loxoprofen sodium 洛索洛芬钠(44)   洛索洛芬钠     Synthesis of Loxoprofen SodiumⅡ .Highly Regioselective Alkylation     洛索洛芬钠合成工艺研究 Ⅱ.高区域选择性烷基化合成法 短句来源     Chiral Separation of Loxoprofen Sodium by High Performance Liquid Chromatography     洛索洛芬钠的高效液相色谱手性拆分 短句来源     Studies on Loxoprofen Sodium Sustained Release Tablets     洛索洛芬钠缓释片的研究 短句来源     SYNTHESIS OF LOXOPROFEN SODIUM BY 1,2 ARYL REARRANGEMENT     洛索洛芬钠的重排合成工艺研究 短句来源     Loxoprofen sodium (Lox), a non-steroidal antinflamma tory drug(NSAID), has maked analgesic and antiphlogistic activeities. It has been mainly used for chronic rheumaticsm arthritis, deformability arthritis, lumbag, scapulaihumeral periarthritis, neck shouder syndrome and analgesic antiphlogistic after operation and tooth extratiom.     洛索洛芬钠(Loxoprofen sodium，Lox)为苯丙酸类非甾体抗炎药(NSAID)，具有优良的镇痛消炎作用，消炎、解热作用和其它同类药物相似，用于慢性风湿关节炎、变形性关节炎、腰痛、肩周炎、颈肩综合症及手术后、拔牙后的镇痛和消炎。 短句来源 更多          “loxoprofen sodium”译为未确定词的双语例句     According to the literature, UV spectrotometry which is selective and sensitive was developed for the determination of loxoprofen sodium during the study of release.     建立了紫外分光光度法，这种方法灵敏度高，无干扰，适用于缓释片的释放度的测定。 短句来源 查询“loxoprofen sodium”译词为用户自定义的双语例句     我想查看译文中含有：的双语例句 为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法，我们为您准备了出自英文原文的大量英语例句，供您参考。   loxoprofen sodium In contrast, the combination of enoxacin at 100 mg/kg and either ketoprofen at 125 mg/kg or pranoprofen at 500 mg/kg induced clonic convulsions, while that of enoxacin at 400 mg/kg and loxoprofen sodium at 600 mg/kg induced no convulsion. 例句来源       The oral administration of ketoprofen, pranoprofen or loxoprofen sodium induced no convulsion up to 1000 mg/kg, 500 mg/kg and 600 mg/kg, respectively, and that of enoxacin induced no convulsion at more than 5000 mg/kg. 例句来源       Convulsions induced by the combination of enoxacin, a new antimicrobial, and nonsteroidal anti-inflammatory drugs including nimesulide, ketoprofen, pranoprofen and loxoprofen sodium, were investigated in mice. 例句来源       Oral loxoprofen sodium at a daily dose of 180?mg resulted in rapid symptom resolution. 例句来源                A facile method for preparation of loxoprofen sodium is disclosed.Ethyl 2 ( p bromomethyl phenyl) propionate,prepared from toluene via acylation,ketalization,rearrangement,hydrolysis,bromination and esterification,was subjected to phase transfer ca talyzed alkylation with ethyl 2 oxocyclopentanecarboxylate,followed by hydrolysis with decarboxylation and salt formation in one pot procedure to afford loxoprofen sodium in about 35% overall yield.             甲苯经酰化、缩酮重排和水解转化成２－对甲苯基丙酸后，经溴代、酯化制成２－对溴代甲苯基丙酸乙酯，再在ＰＥＧ－６００和无水碳酸钾存在下，对２－乙氧羰基环戊酮进行烷基化后，直接水解、脱羧、成盐而得洛索洛芬钠，总收率３５％。 文摘来源          In the presence of sodium t- butoxide and DMSO,ethyl 2 - oxocyclopentanecarboxylate was subjected to C- alkylation with 2 - ( 4- bromomethylphenyl) propanoic acid with high regioselectivity to give 2 - [4 - ( 1 - ethoxycarbonyl- 2 - oxo- 1 - cyclopentanylmethyl) phenyl]propanoic acid ( 4) which was followed by hydrolysis,decarboxylation and saltformation to afford loxoprofen sodium in about72 % overall yield.The effects of reaction temperature and different solvents on yield of4 were a...             在叔丁醇钠和二甲基亚砜的存在下,2-(对溴甲基苯基)丙酸对2-乙氧羰基环戊酮进行C-烷基化,再经水解脱羧,成盐即得洛索洛芬钠,以2-(对溴甲基苯基)丙酸计算,总收率为72%。探索了不同溶剂和反应温度对烷基化收率的影响。 文摘来源          A method for chiral separation of four loxoprofen sodium optical isomers was developed by high performance liquid chromatography on the chiral stationary phase of cellulose tris(4-methylbenzoate) (Chiralcel OJ-R). The effects of pH,concentration and type of the buffer,and organic modifier's kind in the mobile phase on the resolution and retention were investigated. The good resolution was obtained with the mobile phases of methanol/0.1 mol/L acetic acid-triethylamine (or 0.5 mol/L HClO_4-NaClO_4...             使用三 (对甲苯甲酸 )纤维素酯手性固定相 (ChiralcelOJ R手性柱 ) ,建立了洛索洛芬钠 4个手性异构体的高效液相色谱拆分方法。以甲醇与 pH 3.0的 0 .1mol/L醋酸 三乙胺或 0 .5mol/LHClO4 NaClO4按80∶2 0组成流动相 ,4个异构体中相邻峰的分离度均达到 1.7以上。确认了 4个组分的结构按出峰次序依次为 :(1′R ,2R)、(1′S ,2R)、(1′R ,2S)和 (1′S ,2S)。对流动相中不同的pH、缓冲溶液浓度和类型以及有机改性剂类型对分离结果的影响作了系统考察 ,其结果有助于更好地了解这类固定相的手性识别机理。 文摘来源   << 更多相关文摘         相关查询: loxoprofen sodium tablets sodium (sodium sodium glutamate sodium treat sodium disturbances sodium enriched sodium sands (sodium glycolate sodium glycolate) sodium glycolate (sodium glycolate)  对查询结果不满意

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