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retinoblastoma gene
相关语句
  视网膜母细胞瘤基因
     Effect of retinoblastoma gene on human osteosarcoma cell line OS732
     视网膜母细胞瘤基因对人骨肉瘤细胞株OS732的影响
短句来源
     Clinicopathologic study on expression of retinoblastoma gene in human breast cancer and its relation with p16 and c-erbB-2 proteins
     乳腺癌中视网膜母细胞瘤基因蛋白的表达及其与p16和c-erbB-2表达的关系
短句来源
     The average survival phase of positive expression of retinoblastoma gene protein was not more different significantly from the negative one (18.50, 24.19) months, (χ2=0.04,P > 0.05) .
     视网膜母细胞瘤基因蛋白阳性达者的平均生存时间与视网膜母细胞瘤基因蛋白阴性者相比无显著差别[(18.50,24.19)个月,(χ2=0.04,P>0.05)]。
短句来源
     ② Relationship between expressions of cyclinD1, p16 and retinoblastoma gene protein and prognosis of non-small-cell lung cancer: The average survival phase of cyclinD1 positive expression was shorter than that of negative expression (12.40, 35.40) months, (χ2=5.31,P =0.021) .
     ②细胞周期蛋白D1、p16、视网膜母细胞瘤基因蛋白表达与非小细胞肺癌患者预后的关系:细胞周期蛋白D1阳性表达者的平均生存时间较细胞周期蛋白p16阴性者短[(12.40,35.40)个月,(χ2=5.31,P=0.021)];
短句来源
     Relationship between expressions of cyclinD_1, p16 and retinoblastoma gene protein and prognosis of non-small-cell lung cancer
     非小细胞肺癌细胞周期蛋白D_1、p16及视网膜母细胞瘤基因蛋白表达与预后的关系(英文)
短句来源
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  rb基因
     Synergistic Effect of the Expression of P16~(INK4) Gene and Retinoblastoma Gene in Lung Cancer
     p16~(INK4)、Rb基因表达在肺癌发生中协调性研究
短句来源
     Promotion of the senescence of vascular smooth muscle cells by the introduction of retinoblastoma gene
     野生型Rb基因导入促进血管平滑肌细胞衰老的观察
短句来源
     Objective: To study the possibility of complex formation of the E7 protein encoded by human papillomavirus (HPV) binding to retinoblastoma gene product (pRb) in fresh samples of squamous cervical carcinoma (SCC).
     目的:检测子宫颈鳞癌组织中是否存在人乳头状瘤病毒(HPV)E7蛋白与Rb基因产物(pRb)的结合物(HPVE7-pRb)。
短句来源
     The two variable number of tandem repeats(VNTR) regions of retinoblastoma gene(Rb gene) of 42 cases of hepatocellular carcinoma(HCC) tissues and 4 lines of HCC cells were analyzed by PCR technique. LOH of Rb gene were found in 8 of 42 HCC tissues and 2 of 4 HCC cell lines.
     利用PCR技术对42对肝癌及癌旁正常肝组织、4个肝癌细胞株的Rb基因的两个数量可变的重复序列(VNTR)区进行分析,发现8例肝癌组织(19.02%)和2株肝癌细胞存在Rb基因的杂合性丧失(LOH),表明Rb基因的缺失在肝癌的发生发展中起着一定作用。
短句来源
     Alterations of retinoblastoma gene and its protein expression in aggressive bone tumors
     侵袭性骨肿瘤中RB基因及其蛋白产物表达的研究
短句来源
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  “retinoblastoma gene”译为未确定词的双语例句
     BamHI AND RsaI RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN RETINOBLASTOMA GENE IN A CHINESE POPULATION
     BamHI AND RsaI RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN RETINOBLASTOMA GENE IN A CHINESE POPULATION
短句来源
     Structural Abnormalities and Polymorphisms of the Retinoblastoma Gene in Nasopharyngeal Carcinoma
     Structural Abnormalities and Polymorphisms of the Retinoblastoma Gene in Nasopharyngeal Carcinoma
短句来源
     Study on the Dynamic Changes of Retinoblastoma Gene of SO-Rb_(50) Cell Line
     视网膜母细胞瘤细胞系SO-Rb_(50)瘤细胞Rb基因突变动态变化研究
短句来源
     Purpose: To study the dynamic changes of Retinoblastoma Gene of SO-Rb50 cell line.
     目的:研究SO-Rb50细胞系瘤细胞Rb基因突变的动态变化。
短句来源
     p16 INK4a is one of the inhibitors of cyclin dependent kinase(cdk),which inhibits cdk4/cdk6 mediated phosphorylation of retinoblastoma gene product (Rb) that leads to cell cycle arrest in G 1 phase.
     p16 INK4a是一种细胞周期蛋白依赖激酶 (cdk)的抑制因子 ,它通过抑制cdk4与cdk6的活性 ,使视网膜母细胞瘤抑制蛋白Rb处于低磷酸化状态 ,从而使细胞阻滞于G1期 .
短句来源
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  retinoblastoma gene
Loss in expression of the retinoblastoma gene product in human gliomas is associated with advanced disease
      
The retinoblastoma gene encodes a nuclear phosphoprotein (pRb) present in a wide range of human cancer cell lines including colon cancer cell lines.
      
