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-cis-retinoic acid
相关语句
  异维a酸
     Synthesis, Characterization and Anticancer Activity of 13-cis-Retinoic Acid Derivatives
     13-cis-异维A酸衍生物的合成、表征及抗癌活性研究
短句来源
     13-cis-Retinoate derivatives(1a~1d) were synthesized from 13-cis-retinoic acid and formacylphenols using dicyclohexylcarbodiimide as a dewater reagent and 4-dimethylaminopyridine as a catalyst.
     以二环己基碳酰亚胺为脱水剂,4-二甲氨基吡啶为催化剂,异维A酸与甲酰基酚发生酯化反应生成了异维A酸酯(1a~1d);
短句来源
     All-trans-retinoic acid(2, ATRA), 13-cis-retinoic acid(3, 13-c-RA) as well as other retinoids are currently used for treatment of dermatological disorders and certain types of cancer.
     类维生素A的两种重要化合物——全反式维A酸(2,ATRA)和异维A酸(3,13-c-RA)已临床用于治疗皮肤病和某些癌症。
短句来源
     In one way, the relative glycosyl esters(6a~6d) of 13-cis-retinoic acid were prepared by the reaction of O-acetylglucopyranosyl bromide, O-acetylxylopyranosyl bromide, O-acetyllactosyl bromide and O-acetylmaltobiosyl bromide with 13-cis-retinonic acid in the presence of potassium hydroxide and 4-dimethylaminopyridine (DMAP) as phase transfer catalyst in 53 ~ 65 % yields.
     方法二是将异维A酸和1,2:3,4-二异丙叉基半乳糖(8a)在二环己基碳酰亚胺(DCC)和4-二甲氨基吡啶(DMAP)存在下酯化得到6-O-异维A酰-1,2:3,4-二异丙叉基半乳糖(9a),收率为73%。
短句来源
     All-trans-retinoic acid (ATRA), 13-cis-retinoic acid (13-c-RA) as well as other retinoids are currently used for treatment of dermatological disorders and certain types of cancer.
     类维生素A中的重要化合物——异维A酸(3, 13-c-RA)已临床用于治疗皮肤病和某些癌症。
短句来源
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  13-cis-维a酸
     Two methods were devised to synthesize the 13-cis-retinoic acid derivatives N~1-(2-furanidyl)-N~3-(4-ethyl)-5fluorouracil retinoate(RAFU) under mild reaction conditions. The structure was characterized by(()~1HNMR),(()~(13)CNMR) and MS.
     在比较DCC-DMAP和HMPA两种不同合成方法的基础上,在室温下顺利地将在通常反应条件下极易异构化的13-cis-维A酸合成了其衍生物13-cis-维A酸-N1-(2-四氢呋喃烷基)-N3-乙基-5-氟尿嘧啶酯(5,RAFU),其结构通过1HNMR、13CNMR和MS进行了表征。
短句来源
  13-顺式维甲酸
     Simultaneous Determination of All- trans-and 13- cis -Retinoic Acid in Human Serum by HPLC
     高效液相色谱法同时检测人血清中全反式及13-顺式维甲酸浓度
短句来源
     The action of 13-cis-retinoic acid(RA)in combination with 1,25-dihydroxyvitaminD_3(D_3)on two kinds of leukemia cell lines in vitro is reported.
     本文报道了13-顺式维甲酸(RA)和[1,25-二羟维生素 D_3 1,25(OH)_2D_3]合用对两种白血病细胞系的体外实验结果。
短句来源
     Objective:To develop an isocratic HPLC for the simultaneous determination of all- trans -and 13- cis -retinoic acid(ATRA,13-cRA)in human serum.
     目的 :建立高效液相色谱方法同时检测人血清中全反式及 13 -顺式维甲酸浓度。
短句来源
  “13-cis-retinoic acid”译为未确定词的双语例句
     Result AR mRNA was downregulated by 13-cis-retinoic acid of 1×10-5mol/L and 1×10-6 mol/L,and by baicalin of 1×10-4 mol/L(P<0.05).
     结果1×10-5、1×10-6mol/L13-顺维A酸和1×10-4mol/L黄芩苷使SZ95人皮脂腺细胞中ARmRNA的表达下降(P<0.05)。
短句来源
     Objective Study the effect of inhalation 13-cis-retinoic acid(13-cis-RA)on retin- oic acid receptors of rat lung.
     目的研究吸入13顺式维甲酸(13-cis-RA)对鼠肺部维甲酸受体(RAR)的影响。
短句来源
     The effect of inhalation 13-cis-retinoic acid on retinoic acid receptors of rat lung
     吸入13顺式维甲酸对鼠肺部维甲酸受体的影响
短句来源
     The effect of inhibition of proliferation of a novel human megakaryoblastic leukemia cell line (HIMeg) by two physiological factors, 1.25-dihydroxyvitamin D3 [1,25(OH)2 D3] and 13-cis-retinoic acid (RA), was investigated.
     本文报道了两种生理性诱导剂——活性维生素D_3[1,25(OH)_2D_3,简称D_3]和维甲酸(RA)对原始巨核白血病细胞的增殖抑制作用。
短句来源
     The optimized conditions are :2.02 portions of 13-cis-retinoic acid and one portion of quinol were added into a flask,stirring 4 h after DCC was added at a rate of 0.5 drop per second.
     优化条件为:异维生素A酸与对苯二酚摩尔比为2.02∶1,反应时间4 h,DCC滴加速度为0.5滴/秒。
短句来源
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  -cis-retinoic acid
Under an air atmosphere, the decomposition of 13-cis-retinoic acid is an autocatalytic reaction, while all-trans-retinoic acid undergoes a zero-order process.
      
