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transcriptional factor
相关语句
  转录因子
     The Member of Transcriptional Factor ATF3/CERB:ATF3
     转录因子ATF/CERB家族成员——ATF3
短句来源
     PKCζ,as an important message molecular,is involved in many intracellular signaling pathways,such as the mitogen-avtivated protein kinase(MAPK) cascade,transcriptional factor NF-κB activation,ribosomal S6-protein kinase signaling and so on.
     作为信息分子,PKCζ在多种细胞外刺激因素诱导的胞内信号转导通路中发挥重要作用,如丝裂原活化蛋白激酶(m itogen-avtivated protein kinase,MAPK)通路、核转录因子-κB(nuclear transcriptionalfactor-κB,NF-κB)的活化和核糖体S6蛋白激酶通路等。
短句来源
     Inhibition of the Activation of Transcriptional Factor NFκB during Sodium Selenite-Induced Apoptosis in NB4 Cells
     亚硒酸钠在诱导NB4细胞凋亡的过程中抑制了转录因子NFκB的激活
短句来源
     Rearch on Induction Expression of Alien DREB1B and CBF1 Transcriptional Factor in Transgenic Wheat
     外源脱水应答转录因子DREB1B和CBF1基因在转基因小麦中表达研究
短句来源
     Hypoxia inducible factor 1 (HIF-1), the most characterized hypoxia-regulated transcriptional factor, mediates the hypoxia-dependent transcription of these genes.
     乏氧诱导的转录因子-1(hypoxia inducible factor 1,HIF-1)介导了其中绝大部分基因的转录活化。
短句来源
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  “transcriptional factor”译为未确定词的双语例句
     Transcriptional activation of TGFβ_1 by transcriptional factor Zf9
     Zf9对TGFβ_1的转录激活研究
短句来源
     [Conclusion] Transcriptional factor AP-2α upregulates IL-1β-induced COX-2 expression.
     AP-2突变体降低IL-1β诱导的A549细胞COX-2表达。 结论AP-2α上调A549细胞COX-2的表达。
短句来源
     RESULTS:Treatment of Jurkat T cells with Spl antisense ODN (1 μmol/L) dramatically reduced Spl mRNA and protein levels. The inhibition rate was 44.8% (P<0.05) and 57% (P<0.01), respectively. Following the transcriptional factor Spl functionally altering, hTERT mRNA expression were suppressed with a 43.7%inhibition rate (P<0.01).
     结果:sp1反义ODN(1μmol/L)明显抑制Jurkat T细胞Sp1 mRNA和蛋白表达,抑制率分别为44.8%(P<0.05)和57%(P<0.01),并抑制hTERT mRNA表达,抑制率为43.7%(P<0.01);
短句来源
     CBF transcriptional factor passes with CRT/DRE (C-repeat/ Dehydration responsive element) syn-form functional element union activation low temperature and dehydrated response gene expression,Enhances the plant the resistance.
     CBF通过与CRT/DRE(C-repeat/ dehydration responsive element)顺式作用元件的结合激活低温和脱水响应基因的表达,提高植物的抗逆性。
短句来源
     Results After being transfected with pcDNA3-HBV,peritoneal macrophages had the expression of PreS1 mRNA, but have lower level of TNF-α、IL-1β mRNA and transcriptional factor NF-κB, compared with pcDNA3-transfected control group;
     通过与βactin相比,pcDNA3-HBV转染的巨噬细胞中TNF-α、IL-1βmRNA的表达量显著低于空载体对照组(P<0.01); pcDNA3HBV转染的巨噬细胞表达NFκ-BRelA蛋白的百分数与空载体对照组相当,但平均荧光强度显著低于空载体对照组(pcDNA3HBV转染组为125.05;pcDNA3转染组为203.88);
短句来源
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  相似匹配句对
     EMSA was used to identify transcriptional factor.
     采用EMSA(electrophoresismobilityshiftassay)检测与启动子结合的转录因子。
短句来源
     The Mechanism and Physiological Function of Transcriptional Factor Snail
     转录因子Snail的作用机制及其生理功能
短句来源
     economic factor;
     经济因素;
短句来源
     The Factor of Graphs
     图的因子
短句来源
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  transcriptional factor
The X-gene product of human hepatitis B virus is a transacting transcriptional factor which activates a variety of heterologous viral and host promoters/enhancers.
      
