compound was determined by elemental analysis,IR, 1H NMR, 13 C NMR and MS RESULTS The ideal compound was synthesized,and its methods of concentration testing by UV and HPLC were established...

OBJECTIVE To design and synthesize a liver target lamivudine prodrug that would utilizes the human apical sodium dependent bile acid transporter and enhance lamivudine oral bioavailability METHODS Using deoxy cholate and lamivudine,the new prodrug was designed and synthesized,and the structure of the compound was determined by elemental analysis,IR, 1H NMR, 13 C NMR and MS RESULTS The ideal compound was synthesized,and its methods of concentration testing by UV and HPLC were established and it was stable in several resolves CONCLUSIONS The conjugate is stable in several resolves Stable bile acid lamivudine conjugate is obtained to ensure the further liver target study in vivo

目的 设计合成具有人体胆酸转运体结合活性的肝靶向前体药物。方法 运用活泼酯法原理, 设计合成新化合物胆酸拉米夫定酰胺, 使用1H NMR、13 C NMR、IR、MS确认其结构, 并对其稳定性进行初步研究。结果 合成了目标产物, 初步稳定性结果显示其在各种溶剂中较稳定。结论 得到了稳定的目标化合物胆酸 拉米夫定酰胺,为进一步体内肝脏靶向性研究奠定了基础。

 
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