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periodontal regeneration
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  牙周组织再生
     Periodontal regeneration was promoted by MSCs combined with CBHA.
     MSCs复合CBHA可促进牙周组织再生;
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     Conclusion It was concluded that the β TCP/BMP artificial bone can be used in GTR technique to promote periodontal regeneration.
     结论 β TCP/BMP是一种具有较强骨诱导能力 ,生物相容性较好的复合人工骨 ,在引导牙周组织再生术中有良好的应用前景
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     A Study on the Effects of Gingival Fibroblast Transfected by hBMP_2 Gene on Periodontal Regeneration
     hBMP_2基因转染牙龈成纤维细胞对牙周组织再生影响的实验研究
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     Periodontal Regeneration by Gene Therapy
     基因治疗在牙周组织再生中的应用
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     Conclusions:BMP/CPC artificial bone has powerful osteoinductive activity and can be used to promote periodontal regeneration.
     结论 :CPC/BMP具有较强骨诱导活性 ,可有效地提高牙周组织再生
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  牙周再生
     CONCLUSION: The shortest time for placement of a barrier membrane needed to achieve maximum periodontal regeneration is 3 weeks.
     结论 :达到最大量牙周再生所需屏障膜放置的最短时间为 3周
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     The experimental study on relationship between time for placement of a barrier membrane and periodontal regeneration in dogs
     屏障膜放置时间与牙周再生量关系的动物实验研究
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     RESULTS: The group in which the membranes were left in place for 3 weeks showed more new bone and new cementum and less junctional epithelium than the controls. However, no significant difference of periodontal regeneration was found among the 3-week, 4-week and 8-week groups.
     结果 :放膜 3周组的牙槽骨、牙骨质再生量显著大于空白对照组 ,上皮根移被明显抑制 ,但放膜 3、4、8周 3组之间的牙周再生量无显著性差异。
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     Development of Novel Cell Delivery Carrier for Periodontal Regeneration in vitro
     新型牙周再生细胞传递载体的体外建立
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     Conclution: Bio-Oss and Bio-Gide treated periodontal vertical resorption osseous defects could gain integrated periodontal regeneration which included cemant,periodontal ligament and bone.
     结论:B io-Oss和B io-G ide对治疗垂直性骨吸收的牙周骨缺损,可使其获得包括牙骨质、牙周韧带、骨在内的完整牙周再生
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  “periodontal regeneration”译为未确定词的双语例句
     Rh-bFGF-Bio-Oss Collagen Composite Graft Enhances Periodontal Regeneration: A Experimental Study in Dogs
     Rh-bFGF-Bio-Oss Collagen复合物促进犬牙周组织再生的实验性研究
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     Results: Significantly greater periodontal regeneration was noted in the groups of PRP/BioOss/ MSCs /GTR compared with the PRP/BioOss/GTR, MSCs /GTR, GTR treatment alone when newly formed periodontal tissues including alveolar bone, periodontal ligament and cementum were assessed.
     结果:动物实验发现GTR组的新生牙槽骨、牙骨质和牙周膜高度与GTR/PRP/Bio-Oss组、GTR/MSCs组无显著性差异;
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     Conclusions: rhIGF-I and rhBMP-2 can be used as bioactive mediator on periodontal regeneration.
     结论:rhIGF-I、rhBMP-2可望作为牙周再生的生物活性介质,rhIGF-I与rhBMP-2联合应用对PDL细胞的促增殖作用更强。
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     Periodontal regeneration by application of the porous β-TCP/BMP artificial bone to class II furcation defects
     多孔β-0TCP/BMP复合人工骨引导牙周组织再生的实验研究
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     Objective To explore the effect of astragalus polysaccharides-chitosan/polylactic acid (AP-C/PLA)scaffolds and bone marrow stem cells (BMSCs) on periodontal regeneration of experimentally horizontal periodontal defects in dogs. Methods Dog BMSCs were isolated from the bone marrow and then cultured in a conditioned medium to be induced for osteogenesis. The expressions of Type I collagen and alkaline phosphatase (ALP) were examined by immunohistochemistry and histochemistry in the induced BMSCs, respectively.
     目的:探讨以犬骨髓基质干细胞(bone marrow stem cells,BMSCs)为种子细胞、黄芪-壳聚糖/聚乳酸(astragalus polysaccharides-chitosan/polylactic acid,AP-C/PLA)为支架移植对水平型牙周骨缺损再生的影响。
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  periodontal regeneration
To date, various conventional therapies for periodontal regeneration have shown limited and variable clinical outcomes.
      
Periodontal ligament cells (PDL) are thought to play a major role in promoting periodontal regeneration.
      
Within the limits of the present study, it can be concluded that OCHS may favor periodontal regeneration in acute-type intrabony periodontal defects.
      
The OCHS-treated defects consistently revealed periodontal regeneration (i.e., new periodontal ligament, new cementum with inserting collagen fibers, and new bone).
      
In the control group, healing was predominantly characterized by the formation of a long junctional epithelium along the root surface and limited periodontal regeneration at the most apical part of the defect.
      
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Abstract Human periodontal ligament fibroblasts were cultured and treated with inhibitors of PADPR synthetase,10 mM nicotinamide,5 mM 3-aminobenzamide,and 20 mM sodium lactate,and stimulator of PADPR synthetase,1 mM NAD+,respectively.Total RNAs were extracted with modified guanidium-thiocyanate-phenol-chloroform procedure,dotted onto Nytran membrane,and hybridized with 32P labelled cDNA probes,α1(Ⅰ)gene cDNA probe in Hf 677 and α1(Ⅲ) gene cDNA probe in Hf 934 were used.The autographes were analysed with the...

