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transition state analogs
相关语句
  过渡态类似物
    The Development of the Carbenium Transition State Analogs
    正碳离子样的过渡态类似物研究进展
短句来源
  过渡态类似物
    The Development of the Carbenium Transition State Analogs
    正碳离子样的过渡态类似物研究进展
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  transition state analogs
Two recurring observations, that were not expected in theory, have been the binding of inhibitors in ionized forms that are rare in solution, and changes in enzyme configuration that accompany binding of transition state analogs.
      
Sterol Biosynthesis Inhibitors: Potential for Transition State Analogs and Mechanism-Based Inactivators Targeted at Sterol Methy
      
Implications of these calculations for the computer-aided design of transition state analogs for the induction of catalytic antibodies are discussed.
      
This information can be applied to the development of transition state analogs and mechanism-based inhibitors of PurE Class I.
      
This suggests the possibility for abzyme production via the pathway described for antibodies induced by transition state analogs.
      
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An important feature in the enzyme catalyzed reaction is that an enzyme recognizes and binds more tightly to the transition state than to the ground state of the substrate product interconversion.The transition state analog must be a potent inhibitor of the enzyme.The recent development of the carbenium transition state analogs as the enzymatic inhibitors which are designed by the transition state theory of enzyme catalyzed reactions is reviewed.Four types of enzymatic inhibitors including...

An important feature in the enzyme catalyzed reaction is that an enzyme recognizes and binds more tightly to the transition state than to the ground state of the substrate product interconversion.The transition state analog must be a potent inhibitor of the enzyme.The recent development of the carbenium transition state analogs as the enzymatic inhibitors which are designed by the transition state theory of enzyme catalyzed reactions is reviewed.Four types of enzymatic inhibitors including the transition state analogs of isoprenoid pyrophosphate,sialyltransferase,KDO8P and UGT are introduced.

综述了应用酶催化过渡态理论设计的几类正碳离子样的过渡态类似物作为酶的抑制剂的研究进展。其中包括类异戊二烯的正离子过渡态类似物,唾液酸转移酶的过渡态类似物,3-脱氧-D-甘露糖-2-辛酮糖酸酯-8-磷酸酯(KDO8P)合成酶的过渡态类似物,尿苷二磷酸酯葡糖醛酸基转移酶(UGT)的过渡态类似物。

 
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