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人体肺腺癌
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  human lung adenocarcinoma
     A High-resolution Study of Chromosomes in a Human Lung Adenocarcinoma Cell Line (LTEP-a1)
     人体肺腺癌细胞系LTEP-a1的高分辨染色体研究
短句来源
     Chromosomal Analysis on a Human Lung Adenocarcinoma Cell Line GLC-82
     人体肺腺癌细胞系GLC-82的染色体分析
短句来源
     The Preliminary Report of Cytogenetic Studies on the Human Lung Adenocarcinoma Cell Line AGZY 83-a
     人体肺腺癌细胞系AGZY83-a的细胞遗传学研究初报
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     THE EFFECT OF dbcAMP ON SURFACE LECTIN RECEPTORS AND INVASIVE ABILITY OF HUMAN LUNG ADENOCARCINOMA CELLS
     双丁酰cAMP对人体肺腺癌细胞表面凝集素受体及其侵袭能力的影响
短句来源
     G-banding and C-banding techniques were used to investigate human lung adenocarcinoma cell line LGC-7910 at passage 150, 173 and 183. The model number of chromosome of this cell line was 67-69, Sixteen markers involving complex chromosomal rearrangements were observed.
     本文应用G显带和C显带染色体分析的方法,对人体肺腺癌细胞系LGC-7910的第150、173及183三代细胞进行了系统的细胞遗传学研究。 发现本细胞系染色体众数为67至69,具有许多涉及复杂染色体重排的标记染色体。
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  “人体肺腺癌”译为未确定词的双语例句
     Influence of "External Qi" of Qigong on the Human Lung Cancer Cells(SPC-A_1)
     气功“外气”对人体肺腺癌细胞(SPC-A_1)的影响
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     Methods: (1) The antiproliferative effect of AL68 series against A549 and Lovo in vitro was observed by MTT assay.
     方法:(1)采用MTT法对AL68系列化合物进行初步筛选,观察它们在体外对人体肺腺癌A549细胞株和人体结肠癌LOVO细胞株的增殖抑制作用。
短句来源
     Recombinant adenovirus with M. O. I(Multiplicity of Infection) of1000 resulted in almost 100% A549 cells (human lung edenoma cell) death.
     本文报道在感染复数(M.O.I,MultiPlicityofInfection)达到1000时对人体肺腺癌细胞A549的杀伤几乎达到回100%。
短句来源
     The results showed that both hTNFα and hTNFβ significantly inhibited 7Gy γ-ray-induced apoptosis in 2BS cells. In contrast, hTNFα or hTNFβ can increase the sensitivity of tumor cell lines (A549 and SPC cells) to radiation.
     结果显示:hTNFα或hTNFβ均可明显抑制~(60)Co-γ射线诱发正常人胚肺二倍体细胞(2BS)的凋亡,而相同剂量的hTNFα能促进~(60)Co-γ射线诱发的人体肺腺癌细胞系A549细胞凋亡,而对另一株人体肺癌SPC细胞的效应比A549降低1倍;
短句来源
     DRUG SENSITIVITY TESTS ON HUMAN PULMONARY ADENOCARCINOMA XENOGRAFT TRANSPLANTED INTO SUBRENAL CAPSULES OF MICE
     小鼠肾囊膜下移植人体肺腺癌裸小鼠移植瘤的药敏实验研究
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  相似匹配句对
     Chromosomal Analysis on a Human Lung Adenocarcinoma Cell Line GLC-82
     人体腺癌细胞系GLC-82的染色体分析
短句来源
     Morphometrical Study of CEA in Adenocarcinoma of Lung
     腺癌癌胚抗原计量学的研究
短句来源
     The Risk Factors of Female Lung Adenocarcinoma
     女性腺癌危险因素分析
短句来源
     The Preliminary Report of Cytogenetic Studies on the Human Lung Adenocarcinoma Cell Line AGZY 83-a
     人体腺癌细胞系AGZY83-a的细胞遗传学研究初报
短句来源
     A High-resolution Study of Chromosomes in a Human Lung Adenocarcinoma Cell Line (LTEP-a1)
     人体腺癌细胞系LTEP-a1的高分辨染色体研究
短句来源
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  human lung adenocarcinoma
Arachidonic Acid Metabolism in Growth Control of A549 Human Lung Adenocarcinoma Cells
      
The role of individual eicosanoids of the arachidonic acid (AA) cascade in the growth control of A549 human lung adenocarcinoma cells has been studied.
      
They exhibit similar phototoxicities on the cells of A549 human lung adenocarcinoma, which are 40- and 100-fold higher than those of chlorin p6 and the clinically used Photogem, respectively, and are not toxic in the absence of light irradiation.
      
