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   retinoic acid metabolism 在 肿瘤学 分类中 的翻译结果: 查询用时:0.717秒
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retinoic acid metabolism
相关语句
  视黄酸代谢
    Effects of human Homeobox B1 gene transfection on retinoic acid metabolism and IFNα expression HL-60 cells
    HOXB1基因转染对HL-60细胞视黄酸代谢和α-干扰素表达的影响
短句来源
  视黄酸代谢
    Effects of human Homeobox B1 gene transfection on retinoic acid metabolism and IFNα expression HL-60 cells
    HOXB1基因转染对HL-60细胞视黄酸代谢和α-干扰素表达的影响
短句来源
  视黄酸代谢
    Effects of human Homeobox B1 gene transfection on retinoic acid metabolism and IFNα expression HL-60 cells
    HOXB1基因转染对HL-60细胞视黄酸代谢和α-干扰素表达的影响
短句来源
  “retinoic acid metabolism”译为未确定词的双语例句
    These data suggested that there is probably abnormal retinoic acid metabolism in leukocytes from leukemic patients, and this abnormality may be responsible for the leukemogenesis.
    提示白血病患者的白细胞内维甲酸代谢可能存在异常,并可能与白血病的发病有关。
短句来源
    ObjectiveTo investigate the effects of human cytochrome P450 enzyme gene(hp450RAI)transfer on retinoic acid metabolism and cellular proliferation in HL-60 cells.
    目的探讨细胞内一种细胞色素 P45 0 (hp45 0 RAI,也称 CYP2 6 )表达、视黄酸 (RA)代谢与细胞增殖功能的相互关系。
短句来源
    Objective:To investigate the relationship of human HomeoboxB1 gene(HoxB1)expression,retinoic,retinoic acid metabolism and cell apoptosis in HL 60 cell.
    目的 :探讨细胞内 Hox B1表达、视黄酸 ( RA)代谢与细胞凋亡的相互关系。
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  retinoic acid metabolism
Three phase II studies were conducted to determine the efficacy and tolerability of liarozole fumarate (R85246; liarozole), a retinoic acid metabolism blocking agent (RAMBA) and aromatase inhibitor.
      
Murine toxicology and pharmacokinetics of novel retinoic acid metabolism blocking agents
      
A sensitive GC-MS method was developed for the determination of a new retinoic acid metabolism blocking agent R115866 in human plasma samples.
      
Determination of the retinoic acid metabolism blocking agent R115866 in human plasma by gas chromatography-high resolution mass
      
These workers determined the distribution in adult and fetal mouse testis of enzymes and other factors involved in retinoic acid metabolism.
      


All trans retinoic acid(ATRA), 13-cis retinoic acid (CRA) and vitamin A (Vit A)were investigated in the plasma, leukocytes and erythrocytes from leukemia patients and healthy individuals by reverse phase high pressure liquid chromatography(HPLC). The following results were obtained. The ATRA, CRA and Vit A levels of plasma and erythrocytes from leukemia patients were within the range of control value, while ATRA(0.075±0.045 ng/106 cells) and CRA (0.13 ± 0.096 ng/106 cells) contents in leukemic cells were reduced...

All trans retinoic acid(ATRA), 13-cis retinoic acid (CRA) and vitamin A (Vit A)were investigated in the plasma, leukocytes and erythrocytes from leukemia patients and healthy individuals by reverse phase high pressure liquid chromatography(HPLC). The following results were obtained. The ATRA, CRA and Vit A levels of plasma and erythrocytes from leukemia patients were within the range of control value, while ATRA(0.075±0.045 ng/106 cells) and CRA (0.13 ± 0.096 ng/106 cells) contents in leukemic cells were reduced when compared to control (ATRA 0.16 ± 0.06 ng/106 cells)(P < 0.05). These data suggested that there is probably abnormal retinoic acid metabolism in leukocytes from leukemic patients, and this abnormality may be responsible for the leukemogenesis.

应用反相高压液相色谱(HPLC)技术,检测了正常人和白血病病人血浆、白细胞及红细胞内生理性全反式维甲酸(ATRA)、13-顺式维甲酸(13-cis-RA,CRA)和维生素A(VitA)的含量。结果表明,急性早幼粒白血病患者及其它白血病患者血浆及红细胞中内源性ATRA、CRA和VitA均在正常范围内。白血病患者白细胞内ATRA(0.08±0.05ng/106细胞,单位下同)、CRA(0.13±0.10)水平均低于正常人(ATRA0.16±0.06,CRA0.33±0.16)(P<0.05)。提示白血病患者的白细胞内维甲酸代谢可能存在异常,并可能与白血病的发病有关。

Objective[WT5”BZ]To investigate the relationship of human cytochrome p450 enzyme gene(hp450RAI) expression,retinoic acid metabolism and cell apoptosis in HL 60 cell.Methods The plasmid transfer mediated by liposomal transfectin reagent and reverse transcription PCR analysis were used in this study.ResultsThe hp450RAI mRNA was weakly detected in wild HL 60 cells,but the gene transfer made the HL 60 cells express hp450RAI greatly.The ...

