loxoprofen sodium 洛索洛芬钠(44)   洛索洛芬钠     Study of synthetic process of loxoprofen sodium     非甾体抗炎药洛索洛芬钠的合成工艺研究 短句来源     Synthesis of a non-steroid anti-inflammatory drug loxoprofen sodium     非甾体抗炎药洛索洛芬钠的合成改进 短句来源     Pharmacokinetic study on loxoprofen sodium in healthy Chinese volunteers     洛索洛芬钠在健康中国人体内的药代动力学研究 短句来源     Determination of loxoprofen sodium tablets by UV spectrophtometry     紫外分光光度法测定洛索洛芬钠片的含量 短句来源     Study on Relative Bioavailablity of Loxoprofen Sodium Tablet by HPLC     HPLC法测定国产洛索洛芬钠片人体相对生物利用度 短句来源 更多          “loxoprofen sodium”译为未确定词的双语例句     Conclusion: The method is accurate, rapid and simple for the quality control of loxoprofen sodium tablets.     结论:本方法准确、快速、简便,可用于洛索洛芬钠片的质量控制。 短句来源     According to the literature, UV spectrotometry which is selective and sensitive was developed for the determination of loxoprofen sodium during the study of release.     建立了紫外分光光度法，这种方法灵敏度高，无干扰，适用于缓释片的释放度的测定。 短句来源     Conclusion:A shorter new process for synthesis of loxoprofen sodium is established with a yield of >40%. [     结论 :该合成路线较短 ,总收率 40 %以上。 短句来源     Conclusion:A simple and accurate method is established for determina-tion of loxoprofen sodium and its related substances.     结论:本法简便、准确,可用于洛索洛芬钠的含量测定及其有关物质的测定。 短句来源     CONCLUSION A simple, reli able and rugg ed HPLC assay for loxoprofen sodium was developed. The assay method was conveni ent for clinical laboratory.     结论　建立的HPLC法简单快速 ,定量可靠准确 ,适合于洛索洛芬钠临床研究。 短句来源 查询“loxoprofen sodium”译词为用户自定义的双语例句     我想查看译文中含有：的双语例句 为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法，我们为您准备了出自英文原文的大量英语例句，供您参考。   loxoprofen sodium In contrast, the combination of enoxacin at 100 mg/kg and either ketoprofen at 125 mg/kg or pranoprofen at 500 mg/kg induced clonic convulsions, while that of enoxacin at 400 mg/kg and loxoprofen sodium at 600 mg/kg induced no convulsion. 例句来源       The oral administration of ketoprofen, pranoprofen or loxoprofen sodium induced no convulsion up to 1000 mg/kg, 500 mg/kg and 600 mg/kg, respectively, and that of enoxacin induced no convulsion at more than 5000 mg/kg. 例句来源       Convulsions induced by the combination of enoxacin, a new antimicrobial, and nonsteroidal anti-inflammatory drugs including nimesulide, ketoprofen, pranoprofen and loxoprofen sodium, were investigated in mice. 例句来源       Oral loxoprofen sodium at a daily dose of 180?mg resulted in rapid symptom resolution. 例句来源                Objective:For improving and shortening synthetic process and raising yield.Methods:2-(p-bromomrthyl phenyl)propionic acid is prepared from toluene,and alkylated with 2-oxocyclopentane carboxylate in medium of ethanol,DMF,and sodium hydroxide,and loxoprofen sodium is obtained following the product of the former reaction is hydrolyzed and decarboxylated.Results:The product thus obtained is identified with IR and JH1,D,Z-NMR.Conclusion:A shorter new process for synthesis of loxoprofen...             目的 :改进合成工艺 ,缩短合成路线 ,提高总收率。方法 :以甲苯为原料 ,合成 2 对溴代甲基苯基丙酸。再在乙醇、DMF溶剂和氢氧化钠的条件下 ,与 2 乙氧羰基环戊酮进行烷基化后直接水解 ,脱羧成盐得洛索洛芬钠。结果 :经IR ,1 H NMR光谱鉴定 ,产品结构与洛索洛芬钠一致。结论 :该合成路线较短 ,总收率 40 %以上。 文摘来源          Loxoprofen sodium is a kind of a non steroid anti inflammatory and antalgic drug with less side effects and high effect.In this article,the synthesis of the most important intermediate ethyl [ p (chloromethyl)phenyl]propionate in the synthetic route of loxoprofen sodium was improved based on the previous research.The catalyst TiCl 4 instead of SnCl 4 was used in the experiments,and a wonderful result was obtained.The overall yield was increased from 36% to 58%.             洛索洛芬钠是一种副作用小、疗效高的非甾体类抗炎镇痛药。在总结前人工作的基础上 ,对其合成工艺中的重要中间体 2 (4 氯甲基苯基 )丙酸乙酯的合成进行了改进 ,以催化剂四氯化钛替代四氯化锡 ,取得了很好的效果 ,总收率为 5 8% (原文献收率为 36 % )。 文摘来源          OBJECTIVE: To study pharmacokinetics and relative bioavailability following oral administration of loxoprofen sodium tablet in healthy volunteers. METHODS: A single oral domestic and imported loxoprofen tablets were given according to a randomized 2 way cross-over design. Plasma concentration of loxoprofen was determined by HPLC. RESULTS: The main pharmacokinetic parameters after oral administration of domestic and imported loxoprofen sodium tablet(60mg) were: t1/2ke 93. ...             目的:研究健康受试者口服洛索洛芬钠片(loxoprofen sodium)的药代动力学,以进口洛索洛芬钠(loxonin,日本三共株式会社生产)作为参比制剂计算相对生物利用度,判断两种制剂是否生物等效。方法:20名健康受试者按体重指数进行分层随机服用洛索洛芬钠被试制剂或参比制剂60mg,用高效液相色谱法测定血浆中洛索洛芬钠的浓度。结果:经3P97程序拟合,口服国产和进口洛索洛芬钠60mg的主要药代动力学参数分别为:t_(1/2ke)为93.9±19.8min和92.4±16.3min;AUC_(0-t)为596.97±104.12μg·min·mL~(-1)和598.78±109.62μg·min·mL~(-1),C_(max)为6.40±2.12μg·mL~(-1)和6.60±2.04μg·mL~(-1),t_(max)为25.0±14.3min和23.5±10.3min。结论:国产洛索洛芬钠片的相对生物利用度为(101.2±17.4)％。经统计学分析,两制剂具有生物等效性。 文摘来源   << 更多相关文摘         相关查询: loxoprofen sodium tablets sodium (sodium sodium glutamate sodium treat sodium disturbances sodium enriched sodium sands (sodium glycolate sodium glycolate) sodium glycolate (sodium glycolate)  对查询结果不满意

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