Selective gene therapy for human lung adenocarcinoma by tumor-specific expression of herpes simplex virus thymidine kinase gene
      
Alteration of membrane lipid biophysical properties and resistance of human lung adenocarcinoma A549 cells to cisplatin
      
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LTEP-a-2 human pulmonary adenocarcinoma cells were injected subcutan~ eously, intraperitoneally and intramuscularly into NiHnu/nu mice for comparative observation on invasiveness and growth characteristics of lung tumor cells invarous sites. Subcutaneous tumors appeared in single nodules during the early period, then the tumors grew progresively. The tumors showed general features of a adenocarcinoma cell and were surrounded by a multilayered fibrous capsule. No invasion into neighboring tissues was noticed.Intraperitoneal...

LTEP-a-2 human pulmonary adenocarcinoma cells were injected subcutan~ eously, intraperitoneally and intramuscularly into NiHnu/nu mice for comparative observation on invasiveness and growth characteristics of lung tumor cells invarous sites. Subcutaneous tumors appeared in single nodules during the early period, then the tumors grew progresively. The tumors showed general features of a adenocarcinoma cell and were surrounded by a multilayered fibrous capsule. No invasion into neighboring tissues was noticed.Intraperitoneal tumors grew and invaded into different abdominal organs, including diaphragm, pancreas, liver and abdominal wall. The tumors showed characteristics of adenocarcinoma, but without fibrous capsule. Intramuscular tumors were growth in the from of nodule with incompleted thinner fibrous capsule. All tumor were solid adenocarcinoma. They invaded into the skeletal miscle tissues.This result showed subcutaneous tumors were well-del-ineated and noninva-sive with thick fibrous capsule, by contrast, intraperitoneal and intramuscular tumors invaded into abdominal organs and muscle tissues. So the tumor invasiveness in nude mice were shown not to be same in different sites in vivo.

人体肺腺癌(LTEPu-a-2)细胞系在裸小鼠体内移植后,皮下移植组无侵袭,而腹腔内和肌内移植组均有不同程度的侵袭发生,但未见转移。

established in nude mice. Aliqouts (0.2ml) of 1 * 107LTEP-a-2 cells from the same batch were injected s.c. into 11 (1st group) and 5 (2nd group) nude mice. In the 1st group, 7/11 inoculated tumors showed growth (63.6%) , and in the 2nd group, 4/5 inoculated tumors showed growth (80%) . For establishment of human lung camcer cell line, tumor tissue from the 1st passage of growing tumor were transplanted s.c. into unde mice by method of small fragments or single cell suspension of tumor. During a period of two...

established in nude mice. Aliqouts (0.2ml) of 1 * 107LTEP-a-2 cells from the same batch were injected s.c. into 11 (1st group) and 5 (2nd group) nude mice. In the 1st group, 7/11 inoculated tumors showed growth (63.6%) , and in the 2nd group, 4/5 inoculated tumors showed growth (80%) . For establishment of human lung camcer cell line, tumor tissue from the 1st passage of growing tumor were transplanted s.c. into unde mice by method of small fragments or single cell suspension of tumor. During a period of two years, this transplanta'ble human lung cancer cell line has been transplanted in 62 nude mice with tumor growth incidence of 53/62(87.1%). After 7 passages, the tumor began to grow rapidly and attained large size in 4 weeks with maintenance of adenocarcinomatous structure.

人体肺腺癌细胞系(LTEP-a-2)接种于裸小鼠皮下,成功地建立了一株可移植性瘤株模型。历时2年共传15代,共用62只裸小鼠,肿瘤总发生率为(54/62)87.1%。第7代以后肿瘤迅速生长,一般30天左右可长出500mm~3大小瘤体,仍保持肺腺癌的特征。

Since Kohler and Milstein establishedlymphocyte hybridoma technique and obtainedmonoclonal antibodies against the specific an-tigen needed,a large number of reports havebeen published dealing with the human can-cers.By means of this technique,the Minna'slaboratory in U.S.A.first reported theMcAbs against human lung cancer in which,of interest,some McAbs interrupted the growthof tumor cells. We used coated SPC-A-1,the cell lineof human lung adenocarcinoma with mouseanti-normal human lung tissue antibodies asimmunogen...

