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orthotopic
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  原位
    The establishment for orthotopic implantation model of human glioma cells in nude mice
    人脑胶质瘤细胞裸鼠原位移植动物模型建立的实验研究(英文)
短句来源
    Growth characteristics of stereotactically orthotopic implantation of glioma cell line C6 in rat brain
    立体定向接种胶质瘤细胞系C6形成大鼠脑内原位移植瘤的生长特性
短句来源
    Experiment study on bioluminescent signal in orthotopic and heterotopic brain tumors in nude mice
    裸鼠原位和异位脑肿瘤生物发光信号成像实验研究(英文)
短句来源
    Purpose To observe the relationship between the expression of formylpeptide receptor (FPR) and production of vascular endothelial growth factor (VEGF) in human glioma cell line U87 orthotopic transplantation tumors in the brains of nude mice, and to explore the potential roles of FPR during the angiogenesis of malignant glioma.
    目的观测甲酰肽受体(formylpeptide receptor,FPR)在人恶性胶质瘤细胞系U87细胞裸鼠脑原位移植瘤组织中的表达,以及与血管内皮生长因子(VEGF)的关系,探讨FPR在恶性胶质瘤血管生成过程中的作用。
短句来源
    Relationship between expression of formylpeptide receptor in the orthotopic transplantation tumors of malignant human glioblastoma cell line U87
    人恶性胶质瘤细胞裸鼠脑原位移植瘤FPR表达与VEGF关系
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  原位
    The establishment for orthotopic implantation model of human glioma cells in nude mice
    人脑胶质瘤细胞裸鼠原位移植动物模型建立的实验研究(英文)
短句来源
    Growth characteristics of stereotactically orthotopic implantation of glioma cell line C6 in rat brain
    立体定向接种胶质瘤细胞系C6形成大鼠脑内原位移植瘤的生长特性
短句来源
    Experiment study on bioluminescent signal in orthotopic and heterotopic brain tumors in nude mice
    裸鼠原位和异位脑肿瘤生物发光信号成像实验研究(英文)
短句来源
    Purpose To observe the relationship between the expression of formylpeptide receptor (FPR) and production of vascular endothelial growth factor (VEGF) in human glioma cell line U87 orthotopic transplantation tumors in the brains of nude mice, and to explore the potential roles of FPR during the angiogenesis of malignant glioma.
    目的观测甲酰肽受体(formylpeptide receptor,FPR)在人恶性胶质瘤细胞系U87细胞裸鼠脑原位移植瘤组织中的表达,以及与血管内皮生长因子(VEGF)的关系,探讨FPR在恶性胶质瘤血管生成过程中的作用。
短句来源
    Relationship between expression of formylpeptide receptor in the orthotopic transplantation tumors of malignant human glioblastoma cell line U87
    人恶性胶质瘤细胞裸鼠脑原位移植瘤FPR表达与VEGF关系
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  “orthotopic”译为未确定词的双语例句
    Treatment of C6 orthotopic implantation in rat brains with Nordy and its effects on the expression of STAT3 and p-STAT3
    诺帝对大鼠C6脑胶质瘤的诱导分化治疗作用及对信号转导分子STAT3和p-STAT3蛋白表达的影响
短句来源
    By indirect immunofluorescence staining combined with confocal laser scanning microscopy, the expression and localization of FPR in U87 cells and its orthotopic transplantation tumor tissues were detected.
    采用间接免疫荧光染色在激光共聚焦显微镜下分别观测FPR在U87细胞和移植瘤组织的表达;
短句来源
    Orthotopic Grafts of Human Gliomas into Nude Mice and Its MRI Research
    人脑胶质瘤裸小鼠脑内移植模型制作及其MR显像研究
短句来源
    The Value of Perioperative Monitoring Cerebral Blood Flow under Orthotopic Liver Transplantation by Transcranial Doppler Ultrasonography
    经颅多普勒超声对肝移植患者围手术期脑血流变化评估的价值研究
短句来源
    However, Read et al found that the reaction of intracranial and subcutaneousglioma to amiangiogenic theraPy wasn't complcte coincidence, it directs that the ootcome ofsubcutaneous tumor model doesn't comPletCly represent of orthotopic glioma.
    Read等用血管生成抑制剂治疗脑胶质瘤和皮下胶质瘤,两者的反应并不完全一致,表明皮下胶质瘤模型的研究结果并不能完全代表脑胶质瘤。
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  orthotopic
Intra-abdominal hypertension is an independent cause of acute renal failure after orthotopic liver transplantation
      
Orthotopic liver transplantation was performed in two allogeneic rat strain combinations, one with fatal immunosuppression despite a complete major histocompatibility complex mismatch.
      
Combined therapy of p53-wt and drug in an orthotopic multidrug-resistant human lung cancer model
      
In order to understand the allograft rejection in orthotopic liver transplantation (OLT), an allograft rejection rat model was established and studied by proteomic approach.
      
Chemotherapy of multidrug-resistant human lung cancer combined with an MDR1 ribozyme retroviral vector in an orthotopic model
      
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Eighty free autogenous muscle transplants of 30 rabbitts were studied by means of Electromyogra-phy (EMG), The observation time was 3 days-6 months following transplantation. Regenerationbegan 1 week after grafting and reached the maximum after 3 months. It became steady in 5 months.The result has revealed no significant difference between muscles with and without predenervation.The regeneration of musculus palmaris longus was better than musculus flexor digitorum. superficialis.But EMG of heterotopic transplantation...