Objective[WT5”BZ]To investigate the relationship of human cytochrome p450 enzyme gene(hp450RAI) expression,retinoic acid metabolism and cell apoptosis in HL 60 cell.Methods The plasmid transfer mediated by liposomal transfectin reagent and reverse transcription PCR analysis were used in this study.ResultsThe hp450RAI mRNA was weakly detected in wild HL 60 cells,but the gene transfer made the HL 60 cells express hp450RAI greatly.The hp450RAI gene transfer could not affect the growth of HL 60 cells induced by ATRA,Bcl 2 gene was expressed obviously in HL 60 cells,ATRA treatment could inhibit its expression,but hp450RAI transfer,and combined with the ketoconazole or IFN α increased the Bcl 2 mRNA in ATRA treated HL 60 cells.Conclusion hp450RAI may not be the main cytochrome p450 enzyme which modulates the metabolism of retinoic acid in wild HL 60 cells.hp450RAI transfer into HL 60 cells can not affect the cellular proliferation,but Bcl 2 expression can be changed by the hp450RAI transfer,cytochrome enzyme inhibitor or IFN α in HL 60 cells. [

目的探讨细胞内细胞色素氧化酶 p45 0 (CYP)表达、视黄酸 (RA)代谢与细胞凋亡的相互关系。方法采用脂质体介导的质粒转染和逆转录 - PCR等实验技术方法做有关分析检测。结果野生型 HL- 6 0细胞 hp45 0 RAI表达微弱 ,脂质体介导的 hp45 0 RAI质粒转染可使 HL- 6 0细胞稳定表达 hp45 0 RAI;hp45 0 RAI转染对 ATRA诱导的 HL- 6 0细胞增殖能力无明显影响 ;野生型 HL- 6 0细胞有较强 Bcl- 2表达 ,ATRA处理抑制未转染细胞 Bcl- 2表达 ,但单纯 hp45 0 RAI转染、hp45 0 RAI转染 +CYP抑制剂或加用 IFN- α均能增强 Bcl- 2表达 ,其中以加用 ketoconazole作用更为显著。结论 RA敏感 HL- 6 0细胞中影响 RA代谢的主要 CYP并非 hp45 0 RAI,hp45 0 RAI转染能增强 Bcl- 2表达 ,但对 HL - 6 0细胞增殖能力无明显影响 ,CYP抑制剂、IFN-α可能通过抑制细胞内 RA代谢 ,而增加 HL - 6 0细胞Βcl- 2表达。

ObjectiveTo investigate the effects of human cytochrome P450 enzyme gene(hp450RAI)transfer on retinoic acid metabolism and cellular proliferation in HL-60 cells.Methods The plasmid transfection mediated by liposomal transfection reagent, HPLC analysis and reverse transcription-PCR analysis were used in this study. ResultsIt was shown that the hp450RAI mRNA was not induced by the treatment of 2.5×10 -7 mol/L all-trans retinoic acid(ATRA) in HL-60 cells; The hp450RAI gene transfer made the...

ObjectiveTo investigate the effects of human cytochrome P450 enzyme gene(hp450RAI)transfer on retinoic acid metabolism and cellular proliferation in HL-60 cells.Methods The plasmid transfection mediated by liposomal transfection reagent, HPLC analysis and reverse transcription-PCR analysis were used in this study. ResultsIt was shown that the hp450RAI mRNA was not induced by the treatment of 2.5×10 -7 mol/L all-trans retinoic acid(ATRA) in HL-60 cells; The hp450RAI gene transfer made the HL-60 cells express hp450RAI greatly, which did not affect significantly the cell growth and metabolism of ATRA in HL-60 cells, but the use of Ketoconazole or IFN-α could cut down the metabolic rate of ATRA in HL-60 cells,and enhance the growth inhibitory induced by ATRA. ConclusionThe hp450RAI may not be the key cytochrome P450 enzyme to modulate the metabolism of retinoic acid in wild HL-60 cells. The hp450RAI inhibitor ketoconazole or IFN-α can cooperate with ATRA to inhibit the growth of HL-60 cells, which may partly owe to the low metabolism rate of ATRA and over-expression of IFN-α in HL-60 cells. [

目的探讨细胞内一种细胞色素 P45 0 (hp45 0 RAI,也称 CYP2 6 )表达、视黄酸 (RA)代谢与细胞增殖功能的相互关系。方法采用脂质体介导的质粒转染、流式细胞仪分析、逆转录 - PCR及高效液相色谱 (HPL C)分析等实验技术方法做有关分析研究。结果 12 .5× 10 - 7m ol/ L 全反式 RA(ATRA)处理 HL- 6 0细胞 3d未诱导明显的 hp45 0 RAI表达 ,脂质体介导的质粒转染可使 HL- 6 0细胞稳定表达 hp45 0 RAI;2单纯 hp45 0 RAI转染未对 HL- 6 0细胞 ATRA代谢及 ATRA诱导的 HL- 6 0细胞增殖抑制产生显著影响 ,而联合应用 P45 0酶抑制剂 Ketoconazole或 IFN- α则使 HL- 6 0细胞 ATRA代谢减慢 ,ATRA增殖抑制作用增强。结论 RA敏感 HL- 6 0细胞中影响 RA代谢的主要细胞色素 P45 0可能并非 hp45 0 RAI,P45 0酶抑制剂或IFN- α能协同 ATRA抑制细胞增殖 ,后者可能与 HL- 6 0细胞 ATRA代谢减慢及 IFN- α表达增强有关。

 
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