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morphine abstinence
相关语句
  吗啡戒断
     Effect of Electroacupuncture on Immunoregulation of β-EP in Rats with Morphine Abstinence Syndrome
     电针对吗啡戒断大鼠β-EP免疫调节作用的影响
短句来源
     Experimental Study on the Effect of Reinforcing Body Resistance and Elimination Poison of Acupuncture on Morphine Abstinence Syndrome in Rats
     针刺对吗啡戒断大鼠祛毒扶正作用的实验研究
短句来源
     Experimental Study on the Effect of Electroacupuncture in Resisting Apoptosis of Thymocytes in Rats with Morphine Abstinence Syndrome
     电针抗吗啡戒断大鼠胸腺细胞凋亡的实验观察
短句来源
     Morphine,IL-2 and β-EP in blood serum of rats with morphine abstinence were measured to determine the effect of electrical acupuncture on point“Zusanli”Results showed that morphine in blood serum was reduced,and IL-2,β-EP were increased after electrical acupuncture therapy.
     本文观察了电针“足三里”穴对吗啡戒断大鼠血清吗啡含量、IL 2和 β EP的影响。
短句来源
     Chronic morphine dependence was induced by increasing doses of morphine, starting form 5 mg·kg-1·day-1 to 260 mg·kg-1·day-1 in 12 days. The daily dose was given by 3 subcutaneous injections. Chronic morphine abstinence was induced by IP naloxone 5 mg·kg-1 . The animals were killed 24 h later.
     慢性吗啡依赖组每日吗啡用量分3次腹腔注射,从第一天用量5 mg/kg起,直到第12天递增至260 mg/kg,慢性吗啡戒断组在慢性吗啡依赖后的次日腹腔注射纳洛酮5 mg/kg,催促戒断24h后处死大鼠。
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  “morphine abstinence”译为未确定词的双语例句
     Conclusion: Morphine dependence can lower the level of μ opioid receptor in rat brain, and after morphine abstinence by naloxone these changes are difficult to recover in short term, which may be involved in the neurobiological mechaisms of opioid dependence and abstinence.
     结论 :实验结果表明大鼠不同脑区在吗啡依赖过程中 μ阿片受体出现明显下调 ,予纳洛酮催促戒断 ,μ阿片受体较依赖组大鼠有显著回升 ,但仍显著低于正常组水平 ,这可能是阿片类依赖和戒断的重要神经生物学机制之一。
短句来源
     The ratio of cAMP to cGMP was increased (P <0.01) in morphine abstinence Ⅰgroup,the content of cAMP and cGMP was decreased (P <0.01) in brain in morphine abstinence Ⅱgroup.
     戒断Ⅱ组大鼠脑中cGMP、cAMP含量均明显减少(P<0.01);
短句来源
     Levels of NOS activity,NO output in serum,brain tissue around NAc were increased significantly during the period of morphine withdrawal compared with the saline group(P<0.05), while GABA(icv)could inhibit the enhancement of NOS activity, NO output in morphine abstinence session(P<0.05).
     Icv注入10μl(500μg·10μl-1)的GABA可抑制吗啡依赖大鼠血清及脑组织NO含量和血清中NOS活性的增高(P<0.05)。
短句来源
     Intracerebroventricular administration of scopolamine attenuates naloxone precipitated morphine abstinence syndrome
     侧脑室注射东莨菪碱对吗啡依赖大鼠戒断反应的抑制作用(英文)
短句来源
     2. The expression of DBI mRNA obviously increase after morphine abstinence, and electroacpunctrue can prevent the increasing. It shows that electroacpunctrue controls the anxiety related to the mediation of the DBI mRNA expression.
     2.吗啡依赖大鼠戒断后大脑皮质内DBI mRNA表达明显增多,与正常
短句来源
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  相似匹配句对
     Effect of Qingjunyin Ⅱ on abstinence reaction in morphine-dependent mice
     清君瘾Ⅱ号对吗啡依赖性小鼠戒断反应的作用
短句来源
     EFFECT OF ACUPUNCTURE ON NITRIC OXIDE IN RATS WITH MORPHINE ABSTINENCE SYNDROME
     针刺对吗啡戒断大鼠一氧化氮的影响
短句来源
     Morphine Immunoassay
     吗啡的免疫测定
短句来源
     Group M (Morphine group);
     (4)吗啡预处理组(Morphine group, M组);
短句来源
     Abstinence and fatty liver
     戒酒与脂肪肝
短句来源
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  morphine abstinence
This paper concludes that exist brain regional differences in the α2-adrenoreceptors response under morphine-treatment and possibly under naloxone-induced morphine abstinence syndrome.
      
