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partial unilateral ureter obstruction
相关语句
  输尿管部分梗阻
     Objective:To explore the role of connective tissue growth factor(CTGF) and nuclear factor-κB (NF–κB) in the renal on the process of renal interstitialfibrosis caused by unilateral ureteral obstruction(UUO) and partial unilateral ureter obstruction (PUUO) in rats.
     目的:利用大鼠单侧输尿管梗阻(UUO)模型及单侧输尿管部分梗阻(PUUO)模型,探索不同程度输尿管梗阻以后大鼠肾脏结缔组织生长因子(CTGF)与核转录因子-κB(NF-κB)的表达及其意义。
短句来源
     Establishment of a model of partial unilateral ureter obstruction
     可逆性输尿管部分梗阻动物模型的建立
短句来源
     Objective To establish an experimental model of reversible partial unilateral ureter obstruction(PUUO),and investigate the morphological change caused by PUUO.
     目的建立可逆性输尿管部分梗阻(PUUO)动物模型,并观察部分梗阻肾脏形态学改变。
短句来源
     Study on Hydronephrosis and Renal Fibrosis Caused by Partial Unilateral Ureter Obstruction
     输尿管部分梗阻所致肾积水、肾纤维化的实验研究
短句来源
     Objective: To investigate the development of tubulointerstitial fibrosis caused by partial unilateral ureter obstruction(PUUO) and the improvement of tubulointerstitial fibrosis after obstruction was relieved.
     目的:研究单侧输尿管部分梗阻(PUUO)后肾间质纤维化的发生机制及梗阻解除后肾间质纤维化的恢复情况。
短句来源
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  “partial unilateral ureter obstruction”译为未确定词的双语例句
     The Renal Expression of Connective Tissue Growth Factor and Nuclear Factor-κB in Rats with Unilateral Ureteral Obstruction and Partial Unilateral Ureter Obstruction
     不同程度输尿管梗阻大鼠肾脏CTGF与NF-κB的表达及其意义
短句来源
     Methods:Forty - eight rats were randomly assigned to shame operation group (normal group) ,complete obstruction group after unilateral ureteral obstruction, partial obstruction group after partial unilateral ureter obstruction, sixteen per group.
     方法:将48只大鼠随机分成3组,假手术组(Sham-operated rates ,SOR)即对照组,完全梗阻组和部分梗阻组,每组16只。
短句来源
  相似匹配句对
     Renal fibrosis caused by partial unilateral ureter obstruction
     输尿管部分梗阻与肾小管间质纤维化
短句来源
     Establishment of a model of partial unilateral ureter obstruction
     可逆性输尿管部分梗阻动物模型的建立
短句来源
     PARTIAL DIPLOMYELIA
     部分的二重脊髓
短句来源
     On the Unilateral Accomplice
     论片面共犯
短句来源
     On Unilateral Abettor
     论片面教唆犯
短句来源
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Objective To investigate renal function change and the tubulointerstitial fibrosis caused by partial unilateral ureter obstruction(PUUO).Method PUUO was established by the method of embedding upper half of the ureter into ipsilateral psoas.Serum creatine and glomerular filtration rate were determined,and?collagen?Ⅰ?and?Ⅲ?were?semi-quantified?byimmunohistochemistry assay.Result The difference of renal function was not significant at 1st week after operation,but massive accumulation of collagen in...

Objective To investigate renal function change and the tubulointerstitial fibrosis caused by partial unilateral ureter obstruction(PUUO).Method PUUO was established by the method of embedding upper half of the ureter into ipsilateral psoas.Serum creatine and glomerular filtration rate were determined,and?collagen?Ⅰ?and?Ⅲ?were?semi-quantified?byimmunohistochemistry assay.Result The difference of renal function was not significant at 1st week after operation,but massive accumulation of collagen in tubulointerstitium led to renal fibrosis.As the obstruction continued,renal function and fibrosis both deteriorated progressively.Conclusion Damage of renal function and renal fibrosis develope progressively after PUUO.The development of tubulointerstitial fibrosis is earlier than damage of renal function.

目的:研究单侧输尿管部分梗阻后肾功能损害及肾间质纤维化的发生机理。方法:48只雄性SD大鼠,其中24只为对照组,另24只大鼠建立单侧输尿管部分梗阻动物模型,在术后1、2、4、8周各随机选取6只,测定血、尿肌酐浓度,计算肾小球滤过率,免疫组织化学半定量分析肾间质内Ⅰ、Ⅲ型胶原蛋白含量。结果:输尿管部分梗阻后1周血清肌酐和肾小球滤过率无显著改变,但肾间质纤维化明显(P<0.01),随着梗阻时间延长,肾间质纤维化加重,血清肌酐逐渐升高,肾小球滤过率进行性降低(P<0.01)。结论:输尿管部分梗阻后,肾小管间质纤维化发生在肾功能出现损害之前,肾间质纤维化及肾功能损害均呈进行性发展。

Objective: To investigate the development of tubulointerstitial fibrosis caused by partial unilateral ureter obstruction(PUUO) and the improvement of tubulointerstitial fibrosis after obstruction was relieved. Methods: PUUO was induced by the method of embedding upper half of the ureter into ipsilateral psoas.Obstruction was relieved by dissecting the ureter from psoas groove and returning its normal anatomical position.Pathology examination were performed,and collagenⅠand Ⅲ were...

