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ultrasound emulsification
相关语句
  超声乳化
     Methods5-Fu-PLA-NP ware prepared with the method of ultrasound emulsification.
     方法超声乳化法制备5-Fu-PLA-NP载药纳米微粒;
短句来源
     Methods: (1) With the PLGA as matrix and ultrasound emulsification and dissolvent volatilization, PLGA nano-encapsuled BDP of nanoparticals(NP) were prepared.
     方法:(1)采用超声乳化法和去溶剂固化法,以聚乳酸-聚羟乙酸共聚物(PLGA)为基质,制备BDP纳米微囊;
短句来源
     With polylactate poly ethanol acid copolymer(PLGA)as marix materials,we adopted ultrasound emulsification/dissolvent volatilization method to prepare PLGA enveloped norcantharidin of nano particles(NP),proceeding the appearance signs of PLGA norcantharidin NP,making use of scanning electricity microsopy to look into the morphorlogy of nanoparticles through laser optical scattering experiment and determine its diameter distribution.
     [方法]以聚乳酸 聚乙醇酸共聚物(PLGA)作为基质材料 ,采用超声乳化/溶剂挥发法制备PLGA包载去甲斑蝥的纳米级微粒(NP) ,对PLGA 去甲斑蝥素 NP进行表征 ,借助扫描电镜观察微粒形态 ,通过激光光散射实验测定纳米微粒的粒径分布 ;
短句来源
     Methods The slow released BDP-PLGA nanocapsule were prepared by ultrasound emulsification and dissolvent volatilization.
     方法 采用超声乳化法和去溶剂固化法 ,制备BDP -PLGA纳米缓释微囊 ;
短句来源
     Methods 30 children (48 eyes) suffering from congenital cataract with eyesight dysfunction received ultrasound emulsification suction together with intraocular lens implantation and postoperative visual function exercise.
     方法对于30例(48眼)视力不同的先天性白内障患儿进行白内障超声乳化吸出联合人工晶体植入术,术后进行视功能康复。
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  “ultrasound emulsification”译为未确定词的双语例句
     1.1 Optimization HCFC - SLN technological processBy the method of uniform design to optimize various kinds of technological conditions and to confine the concentration of HCFC, lecithin, tristearin, Plu-ronic F68, ultrasound emulsification time as examination factors.
     采用均匀设计法优化各种工艺条件,确定HCgu量A磷脂量、三硬脂酸甘油酯浓度、Plurnic F68浓度、超声时间为考察因素,每个因素设定五个水平,按方法要求进行实验。
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  相似匹配句对
     External ultrasound liposuction and fat cell emulsification
     体外超声抽脂术及其脂肪乳化效应
短句来源
     Analysis of Cataract Ultrasound-Emulsification and Artificial Crystal Implantstion
     白内障超声乳化吸除及人工晶状体植入术的分析
短句来源
     The results by ultrasound.
     结果表明超声可以强化臭氧向水中传质,并加快臭氧在水中的自分解;
     Ultrasound of the Elbow
     肘部超声显像
短句来源
     Emulsification of chlorinated polypropylene
     氯化聚丙烯的乳化
短句来源
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Objective The preparation technique and blood glucose regulating effect of a nanoparticle slow released preparation of insulin were studied in vivo.Methods The polylactate-polyethanol acid copolymer(PLGA) microencapsulated insulin of nanoparticles(NP) was prepared by using PLGA as matrix and ultrasound emulsification/dissolvent volatilization. The morphology of the nanoparticle was observed with scanning electron microscope and its diameter was determined by laser emission. The drug carrying ratio of...

Objective The preparation technique and blood glucose regulating effect of a nanoparticle slow released preparation of insulin were studied in vivo.Methods The polylactate-polyethanol acid copolymer(PLGA) microencapsulated insulin of nanoparticles(NP) was prepared by using PLGA as matrix and ultrasound emulsification/dissolvent volatilization. The morphology of the nanoparticle was observed with scanning electron microscope and its diameter was determined by laser emission. The drug carrying ratio of this preparation was determined by high performance liquid chromatograph(HPLC), and its pharmacodynamics in diabetic animal model was studied. Results It showed that the characteristics of PLGA insulin NP was as follow:①smooth surface;②112.4μm in average diameter, with normal distribution;③drug carrying ratio 7.4%. It was demonstrated in vivo that there was no difference in biological activity from that in vitro. It showed that it provided slow releasing within at least 72h effectively in lowering blood glucose and keeping it in normal range. There was apparent dosage-effective relationship. Any of adverse effects was not occurred.Conclusion Nanoparticles may be adopted as an effective carrier of insulin achieving of long performing and stable releasing of insulin and resulted in more effective in lowering blood glucose.