Injections of actinomycin D (10 μg/kg, i.p., made before each morphine injection) decreased the level of morphine abstinence only in old rats.
      
Thus, the paradoxical response of PFC DA to morphine and morphine abstinence may be explained by the fact that extracellular DA in the PFC mainly represents the amine co-released from NA terminals.
      
The results indicate that apomorphine hypermotility is controlled by dihydropyridine calcium channels and that enhancement of calcium channel density produced by morphine abstinence and by chronic ECS potentiates the hypermotility response.
      
All benzodiazepines tested induced similar changes in some of the signs of morphine abstinence: decreased jumping behavior and increased wet dog shake frequency.
      
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In a previous study(Drug Alcohol Dependence 1993,31:169)we have shown that naloxone-induced morphine abstinence syndrome in rats can be suppressed by electroacupuncture(EA)of 2Hz or 100Hz,Since EA or TENS of 2Hz isknown to release central β-endorphin and enkephalin,and that of 100Hz to release dynorphin in the spinal cord(News Physiol Sci 1992,7:176),the effectiveness of 100Hz stimulation may suggest the involvement of dynorphin in this event.In the present study a special TENS device,Han's Acupoint Nerve...

In a previous study(Drug Alcohol Dependence 1993,31:169)we have shown that naloxone-induced morphine abstinence syndrome in rats can be suppressed by electroacupuncture(EA)of 2Hz or 100Hz,Since EA or TENS of 2Hz isknown to release central β-endorphin and enkephalin,and that of 100Hz to release dynorphin in the spinal cord(News Physiol Sci 1992,7:176),the effectiveness of 100Hz stimulation may suggest the involvement of dynorphin in this event.In the present study a special TENS device,Han's Acupoint Nerve Stimulator,HANS,was used to treat 212 heroin addicts(161 male,51 female,aged 15-38) subjected to abrupt abstinence.HANS was used 30 min per day from day 1 to day 10.Two pairs of skin electrodes were placed on Heku point on one hand and Neiguang point on the other forearm. Frequency of HANS was set at one of the foloowing:2,100,or 2/100(2Hz alternating with 100Hz,each lasting for 3s).Comparison was made by sequential analysis between two groups or by ANOVA between multiple groups.Among the objective indices,the decrease of heart rate was most obvious,which returned from 110/min to normal level within 4-5 days of HANS treatment,whereas in the control group receiving placebo electrodes,the tachycardia remained for at least 10 days.Comparison of different frequencies revealed:(1)Overall clinical effec,2/100>2=100Hz;(2)Suppression of tachycardia,2/100>2=100Hz;(3)Euphoria-like effect,2100>100=2Hz;(4)Warm feeling,2/100>2>100Hz;(5)hypnotic effect,2/100>100=2Hz;(6)Increase of body weight,2=100=2/100Hz >control group.It is thus obvious that HANS was effective in relieving the opiate withdrawal syndrome,and2/100Hz seems to be the most favorable frequency.It is interesting to mention that 2/100Hz has also been shown to be the most effective frequency to induce analgesia in rats and in humans.A synergistic effect between enkephalin and dynorphin(in the case of 2/100Hz stimulation) may underlye this interesting clinical finding.It is anticipated that HANS may also be useful to prevent recurrence of drug use after the abstinence.

根据电针刺激可促使中枢神经系统释放内源性阿片肽的原理,应用韩氏穴位神经刺激仪(HANS),每天刺激一次,每次30分钟,治疗阿片成瘾者的戒断综合征。首次治疗后便可使过高的心率下降,产生温热感和欣快感,并可使烦躁不安的患者转入睡眠状态,缓解戒断症状。4~5天即可消除“心慌”,明显增加体重,7~10天可使阿片成瘾者完全脱瘾。在所进行试验的三种频率(2Hz、2/100Hz、100Hz)中,依其有效程度依次为2/100Hz>2Hz≈100Hz。单独应用HANS有明显的临床效果,如与其它药物合并应用,可减少替代药物的用量,进一步缩短戒毒疗程。是否能用HANS防止复吸,有待进一步研究。

