loxoprofen sodium 洛索洛芬钠(44)   洛索洛芬钠     Determination and Dissolution of Loxoprofen Sodium Tablets     洛索洛芬钠片的含量及体外溶出度测定 短句来源     Chiral Separation of Loxoprofen Sodium by High Performance Liquid Chromatography     洛索洛芬钠的高效液相色谱手性拆分 短句来源     A method for chiral separation of four loxoprofen sodium optical isomers was developed by high performance liquid chromatography on the chiral stationary phase of cellulose tris(4-methylbenzoate) (Chiralcel OJ-R).     使用三 (对甲苯甲酸 )纤维素酯手性固定相 (ChiralcelOJ R手性柱 ) ,建立了洛索洛芬钠 4个手性异构体的高效液相色谱拆分方法。 短句来源     Improved synthesis of 2-(4-bromomethylphenyl)propionic acid,the key intermediate for loxoprofen sodium,was investigated.     对洛索洛芬钠的关键中间体2-(4-溴甲基苯基)丙酸的合成工艺进行了改进研究。 短句来源 查询“loxoprofen sodium”译词为用户自定义的双语例句     我想查看译文中含有：的双语例句 为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法，我们为您准备了出自英文原文的大量英语例句，供您参考。   loxoprofen sodium In contrast, the combination of enoxacin at 100 mg/kg and either ketoprofen at 125 mg/kg or pranoprofen at 500 mg/kg induced clonic convulsions, while that of enoxacin at 400 mg/kg and loxoprofen sodium at 600 mg/kg induced no convulsion. 例句来源       The oral administration of ketoprofen, pranoprofen or loxoprofen sodium induced no convulsion up to 1000 mg/kg, 500 mg/kg and 600 mg/kg, respectively, and that of enoxacin induced no convulsion at more than 5000 mg/kg. 例句来源       Convulsions induced by the combination of enoxacin, a new antimicrobial, and nonsteroidal anti-inflammatory drugs including nimesulide, ketoprofen, pranoprofen and loxoprofen sodium, were investigated in mice. 例句来源       Oral loxoprofen sodium at a daily dose of 180?mg resulted in rapid symptom resolution. 例句来源                A method for chiral separation of four loxoprofen sodium optical isomers was developed by high performance liquid chromatography on the chiral stationary phase of cellulose tris(4-methylbenzoate) (Chiralcel OJ-R). The effects of pH,concentration and type of the buffer,and organic modifier's kind in the mobile phase on the resolution and retention were investigated. The good resolution was obtained with the mobile phases of methanol/0.1 mol/L acetic acid-triethylamine (or 0.5 mol/L HClO_4-NaClO_4...             使用三 (对甲苯甲酸 )纤维素酯手性固定相 (ChiralcelOJ R手性柱 ) ,建立了洛索洛芬钠 4个手性异构体的高效液相色谱拆分方法。以甲醇与 pH 3.0的 0 .1mol/L醋酸 三乙胺或 0 .5mol/LHClO4 NaClO4按80∶2 0组成流动相 ,4个异构体中相邻峰的分离度均达到 1.7以上。确认了 4个组分的结构按出峰次序依次为 :(1′R ,2R)、(1′S ,2R)、(1′R ,2S)和 (1′S ,2S)。对流动相中不同的pH、缓冲溶液浓度和类型以及有机改性剂类型对分离结果的影响作了系统考察 ,其结果有助于更好地了解这类固定相的手性识别机理。 文摘来源          Improved synthesis of 2-(4-bromomethylphenyl)propionic acid,the key intermediate for loxoprofen sodium,was investigated.Toluene reacted with propionyl chloride to give 1-(4-methylphenyl)-1-propanone in 87.8% yield,which was treated with iodine and triethyl orthoformate to give ethyl 2-(4methylphenyl) propionate in 88% yield.Ethyl 2-(4-methyl phenyl)propionate was hydrolysed in KOH-MeOH-H_2O to afford 2-(4-methylphenyl)propionic acid in 93% yield followed by bromination with NBS and AIBN in CCl_4...             对洛索洛芬钠的关键中间体2-(4-溴甲基苯基)丙酸的合成工艺进行了改进研究。甲苯与丙酰氯经Friedel-Crafts反应生成1-(4-甲基苯基)-1-丙酮,收率87.8%;1-(4-甲基苯基)-1-丙酮与碘和原甲酸三乙酯进行芳基重排反应,生成2-(4-甲基苯基)丙酸乙酯,收率88%;2-(4-甲基苯基)丙酸乙酯在氢氧化钾-甲醇-水体系中水解生成2-(4-甲基苯基)丙酸,收率93%;2-(4-甲基苯基)丙酸在偶氮双异丁腈引发下于四氯化碳-石油醚二元溶剂体系中,用N-溴代琥珀酰亚胺溴化,收率72.9%,四步反应总收率58.6%。反应步骤少、操作简便、原料易得。 文摘来源       相关查询: loxoprofen sodium tablets sodium (sodium sodium glutamate sodium treat sodium disturbances sodium enriched sodium sands (sodium glycolate sodium glycolate) sodium glycolate (sodium glycolate)  对查询结果不满意

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