Since Kohler and Milstein establishedlymphocyte hybridoma technique and obtainedmonoclonal antibodies against the specific an-tigen needed,a large number of reports havebeen published dealing with the human can-cers.By means of this technique,the Minna'slaboratory in U.S.A.first reported theMcAbs against human lung cancer in which,of interest,some McAbs interrupted the growthof tumor cells. We used coated SPC-A-1,the cell lineof human lung adenocarcinoma with mouseanti-normal human lung tissue antibodies asimmunogen to immunize BALB/C mice.Sple-ens taken from 3 days after last injectionwere fused with mouse myelomas NS-1 andSP 2/O.Seven monoclonal antibodies chosenrandomly from 75 hybridomas after cloning3—7 times were screened with a variety ofnormal human adult tissues,tumor and embr-yonic tissues with ELISA,immunofluorescenceand ABC staining. 1.To answer the question that whetherthe SPC-A-1 adenocarcinoma cells and othertumor cells share the common antigens orcross reactive antigens with normal lung tis-sue,we incubated the anti-normal lung tissueantibodies with three established tumor celllines and detected by immunofluorescence me-thod.Results in Table 1 indicate that threedifferent tumor cell lines react more or lesswith anti-normal lung Ab.ranging from 28.0% to 47.8% and that not all the cells inthe population are positive,indicating thatthe cells in SPC-A-1 cell line are heteroge-neous and that "coating" the cells showingpositive reactions with anti-normal lung tissueantibody could diminish the antigenicity ofnormal antigens. 2.The cross reaction of anti-"coated"SPC-A-l antibody with some tumor cells.Results in Table 2 show non-absorbed antiSPC-A-1 antiserum can react with both ade-nocarcinoma cell lines,SPC-A-1,SPC-A-2. However,when this antiserum absorbed withSPC-A-1,all the reaction with these threecell lines disappeared,when antiserum wasabsorbed with SPC-A-1 and SPC-A-2 cellsseparately it still retains some reaction withSPC-A-1 cells.These results indicated thatthere was presence of common antigenic deter-minants on both SPC-A-1 cells and SPC-A-2cells but SPC-A-1 had some other determina-nts which were absence on the SPC-A-2 cells.The fact that antiserum against the coatedSPC-A-1 cells did not react with SMC-1 cellsindicated that after coating,the normal lungantigenic presented on the tumor cells disap-peard or diminished their antigenicity in vivo. Table 2.The effect of absorbing anti SPC-A-l antibodies against various cell lines on its reactivity 3.McAbs The seven McAbs designated as LAC-122.LAC-163,LAC-210,LAC-201,LAC-206.LAC-207 and LAC-216 were shown in Table3.Their reactions with various tumor tissuesand various normal adult and embryonic tis-sues by immunofluorescence and ABC stainingwere show in Table 4—6 and in Figures 1 — 6.Only LAC-122.LAC-163 and LAC-210showed no cross reactions with normaltissue cells,embryonic cells and othertumor cells.These results showed that McAbs,LAC-122,LAC-163 and LAC-210 havespecificity for lung cancer. 4.Further demonstrations of McAbsLAC-122,LAC-163 and LAC-210 reactingwith histologically different cancer cells,nor-mal adult and embryonic lungs,normal adultpooled WBC and type AB RBC.On the basisof the results above,we attempted to useMcAbs LAC-122,LAC-163 and LAC-210 totest a session of lung cancer including of his- Table 4.The immunofluorescence reaction of monoclonal anti-lung cancer antibodies with several tumor cell linestologically mainly different types with frozensections of the samples from patients by ABCstaining.The results were listed in Table 7and 8.LAC-122 reacted with 12 out of 16specimens of human lung adenocarcinoma andsquamo-carcinoma accounting for 75.0% Po-sitive rate,LAC-163 showed 78.3% positiverate at 18 out of 23 specimens and LAC-210showed 75.0% positive rate at 18 out 24 spe-cimens,They have no reaction with 6 sam-ples of small cell carcinoma.The results de-monstrated the specificity of these McAbs tolung adeno and squamo-cancer cells.Up tonow the mechanism of tumor cells,"coated" arttibTable 6.The reaction of monoclonal anti-lung cancer antibodies with normal adult or feotal tissues by ABC stainingTable 7.Reactiviy of LAC-122 LAC-163 LAC-210 with lung cancer tissues by ABC staining and immunofluorescenceTable 8.The cross reaction of LAC-122 LAC-163 LAC-210 with normal human tissues and blood cells by ABC staining and immunofluorescencewith anti normal tissue antibody used as im- discussed in this paper,munogen is not clear several possibilities are discussed in this paper.

人肺腺癌细胞株SPC-A-1,经抗人正常肺抗血清复被后免疫小鼠,脾细胞和同系NS-1或SP 2/0融合,获得17株单克隆抗体。本文报道其建株过程及其中7株单克隆抗体的一些特征。LAC-122、LAC-163与LAC-210对人体肺腺癌和肺鳞癌的阳性反应率分别为75%、78.3%和75%,除LAC-122对一例胃癌细胞株有微弱交叉反应外,三株单抗对肺小细胞癌, 其它肿瘤组织及正常、胚胎组织均呈阴性。对利用抗体复被瘤细胞及肺癌相关抗原问题作了较详细的讨论.

 
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