The results show that F951 inhibit the HL-60 cells proliferation significantly in the range of dosages studied, which indicated dose-dependent effects and synergistic effects while in combination with low-dose Ara-C.
The results showed that XK469 could inhibit H460 cells growth in vitro in dose-dependent manners, after being treated for 24h, the cellular growth inhibitory rate were 65.96%(10ug/ml), 75%(20ug/ml), 81.1%(40ug/ml), 85.64%(80ug/ml), 88.57%(120ug/ml).
As aspirin,an known cyclooxygenase inhibitor,and dazo xiben,an known selective thromboxane synthetase inhibitor,their inhibitory effect on the platelet aggregation induced by arachidonic acid was much stronger than that induced by ADP. Radioimmuno-assay of TXB2 and PGE2 showed that econazole andclotrimazole 0.5-50nmol/L inhibited TXB2 synthesis in rat platelets in a dose-dependent manner with corresponding increase in PGE2 production.
There exist a dose-dependent relation between Ru_(486)and IL-1 activity. Result indi-cated that either in vivo or in vitro study,on hemorrhagic or normal rats, GR mightbe an important mediator of IL-1 activity,i.
(2) it was possible to establish a dose effect calibration curve for doses above 5 Gy by adding Cyt-B and prolonging the cultural time, so that its value as a biological dosimeter for clinical application might be increased than before.
DEC could markedly inhibit the contraction of thoracic aortic rings induced by KCl and norepinephrine(NE) in a concentration-dependent manner,shifted the cumulative dose-response curves of KCl and NE to right,and reduced the maximal efficacy of contraction in a nonCompetitive antagonistic manner. The pD'2 values of KCl and NE were 1.991 and 2.271 respectively.
AIM:Antipyretic dose-response and time-effect relationship of promethazine have been observedRESULTS:(1)Different antipyretic effect of promethazine on endotoxin-induced febrile rabbits were produced at 3 defferent dosage of 1mg,5mg,10mg/kg.
No linear dose-effect relationships have been revealed for both physiological and biochemical parameters.
As for individual solvents, the action of their mixtures with water obeys the "dose-effect" law, with a greater influence of small doses of absorbed vapors on the polymer structure and optical activity.
The dose-effect dependence indicated stimulating effects of β-endorphin, DAGO, and DADLE on the proliferative response in the presence of phytohemagglutinin (PHA).
The curve of the dose-effect dependence of C6-AHB had a breaking point within the submillimolar (10-4 M) concentration range.
The phytotoxicity variation is maximum in a moderately polluted plot, where both very high and very low pollution levels were observed, which determines a substantially nonlinear dose-effect relationship.
The disorder parameter plays a determining role in the manifestation of the dose effect; when it decreases (>amp;lt;0.4), both the magnitude of the dose effect and the time required for its annealing strongly increase.
On the high-dose effect in the case of ion implantation of silicon
In order to gain insight into the mechanism of the so-called high-dose effect, several experiments were performed with ion implantation of phosphorus into silicon.
It was shown that neither the distinct dose effect nor its long annealing time can be explained unless the radiation-chemical aspect of irradiation is taken into account.
In the newborn only the high-dose (above 3×10-6 mol/l) effect was seen but in rats older than 5 days a mixed low-dose (below 3×10-6 mole/l)/high-dose effect was apparent.
The analysis of dose-response relationships indicated that when the hemodynamic scores in patients with hypertension were lower than 75 points, the RR of stroke at 75, 60, 45, 30 and 15 points were 2.85, 4.43, 4.54, 5.40 and 9.88, respectively.
Dose-Response Functions as Estimates of the Effect of Acid Precipitates on Materials
Presented and discussed are dose-response functions for structural metals and alloys (bronze, copper, weathering steel, zinc, aluminum, nickel and tin), stone materials (limestone and sandstone), paint coatings and glasses.
The Classification System of ISO 9223 Standard and the Dose-Response Functions Assessing the Corrosivity of Outdoor Atmospheres
A model and dose-response functions characterising the corrosivity of the outdoor atmospheres are described.