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fos genes
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  fos基因
     Observation on expressions of fos genes and electronic microscopy in the hippocampal tissues of epilepsy model of rats
     癫痫模型大鼠海马内fos基因表达及电子显微镜观察
短句来源
     Apparent amplification(>50 folds)of erbB and fos genes in malignant gliomas and of these four oncogenes in meningiomas and brain hematoma tissues is found.
     发现 erbB 基因和 fos 基因在恶性胶质瘤中扩增显著(>50倍)。
短句来源
  “fos genes”译为未确定词的双语例句
     During the process of sodium butyrate (NaBu) induced apoptosis in 2BS cells, p21 WAF1 gene expression decreased obviously and gradually,bcl 2 gene expression did not decrease until apoptosis happened, c myc and c fos genes expression enhanced , while p53 and HER 2 genes expression had no obvious change.
     用丁酸钠 (NaBu)诱导了人胚肺二倍体成纤维细胞凋亡 (2BS) ,检测其诱导过程中凋亡相关基因的表达变化 ,结果表明 ,p2 1WAF1的表达在凋亡发生前即有明显下降 ,并持续至凋亡发生时 ,bcl 2的表达仅在凋亡发生时有所下降 ,c myc和c fos的表达有所上升 ,而 p5 3和HER 2的表达无明显变化 .
短句来源
     These observations suggest that the effect of selenium onproliferation and differentiation of tumor cells may be correlated with alteration in expression ofmye and fos genes.
     以上结果提示硒的抑增殖促分化作用可能与调节癌基因的表达(myc 和 fos)有关。
短句来源
     Results:The genes expression level,such as c myc and c fos genes,distinctly increased comparing with normal adult lung,but these changes occurred in fetal lung genes expression profile pattern.
     结果:肺癌组织中cmyc、cfos 相关基因等多个较正常肺组织表达增加的基因,其中有些基因表达变化与胚胎肺组织相似。
短句来源
     and (5) the transcription of mRNAs related to Bcl 2,Bax,P53, and c Fos genes,as revealed by RT PCR assay,showed roughly corresponding changes as compared with their protein products. These results suggest that the down regulation of expresion of Bcl 2 and up regulation of Bax genes might be initial events for apoptosis while the up regulation of P53 and c Fos genes might be important for the further development of apoptotic processes.
     与此相反,bax 蛋白表达在1~4 h 期间呈现稳定上调,而p53 和cfos 两种蛋白表达也显示上调,其p53 蛋白在2 h 达最高峰,cfos 蛋白则在2 h 开始上调; (5)用RTPCR
短句来源
     Ventricular fibroblasts were cultured using conditioned growth medium for ventricular fibroblasts (FCGM). The rate of the total collagen synthesis of ventricular fibroblasts was measured by assaying the incorporation rate of [ 3H] proline, whereas the proliferation of ventricular fibroblasts was assessed by determining the incorporation rate of [ 3H] TdR and the expression of c fos genes.
     采用心室成纤维细胞条件培养液培养心室成纤维细胞 ,通过测定 [3H] 脯氨酸 ([3H] proline)的掺入率来了解心室成纤维细胞总胶原合成速率 ,通过测定 [3H] 胸腺嘧啶核苷 ([3H] TdR)的掺入率以及c fos基因的表达丰度来了解心室成纤维细胞的增殖速率。
短句来源
  相似匹配句对
     c-fos Genes and Cerebrovascular Disease and Learning and Memory
     即早基因c-fos与脑血管病及学习记忆
短句来源
     Expression of c-fos and c-jun genes were detected by the method of hybridization in situ.
     用原位杂交法观察 3组兔肺内c fos和c jun基因水平。
短句来源
     cytoskeleton genes ;
     细胞骨架相关基因;
短句来源
     RADIOSENSITIVITY AND GENES
     辐射敏感性和基因(英文)
短句来源
     C-fos, c-jun and epilepsy
     c-fos、c-jun与癫痫
短句来源
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  fos genes
The expression of proenkephalin (PENK), prodynorphin (PDYN) and c-fos genes was studied in the striatum of C57B1/6 mice treated with 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine (MPTP), which are used as a rodent model of Parkinson's disease (PD).
      
Expression of fos genes has been observed in the motor cortex during the formation of specialized movements.
      
The promoter activity of skeletal a-actin and c-fos genes was increased by Ang II, and the increase was partly inhibited by overexpression of Rho-GDI and the pretreatment with C3 exoenzyme.
      
Expression of tumor necrosis factor andc-fos genes in peritoneal macrophages of hypothyroid mice
      
In this study, the nucleotide sequences of the 3' untranslated regions (UTR) of the mouse and human c-fos genes, and the rat and human β-actin genes were examined.
      