The solid-state stabilities of 13-cis-retinoic acid and all-trans-retinoic acid in the presence and absence of oxygen were investigated.
      
Solid-State Stability Studies of 13-cis-Retinoic Acid and All-trans-Retinoic Acid Using Microcalorimetry and HPLC Analysis
      
In a phase II clinical trial, we sought to determine if combining celecoxib with 13-cis-retinoic acid (13-cRA, Accutane?) was efficacious in the treatment of recurrent (progressive) glioblastoma multiforme (GBM).
      
Combination chemotherapy with 13-cis-retinoic acid and celecoxib in the treatment
      
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The effect of inhibition of proliferation of a novel human megakaryoblastic leukemia cell line (HIMeg) by two physiological factors, 1.25-dihydroxyvitamin D3 [1,25(OH)2 D3] and 13-cis-retinoic acid (RA), was investigated. At the range of 10-9 - 10-6 mol/L, 1,25(OH)2 D3 and RA showed significant inhibition of proliferation of the megakaryoblastic leukemia cells,which was demonstrated by count of survival cells,incorporation of [3H]-TdR and [3H]-UR, and cloning efficiency. From above, it can further explain...

The effect of inhibition of proliferation of a novel human megakaryoblastic leukemia cell line (HIMeg) by two physiological factors, 1.25-dihydroxyvitamin D3 [1,25(OH)2 D3] and 13-cis-retinoic acid (RA), was investigated. At the range of 10-9 - 10-6 mol/L, 1,25(OH)2 D3 and RA showed significant inhibition of proliferation of the megakaryoblastic leukemia cells,which was demonstrated by count of survival cells,incorporation of [3H]-TdR and [3H]-UR, and cloning efficiency. From above, it can further explain the m.echanism of differentiation-inducers and the effect of 1,25(OH)2D3 on myelofibrosis. It is possible for 1,25(OH)2D3 and RA to be used for a new -treatment.

本文报道了两种生理性诱导剂——活性维生素D_3[1,25(OH)_2D_3,简称D_3]和维甲酸(RA)对原始巨核白血病细胞的增殖抑制作用。采用活细胞计数、[~3H]-TdR和[~3H]-UR参入以及克隆形成率测定3项指标,对一株新建的人原始巨核白血病细胞系(HIMeg)进行实验,结果表明:10~(-9)~10~(-6)mol/LD_3和RA对巨核白血病细胞的生长抑制作用呈明显量效与时效关系,10~(-7) mol/L D_3可使其克隆形成率减少90%以上。从而进一步说明了诱导分化剂对白血病及D_3对骨髓纤维化的治疗机制,提示D_3和RA可能有新的治疗用途。

The action of 13-cis-retinoic acid(RA)in combination with 1,25-dihydroxyvitaminD_3(D_3)on two kinds of leukemia cell lines in vitro is reported.At the concentrationof 10~(-7) mol/L,RA and D_3 could inhibit the cell proliferation and they have additiveeffect on the human promyelocytic leukemia cell line(HL-60),and also have synergiceffect on the human megakaryoblastic leukemia cell line(HIMeg)in inducing celldifferentiation.The results suggest that RA in combination with D_3 may be used forthe treatment...

