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pregnant mice     
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  孕鼠
     The pregnant mice are divided into 7 groups: i.e., control group, ethanol group and 0.025mg, 0.05mg, 0.075mg, 0.1mg, 0.2mg of bromocritine groups.
     将孕鼠分为对照组、酒精组及0.025、0.05、0.075、0.1、0.2mg不同剂量溴隐亭组,于孕5~7d皮下注射,孕10d观察妊娠结局。
短句来源
     Methods An one-way mixed lymphocyte reaction system characterized by labeling responder cells with CFSE and stimulator cells with SNARF-1 was established to measure the alloresponse mediated by syngeneic(BALB/c×BALB/c) and allogeneic(BALB/c×C57) pregnant mice,called syn-BALB/c and allo-BALB/c respectively,to C57 alloantigens at 10.5 days post coitus.
     方法采用CFSE标记应答细胞、SNARF-1标记刺激细胞的单向混合淋巴细胞培养体系,对孕10.5d的同基因交配孕鼠BALB/c×BALB/c(syn-BALB/c)和异基因交配孕鼠BALB/c×C57(allo-BALB/c)对C57小鼠同种抗原的应答强度进行比较;
短句来源
     Effect of millimeter wave irradiation with 42.2GHz on the posterities of pregnant mice
     42.2GHz毫米波辐射孕鼠对子代的影响
短句来源
     Methods: The pregnant mice were treated with benzene extract of Achyranthes bidentata BI from pregnant 1 d(ig 2 g/L× 2 ml/d× 5 d) .
     方法:孕鼠自孕1d起连续灌眼怀牛膝苯提取物5d(2g/L×2ml/d×5d);
短句来源
     Objective: To study the effect of rhuIL-2 on embryos and the trend of T cell subsets and nature killer cells of spleen of pregnant mice infected with Toxoplasma gondii.
     目的:用不同剂量的rhuIL-2给弓形虫感染的孕鼠腹腔注射,研究感染弓形虫后孕鼠的T细胞亚群、NK细胞的动态变化以及rhuIL-2对孕鼠外周免疫及胚胎的作用。
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  妊娠小鼠
     Methods C57BL/6 and BALB/c male mice were randomly mated with C57BL/6 female mice to obtain syn-/allogeneically pregnant C57BL/6 mice. The pregnant mice were divided into control,solvent and drug-given groups.
     方法选择健康C57BL/6雄鼠、BALB/c雄鼠分别和C57BL/6雌鼠交配,得到C57BL/6同/异种系妊娠小鼠,并分为对照组、溶剂组和不同剂量给药组。
短句来源
     Objective To study the effect of mifepristone on the expression of Dickkopf-1(DKK-1) in endometrium of pregnant mice during the peri-implantation period and the role of DKK-1 in the embryo implantation in mice.
     目的研究孕酮抑制剂米非司酮对妊娠小鼠围着床期子宫内膜Dickkopf-1(DKK1)表达的影响,探讨DKK1在胚胎着床过程中的作用。
短句来源
     INFLUENCE OF PROGESTERONE ANTAGONIST-RU486 ON THE MACROPHAGES IN THE UTERI OF PREGNANT MICE AND ITS RELEVANCE TO PREGNANCY
     孕酮拮抗物RU486对妊娠小鼠子宫巨噬细胞的影响及与妊娠相关性的研究
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     Pregnant mice were separated into three groups: group 1 was treated with cocaine HCl at 10 mg/kg twice daily (COC) ;
     妊娠小鼠分为3组:可卡因注射组(每日两次注射盐酸可卡因10mg/kg,COC);
短句来源
     Purpose of studyTo invest the change of splenic T cell subsets of BALB/c pregnant mice infected with Toxoplasma gondii, suppression of Diethylstilbestrol on splenic T cell subsets of BALB/c pregnant mice infected with T.
