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auto-antibody
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  自身免疫性抗体
     Expression of auto-antibody in acute pancreatitis patients and its clinical significance
     自身免疫性抗体在急性胰腺炎病程中的表达及意义
短句来源
     Objective To discuss the expression of an auto-antibody against the interstitial tissue of the pancreas in acute pancreatitis patients and analyze its possible significance.
     目的 探讨一种针对胰腺间质结构的自身免疫性抗体在急性胰腺炎不同病程中的表达情况 ,并分析其可能的意义。
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  “auto-antibody”译为未确定词的双语例句
     The auto-antibody level of BCP (0.21±0.18 ng/ml) and PGCP (0.36±0.24 ng/ml) in positive patients were lower than that in negative patients (0.69±0.35 ng/ml;1.06±0.61 ng/ml) (P<0.05).
     抗体阳性组 BCP(0.21± 0.18 ng/ml)和 PGCP(0.36±0.24 ng/ml)低于抗体阴性组(0.69±0.35 ng/ml;1.06±0.61 ng/ml)。
短句来源
     Sensitivity,specificity,positive and negative predictive value of combined auto-antibody determination were 87.8%,75.0%,84.3% and 80.0%.
     3种自身抗体联合检测1型糖尿病的敏感性、特异性、阳性预测值、阴性预测值分别为87.8%、75.0%、84.3%和80.0%。
短句来源
     Auto-antibody of liver antigens SLA/LP, LKM-1, LC-1, and AMA-M2 were identified by indirect immunofluorescence (IIF) assay and Immunoblot assay.
     分别用间接免疫荧光法、免疫印迹法检测肝抗原 (SAL/LP、LKM 1、LC 1、AMA M2 )自身抗体。
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     The prevalence of autoimmune disorders other than liver in AIH、PBC、PSC and PBC-AIH overlap syndrome were 47%、11%、27%and 24%respectively and with high prevalence of auto-antibody in these autoimmune hepatic diseases.
     AIH、PBC、PSC和PBCAIH肝外自身免疫性疾病的发生率分别为47%、11%、27%和24%,各自身免疫性肝病患者均有较高的自身抗体发生率。
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     Study on relationship between the conservation property of molecular structure of type Ⅱ collagens and their auto-antibody formation
     Ⅱ型胶原抗原分子结构的保守性与自身抗体形成关系的研究
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  相似匹配句对
     Auto-antibody to Koc in patients with cancers
     恶性肿瘤患者的抗Koc自身抗体
短句来源
     Significance of Auto-antibody in Diagnosis of Liver Disease
     自身抗体在肝病患者诊断中的意义
短句来源
     Anti-Idiotype Antibody and Auto-Immune Disease
     独特型网络与自身免疫病
短句来源
     Significance of auto-antibody determination in autoimmune hepatitis
     自身免疫性肝病患者血清自身抗体检测意义
短句来源
     The Immune Modulation of Auto Anti-Idiotypic Antibody of PRRSV
     猪繁殖与呼吸综合征自身抗独特型抗体及其免疫调节作用研究
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  auto-antibody
These results suggest that insulin auto-antibody production may occur in diabetics and that such antibodies may play a role in the pathogenesis or later evolution of the disease.
      
In this study, we describe for the first time the selection and characterization of recombinant human monoclonal anti-P protein (auto)-antibody fragments from an autoimmune patient-derived phage display antibody library.
      
The diagnosis of a Wegener's granulomatosis-microscopic polyarteritis disorder was made on the basis of clinical presentation and a positive anti-neutrophil cytoplasmic auto-antibody (ANCA).
      
The effect of thyroxine treatment on thyroid auto-antibody titers was not significant.
      
Alpha-fodrin auto-antibody in Sj?gren syndrome and other auto-immune diseases in childhood
      
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35 cases of systemic scleroderma were observed in the period 1970-1978. 30 were females and 5 males, ratio of 6:1. Age of onset varied from 8 to 67 years of age. Raynaud's phenomenon occurred in more than 90% and often heralded the onset of the disease. Cutaneous findings included sclerodactylia 45.7%, ulceration 48.60%, telangiectasis 25.7% and calcinosis 14.3%. Gastrointestinal involvement was also commonly seen with dysphagia in 82.9%. By roentgenologic studies, 34.3% of the patients had abnormal esophageal...

35 cases of systemic scleroderma were observed in the period 1970-1978. 30 were females and 5 males, ratio of 6:1. Age of onset varied from 8 to 67 years of age. Raynaud's phenomenon occurred in more than 90% and often heralded the onset of the disease. Cutaneous findings included sclerodactylia 45.7%, ulceration 48.60%, telangiectasis 25.7% and calcinosis 14.3%. Gastrointestinal involvement was also commonly seen with dysphagia in 82.9%. By roentgenologic studies, 34.3% of the patients had abnormal esophageal function, 3 patients had involvement of stomach and small intestine. Arthralgia was present in 80% and osteoporosis and absorption of the tips of the distal phalanges in more than 50%. There were 5 cases of fractures involving ribs, metatarsals, and neck of femur. Pulmonary fibrosis was present in 45.7% of the patients. 6 of the 10 patients studied showed a deteriorated pulmonary function. 5 were found to have cardiomegaly and another 3 had pulmonary hypertension. Laboratory studies revealed anemia, elevated sedimentation rate and elevated gamma globulin. The abnormal liver function tests and the positive LE and ANA and the presence of other auto-antibodies might be related to the immunological etiology of this disease.

