loxoprofen sodium 洛索洛芬钠(39)   洛索洛芬钠      RESULTS: The main pharmacokinetic parameters after oral administration of domestic and imported loxoprofen sodium tablet(60mg) were: t1/2ke 93. 9 ± 19.8min, 92.4± 16.3min; AUC0-t 596.97 ± 104.l2μg. min.      结果:经3P97程序拟合,口服国产和进口洛索洛芬钠60mg的主要药代动力学参数分别为:t_(1/2ke)为93.9±19.8min和92.4±16.3min; 短句来源      Calibration curves were linear within 0.2～12.0 μg·ml -1(r=0.9998) and the minimum detection concentration was 0.2 μg·ml -1.The main pharmacokinetic parameters after oral administration of dome stic and imported loxoprofen sodium tablet (60 mg)were:t 1/2 were 1.3 9±0.15 h and 1.41±0.15 h;      主要药动学参数分别为 :国产洛索洛芬钠片 :t1/2 为 1. 39± 0 . 15h ,AUC0 . 6h10 . 71± 1 .4 5 μg·h·ml 1,Cmax7. 2 3± 1 .0 2 μg·ml 1,tmax0 4± 0 1h ; 短句来源      Study of synthetic process of loxoprofen sodium      非甾体抗炎药洛索洛芬钠的合成工艺研究 短句来源      Pharmacokinetic study on loxoprofen sodium in healthy Chinese volunteers      洛索洛芬钠在健康中国人体内的药代动力学研究 短句来源      Studies on Loxoprofen Sodium Sustained Release Tablets      洛索洛芬钠缓释片的研究 短句来源 更多          “loxoprofen sodium”译为未确定词的双语例句      Conclusion: The method is accurate, rapid and simple for the quality control of loxoprofen sodium tablets.      结论:本方法准确、快速、简便,可用于洛索洛芬钠片的质量控制。 短句来源      Conclusion:A simple and accurate method is established for determina-tion of loxoprofen sodium and its related substances.      结论:本法简便、准确,可用于洛索洛芬钠的含量测定及其有关物质的测定。 短句来源      Objective:To study the efficacy and safety of loxoprofen sodium in the treatment of patients with knee osteoarthritis(OA).      目的 :观察洛索洛芬 (乐松 )治疗膝骨关节炎 (OA)的疗效和安全性。 短句来源      After 4 weeks of treatment, 92.42% of the AS patients responded to loxoprofen sodium. Significant improvements were noticed in all 3 primary outcome measurements( P <0.05).      经过 4周的治疗 ,乐松对AS患者的总有效率为 92 .4 2 % ,其中对各主要疗效指标均有明显改善 (P <0 .0 5 )。 短句来源      METHODSAll 80 patients from the HuBei Provincial TCM Hospital conforming to the diagnostic standard, were randomly divided into two groups: therapeutic group of TongBi 2 (GroupA, n=40) and comparative group of Loxoprofen Sodium Tablets(GroupB, n=40), with MTX for both groups as basic treatment.      所选80例患者均来自湖北省中医院风湿科门诊及病房，均符合类风湿关节炎的诊断及中医辨证属痹证，寒湿阻络证标准。 将患者随机分为两组：治疗组(A组)，对照组(B组)各40例。 短句来源 更多          相似匹配句对      Study of synthetic process of loxoprofen sodium      非甾体抗炎药洛索洛芬钠的合成工艺研究 短句来源      Determination and Dissolution of Loxoprofen Sodium Tablets      洛索洛芬钠片的含量及体外溶出度测定 短句来源      Cefazolin sodium      唑啉头孢菌素钠盐 短句来源      sodium citrate;      柠檬酸钠; 短句来源 查询“loxoprofen sodium”译词为用户自定义的双语例句     我想查看译文中含有：的双语例句 为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法，我们为您准备了出自英文原文的大量英语例句，供您参考。   loxoprofen sodium In contrast, the combination of enoxacin at 100 mg/kg and either ketoprofen at 125 mg/kg or pranoprofen at 500 mg/kg induced clonic convulsions, while that of enoxacin at 400 mg/kg and loxoprofen sodium at 600 mg/kg induced no convulsion. 