     目的 研究BALB/c妊娠小鼠感染弓形虫后脾脏T淋巴细胞亚群的变化,己烯雌酚(DES)对弓形虫感染孕鼠脾脏T细胞亚群的抑制作用,DES对弓形虫垂直传播的影响及其作用机制。
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  孕小鼠
     EFFECT OF 15-METHYL PROSTAGLANDIN F_(2α) UPON IN VITRO UTERUS CONTRACTION OF EARLY PREGNANT MICE
     15甲基前列腺素F_(2α)对离体早孕小鼠的子宫收缩作用
短句来源
     Expression of ICAM-1 on Endometrium of Early Pregnant Mice and its Functions
     早孕小鼠子宫内膜ICAM-1的表达及意义
短句来源
     Methods: A total of pregnant mice were randomly divided into 5 groups,Group A,B,C,D and E,and injected subcutaneously(sc) with estradiol benzoate at the dose of 0,(0.2),1,5 and 25 mg · kg~(-1)· d~(-1) respectively from the 12th to the 16th gestational day.
     方法:100只ICR孕小鼠随机分成A、B、C、D、E 5组,每组20只,在孕12~16 d连续5 d各组每只皮下分别注射苯甲酸雌二醇0、0.2、1、5、25 mg. kg-1.d-1,出生时观察仔鼠死亡率。
短句来源
     The Effect of Mifepristone on the Morphology of Gonadotropic Cells in Early Pregnant Mice
     米非司酮对早孕小鼠促性腺激素细胞的形态学影响
短句来源
     Endometrium samples were collected from Day 1 to Day 5 in early pregnant mice, and the expression level of ICAM-1 (intercellular adhesion molecule-1) mRNA on it was determined by RT-PCR and the expression level of ICMA-1 were determined by immunohisto chemistry and Western blotting.
     探讨细胞间粘附分子-1(ICAM-1)基因及蛋白在早孕小鼠子宫内膜的表达及其意义方法:收集妊娠1-5d的早孕小鼠子宫内膜,利用RT-PCR、免疫组织化和Western-blot方法检测ICAM-1基因及蛋白的表达及分布;
短句来源
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  小鼠妊娠
     Methods In LPS groups,pregnant mice were injected intraperitoneally with different doses of LPS(0.1~0.5 mg/kg) on gestational day(gd) 17;
     方法小鼠妊娠第17天分别注射不同剂量LPS(0.1~0.5mg/kg,ip);
短句来源
     Methods Groups of pregnant mice, 10 mice in each group, were orally administrated with TCDD in a dose of 0, 2, 50 or 100 ng·(kg·d) -1 during 1~8 d, 1~3 d, and 4~8 d of pregnancy.
     方法在NIH小鼠妊娠早期的1~8d,胚泡着床前期的1~3d和着床后期的4~8d,经口腔灌服0、2、50和100ng(kg·d)剂量的TCDD,在小鼠妊娠第9天和第18天时观察子宫内的胚胎发育形态。
短句来源
     The effects of 0 025—0 40? μg/(kg·d) dibutyltin chloride (DBTCl) on pregnant mice and fetuses were studied under 22±2℃,light:dark=12?
     雌性小鼠妊娠第 6天开始每天 1次腹腔注射 0 0 2 5— 0 40 μg/(kg·d)氯化二丁基锡 (DBTCl) ,共染毒 7d .
短句来源
     The Effect of Pu-Huang Water-Decoction on Pregnant Mice
     蒲黄水煎液对小鼠妊娠影响的实验研究
短句来源
     Meanwhile,blood was kept from pregnant mice for the determination of serum VA. In situ hybridization was used to determine Hox-3\^5 mRNA expression in the mouse embryos by digxigenin-labeled cDNA probes.
     结果 在正常情况下 ,小鼠妊娠第 12d胚胎组织Hox -3 5mRNA有表达 ,孕鼠血清VA缺乏时 ,妊娠第 12d胚胎组织Hox - 3 5mRNA的含量明显减少 ;
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      pregnant mice
    Pregnant mice were each infected with 300 larvae 5, 7, 15 and 17 days after fertilization.
          
