Objective To probe into the role of high mobility group box chromosomal protein 1(HMGB-1)in the pathogenesis of hearing loss induced by infection of murine cytomegalovirus(MCMV).
目的:探讨高迁移率族蛋白B1(high mobility group box chromosomal protein 1,HMGB-1)在小鼠巨细胞病毒(murine cytomegalovirus,MCMV)感染导致听力损失发病机制中的作用。
The results showed that the genes of GSTM1 and GSTT1 had no combined action,those with GSTM1(-)and GSTT1(-)genotype had high risk of developing noise-induced hearing loss than those with GSTM1(+)and GSTT1(+)(OR=1.11,2=0.16,P>0.05).
The high-frequency hearing loss in the exposed group was 305(34.3%) cases,which was significantly higher than that of the control group(20,12.5%)(P<0.01).
By analysis of multivariate condition Logistic stepwise regression mode, family history of hearing loss( OR =16.945,95%CI 1.21-237.369) and craniofacial anomalies ( OR =6.703,95%CI 0.61-73.85)were 2 independent risk factors of newborn hearing loss.
Conclusion: The medical history and auditory analysis of the members of the four pedigrees show that the hearing impairment in these pedigrees are nonsyndromic autosomal recessive hereditary hearing loss. The screening of the GJB2 ,GJB3,GJB6,and mitochondrial genes show that the F,G pedigrees are related with GJB2 mutations.
Results The ratio of hearing lost before operation was 74%, the abnormal tympanic graph rate was 80% (82% before 3-year-old). Hearing was improved at a certain degree 6 months after operation, the abnormal tympanic graph rate was 42%. The G + and G - positive rate of organism culture of tympanic scretion was 23% and 24%, most organisms were low poisonous and conditional infective.
Objective To research the factors which influense on noise-induced temporary threshold shift ( TTS) and noise -induced hearing lost, and research the relationship of the factors.
The organism culture of tympanic secretion was done before operation. Results The rate of hearing lost before operation was 74.17 %,the abnormal tympanic graph rate was 20%( 81.6 % before 3 year-old). Hearing was improved at a certain degree 6 months after operation,the abnormal tympanic graph rate was 58.33 %.
All the infants who were still abnormal in ABR would be diagnosed and evaluated by audiology in 3 months and then the degrees of hearing lose would be confirmed.
All the infants who were still abnormal in ABR would be diagnosed and evaluated by audiology in three months and then the degrees of hearing lose would be confirmed.
All the infants who were still abnormal in ABR would be diagnosed and evaluated by audiology in three months and then the degrees of hearing lose would be confirmed.
In addition to congenital ichthyosis he had also strabismus, horizantal nystagmus, bilateral neurosensory hearing loss, hepatomegaly and splenomegaly.
Hearing loss up to 30 dB (preserved socially adequate hearing) was found in 25 workers.
Some measures for preventing occupational noise-induced hearing loss were suggested.
Conclusion: The primary symptom of the patient was unilateral hearing loss.
In 73% of the cases the EAEP indicated the retrocochlear site of the lesion; in 27%, however, the results did not localize the exact site of the lesion owing to a lack of waves I, II and III due to a pronounced hearing loss.
Two missense mutations (686A→G, H229R; 25C→T, L9F) were detected in two sensorineural hearing impairment families.
A heterologous deletion of 18 bp within intron was found in 3 families with heredity hearing impairment, and in one of the 3 families, a missense mutation (R265P) was identified also.
But the deletion and missense mutation seemed not segregating with hearing impairment in the family.
Hearing impairment among workers occupationally exposed to excessive levels of noise
The hearing impairment was confirmed by distortion products of otoacoustic emissions measurements.
Two patients (grade 3 and 4 hearing) lost all hearing within 24 hours of treatment; another patient with grade 3 hearing lost residual hearing over 6 months.
In otolaryngology this surgical method was reported as meatoneuromyosynangiosis and suggested for the therapy of sensori-neural hearing lost.