本文对1970~1978年间35例系统性硬皮病进行了临床分析,并讨论了本病的治疗和预后,在中西医结合治疗下本组病例的生存率较高,观察期中仅1例死亡。

Immunologic function in sera of 48cases of sporadic encephalitis were es-timated. The average level of totalprotein, albumin and gamma globulinare in normal range. The mean valuesof IgG, IgA and IgM investigated atacute stage are higher than those of thenormal control(P<0. 05, P<0. 0025,P<0.001 respectively). The value ofIgM is significantly higher than thatof normal. All of them were increasedat the early stage. After pertaining for20 days, the mean value of IgM return-ed to normal level and after 30 daysthe...

Immunologic function in sera of 48cases of sporadic encephalitis were es-timated. The average level of totalprotein, albumin and gamma globulinare in normal range. The mean valuesof IgG, IgA and IgM investigated atacute stage are higher than those of thenormal control(P<0. 05, P<0. 0025,P<0.001 respectively). The value ofIgM is significantly higher than thatof normal. All of them were increasedat the early stage. After pertaining for20 days, the mean value of IgM return-ed to normal level and after 30 daysthe mean value of IgG returned to nor-mal, but after 31 days the mean valueof IgG was still higher than that of theinitial stage. These abnormal high levelof immunoglobulins indicate the pre-sence of an infectious disease. Oneweek after stopping of the therapy, themean values of IgG, IgA and IgMwere returned to normal. IgG, IgAand IgM values in patients were mild-ly influenced by receiving steroidtherapy. The auto-antibodies (forexample anti-myelin antibodies, anti-brain antibodies) were not detectedby indirect immunofluorescence in 20cases. The average value of lymphocytetransformation rate in the 27 caseswere significantly decreased. Sucha inhibition of cell-mediated im-mune observed in our patients, it issuggested that sporadic encephalitis isprobably due to virus infection. TheIgG, IgA and IgM values are also in-creased at the early stage and it isthat an allergic reaction may be existed.And therefore, we speculated that bothvirus infections and allergy are possiblyresponsible for the sporadic encepha-litis.

本文对散发性脑炎患者的血清蛋白、血清免疫球蛋白、免疫萤光抗体以及细胞免疫水平等项目进行了测定,发现48例患者急性期的各种免疫球蛋白的平均值均增高,尤以IgM明显。并观察了病程、病型,治疗前后用皮质类固醇与其他药物以及预后等对免疫功能的关系。

In 30 cases with SLE, the appearance of LE cells in the blood in relationto the titers of ANA was observed. Dynamic observations were made on 5cases who showed remission and 1 case who showed exacerbation of the dise-ase during treatment with steroids, 10 cases of rheumatic arthritis and other disases were observed as controle. It is preliminarily assumed that the auto-antibodies antinuclear antibodies (ANA), react with the antigens in nucle-us. The degree and extent of the degeneration is directly proportional...

In 30 cases with SLE, the appearance of LE cells in the blood in relationto the titers of ANA was observed. Dynamic observations were made on 5cases who showed remission and 1 case who showed exacerbation of the dise-ase during treatment with steroids, 10 cases of rheumatic arthritis and other disases were observed as controle. It is preliminarily assumed that the auto-antibodies antinuclear antibodies (ANA), react with the antigens in nucle-us. The degree and extent of the degeneration is directly proportional to thetiters of ANA in the patient's blood. If the titers of ANA are low (less than1:100) there may be slight degeneration of the nucleus, part of the normalchromatin structure is still persisted and only the center of it tends to fusetogether or there may be fissures on it. The cleft on it may widen or it maybreak into pieces. According to the characteristics of the degenerated chromat-in described above, we call them "small pattern", and "speckled", LE cells. Ifthe titers of ANA increase more than 1:100, the normal chromatin pattern,under the action of ANA, would be partly dissolved, forming large vacuolesand we call it "reticular", LE cells. All kinds of them are called "atypical LEcells". In the titers of ANA increase up to 1:250 or more, there would befurther of the degenerated chromatin. The chromatin became loose, swelled andfinally lost its normal pattern, giving rise to a large hemogeneous mass-LEbody. When it engulfed by a polymorphonuclear leukocytes, it is called "ty-pical LE cell". With the number of this cells can reach 35 per cent of theneutroleukocytes. In 5 cases of SLE (ANA 1:250), the clinical symptoms subsided aftertreating with steroids with the decreasing of ANA, typical LE cells and LEbodies in the patient's blood disappeared. In one case (ANA 1:1,250), whobecame worse during treatment with steroids, typical LE cells and LE bodiesdid not disappear from the blood, and the titers of ANA did not come down. The presence of typical LE cells in the peripheral blood is valuable forthe diagnosis of SLE. But according to the observation mentioned above, typ-ical LE cells were only present in peripheral blood while the titers of ANA isabove 1:250. Below this level, only different kinds of atypical LE cells couldbe found. Therefore, if the number of these atypical LE cells below 1‰, thediagnosis of SLE would be questionable. If the number of them is above 1‰,SLE and other autoimmune disease could be considered. However, if the numb-er of them is beyond 5‰, it is most likely that the disease is SLE.

本文探讨了典型LE细胞的形成与ANA滴度的关系,认为非典型LE细胞的出现与数量的增多对诊断SLE有参考价值。对典型LE细胞的临床意义本文作了分析。

 
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