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loxoprofen sodium
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  洛索洛芬钠
     RESULTS: The main pharmacokinetic parameters after oral administration of domestic and imported loxoprofen sodium tablet(60mg) were: t1/2ke 93. 9 ± 19.8min, 92.4± 16.3min; AUC0-t 596.97 ± 104.l2μg. min.
     结果:经3P97程序拟合,口服国产和进口洛索洛芬钠60mg的主要药代动力学参数分别为:t_(1/2ke)为93.9±19.8min和92.4±16.3min;
短句来源
     Calibration curves were linear within 0.2~12.0 μg·ml -1(r=0.9998) and the minimum detection concentration was 0.2 μg·ml -1.The main pharmacokinetic parameters after oral administration of dome stic and imported loxoprofen sodium tablet (60 mg)were:t 1/2 were 1.3 9±0.15 h and 1.41±0.15 h;
     主要药动学参数分别为 :国产洛索洛芬钠片 :t1/2 为 1. 39± 0 . 15h ,AUC0 . 6h10 . 71± 1 .4 5 μg·h·ml 1,Cmax7. 2 3± 1 .0 2 μg·ml 1,tmax0 4± 0 1h ;
短句来源
     Study of synthetic process of loxoprofen sodium
     非甾体抗炎药洛索洛芬钠的合成工艺研究
短句来源
     Pharmacokinetic study on loxoprofen sodium in healthy Chinese volunteers
     洛索洛芬钠在健康中国人体内的药代动力学研究
短句来源
     Studies on Loxoprofen Sodium Sustained Release Tablets
     洛索洛芬钠缓释片的研究
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  “loxoprofen sodium”译为未确定词的双语例句
     Conclusion: The method is accurate, rapid and simple for the quality control of loxoprofen sodium tablets.
     结论:本方法准确、快速、简便,可用于洛索洛芬钠片的质量控制。
短句来源
     Conclusion:A simple and accurate method is established for determina-tion of loxoprofen sodium and its related substances.
     结论:本法简便、准确,可用于洛索洛芬钠的含量测定及其有关物质的测定。
短句来源
     Objective:To study the efficacy and safety of loxoprofen sodium in the treatment of patients with knee osteoarthritis(OA).
     目的 :观察洛索洛芬 (乐松 )治疗膝骨关节炎 (OA)的疗效和安全性。
短句来源
     After 4 weeks of treatment, 92.42% of the AS patients responded to loxoprofen sodium. Significant improvements were noticed in all 3 primary outcome measurements( P <0.05).
     经过 4周的治疗 ,乐松对AS患者的总有效率为 92 .4 2 % ,其中对各主要疗效指标均有明显改善 (P <0 .0 5 )。
短句来源
     METHODSAll 80 patients from the HuBei Provincial TCM Hospital conforming to the diagnostic standard, were randomly divided into two groups: therapeutic group of TongBi 2 (GroupA, n=40) and comparative group of Loxoprofen Sodium Tablets(GroupB, n=40), with MTX for both groups as basic treatment.
     所选80例患者均来自湖北省中医院风湿科门诊及病房,均符合类风湿关节炎的诊断及中医辨证属痹证,寒湿阻络证标准。 将患者随机分为两组:治疗组(A组),对照组(B组)各40例。
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  相似匹配句对
     Study of synthetic process of loxoprofen sodium
     非甾体抗炎药洛索洛芬钠的合成工艺研究
短句来源
     Determination and Dissolution of Loxoprofen Sodium Tablets
     洛索洛芬钠片的含量及体外溶出度测定
短句来源
     Cefazolin sodium
     唑啉头孢菌素钠盐
短句来源
     sodium citrate;
     柠檬酸钠;
短句来源
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  loxoprofen sodium
In contrast, the combination of enoxacin at 100 mg/kg and either ketoprofen at 125 mg/kg or pranoprofen at 500 mg/kg induced clonic convulsions, while that of enoxacin at 400 mg/kg and loxoprofen sodium at 600 mg/kg induced no convulsion.
      
The oral administration of ketoprofen, pranoprofen or loxoprofen sodium induced no convulsion up to 1000 mg/kg, 500 mg/kg and 600 mg/kg, respectively, and that of enoxacin induced no convulsion at more than 5000 mg/kg.
      
