After 4 weeks of treatment, 92.42% of the AS patients responded to loxoprofen sodium. Significant improvements were noticed in all 3 primary outcome measurements( P <0.05).
In contrast, the combination of enoxacin at 100 mg/kg and either ketoprofen at 125 mg/kg or pranoprofen at 500 mg/kg induced clonic convulsions, while that of enoxacin at 400 mg/kg and loxoprofen sodium at 600 mg/kg induced no convulsion.
The oral administration of ketoprofen, pranoprofen or loxoprofen sodium induced no convulsion up to 1000 mg/kg, 500 mg/kg and 600 mg/kg, respectively, and that of enoxacin induced no convulsion at more than 5000 mg/kg.
Convulsions induced by the combination of enoxacin, a new antimicrobial, and nonsteroidal anti-inflammatory drugs including nimesulide, ketoprofen, pranoprofen and loxoprofen sodium, were investigated in mice.
Objective:To study the efficacy and safety of loxoprofen sodium in the treatment of ankylosing spondylitis (AS) patients.Methods:52 AS patients were enrolled in a random order,open trial.Each patient received loxoprofen sodium at a dosage of 60mg,tid,taking after meals.The efficacy and safety assessment were performed at 0 and 4 weeks after taking the medicine.Results:All data were available in 50 patients who completed the trial with 2 drop outs.After 4 weeks of treatment, 92.42%...