The previous study (Chinese Journal of Pain Medicine 1995, 1: 30~38) have shown that morphine abstinence syndrome in patients with opioid addicts can be suppressed by Han's Acupoint Nerve Stimulator(HANS) of 2Hz or 100Hz or 2/100Hz. In the present study we have observed that the tachycardia of heroin addicts subjected to abrupt abstinence can be suppress by HANS of 2/100Hz. In the control group the heart rate remained 107±3. 0~104±2. 7b/miN within 60 minute. In the group receiving HANS of 2/100Hz...

The previous study (Chinese Journal of Pain Medicine 1995, 1: 30~38) have shown that morphine abstinence syndrome in patients with opioid addicts can be suppressed by Han's Acupoint Nerve Stimulator(HANS) of 2Hz or 100Hz or 2/100Hz. In the present study we have observed that the tachycardia of heroin addicts subjected to abrupt abstinence can be suppress by HANS of 2/100Hz. In the control group the heart rate remained 107±3. 0~104±2. 7b/miN within 60 minute. In the group receiving HANS of 2/100Hz treatment heart rate decreased to 103±2. 5b/min (5min), 98±1. 6b/min (10min, compared with control P<0. 05), 95±1. 3b/min(15min, compered with control P<0. 01), 91±1. 4b/min(30min, compared with control P<0. 001) after first treatment(30min), an effects lasting for at least 20 minute. Within 4 days of HANS treatment, the heart rate returned from 105±2. 4b/min to normal level(72±1.1~82±1.5b/min).

本研究根据一定频率的电刺激可促使中枢神经系统释放阿片肽的原理,应用韩氏穴位神经刺激仪(HANS),治疗75例海洛因戒断者,观察到HANS对海洛因戒断者的心动过这具有明显的抑制作用。每日刺激1次,在首次治疗的5min后,心率即开始下降,由治疗前的109±3次/分降至103±2.5次/分;至10min时心率降至98±1.6次/分,与对照组相比有显著性差异(P<0.01);至30min时心率下降为91±1.4次/分(P<0.001)。连续治疗4天以后,心率可稳定在正常水平(72±1.1~82±1.5次/分之间)。

Objective: To study the receptor mechanism of 100 Hz electroacupuncture (EA) amelioration of tachycardia of morphine withdrawal rats. Methods: Morphine dependence was induced in Wistar rats using 8 day morphine injection regime. Heart rate and blood pressure of the rats were recorded after 18 24 h of morphine abstinence, and 100 Hz EA stimulation was then given. Results: Tachycardia of the rats was ameliorated by 100 Hz EA, those effect was reversed by injecting opioid receptor antagonist naloxone...

Objective: To study the receptor mechanism of 100 Hz electroacupuncture (EA) amelioration of tachycardia of morphine withdrawal rats. Methods: Morphine dependence was induced in Wistar rats using 8 day morphine injection regime. Heart rate and blood pressure of the rats were recorded after 18 24 h of morphine abstinence, and 100 Hz EA stimulation was then given. Results: Tachycardia of the rats was ameliorated by 100 Hz EA, those effect was reversed by injecting opioid receptor antagonist naloxone (i.p. at 1 mg·kg -1 ), or by administrating selective κ opioid receptor antagonist nor BNI (intracerebro ventricular injection i.c.v. at 12 nmol). Conclusion:The effect of 100 EA in ameliorating tachycardia during morphine abstinence was mediated by κ opioid receptors in CNS.

目的:研究100Hz电针缓解吗啡戒断大鼠心动过速的受体机制。方法:在吗啡戒断18~24h的大鼠模型上,腹腔注射阿片受体拮抗剂纳络酮(naloxone,NX)或侧脑室注射κ阿片受体拮抗剂norbinaltorphimine(norBNI),给予100Hz电针刺激,记录吗啡戒断大鼠清醒状态下的心率和血压。结果:100Hz电针的作用可被腹腔注射NX1mg·kg-1完全翻转、被侧脑室注射NorBNI12nmol完全阻断。结论:100Hz电针抑制吗啡戒断大鼠心动过速的作用主要是通过中枢κ阿片受体介导的。

 
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