Convulsions induced by the combination of enoxacin, a new antimicrobial, and nonsteroidal anti-inflammatory drugs including nimesulide, ketoprofen, pranoprofen and loxoprofen sodium, were investigated in mice.
      
Oral loxoprofen sodium at a daily dose of 180?mg resulted in rapid symptom resolution.
      


A facile method for preparation of loxoprofen sodium is disclosed.Ethyl 2 ( p bromomethyl phenyl) propionate,prepared from toluene via acylation,ketalization,rearrangement,hydrolysis,bromination and esterification,was subjected to phase transfer ca talyzed alkylation with ethyl 2 oxocyclopentanecarboxylate,followed by hydrolysis with decarboxylation and salt formation in one pot procedure to afford loxoprofen sodium in about 35% overall yield.

甲苯经酰化、缩酮重排和水解转化成2-对甲苯基丙酸后,经溴代、酯化制成2-对溴代甲苯基丙酸乙酯,再在PEG-600和无水碳酸钾存在下,对2-乙氧羰基环戊酮进行烷基化后,直接水解、脱羧、成盐而得洛索洛芬钠,总收率35%。

In the presence of sodium t- butoxide and DMSO,ethyl 2 - oxocyclopentanecarboxylate was subjected to C- alkylation with 2 - ( 4- bromomethylphenyl) propanoic acid with high regioselectivity to give 2 - [4 - ( 1 - ethoxycarbonyl- 2 - oxo- 1 - cyclopentanylmethyl) phenyl]propanoic acid ( 4) which was followed by hydrolysis,decarboxylation and saltformation to afford loxoprofen sodium in about72 % overall yield.The effects of reaction temperature and different solvents on yield of4 were also investigated....

In the presence of sodium t- butoxide and DMSO,ethyl 2 - oxocyclopentanecarboxylate was subjected to C- alkylation with 2 - ( 4- bromomethylphenyl) propanoic acid with high regioselectivity to give 2 - [4 - ( 1 - ethoxycarbonyl- 2 - oxo- 1 - cyclopentanylmethyl) phenyl]propanoic acid ( 4) which was followed by hydrolysis,decarboxylation and saltformation to afford loxoprofen sodium in about72 % overall yield.The effects of reaction temperature and different solvents on yield of4 were also investigated.

在叔丁醇钠和二甲基亚砜的存在下,2-(对溴甲基苯基)丙酸对2-乙氧羰基环戊酮进行C-烷基化,再经水解脱羧,成盐即得洛索洛芬钠,以2-(对溴甲基苯基)丙酸计算,总收率为72%。探索了不同溶剂和反应温度对烷基化收率的影响。

Objective:For improving and shortening synthetic process and raising yield.Methods:2-(p-bromomrthyl phenyl)propionic acid is prepared from toluene,and alkylated with 2-oxocyclopentane carboxylate in medium of ethanol,DMF,and sodium hydroxide,and loxoprofen sodium is obtained following the product of the former reaction is hydrolyzed and decarboxylated.Results:The product thus obtained is identified with IR and JH1,D,Z-NMR.Conclusion:A shorter new process for synthesis of loxoprofen sodium is established...

Objective:For improving and shortening synthetic process and raising yield.Methods:2-(p-bromomrthyl phenyl)propionic acid is prepared from toluene,and alkylated with 2-oxocyclopentane carboxylate in medium of ethanol,DMF,and sodium hydroxide,and loxoprofen sodium is obtained following the product of the former reaction is hydrolyzed and decarboxylated.Results:The product thus obtained is identified with IR and JH1,D,Z-NMR.Conclusion:A shorter new process for synthesis of loxoprofen sodium is established with a yield of >40%. [

目的 :改进合成工艺 ,缩短合成路线 ,提高总收率。方法 :以甲苯为原料 ,合成 2 对溴代甲基苯基丙酸。再在乙醇、DMF溶剂和氢氧化钠的条件下 ,与 2 乙氧羰基环戊酮进行烷基化后直接水解 ,脱羧成盐得洛索洛芬钠。结果 :经IR ,1 H NMR光谱鉴定 ,产品结构与洛索洛芬钠一致。结论 :该合成路线较短 ,总收率 40 %以上。

 
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