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The c-fos gene was used as a probe todetect the Bam HI-digested brain DNA andtotal RNA isolated from 2 cases of normalhuman brain and 11 cases of human braintumor by Southern blot analysis and RNAdot hybridization technique. The resultshowed an amplification and over-expres-sion of c-fos gene in one case of glioblasto-ma multiforme.These data suggest that thec-fos gene may take an important role inthe carcinogenesis of human primary braintumor, and the level of c-fos expressionmay be...

The c-fos gene was used as a probe todetect the Bam HI-digested brain DNA andtotal RNA isolated from 2 cases of normalhuman brain and 11 cases of human braintumor by Southern blot analysis and RNAdot hybridization technique. The resultshowed an amplification and over-expres-sion of c-fos gene in one case of glioblasto-ma multiforme.These data suggest that thec-fos gene may take an important role inthe carcinogenesis of human primary braintumor, and the level of c-fos expressionmay be correlated with the degree of differ-entiation of brain tumor cells. We also found that there was a rearran-gement of c-fos gene in one case of epen-dymoma. This suggests that, in ependymo-ma, the c-fos gene may be activated in away different from that in the brain tumorsof astroglia origin.

以c-fos基因为分子探针,对2例正常人脑和11例人脑原发性肿瘤DNA进行Southern吸印杂交分析,同时对上述部分样品的总RNA进行斑点杂交分析。结果表明:1例多形性胶质母细胞瘤发生c-fos基因的扩增和过强表达;1例室管膜瘤在发生c-fos基因扩增的同时,还发生c-fos基因的重排,提示c-fos基因在人脑原发性肿瘤的恶变过程中起着重要作用,其表达水平与肿瘤细胞的分化程度有着密切关系。

Rearrangement and amplificarion of erbB,sis,myc and fos in brain tumors are studied with DNA dot blot and Southern blot analysis.Apparent amplification(>50 folds)of erbB and fos genes in malignant gliomas and of these four oncogenes in meningiomas and brain hematoma tissues is found.However fewer copies of these four oncogenes in oligodendrogliomas are found.Rearrangement of these four oncogenes in brain tumors and some hybridized-fragments more specific for brain tumors is also found.The mechanism of...

Rearrangement and amplificarion of erbB,sis,myc and fos in brain tumors are studied with DNA dot blot and Southern blot analysis.Apparent amplification(>50 folds)of erbB and fos genes in malignant gliomas and of these four oncogenes in meningiomas and brain hematoma tissues is found.However fewer copies of these four oncogenes in oligodendrogliomas are found.Rearrangement of these four oncogenes in brain tumors and some hybridized-fragments more specific for brain tumors is also found.The mechanism of carcinogenesis,relationship between amplification of onco- gene and malignant degree are discussed.

本文用 DNA 斑点杂交法和 Southen 印迹法对脑瘤中 erbB、sis、myc 和 fos 这四种癌基因的扩增和重排进行了研究。发现 erbB 基因和 fos 基因在恶性胶质瘤中扩增显著(>50倍)。脑膜瘤和脑血肿组织中,这四种癌基因扩增都很显著,而少枝胶质瘤中这四种癌基因的拷贝数均较少。另外还发现脑瘤中这四种癌基因均有重排,并呈现一些对脑瘤比较特异的杂交片段。本文还对肿瘤的发生机制、癌基因扩增和恶性程度之间的关系等进行了探讨。

Transformation of NIH3T3 cells with high molecular weight DNA isolated from human squa- mous cell carcinoma of lung,was performed by the calcium phosphate precipitation technique.The morpho- logically transformed cells could grow in colony on soft agar.The DNA isolated from primary transformants could induce second round transfection.These transformants were tumorigenic in nude mice.Hybridization of DNA from transformants digested with restriction endonuclease EcoRI with human ALu repeat sequence was positive.Amplification...

Transformation of NIH3T3 cells with high molecular weight DNA isolated from human squa- mous cell carcinoma of lung,was performed by the calcium phosphate precipitation technique.The morpho- logically transformed cells could grow in colony on soft agar.The DNA isolated from primary transformants could induce second round transfection.These transformants were tumorigenic in nude mice.Hybridization of DNA from transformants digested with restriction endonuclease EcoRI with human ALu repeat sequence was positive.Amplification of c-myc gene and DNA sequence homologous to v-fos gene were found in these transformants.

本文用磷酸钙沉淀技术,以人肺鳞癌组织高分子量 DNA 进行了小鼠成纤维细胞NIH3T3的转化实验。得到的转化细胞能在软琼脂板上生长;可诱导 NIH3T3细胞二轮转化;在裸鼠体内有明显的致瘤性;其 DNA 经酶切后与人 ALU 重复序列探针杂交呈阳性反应;并证明有 c~myc 基因扩增及有 v-fos 同源宁列的存在。

 
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