The U3 region of the LTR of P1OLV lacks the sequence repeats that are present in the LTRs of WLC-1 and MVV prototype K1514 and that contain additional binding sites for the AML(vis) transcriptional factor.
      
Peroxisome proliferator-activated receptor (PPAR)-α is a ligand-activated transcriptional factor that belongs to the family of nuclear receptors.
      
The transcriptional factor SOX10 is one of the key determinants of oligodendroglial differentiation.
      
Oligodendroglial-specific Transcriptional Factor SOX10 is Ubiquitously Expressed in Human Gliomas
      
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From 6.6×105 clones of human genomic library inserted in λvector Charon 30, PCNA gene was obtained by colony in situ hybridization.According to the southern hybridization analysis, this gene is about 14 kb long,contains a long 5'upstream region but lacks a the small part at the 3' region.The sequences of a total of 4969 bp spanning from 1266bp upstream of the transcriptional start site to the 3'conjugation site to λvector were determined.A comparison between the PCNA promoter to promoters of DNA polymerase...

From 6.6×105 clones of human genomic library inserted in λvector Charon 30, PCNA gene was obtained by colony in situ hybridization.According to the southern hybridization analysis, this gene is about 14 kb long,contains a long 5'upstream region but lacks a the small part at the 3' region.The sequences of a total of 4969 bp spanning from 1266bp upstream of the transcriptional start site to the 3'conjugation site to λvector were determined.A comparison between the PCNA promoter to promoters of DNA polymerase a,TopoisomeraseⅡ a and Thymidine kinase showed more than 30% homology and are characterized as "house keeping gene". They all contain similar sequences to the binding sites of transcriptional factors CAT,SP1,E2F,NFHB Oct 1 and ATF within several hundred base pairs upstream the transcriptional start sites.

经6.6×105个克隆筛选,从装在λ噬菌体载体Charon30中的人基因库中筛选到了一个含人分裂细胞核抗原(PCNA)基因的克隆。经Southern杂交分析插入基因长约14kb,有较长的5'上游区,但3'端缺少一部分。经亚克隆和测序已确定从5'上游1263bp到3'端与λ载体接点共4969bpPCNA基因片段的核苷酸序列。将PCNA基因启动子核苷酸序列与DNA聚合酶α,拓扑异构酶Ⅱα,胸苷酸激酶基因的启动子进行比较有30%以上同源性,具有“看家基因”特征。在转录起始点的5'上游几百bp的范围内都有与CAT,SP1,E2F,NFHB,Oct1和ATF等转录因子的结合位点相似的核苷酸序列。

Using site-directed mutagenesis insertion or deletion,PHO2 gene was changed in strueture, the effect of these changes on its funetion was observed.The homeodomain of PHO2 protein has such structure as a-helix 2-turn-a-helix 3,which acts as DNA binding domain of transcriptional factor,A site-driected mutant of Ile123 to Pro123 in a-helix 3 or insertion of four amino acids(PDPD) into a-helix 2 can destroy the a-helix structure, and lead to inaotivation of PHO2.Deletion analysis of the Gln-rich region of...

Using site-directed mutagenesis insertion or deletion,PHO2 gene was changed in strueture, the effect of these changes on its funetion was observed.The homeodomain of PHO2 protein has such structure as a-helix 2-turn-a-helix 3,which acts as DNA binding domain of transcriptional factor,A site-driected mutant of Ile123 to Pro123 in a-helix 3 or insertion of four amino acids(PDPD) into a-helix 2 can destroy the a-helix structure, and lead to inaotivation of PHO2.Deletion analysis of the Gln-rich region of the N-terminal had no effect on PHO2 functions,while deletion of the acidic region(residue 249~261) inactivate the PHO2 protein These results show that the acidic region may act as a transpriptional activation domain of PHO2. A short cluster of residues(241~258) shared 50% homology with residues 32 to 50 of the negative factor WHO80 and deletion of this ragion inactivated the PHO2 protein.So we concluded that this region might be an association domain of PHO2 and PHO4 protein.