    Excessive dexamethasone (Dex) administrated into pregnant mice during critical periods of palatal development can produce a high incidence of cleft palate.
          
    This study examined the expression and distribution of angiopoietin-1/-2 (Ang-1/-2) in the endometrium of early pregnant mice.
          
    With gestation time, the positive reactions of Ang-1/-2 were stronger in the endometria of the pregnant mice (P>amp;lt;0.01).
          
    Exposure of pregnant mice to RE leads to rapid placental transfer of RE; 14.1% of the total amount of RE administered was detected in newborn mice.
          
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    The present experiment was conducted with sexually mature,virgin female rats and mice.The body weight of the female rats was 180-280g and that of the male was 250—350g;the body weight of the female micewas 25-40g and that of the male micewas 25—35g.The females and maleswere mated over-night,♀∶♂ ratio ofthe rats was 3∶1;that of mice was2∶1.The female rats were conside-red day-o of gestation when the spermswere found in the vagina.If thecopulation plug was found in the fe-male mice,then that day was assig-ned...

    The present experiment was conducted with sexually mature,virgin female rats and mice.The body weight of the female rats was 180-280g and that of the male was 250—350g;the body weight of the female micewas 25-40g and that of the male micewas 25—35g.The females and maleswere mated over-night,♀∶♂ ratio ofthe rats was 3∶1;that of mice was2∶1.The female rats were conside-red day-o of gestation when the spermswere found in the vagina.If thecopulation plug was found in the fe-male mice,then that day was assig-ned day-o of gestation.Then the preg-nant rats and mice were divided intogroups:the rats,into ten test-groups(6—15days) and one control;the mice,into five test-groups (7—11 days) andone control.The pregnant female rats of eachgroup were given single p.o.with thetest—chemical from day-6 to day-15of gestation daily respectively;the pre-gnant mice received single p.o.of thesame drug from day-7 to day-11 of ges-tation daily respectively.The dosagewas 7.5 mg/kg for the pregnant ratsand 150 mg/kg for the pregnant mice.All pregnant rats were killed on day-20 of gestation so as to count the number of corpora lutea,implantation,resorption sites and live fetuses.After giving birth the female mice were kil-led on the day of parturition.Thenumber of implantation,resorptionsites and living fetuses were also coun-ted.The living fetuses of the rats andmice were removed,weighted,inspec-ted for gross abnormalities and sexes;but only the internal and skeletal mal-formations of the rats were examined.Under present experimental con-ditions,determination of the rats ter-atogenic susceptibility in different deve-lopmental periods showed that embryoswere most susceptible on day-9,day-10and day-11 of gestation,whereas themice were most susceptible on day-7,day-8,and day-9 of gestation.The rats were most susceptible toteratogenesis on day-10,day-11,andday-12;whereas the mice,on day-9,day-10,and day-11.The abnormalities of the rats,ex-cept exencephaly and absence of ma-xilla,were the same as teratogenesis ofDI-KU-SHUANG Bis-A-TDA);however,all the abnormalities of the mice consist with teratogenesis of DI-KUSHUANG (Bis-A-TDA).

    本文主要讨论了大、小白鼠的致畸敏感期。根据我们的实验结果认为:大白鼠胚胎对Bis-HM-A-TDA 的反应以妊娠的第9、10和11天者最为敏感;在畸形发生上则以妊娠的第10、11和12天的胚胎最为敏感。小白鼠的胚胎以妊娠的第7、8和9天者反应最为敏感;在畸形发生上又以妊娠第9、10和11天的胚胎为敏感,尤其妊娠第9天的胚胎反应更为强烈。随着胚胎发育时间的延长,胚胎对于致畸因素的抵抗力逐渐提高。

    In this experiment, teratogenic effect of Hydroxypiperaquine Phosphate has been studied in mice.We divided the pregnant mice into five groups: (1) normal control' (2) positive control, (the mice were administered 0.3 ml concentrated cod liver oil containing vit A 15)000 IU per day.) (3) the highest dose group of HPQP, (1/3LD50 per mouse per day), (4) medium close group (1/9LD50), (5) lower dose group (1/27 LD50).HPQP was given to the mice on the 9th day to the 14th day of gestation.Dams...