Eighty free autogenous muscle transplants of 30 rabbitts were studied by means of Electromyogra-phy (EMG), The observation time was 3 days-6 months following transplantation. Regenerationbegan 1 week after grafting and reached the maximum after 3 months. It became steady in 5 months.The result has revealed no significant difference between muscles with and without predenervation.The regeneration of musculus palmaris longus was better than musculus flexor digitorum. superficialis.But EMG of heterotopic transplantation showed less Satisfactory results than the orthotopic. It can beseen that EMG is an indispensable examination in free autogenous muscle transplantation. It providesreliable and objectivc information for muscle grafting.

对30只家兔的80块自体游离肌肉移植物进行肌电图检查,时间为移植后3天至6个月。肌电图示肌肉再生开始于移植后1周,3月后达高峰,5月后稳定;提前去神经移植物的肌电图与未去神经者无明显区别,掌长肌较屈趾浅肌再生好,原位移植物较异位者好。提示肌电图应作为自体游离肌肉移植的一项必要检查,为肌肉移植成活提供客观指标。

Objective Hepatic transplantation was performed on patients with Wilson disease to correct the disorder of copper metabolism, and to prolong lifetime and improve living quality. Methods Two cases of Wilson disease were treated with classic homograft orthotopic hepatic transplantation and 3 case by piggyback homograft orthotopic hepatic transplantation with administration of cyclosporin A. [WT9.HZ〗Results The former 2 cases died 17 and 39 days after operation whereas so...

Objective Hepatic transplantation was performed on patients with Wilson disease to correct the disorder of copper metabolism, and to prolong lifetime and improve living quality. Methods Two cases of Wilson disease were treated with classic homograft orthotopic hepatic transplantation and 3 case by piggyback homograft orthotopic hepatic transplantation with administration of cyclosporin A. [WT9.HZ〗Results The former 2 cases died 17 and 39 days after operation whereas so far 2 of the later 3 cases have been alive with evidently good living quality. Conclusion Piggyback liver transplatations is a good treatment for Wilson disease.

目的探讨背驼式肝移植术,解决肝豆状核变性铜代谢障碍,延长患者生存时间,改善患者的生存质量。方法2例病人采用经典式同种异体原位肝移植术,3例采用背驼式同种异体原位肝移植术,术后应用环孢霉素A抗免疫治疗。结果采用经典式手术2例病人手术后分别于17、39天死亡,采用背驼式3例病人中2例存活至今(分别术后2.3年和08年),且生存质量明显改善。结论背驼式肝移植是治疗肝豆状核变性的一种优选方法。

Objective To establish an orthotopic implantation model of C6 cells in Wistar rats with stereotactic technique and to study the growth patterns of the tumors formed in the rat brain. Methods The C6 cells (10 6/10 μl) were stereotaticallly implanted into the right caudate nuclei of 27 Wistar rats. All rats were divided into two groups according to their survival time. After C6 inoculation, the living and survival states of rats with glioma were observed and the formation and their volumes of tumors,...

Objective To establish an orthotopic implantation model of C6 cells in Wistar rats with stereotactic technique and to study the growth patterns of the tumors formed in the rat brain. Methods The C6 cells (10 6/10 μl) were stereotaticallly implanted into the right caudate nuclei of 27 Wistar rats. All rats were divided into two groups according to their survival time. After C6 inoculation, the living and survival states of rats with glioma were observed and the formation and their volumes of tumors, metastasis, histopathology, expression of glial fibrillary acidic protein (GFAP), vascular endothelial growth factor (VEGF) and factor Ⅷ related antigen in the tumors were investigated. Results All the tested rats developed brain tumors without extracranial metastasis. The mean survival of the tumor-bearing rats was (25.50±5.75) d. The tumor volumes increased in a time-dependent manner and reached maximum between 3 to 4 weeks. The tumors were highly cellular, with remarkable cytoplasmic and nuclear polymorphism, intratumoral pseudopalisade necrosis, mitotic figures and abundant vessels which are immunostained with anti-factor Ⅷ related antigen polyclonal antibody. Immunohistochemical staining showed the distribution of VEGF protein was mainly in tumor cells of malignant glioma. The tumor margins displayed an invasive zone with tumor cells infiltrating the surrounding normal brain tissue matrix. The GFAP positive expression of glioma showed glial-derived tumor. Conclusion The orthotopic tumors formed by C6 cells in the rat brain shared similarities with human glioblastoma in morphology and differentiation, which could be used for experimental therapeutic studies on malignant gliomas.

目的 通过立体定向技术建立大鼠脑原位移植瘤模型,观察其生长特性。方法 在立体定向仪引导下,将体外培养的大鼠C6胶质瘤单细胞悬液(1×10 6/10 μl)接种于2 7只Wistar大鼠右尾状核区。以接种C6细胞后大鼠的允许生存期,将大鼠分成2组,观察大鼠生存状态、成瘤情况、肿瘤体积、脏器转移灶、组织学形态、胶质纤维酸性蛋白(GFAP)、血管内皮生长因子(VEGF)、兔抗人因子Ⅷ相关抗原免疫组化染色。结果 大鼠成瘤率为10 0 % ,无颅外转移。荷瘤大鼠平均生存期为(2 5 5 0±5 75 )d。肿瘤体积在第3~4周时肿瘤迅速增大。肿瘤呈浸润性生长,甚至侵袭颅骨;瘤细胞病理性核分裂像多见,GFAP蛋白呈散在阳性表达,VEGF蛋白强阳性表达;瘤组织内有典型的栅栏状坏死和丰富的微血管。结论 C6细胞在大鼠脑内原位移植瘤与人脑胶质母细胞形态和生长特性十分相似,具有分化程度低、微血管丰富、生长速度快且高度侵袭等特点。

 
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