The action of 13-cis-retinoic acid(RA)in combination with 1,25-dihydroxyvitaminD_3(D_3)on two kinds of leukemia cell lines in vitro is reported.At the concentrationof 10~(-7) mol/L,RA and D_3 could inhibit the cell proliferation and they have additiveeffect on the human promyelocytic leukemia cell line(HL-60),and also have synergiceffect on the human megakaryoblastic leukemia cell line(HIMeg)in inducing celldifferentiation.The results suggest that RA in combination with D_3 may be used forthe treatment of acute megakaryoblastic leukemia and acute promyelocytic leukemia.It ispresumed that they had additive or synergic action in the differentiation of hemopoieticcells in vivo.

本文报道了13-顺式维甲酸(RA)和[1,25-二羟维生素 D_3 1,25(OH)_2D_3]合用对两种白血病细胞系的体外实验结果。在10~(-7)mol/L 浓度下,应用 ~3H-TdR 掺入、NBT 还原试验、流式细胞分析等技术,测得:RA 和1,25(OH)_2D_3合用后可进一步抑制细胞的增殖;在诱导分化作用方面,二者对人原始巨核白血病细胞株(HIMeg)有相加作用,而对人早幼粒细胞白血病细胞系(HL-60)则有一定协同作用。上述结果提示可将 RA 联合1,25(OH)_2D_3试用于治疗白血病;推测二者在体内巨核系和粒单系造血细胞分化中发挥着相加或协同的促进效应。

Changes of cell cycle kinetics of HL-60 cell line after ALL-trans retinoic acid(ATRA)and 9-cis retinoic acid(9-cis RA)induction were studied with BrdU/DNA bivariated flow cytometry. HL-60 cells were exposed to ATRA or 9-cis RA for 96 h. During the exposure, the RA-treated cells were obtained at 24,48,72 and 96 h and then the cell cycle kinetics was meas ured with BrdU/DNA bivariated flow cytometry.Data from 4 parameters of cell cycle showed that treatment with ATRA or 9-cis RA for 96 h resulted in...

Changes of cell cycle kinetics of HL-60 cell line after ALL-trans retinoic acid(ATRA)and 9-cis retinoic acid(9-cis RA)induction were studied with BrdU/DNA bivariated flow cytometry. HL-60 cells were exposed to ATRA or 9-cis RA for 96 h. During the exposure, the RA-treated cells were obtained at 24,48,72 and 96 h and then the cell cycle kinetics was meas ured with BrdU/DNA bivariated flow cytometry.Data from 4 parameters of cell cycle showed that treatment with ATRA or 9-cis RA for 96 h resulted in a decrease in the cell BrdU LI,production rate and an increase in Ts and Tpot. Mean while the ability of the cell to reduce NBT was enhanced by RA induction, and the percentage of matured cells was increased by cell morphology assessment.These results suggested that both ATRA and 9-cis-RA may induce HL-60 cell differentiation.

用Brdu/DNA双参数流式细胞仪技术研究了HL-60细胞经全反式维甲酸(ATRA)和9-顺式维甲酸(9-cisRA)诱导24,48和96h后,细胞周期动力学各参数,BrdULI,Ts,Tpot和PR的变化,同时测定细胞NBT还原试验和细胞形态学的变化,发现随着维甲酸诱导时间的延长,BrdULI逐渐降低,PR亦是逐渐减少,而Ts和Tpot则逐渐延长。NBT还原试验结果表明NBT阳性细胞百分比呈现上升趋势:细胞形态学观察显示稍成熟阶段细胞百分比上升,早幼粒阶段细胞所占百分比下降。本文观察了ATRA和9-cisRA在诱导HL-60细胞过程中以上各参数的变化,结果提示两类维甲酸对HL-60细胞均有诱导分化功能。

 
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