    In this experiment, teratogenic effect of Hydroxypiperaquine Phosphate has been studied in mice.We divided the pregnant mice into five groups: (1) normal control' (2) positive control, (the mice were administered 0.3 ml concentrated cod liver oil containing vit A 15)000 IU per day.) (3) the highest dose group of HPQP, (1/3LD50 per mouse per day), (4) medium close group (1/9LD50), (5) lower dose group (1/27 LD50).HPQP was given to the mice on the 9th day to the 14th day of gestation.Dams were killed for the teratological examination on the 18th day.We found that the number of the resorbed and dead fetuses markedly increased in the positive control group.The changes of those fetuses included growth retardation and external abnormalities such as microcephaly, encephalocele.open eyes, small ears, phocomelia, syndactylia, ectrodactyly and gastroschiasis were observed.Besides, the cleft palate and some skeletal alterations such as delayed ossifications of skull bones and dilatant ribs were observed too.We have not found in this experiment any evidences of embryotoxicity in the normal and ail of HPQP groups, The experimental results showed that the drug did not exert teratogenic effect on mice.

    本实验应用小鼠进行了磷酸羟基喹哌的致畸性研究。实验将已交配的雌鼠分为五组,即正常对照组、阳性对照组(阳性物是浓缩鱼肝油,每次给予量含维生素A1.5万单位/0.3ml)、磷酸羟基喹哌高剂量组(每次给药1/3LD_(50))、中剂量组(1/9LD_(50))和低剂量组(1/27LD_(50))。于受孕第9天给药,连续给药6天。受孕第18天处死动物作畸胎学检查。 经从胚胎死亡,生长发育、外形、头部器官、内脏和骨胳等方面的检查,发现阳性对照组吸收胎和死胎数显著增加,生长发育迟缓,有头小、脑突出、开眼、耳小、短肢,并趾、缺趾、无趾和腹裂等外观畸形,并有腭裂和鼻道扩大,骨胳有颅骨骨化迟缓、脊柱弯曲和肋骨游离端膨大等畸形。同样实验条件下,各用药组与正常组完全一致,未见任何胚胎毒性的表现,故根据实验结果认为:磷酸羟基喹哌无致畸性。

    Partially depolarized isolated uterine smooth muscles of early pregnant mice(D 6,7)induced by K~+(28 mM)-Krebs’solution were used to test the effects of(15 S)15-methylPGF_(2a),and oxytocin and their relation to Calciumion.The tension of this preparation wasincreased by(15 S)15-methyl PGF_(2a)or oxytocin in a dose-dependent manner.The con-tractile effects of these 2 drugs were inhibited by the Ca~(++)antagonist,verapamil,and thedegree of inhibition was increased as the concentration of verapamil was raised.Completeinhibition...

    Partially depolarized isolated uterine smooth muscles of early pregnant mice(D 6,7)induced by K~+(28 mM)-Krebs’solution were used to test the effects of(15 S)15-methylPGF_(2a),and oxytocin and their relation to Calciumion.The tension of this preparation wasincreased by(15 S)15-methyl PGF_(2a)or oxytocin in a dose-dependent manner.The con-tractile effects of these 2 drugs were inhibited by the Ca~(++)antagonist,verapamil,and thedegree of inhibition was increased as the concentration of verapamil was raised.Completeinhibition of the contraction was seen when the concentration of verapamil reached 5×10~(-4)M.In addition,in calcium free solution,neither(15 S)15-methyl PGF_(2α) nor oxy-tocin could cause contraction of the partially depolarized uterine smooth muscles.There-fore,it may be deduced that the Ca~(++) influx mechnism might play an important role in thecontractile effects of (15 S) 15-methyl PGF_(2a) and oxytocin on the partially depolarizeduterine smooth muscles of early pregnant mice.

    15(S)-15-甲基前列腺素F_(2α)(15-甲基PGF_(2α))和催产素,能使以高钾处理的早孕小鼠部分去极化离体子宫平滑肌的张力增高,其作用随两药浓度上升而增大。戊脉安能抑制两药的收缩效应,其抑制作用随戊脉安浓度的提高而增加,当戊脉安浓度达到5×10~(-4)M 时,收缩效应完全被抑制。此外,在无钙溶液中,15-甲基PGF_(2α)和催产素都不能引起部分去极化子宫平滑肌的收缩效应。从而提示钙的内流机制在15-甲基PGF_(2α)和催产素所引起的去极化子宫肌的收缩效应中起了重要的作用。

     
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