目的 研究胰岛素纳米级粒子缓释制剂的体内生物作用 ,以期在临床上实现胰岛素注射剂的更长效稳定释放给药治疗糖尿病。方法 以聚乳酸 -聚乙醇酸共聚物 (PLGA)作为基质材料 ,采用超声乳化 /溶剂挥发法制备PLGA包囊胰岛素的纳米级微粒 (NP) ,借助扫描电镜观察微粒形态 ,通过激光光散射实验测定纳米微粒的粒径分布 ;利用高效液相色谱 (HPLC)测定纳米微粒制剂的载药率 ;并做纳米胰岛素制剂在糖尿病动物模型体内的药效学研究。结果经电镜观察PLGA -胰岛素NP为表面光滑的球形微粒 ,粒径分布平均值是 112 4nm ,呈正态分布 ;PLGA -胰岛素NP载药率为 7 4 % ;体内研究表明 ,所制备的纳米制剂生物活性没有改变 ;皮下注射途径给药纳米胰岛素可以在至少 72小时内长效控释 ,有效降低血糖并保持在正常范围。此外纳米制剂的量 -效关系明显 ,未见任何不良反应。结论PLGA纳米粒子可以作为胰岛素的有效载体 ,达到更长效稳定控制释放的目的 ,发挥药物更佳的降糖作用。

To investigate the preparation techinics and anti tumor effects both in vitro & in vivo of a novel nanosphere control releasing preparation of norcantharidin(an water insoluble anti cancer drug)by intravenous injection.With polylactate poly ethanol acid copolymer(PLGA)as marix materials,we adopted ultrasound emulsification/dissolvent volatilization method to prepare PLGA enveloped norcantharidin of nano particles(NP),proceeding the appearance signs of PLGA norcantharidin NP,making use of scanning...

To investigate the preparation techinics and anti tumor effects both in vitro & in vivo of a novel nanosphere control releasing preparation of norcantharidin(an water insoluble anti cancer drug)by intravenous injection.With polylactate poly ethanol acid copolymer(PLGA)as marix materials,we adopted ultrasound emulsification/dissolvent volatilization method to prepare PLGA enveloped norcantharidin of nano particles(NP),proceeding the appearance signs of PLGA norcantharidin NP,making use of scanning electricity microsopy to look into the morphorlogy of nanoparticles through laser optical scattering experiment and determine its diameter distribution.By means of HPLC we carry out the drug carrying coefficient(ratio)of the nanoparticles and its releasing curve in vitro.MTT method was adopted for the cancer cell bloodsheding test;Also the anti tumor effects of bi species neoplasm spetrum under different dosages,frequences of taking medicine and with various preparation techinics circumstances were observed.Observation of EM showed that PLGA norcantharidin NP nanospheres with smooth surfaces,the average diameter value was 126.4nm under normality distribution;the drug carring amount of PLGA norcantharidin NP was 36.3%.In vitro tests manifested that NP let out nearly 60% drug of its carriages in 7 days,in 12 days almost finished release totally without marked explosive discharge.As a result,experimentation in vivo indicated:nanoparticles showing apparent dosage efficacy relationship,and efficacy advantages over the unenveloped drug by interval drug delivery vs.per diem drug delivery,even with low toxicity.No mal reactions was found by introvenous injection probation.[Conclusion]Nanoparticles may serve as availability carrier of norcantharidin,anti cancer drug,and can be successesfully used in the prepation of its introvenous injection dose,so as to play more efficiency anti_tumor effects.

[目的]研究不溶于水的抗癌药物去甲斑蝥素纳米控释静脉注射制剂的制备工艺及其体内外抗肿瘤作用。[方法]以聚乳酸 聚乙醇酸共聚物(PLGA)作为基质材料 ,采用超声乳化/溶剂挥发法制备PLGA包载去甲斑蝥的纳米级微粒(NP) ,对PLGA 去甲斑蝥素 NP进行表征 ,借助扫描电镜观察微粒形态 ,通过激光光散射实验测定纳米微粒的粒径分布 ;利用高效液相色谱(HPLC)测定纳米微粒制剂的载药率及体外释放曲线 ;以MTT方法做体外杀伤癌细胞实验 ;进行两种肿瘤瘤谱在不同剂量、给药频度及制剂工艺条件下体内抑瘤实验 ;委托完成动物急性毒性试验。[结果]经电镜观察PLGA 去甲斑蝥素 NP为表面光滑的球形微粒 ,粒径分布平均值是126.4nm ,呈正态分布 ;PLGA 去甲斑蝥素 NP载药率为36.3 % ;体外释放实验提示 ,7天可释放出所载60%左右的药物 ,12天基本释放完全 ,没有显著的爆破释放 ;体内抑瘤实验表明 :控释制剂间隔给药疗效已优于未包载药物每日给药的疗效 ,量_效关系明显 ,且毒性低 ,经静脉途径试用无任何不良反应。[结论]PLGA纳米粒子可以作为抗肿瘤药物去甲斑蝥素的有效载体 ,并可成功制备其...

