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lomefloxacin
相关语句
  洛美沙星
    Preparation and Antibacterical Activity of Four New Complexes Between La, Pr, Nd or Sm and Lomefloxacin
    La、Pr、Nd、Sm-洛美沙星配合物的制备及其抗菌活性
短句来源
    CLINICAL EVALUATION OF FLEROXACIN AND LOMEFLOXACIN IN TREATMENT OF BACTERIAL INFECTIONS
    氟罗沙星与洛美沙星治疗细菌性感染的临床评价
短句来源
    Clinical efficacy of lomefloxacin
    洛美沙星片剂临床疗效观察
短句来源
    ISOLATION AND IDENTIFICATION OF 1-ETHYL-6, 8-DIFLUORO-1,4-DIHYDRO-7-(3-METHYL-PIPERAZIN-1-YL)-4-OXOQUINOLINE,A DECARBOXYLATED COMPOUND FROM LOMEFLOXACIN INJECTION
    洛美沙星注射液中脱羧产物1-乙基-6,8-二氟-1,4-二氢-7-(3-甲基-1-哌嗪基)-4-氧代喹啉的分离与鉴定
短句来源
    Determination of lomefloxacin hydrochloride in capsule by spectrofluorometry
    荧光分光光度法测定盐酸洛美沙星胶囊含量
短句来源
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  “lomefloxacin”译为未确定词的双语例句
    A STUDY OF PHARMACODYNAMICS OF LOMEFLOXACIN
    洛美沙星的药效学研究
短句来源
    THE PRECLINICAL PHARMACOLOGY STUDIES OF LOMEFLOXACIN
    新氟喹诺酮抗菌药洛美沙星的临床前药理学研究
短句来源
    THE CLINICAL PHARMACOKINETICS OF LOMEFLOXACIN
    洛美沙星的临床药物动力学研究
短句来源
    CLINICAL AND EXPERIMENTAL STUDIES ON DOMESTIC LOMEFLOXACIN
    国产洛美沙星的临床和实验研究
短句来源
    Randomized Controlled Clinical Study of Sparfloxacin Compared with Lomefloxacin
    司帕沙星和洛美沙星的随机对照临床研究
短句来源
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  lomefloxacin
The antiviral activity against herpes simplex virus type 2 (HSV-2) of five fluoroquinolones (ciprofloxacin, lomefloxacin, ofloxacin, pefloxacin, rufloxacin) was tested in vitro.
      
pneumoniae, with deep ultrastructural changes in the cells recorded under the effect of lomefloxacin (Maxaquin).
      
We have studied the effect of lomefloxacin hydrochloride (Maxaquin.
      
Influence of lomefloxacin on the morphology and ultrastructure of Gram-negative bacterial cells
      
Activity of lomefloxacin hydrochloride (Maxaquin) in comparison with ciprofloxacin and pefloxacin on models of meningoencephalit
      
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A facile preparation of lomefloxacin hydrochloride(1),startingfrom 2,3,4-trifluoronitrobenzene,via reduction,condensation-cyclization,ethyla-tion,chelation,piperazination,hydrolysis,etc,was described.The reactions of allsteps were carried out in very moderate conditions to afford overall yield of 40%.

盐酸洛美沙星由2,3,4-三氟硝基苯经还原、缩合环合、乙基化、螯合、与哌嗪缩合、水解成盐等六步反应制得。工艺简便,反应条件温和,总收率达40%。

Lomefloxacin was a new fluoro quinolone. The in vitro and in vivo antibacterial activities of Lomefloxacin were compared with those of Norfloxacin, Enoxacin, Gentamicin and others. Lomefloxacin had a strong antibacterial activity against both Gram-negative and Gram-positive bacteria. The antibacterial activity of Lomefloxacin against Enterobacteriaceas was strong than those of Amikacin, Gentamicin and was 2 ~ 8 times higher than Norfloxacin and Enoxacin.

洛美沙星对革兰氏阴性菌具有强的抑菌活力。对克氏肺炎杆菌的抗菌活性最强,MIC_(50)为0.12mg/L;对痢疾杆菌、产气杆菌、粘质沙雷氏菌、不动杆菌和枸椽酸杆菌的MIC_(50)分别为1和4mg/L。洛美沙星对肠细菌科细菌的活力比诺氟沙星和依诺沙星强2~16倍,明显地比丁胺卡那霉素、庆大霉素强。对金葡球菌MIC_(50)为1mg/L, MRSA对洛美沙星同样敏感。洛美沙星对表葡球菌、链球菌、粪链球菌及肺炎双球菌等的抗菌活性与地氟沙星相似,比诺氟沙星、依诺沙星、丁胺卡那霉素、庆大霉素和头孢三嗪分别强2~4倍。 洛美沙星对小鼠全身感染的疗效优于诺氟沙星。对大肠杆菌、克氏肺炎杆菌和绿脓杆菌感染小鼠iv的ED_(50)分别是0.74、0.13和3.45mg/kg, po的ED_(50)分别是0.94、1.46和6.20mg/kg。

ABSTRACT The in vitro antibacterial activity of Lomef loxacin, a new Fluoroquinolone, against 1,059 strains of bacteria was studied. Except for 9 strains of Providencia rettgeri with MIC_(50) of 64mg/L, the MIC_(50) of most other Gram negative aerobic bacteria were 0.06~0.5mg /L. H. influenzas, N. gonorrhoeae and E. coli were highly susceptible to Lomef loxacin. Against MRSA, Staph. epideomidis, Enterococci, Pn-eumococci and other Streptococci were weak. Bacteroides sp. were resistant to Lomefloxacin....

ABSTRACT The in vitro antibacterial activity of Lomef loxacin, a new Fluoroquinolone, against 1,059 strains of bacteria was studied. Except for 9 strains of Providencia rettgeri with MIC_(50) of 64mg/L, the MIC_(50) of most other Gram negative aerobic bacteria were 0.06~0.5mg /L. H. influenzas, N. gonorrhoeae and E. coli were highly susceptible to Lomef loxacin. Against MRSA, Staph. epideomidis, Enterococci, Pn-eumococci and other Streptococci were weak. Bacteroides sp. were resistant to Lomefloxacin. It was effective in the control of experimental infections of mice with E. coli and K. pneumoniae but in infections caused by Staph. aureus and Pseudomonas aeruginosa.

洛美沙星为一新型氟喹诺酮类药物,其抗菌谱广,抗菌作用强,本文报道其体内外抗菌作用的研究结果。洛美沙星对革兰氏阴性菌具强大的抗菌作用,其MIC_(90)大都≤2mg/L,对大肠杆菌、流感杆菌和淋球菌的抗菌作用尤强,对肺炎球菌和其他链球菌的抗菌作用较弱。对大部分耐庆大霉素和哌拉西林的革兰氏阳性杆菌仍具良好抗菌活性。洛美沙星的抗菌作用略逊于环丙沙星,与氧氟沙星相似,稍优于诺氟沙星。洛美沙星对小鼠实验性细菌感染,尤其是革兰氏阳性杆菌感染具有明显保护作用,其口服用药后的体内抗菌作用明显优于诺氟沙星。

 
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