Abstract Human periodontal ligament fibroblasts were cultured and treated with inhibitors of PADPR synthetase,10 mM nicotinamide,5 mM 3-aminobenzamide,and 20 mM sodium lactate,and stimulator of PADPR synthetase,1 mM NAD+,respectively.Total RNAs were extracted with modified guanidium-thiocyanate-phenol-chloroform procedure,dotted onto Nytran membrane,and hybridized with 32P labelled cDNA probes,α1(Ⅰ)gene cDNA probe in Hf 677 and α1(Ⅲ) gene cDNA probe in Hf 934 were used.The autographes were analysed with the densitometer.The results showed that the inhibitors of PADPR synthetase increase the mRNA levels of α1(Ⅰ)and α1(Ⅲ)genes significantly.and the stimulator of PADPR synthetase decreses the mRNA levels of α1(Ⅰ)and α1(Ⅲ)genes.These results indicate that the collagen synthesis which is the main process of periodontal regeneration,could be regulated through regulating the synthesis of PADPR.

采用牙周膜成纤维细胞体外培养,观察多聚腺嘌呤二磷酸核糖合成酶抑制剂及诱导剂对体外培养的牙周膜成纤维细胞α1(1)和α1(Ⅲ)胶原基因mRNA水平的影响,α1(Ⅰ)和α1(Ⅲ)胶原基因cDNA探针分别来自Hf677和Hf934。结果发现,多聚腺嘌呤二磷酸核糖合成酶抑制剂(10mmol/L尼克酰胺,5mmol/L3-氨基苯胺和20mmol/L乳酸钠)都能明显增加α1(Ⅰ)和α1(Ⅲ)胶原基因mRNA水平,而多聚腺嘌呤二磷酸核糖合成酶诱导剂(1mmol/L 辅酶Ⅰ)则明显降低α1(Ⅰ)和α1(Ⅲ)胶原基因mRNA水平。提示可以通过抑制多聚腺嘌呤二磷酸核糖的合成促进牙周膜成纤维细胞胶原的合成,这为牙周组织再生的研究提供了新的方向。

Objective To evaluate the effects of BMP on the repair of animal periodontal defects by using GTR technique. Methods 30 experimental mandibular buccal alveolar periodontal defects were produced surgically around premolar and molar teeth in 8 young mongrel dogs. The exposed root surfaces were curetted to remove the periodontal ligament and the cementum. The defects were devided into 3 equal groups (collagen, collagen+BMP, control). The results were examined histologically 1 month and 3 months respectively....

Objective To evaluate the effects of BMP on the repair of animal periodontal defects by using GTR technique. Methods 30 experimental mandibular buccal alveolar periodontal defects were produced surgically around premolar and molar teeth in 8 young mongrel dogs. The exposed root surfaces were curetted to remove the periodontal ligament and the cementum. The defects were devided into 3 equal groups (collagen, collagen+BMP, control). The results were examined histologically 1 month and 3 months respectively. Results In experimental groups the JE downgrowth was inhibital in the early healing, and the new attachment formation was promoted while comparing with the controls. Compound membrane (with BMP) showed the capacity to support more new bone and cementum formation than the other two groups. Conclusion It is suggested that exogenous BMP can be used in GTR technique to promote periodontal regeneration.

目的将骨形成蛋白(bonemorphogeneticprotein,BMP)联合应用于牙周引导组织再生(guidedtissueregeneration,GTR)技术中,观察和比较其对牙周组织再生修复的影响和意义。方法制备狗下颌后牙区人工骨缺损,于清创后分组置入引导膜材料和BMP,以常规翻瓣术为对照;分不同时期取材做组织学观察和评价。结果实验组较对照组新生组织量多,而以复合BMP组效果最为显著;膜材料在早期有一定抑制结合上皮根向迁移的作用。结论利用外源性BMP的主动生物诱导活性,可望应用于临床促进牙周硬组织成分的新生修复。

Aim: To study the effect of recombinant human Insulin-like growth factor-I and recombinant human bone morphogenetic protein-2 on human periodontal ligament cells proliferation. Methods: Human periodontal ligament cells were cultured by tissue explant and its proliferation were mesured by MTT colorimetric assay. Results: rhIGF-I or rhBMP-2 can stimulate human PDL cells proliferation in dose-dependent manner. The co-ordinate use of rhIGF-I and rhBMP-2 has synergetic effect on PDL cells proliferation. Conclusions:...

Aim: To study the effect of recombinant human Insulin-like growth factor-I and recombinant human bone morphogenetic protein-2 on human periodontal ligament cells proliferation. Methods: Human periodontal ligament cells were cultured by tissue explant and its proliferation were mesured by MTT colorimetric assay. Results: rhIGF-I or rhBMP-2 can stimulate human PDL cells proliferation in dose-dependent manner. The co-ordinate use of rhIGF-I and rhBMP-2 has synergetic effect on PDL cells proliferation. Conclusions: rhIGF-I and rhBMP-2 can be used as bioactive mediator on periodontal regeneration.

目的:重组人胰岛素样生长因子-I(rhIGF-I)、重组人骨形态发生蛋白-2(rhBMP-2)分别或联合应用对人牙周膜(PDL)细胞增殖的影响。方法:采用组织块法体外培养人PDL细胞,MTT法测定PDL细胞在不同生长因子刺激下的增殖情况。结果:rhIGF-I、rhBMP-2都可促进人PDL细胞的增殖,这种促增殖作用呈一定的浓度依赖性,rhIGF-I与rhBMP-2联合应用对人PDL细胞的增殖有协同作用,且与单独应用相比相差显著。结论:rhIGF-I、rhBMP-2可望作为牙周再生的生物活性介质,rhIGF-I与rhBMP-2联合应用对PDL细胞的促增殖作用更强。

 
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