Along with treatment, no marked alteration of mRNAs for cell cycle-regulating genes was found and the retinoblastoma gene product remained hyperphosphorylated throughout treatment.
      
The inability to arrest the cell cycle at the G1/S-check-point due to a lack of retinoblastoma gene product RB has been suggested as one potential explanation for this feature.
      
Overexpression of cyclin D1 increased both phosphorylation of the retinoblastoma gene product (RB) and passage through the G1-S phase transition, resulting in increased proliferation of cells.
      
更多          


Retinoblastoma gene (Rb) is a well-known tumorsuppressor gene.Rb deletion or aberration was found in many kinds of tumors, but no report has been appeared in the literature concerning the relationship between Rb gene and Wilms tumor(WT).By the use of a 3.8 kb cDNA Rb probe,a case of WT with deletion of the Rb gene was demonstrated after screening of 14 WT cases.Further indirect evidence was obtained by using PCR-amplification of exon 8,12,and 27 of the Rb gene.The results were briefly...

Retinoblastoma gene (Rb) is a well-known tumorsuppressor gene.Rb deletion or aberration was found in many kinds of tumors, but no report has been appeared in the literature concerning the relationship between Rb gene and Wilms tumor(WT).By the use of a 3.8 kb cDNA Rb probe,a case of WT with deletion of the Rb gene was demonstrated after screening of 14 WT cases.Further indirect evidence was obtained by using PCR-amplification of exon 8,12,and 27 of the Rb gene.The results were briefly discussed.

用视网膜母细胞瘤(Rb)基因3.8kb的cDNA探针,以Southern印迹杂交法,在14例肾母细胞瘤中,发现1例有Rb基因的缺失,在文献中尚未见报道。

The two variable number of tandem repeats(VNTR) regions of retinoblastoma gene(Rb gene) of 42 cases of hepatocellular carcinoma(HCC) tissues and 4 lines of HCC cells were analyzed by PCR technique.LOH of Rb gene were found in 8 of 42 HCC tissues and 2 of 4 HCC cell lines.This result suggested that the deletion of Rb gene should play a role in the carcinogenesis and development of hepatocellular carcinoma.

利用PCR技术对42对肝癌及癌旁正常肝组织、4个肝癌细胞株的Rb基因的两个数量可变的重复序列(VNTR)区进行分析,发现8例肝癌组织(19.02%)和2株肝癌细胞存在Rb基因的杂合性丧失(LOH),表明Rb基因的缺失在肝癌的发生发展中起着一定作用。对PCR-VNTR技术在快速检测Rb基因缺失上的价值进行了讨论。

Objective: To study the possibility of complex formation of the E7 protein encoded by human papillomavirus (HPV) binding to retinoblastoma gene product (pRb) in fresh samples of squamous cervical carcinoma (SCC). Methods: HPV 6/11, 16, 18, 33 DNA were detected in 40 samples of by polymerase chain reaction technique (PCR). The complexes of HPV E7pRb were examined in fresh tissues of HPV contained SCC through capture enzeme linked immunosorbent assay (captureELISA). Results: 45.0% (18/40) of the samples...

Objective: To study the possibility of complex formation of the E7 protein encoded by human papillomavirus (HPV) binding to retinoblastoma gene product (pRb) in fresh samples of squamous cervical carcinoma (SCC). Methods: HPV 6/11, 16, 18, 33 DNA were detected in 40 samples of by polymerase chain reaction technique (PCR). The complexes of HPV E7pRb were examined in fresh tissues of HPV contained SCC through capture enzeme linked immunosorbent assay (captureELISA). Results: 45.0% (18/40) of the samples were proved to be HPV positive by PCR. Out of 18 samples with HPV positive samples, the complexes of HPV E7pRb were deteced in 9 cses, including 1 HPV18 positive and 8 HPV16 positives. The complexes of HPV E7pRb were not found in 2 cases of positive HPV 6/11. No correlation was observed between the E7 protein binding to pRb and the histological grade of cervical carcinoma (P<0.05). There was correlation with clinical staging, the number of cases showing that the E7 protein pRb complex in stage Ⅰ was significantly higher than that in stages ⅡⅣ (P<0.05). Conclusions: The complex of “high risk” HPV E7pRb was demonstrated in fresh tissues of SCC. There is no correlation between the complex and histological grade of SCC. The complex formation may occur in the early developmental stage of cervical cancer.

目的:检测子宫颈鳞癌组织中是否存在人乳头状瘤病毒(HPV)E7蛋白与Rb基因产物(pRb)的结合物(HPVE7-pRb)。方法:运用聚合酶链反应(PCR)技术,对40例宫颈鳞癌组织中HPV6/11、16、18、33型DNA进行检测,并用捕获酶联免疫吸附试验,探查HPV感染的标本中有否HPVE7-pRb存在。结果:40例中,检出HPVDNA18例(45.0%)。18例中9例存在HPVE7-pRb,其中1例为HPV18,8例为HPV16。2例HPV6/11未检出HPVE7-pRb。临床Ⅰ期患者HPVE7-pRb的检出率高于Ⅱ~Ⅳ期患者(P<0.05)。HPVE7与pRb的结合,与宫颈癌病理分级无关(P>0.05)。结论:在宫颈鳞癌组织中存在HPVE7-pRb;HPVE7与pRb的结合过程发生在宫颈癌变的较早阶段。

 
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