例句来源       The oral administration of ketoprofen, pranoprofen or loxoprofen sodium induced no convulsion up to 1000 mg/kg, 500 mg/kg and 600 mg/kg, respectively, and that of enoxacin induced no convulsion at more than 5000 mg/kg. 例句来源       Convulsions induced by the combination of enoxacin, a new antimicrobial, and nonsteroidal anti-inflammatory drugs including nimesulide, ketoprofen, pranoprofen and loxoprofen sodium, were investigated in mice. 例句来源       Oral loxoprofen sodium at a daily dose of 180?mg resulted in rapid symptom resolution. 例句来源                A facile method for preparation of loxoprofen sodium is disclosed.Ethyl 2 ( p bromomethyl phenyl) propionate,prepared from toluene via acylation,ketalization,rearrangement,hydrolysis,bromination and esterification,was subjected to phase transfer ca talyzed alkylation with ethyl 2 oxocyclopentanecarboxylate,followed by hydrolysis with decarboxylation and salt formation in one pot procedure to afford loxoprofen sodium in about 35% overall yield.             甲苯经酰化、缩酮重排和水解转化成２－对甲苯基丙酸后，经溴代、酯化制成２－对溴代甲苯基丙酸乙酯，再在ＰＥＧ－６００和无水碳酸钾存在下，对２－乙氧羰基环戊酮进行烷基化后，直接水解、脱羧、成盐而得洛索洛芬钠，总收率３５％。 文摘来源          In the presence of sodium t- butoxide and DMSO,ethyl 2 - oxocyclopentanecarboxylate was subjected to C- alkylation with 2 - ( 4- bromomethylphenyl) propanoic acid with high regioselectivity to give 2 - [4 - ( 1 - ethoxycarbonyl- 2 - oxo- 1 - cyclopentanylmethyl) phenyl]propanoic acid ( 4) which was followed by hydrolysis,decarboxylation and saltformation to afford loxoprofen sodium in about72 % overall yield.The effects of reaction temperature and different solvents on yield of4 were a...             在叔丁醇钠和二甲基亚砜的存在下,2-(对溴甲基苯基)丙酸对2-乙氧羰基环戊酮进行C-烷基化,再经水解脱羧,成盐即得洛索洛芬钠,以2-(对溴甲基苯基)丙酸计算,总收率为72%。探索了不同溶剂和反应温度对烷基化收率的影响。 文摘来源          Objective:For improving and shortening synthetic process and raising yield.Methods:2-(p-bromomrthyl phenyl)propionic acid is prepared from toluene,and alkylated with 2-oxocyclopentane carboxylate in medium of ethanol,DMF,and sodium hydroxide,and loxoprofen sodium is obtained following the product of the former reaction is hydrolyzed and decarboxylated.Results:The product thus obtained is identified with IR and JH1,D,Z-NMR.Conclusion:A shorter new process for synthesis of loxoprofen...             目的 :改进合成工艺 ,缩短合成路线 ,提高总收率。方法 :以甲苯为原料 ,合成 2 对溴代甲基苯基丙酸。再在乙醇、DMF溶剂和氢氧化钠的条件下 ,与 2 乙氧羰基环戊酮进行烷基化后直接水解 ,脱羧成盐得洛索洛芬钠。结果 :经IR ,1 H NMR光谱鉴定 ,产品结构与洛索洛芬钠一致。结论 :该合成路线较短 ,总收率 40 %以上。 文摘来源   << 更多相关文摘         相关查询: loxoprofen sodium tablets (sodium sodium sodium nitrate faropenem sodium sodium valproic sodium triphosphate sodium monofluorophosphate sodium glutamine sodium hyaluronate sodium curve pentachlorophenol sodium  对查询结果不满意

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