Objective: To investigate the development of tubulointerstitial fibrosis caused by partial unilateral ureter obstruction(PUUO) and the improvement of tubulointerstitial fibrosis after obstruction was relieved. Methods: PUUO was induced by the method of embedding upper half of the ureter into ipsilateral psoas.Obstruction was relieved by dissecting the ureter from psoas groove and returning its normal anatomical position.Pathology examination were performed,and collagenⅠand Ⅲ were semi-quantified by immunohistochemistry assay. Results: Massive accumulation of TypeⅠand Ⅲ collagen in tubulointerstitium leads to renal fibrosis.Renal fibrosis can recover if obstruction be relieved within 4 weeks. Conclusion: The results indicated tubuloinsterstitisl fibrosis develop progressively after PUUO,and fibrosis reduce by obstruction relief.

目的:研究单侧输尿管部分梗阻(PUUO)后肾间质纤维化的发生机制及梗阻解除后肾间质纤维化的恢复情况。方法:144只雄性SD大鼠,24只作为对照组,另外120只大鼠建立单侧PUUO动物模型,其中梗阻组24只,在术后1、2、4和8周各随机选取6只,行肾组织病理学检查,免疫组化测定肾间质内Ⅰ型、Ⅲ型胶原蛋白(ColⅠ、ColⅢ);梗阻解除组96只,于梗阻后1、2、4和8周各为24只大鼠解除梗阻,分别于解除后1、2、4和8周各随机选取6只,行病理学观察及免疫组化分析。结果:输尿管部分梗阻后1周,肾间质ColⅠ、ColⅢ表达明显增加(与对照组比较,P<0.01),并随时间延长而逐渐加重(与前一时间段比较,P<0.01)。1、2和4周时解除梗阻,ColⅠ、ColⅢ逐渐恢复,与梗阻解除前比较差异有显著性意义(P<0.01),8周时解除梗阻,胶原蛋白无显著变化。结论:PUUO后肾间质纤维化进行性发展,早期解除梗阻,肾间质纤维化可有不同程度的恢复;若梗阻超过8周,则成为不可逆性改变。

Objective To establish an experimental model of reversible partial unilateral ureter obstruction(PUUO),and investigate the morphological change caused by PUUO.Methods Twenty-four rats were subjected to right upper ureter obstruction by embedding upper half of the ureter into ipsilateral psoas,and ultrasound and pathology examinations were performed at 1,2,4,and 8 weeks after operation.48 rats were established PUUO and then relieved the obstruction by dissecting the ureter...

Objective To establish an experimental model of reversible partial unilateral ureter obstruction(PUUO),and investigate the morphological change caused by PUUO.Methods Twenty-four rats were subjected to right upper ureter obstruction by embedding upper half of the ureter into ipsilateral psoas,and ultrasound and pathology examinations were performed at 1,2,4,and 8 weeks after operation.48 rats were established PUUO and then relieved the obstruction by dissecting the ureter from psoas groove and returning its normal anatomical position at 2 and 4 weeks after PUUO,and ultrasound and pathology examinations were performed at 1,2,4,and 8 weeks after obstruction was relieved.Results The collecting-system of the obstructed kidney was dilated progressively,APD and V were higher,and RCT was thinner than those of normal control at every interval(P<0.01). Hydronephrosis recovered following the relief of obstruction.The earlier relief gains the quicker improvement.Conclusion Embedding upper half of ureter into ipsilateral psoas produced severe PUUO.Obstruction can be easily reversed by dissecting the ureter from psoas groove and returning its normal anatomical position.It is a reliable and simple technique for the production of reversible PUUO.

目的建立可逆性输尿管部分梗阻(PUUO)动物模型,并观察部分梗阻肾脏形态学改变。方法成年雄性SD大鼠72只,将右侧输尿管上段埋入腰大肌建立PUUO动物模型,随机分为观察组和梗阻解除组。观察组24只,分别于1、2、4、8周各取6只,行二维超声检查及病理学检查;梗阻解除组48只,分别在2、4周各为24只大鼠解除梗阻,于梗阻解除后1、2、4、8周各取6只,行二维超声及病理学检查。结果梗阻后积水肾盂前后径(APD)、肾盂容积(V)逐渐增大,最大肾实质厚度(RCT)逐渐减小,与正常值比较有显著性差异(P<0.01),各时间段之间比较有显著性差异(P<0.01);梗阻解除后,APD、V逐渐变小,RCT逐渐增加,与梗阻解除前比较有显著性差异(P<0.01),各时间段之间比较有显著性差异(P<0.01)。梗阻解除越早,恢复越快,病理学检查也支持这一结果。结论该模型成功复制了PUUO所致肾脏形态学改变,是一种理想的PUUO动物模型。

 
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