Methods:114 patients with OA in knees were enrolled in a random order,open trial. Each patient received loxoprofen sodium at a dosage of 60mg, tid, taking after the food.
The efficacy and safety of loxoprofen sodium was evaluated prior to and after 3 weeks of medication. The efficacy indices include rest pain index, active pain index, tenderness index, swelling index and activity degree of the knee joint.
In contrast, the combination of enoxacin at 100 mg/kg and either ketoprofen at 125 mg/kg or pranoprofen at 500 mg/kg induced clonic convulsions, while that of enoxacin at 400 mg/kg and loxoprofen sodium at 600 mg/kg induced no convulsion.
The oral administration of ketoprofen, pranoprofen or loxoprofen sodium induced no convulsion up to 1000 mg/kg, 500 mg/kg and 600 mg/kg, respectively, and that of enoxacin induced no convulsion at more than 5000 mg/kg.
Convulsions induced by the combination of enoxacin, a new antimicrobial, and nonsteroidal anti-inflammatory drugs including nimesulide, ketoprofen, pranoprofen and loxoprofen sodium, were investigated in mice.
Objective:To study the efficacy and safety of loxoprofen sodium in the treatment of patients with knee osteoarthritis(OA).Methods:114 patients with OA in knees were enrolled in a random order,open trial. Each patient received loxoprofen sodium at a dosage of 60mg, tid, taking after the food.The efficacy and safety of loxoprofen sodium was evaluated prior to and after 3 weeks of medication.The efficacy indices include rest pain index, active pain index, tenderness index,...
Objective: To evaluate the efficacy and safety of loxoprofen sodium in treatment of patients with osteoarthritis (OA). Methods: The study was conducted in 40 patients of OA by a random, open and controlled method. All of them were in line with the criteria of American College of Rheumatology. They were divided to receive oral loxoprofen 60 mg tid or sustained release ibuprofen 300 mg bid for 4 weeks. Results: After 4 weeks treatment, all parameters including active pain of knee, time for w...