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faropenem sodium
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  法罗培南钠
     A penem antibiotic faropenem sodium was synthesized by condensation of(3R,4R)-4-acetoxy- 3-[(1R)-(tert-butyldimethylsilyoxy)ethyl]-2-azetidinone and(R)-tetrahydrofuran-2-thiolcarboxylic acid,followed by acylation,Wittig reaction,deprotection and hydrolysis with an overall yield of about 37%.
     (3R,4R)-4-乙酰氧基-3-[(1R)-(叔丁基二甲基硅氧基)乙基]氮杂环丁-2-酮与(R)-四氢呋喃-2-硫代羧酸经缩合、酰化、Wittig反应、脱保护、水解等反应制得青霉烯类抗生素法罗培南钠,总收率约37%。
短句来源
     RESULTS The plasma concentration-time curves of Faropenem are fitted to an one-compartment model after an oral Faropenem sodium tablet in single dose(200, 400, 600 mg). The main pharmacokinetic parameters were as follows:t_ max (0.85±0.29),(0.73±0.34) and (0.88±0.29)h;
     结果法罗培南钠的体内经时过程符合有滞后时间的一室模型,口服低、中、高3个剂量组的tmax分别为(0·85±0·29),(0·73±0·34)和(0·88±0·29)h;
短句来源
     A multicenter,randomized controlled clinical study on faropenem sodium tablets in the treatment of bacterial infections
     法罗培南钠片治疗细菌性感染的随机双盲对照临床研究
短句来源
     METHODS 30 Healthy volunteers (15 male, 15 female) were divided into three groups randomly,and were given a single oral dose (200, 400, 600 mg) of Faropenem sodium tablet. Blood samples were collected from elbow vein at certain sampling times.
     方法30名健康受试者(男性15名,女性15名)按性别随机分为3组,分别口服低、中、高(200,400,600mg)3个剂量的法罗培南钠片,于不同时间分别从受试者肘静脉取血4mL,离心分离血浆,对低浓度和高浓度样品分别处理后,高效液相色谱法测定血浆中法罗培南钠浓度。
短句来源
     Synthesis of Faropenem Sodium
     法罗培南钠的合成
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  “faropenem sodium”译为未确定词的双语例句
     Detection of Residual Solvents in Faropenem Sodium by GC
     GC法测定法罗培南钠有机溶剂残留量
短句来源
     Determination of the Dissolution of Faropenem Sodium Tablets by UV Spectrophotometry
     紫外分光光度法测定法罗培南钠片的溶出度
短句来源
     Methods: The residual solvents in Faropenem sodium were determined by GC with HP-5 capillary column (30 m×0.53 mm, 1.5 μm) , FID detector and using nitrogen as carrier gas. The injector temperature was 200 ℃ and the detector temperature was 250 ℃.
     方法:采用气相色谱法测定,色谱柱为HP-5弹性石英毛细管柱(30 m×0.53 mm,1.5 μm,以5%苯基-95%甲基聚硅氧烷为固定液),进样口温度:200℃,氢火焰离子化检测器(FID),检测器温度:250℃;
短句来源
     Study on dissolution of faropenem sodium tablets by UV spectrophotometry
     紫外分光光度法测定法罗培南钠片的溶出度
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Objective: To establish a method for detection of the residual solvents in Faropenem sodium. Methods: The residual solvents in Faropenem sodium were determined by GC with HP-5 capillary column (30 m×0.53 mm, 1.5 μm) , FID detector and using nitrogen as carrier gas. The injector temperature was 200 ℃ and the detector temperature was 250 ℃. The column temperature was raised by program, the initial temperature was 35 ℃, maintained for 5 min, raised to 120 ℃ with a rate of 10 ℃/min, maintained for 2...

Objective: To establish a method for detection of the residual solvents in Faropenem sodium. Methods: The residual solvents in Faropenem sodium were determined by GC with HP-5 capillary column (30 m×0.53 mm, 1.5 μm) , FID detector and using nitrogen as carrier gas. The injector temperature was 200 ℃ and the detector temperature was 250 ℃. The column temperature was raised by program, the initial temperature was 35 ℃, maintained for 5 min, raised to 120 ℃ with a rate of 10 ℃/min, maintained for 2 min, then raised to 250 ℃ with a rate of 35 ℃/min, and maintained for 5 min. The flow rate of nitrogen was 2 mL/min. The split ratio was 1:1. The make-up gas rate was 30 mL/min. Results: The solvents can be completely separated and the calibration curves of each solvent showed good linear relationship within a certain range. Conclusions: The method is accurate and reliable. It can be applied in detection of residual solvents in Faropenem sodium.