[目的]研究不溶于水的抗癌药物去甲斑蝥素纳米控释静脉注射制剂的制备工艺及其体内外抗肿瘤作用。[方法]以聚乳酸 聚乙醇酸共聚物(PLGA)作为基质材料 ,采用超声乳化/溶剂挥发法制备PLGA包载去甲斑蝥的纳米级微粒(NP) ,对PLGA 去甲斑蝥素 NP进行表征 ,借助扫描电镜观察微粒形态 ,通过激光光散射实验测定纳米微粒的粒径分布 ;利用高效液相色谱(HPLC)测定纳米微粒制剂的载药率及体外释放曲线 ;以MTT方法做体外杀伤癌细胞实验 ;进行两种肿瘤瘤谱在不同剂量、给药频度及制剂工艺条件下体内抑瘤实验 ;委托完成动物急性毒性试验。[结果]经电镜观察PLGA 去甲斑蝥素 NP为表面光滑的球形微粒 ,粒径分布平均值是126.4nm ,呈正态分布 ;PLGA 去甲斑蝥素 NP载药率为36.3 % ;体外释放实验提示 ,7天可释放出所载60%左右的药物 ,12天基本释放完全 ,没有显著的爆破释放 ;体内抑瘤实验表明 :控释制剂间隔给药疗效已优于未包载药物每日给药的疗效 ,量_效关系明显 ,且毒性低 ,经静脉途径试用无任何不良反应。[结论]PLGA纳米粒子可以作为抗肿瘤药物去甲斑蝥素的有效载体 ,并可成功制备其静脉注射剂型 ,发挥药物更佳的抗肿瘤作用

Objective: To investigate the preparation technics and anti-tumor effects both in vitro and in vivo of a novel nanosphere control-releasing preparation of colchicines (an water-insoluble anti-cancer drug) by intravenous injection. Methods: With polylactate-poly ethanol acid copolymer (PLGA) as marix materials, we adopted ultrasound emulsification/dissolvent volatilization method to prepare PLGA enveloped colchicines of nano-particles (NP), proceeding the appearance signs of PLGA- colchicine-NP, making...

Objective: To investigate the preparation technics and anti-tumor effects both in vitro and in vivo of a novel nanosphere control-releasing preparation of colchicines (an water-insoluble anti-cancer drug) by intravenous injection. Methods: With polylactate-poly ethanol acid copolymer (PLGA) as marix materials, we adopted ultrasound emulsification/dissolvent volatilization method to prepare PLGA enveloped colchicines of nano-particles (NP), proceeding the appearance signs of PLGA- colchicine-NP, making use of scanning electricity microscopy to look into the morphology of nanoparticles through laser optical scattering experiment and determine its diameter distribution. We carry out the drug-carrying coefficient (ratio) of the nanoparticles by means of HPLC, use MTT test to do the cancer cell bloodsheding test in vitro, and pursue the anti-tumor effects of different dosages, frequencies of taking medicine, and preparation techinics circumstances. Results: The average value of particle diameter was 104.9 nm with a normality distribution, and the drug-carrying amount of PLGA-colchicine-NP was 33.0% . NP had the same anti-cancer effect as unenveloped drug in vitro tests. Nanoparticles showed an apparent dosage-efficacy relationship, and the efficacy by interval drug delivery was better than unenveloped drug by per diem drug delivery. The toxicity decreased significantly. No mal-reaction was found by intravenous injection. Conclusion: Nanoparticles may serve as availability carrier of colchicines, and can be succeessesfuly used in the preparation of its intravenous injection dose. It can play more efficient role of anti-cancer effects of the drug.

目的:研究不溶于水的植物性抗癌药秋水仙碱纳米控释静脉注射微粒的制备工艺及其体内外抗肿瘤作用。方法:以聚乳酸-聚乙醇酸共聚物(PLGA)作为基质材料,采用超声乳化-溶剂挥发法制备PLGA包载秋水仙碱的纳米级微粒(NP)。借助扫描电镜观察PLGA-秋水仙碱-NP微粒形态,通过激光光散射实验测定纳米微粒的粒径分布。利用高效液相色谱(FIPLC)测定纳米微粒制剂的载药率,以MTT方法做体外杀伤癌细胞实验,进行不同剂量、给药频度条件下体内抑瘤实验。结果:经电镜观察PLGA-秋水仙碱-NP为表面光滑的球形微粒,粒径分布平均值是104.9 nm,呈正态分布。PLGA-秋水仙碱-NP载药率为33.0%。体外MTT实验提示纳米粒子与裸药作用相同且显著控释。体内抑瘤实验表明:控释制剂间隔给药疗效优于未包载药物每日给药的疗效,量-效关系明显,且毒性显著减低,经静脉途径试用无任何不良反应。结论:PLGA纳米粒子可以作为抗肿瘤药物秋水仙碱的有效载体,并可在不添加助溶剂等前提下成功制备其静脉注射剂型,实现药物控制释放并减低毒性,发挥药物更佳的抗肿瘤作用。

 
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