利用定点诱变,氨基酸插入或缺失的方法对PHO2进行结构改造,观察对其功能的影响。PHO2蛋白的同源域中有α-螺旋2-β-转角-α螺旋3的结构,是转录因子结合DNA的功能域。定点诱变α-螺旋3上的Ile123为Pro123.或者在α-螺旋2中插入PDPD4个氨基酸,破坏α-螺旋的结构,可导致PHO2功能的丧失。氨基酸片段的缺失分析表明,N端Gln丰富区大部缺失,对PHO2功能没有影响;而包含酸性氨基酸丰富区的第263~368位肽段的缺失,则导致PHO2的失活。酸性区可能是PHO2的转录激活功能域,在PHO2的第241~258位肽段与PHO80第32~50肽段有50%的同源性。它的缺失也使PHO2失活,该区可能是PHO2与PHO4相作用的位点。

The interleukin-1(IL-1),enkephalin,β-endorphin and immediate early genes c-fos and c-jun are intimately related to the pathogenesis of epilepsies. Our results showed that IL-1,IL-1 receptor antagonist(IL-lra),β-endorphin,antiserum of anti-β-endorphin,leuenkephalin enhanced c-fos and c-jun mR-NA expression of rat cortico-cerebral cells. Induction of c-fos and c-jun mRNA by IL-lra and antiserum of anti-β-endorphin was less than that by IL-1,leu-enkephalin and β-endorphin. IL-lra and anti-serum of anti-β-endorphin...

The interleukin-1(IL-1),enkephalin,β-endorphin and immediate early genes c-fos and c-jun are intimately related to the pathogenesis of epilepsies. Our results showed that IL-1,IL-1 receptor antagonist(IL-lra),β-endorphin,antiserum of anti-β-endorphin,leuenkephalin enhanced c-fos and c-jun mR-NA expression of rat cortico-cerebral cells. Induction of c-fos and c-jun mRNA by IL-lra and antiserum of anti-β-endorphin was less than that by IL-1,leu-enkephalin and β-endorphin. IL-lra and anti-serum of anti-β-endorphin partly inhibited the effect of IL-1 and β-endorphin ,respectively.The c-fos mRNA expression induced by IL-1,leu-enkephlin and β-endrophin revealed dose response curve at a scale of certain doses. The induction of c-fos and c-jun by IL-1 also revealed time course and was transient expression. Based on the different levels of c-fos and c-jun mRNA expression induced by various factors which have different biological effects,our results suggested that fos and jun acting as third messenger molecules and transcriptional factor,have biphasic regulation in target genes and different actions on the excitation of corticocerebral cells.

对白细胞介素-1(IL-1)、脑啡肽、β-内啡肽及即刻早期基因c-fos、c-jun与癫痫发病机理的研究。结果显示IL-1、IL-1受体拮抗剂、β-内啡肽、抗β-内啡肽抗血清、亮-脑啡肽(LE)均能促进大脑皮层神经细胞c-fos、c-junmRNA表达,但IL-1受体拮抗剂、抗β-内啡肽抗血清促c-fos、c-junmRNA表达量明显低于IL-1、LE及β-内啡肽的作用,并能部分抑制后者的作用;IL-1、β-内啡肽、LE促c-fosmRNA表达在一定范围呈现量效关系;IL-1诱导c-fos、c-junmRNA表达呈现时间效应关系,均为短暂表达。由于具有不同生物学效应的因子均能诱导不同程度c-fos、c-junmRNA表达,提示它们对靶基因的调控具有正性及负性双向性,对神经细胞兴奋性产生不同作用。

 
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