目的:建立法罗培南钠原料药中有机溶剂残留量测定方法。方法:采用气相色谱法测定,色谱柱为HP-5弹性石英毛细管柱(30 m×0.53 mm,1.5 μm,以5%苯基-95%甲基聚硅氧烷为固定液),进样口温度:200℃,氢火焰离子化检测器(FID),检测器温度:250℃;柱温:程序升温,初始温度35℃,保持5 min,以每分钟10℃的升温速率升温至120℃,保持2 min,再以每分钟35℃的升温速率升温至250 ℃,保持5 min,载气:氮气,流速:2 mL/min,分流比:1:1,尾吹流速:30mL/min,以N-甲基吡咯烷酮为溶剂。结果:待测物均能得到很好的分离,峰面积与浓度呈良好的线性关系,精密度良好。结论:该法可用于法罗培南钠原料药中有机溶剂残留量的检测。

OBJECTIVE To develop a HPLC method for determination of related substances of faropenem sodium METHODS Faropenem sodium and its related substances were separated by using a mobile phase consisted of acetonitrile 0 02 mol·L -1 triethylamine ( 14∶86 ,pH 2 5) at a flow rate of 1 0 mL·min -1 on an Aglient Zorbax Zclipse XDB C 18 column and detected at 247 nm RESULTS The resolution and sensitivity of related substances were acceptable The detection limit was 2 4 ng...

OBJECTIVE To develop a HPLC method for determination of related substances of faropenem sodium METHODS Faropenem sodium and its related substances were separated by using a mobile phase consisted of acetonitrile 0 02 mol·L -1 triethylamine ( 14∶86 ,pH 2 5) at a flow rate of 1 0 mL·min -1 on an Aglient Zorbax Zclipse XDB C 18 column and detected at 247 nm RESULTS The resolution and sensitivity of related substances were acceptable The detection limit was 2 4 ng CONCLUSION This method was found to be simple and selective It could be used to control the quality of product effectively

目的 建立使用HPLC测定法罗培南钠中有关物质的方法。方法 AgilentZorbaxEclipse XDB C18色谱柱 (4 6mm× 15 0mm ,5 μm) ,以 0 0 2mol·L-1三乙胺三氟醋酸缓冲液 (取三乙胺 2 7mL ,加水至 90 0mL ,用三氟醋酸调节pH 2 5后 ,加水稀释至10 0 0mL) 乙腈 (86∶14 )为流动相 ,检测波长 2 4 7nm ,流速 :1 0mL·min-1,柱温 :4 0℃。结果 样品中各成分的分离度及检出灵敏度完全满足有关物质限度的测定要求。最小检出量为 2 4ng。结论 本法简便、专属、能有效控制产品的质量。

Objective To investigate the thermal kinetic characteristics of faropenem sodium at 60℃ and determine the main thermal degradation impurity. Methods An HPLC method was carried out to (detect) the quantity of faropenem at 60℃ in different period of times. The data was fitting in with appropriate dynamic equations to calculate the half-life. The main thermal degradation impurity was isolated by preparation HPLC and identified by MS, ()~1H-NMR, ()~(13)C-NMR, IR and UV. Results The chemical kinetic equation...

Objective To investigate the thermal kinetic characteristics of faropenem sodium at 60℃ and determine the main thermal degradation impurity. Methods An HPLC method was carried out to (detect) the quantity of faropenem at 60℃ in different period of times. The data was fitting in with appropriate dynamic equations to calculate the half-life. The main thermal degradation impurity was isolated by preparation HPLC and identified by MS, ()~1H-NMR, ()~(13)C-NMR, IR and UV. Results The chemical kinetic equation of faropenem performed at 60℃ was LnC/C_0=-0.0042t +0.35, r~2= 0.9911, and the structure of the main thermal degradation impurity was 5-tetrahydrofuran-thiazole-4-sodium formate. Conclusion The thermal kinetic characteristics of faropenem accords to the first grade dynamic equation.

目的探讨法罗培南钠的热降解动力学特性,并推断其主要热降解产物的结构。方法通过加速试验探讨法罗培南钠的热降解动力学方程,进而确定其在60℃条件下的热降解反应级数;应用MS1、H-NMR1、3C-NMR、IR及UV推断其主要的热降解产物结构。结果法罗培南钠在60℃放置条件下的热降解动力学方程为LnC/C0=-0.0042t+0.35,r2=0.9911;其主要热降解杂质为5-四氢呋喃基-噻唑-4-甲酸钠。结论法罗培南钠的热降解特性符合一级化学反应动力学特性。

 
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