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morphine sulphate
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  硫酸吗啡
     The steady state plasma concentration of morphine sulphate in cancer patients after multiple doses was achieved, C max of CRMS and IRMS was 27.43±0.33 ng/ml and 22.68±0.16 ng/ml, C min of CRMS and IRMS was 19.45±1.44 ng/ml and 18.14±0.49 ng/ml, respectively.
     癌症病人多次口服硫酸吗啡至稳态,CRMS和IRMS的峰浓度分别为27.43±0.33ng/ml,22.68±0.16ng/ml; 谷浓度分别为19.45±1.44ng/ml;
短句来源
     Clinical observation of treatment of cancer pain with morphine sulphate controlled release tablets by rectal administration
     硫酸吗啡控释片直肠给药治疗癌痛的临床观察
短句来源
     The steady state concentration of morphine sulphate tablets and its clinical analgesic effect in cancer patients
     硫酸吗啡片剂在癌痛患者中的稳态浓度及临床镇痛效果
短句来源
     CLINICAL EVALUTION OF ANALGESIC EFFECT OF CONTROLLED RELEASE MORPHINE SULPHATE TABLETS IN PATIENTS WITH CANCER PAIN
     硫酸吗啡控释片对晚期癌痛病人镇痛效果临床评价
短句来源
     The pharmacokinetics of morphine sulphate was studied in 10 Chinese healthy volunteers after a single oral dose(20mg).
     中国健康志愿者10名,一次口服硫酸吗啡普通片20mg,分别于服药后不同时间采取静脉血,用GC-MS测定血浆中吗啡含量。
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  “morphine sulphate”译为未确定词的双语例句
     Fifty-four patients with severe cancer pain were treated with morphine sulphate controlled-release tablets(MS Contin), 30-90 mg each time,po, twice daily. The total response rate and complete remission rate were 96.3%(52/54) and 87%(47/54) respectively.
     本组54例重度癌痛晚期病人,给予口服美施康定30-90mg,每12h一次治疗,有效率96.3%(52/54),完全缓解率达87.0%(47/54)。
短句来源
     MANAGING CANCER PAIN WITH MORPHINE SULPHATE CONTROLLED-RELEASE TABLETS
     美施康定对癌症疼痛的镇痛效果
短句来源
     METHODS: 17 cancer patients were randomly given 30 mg controlled release morphine sulphate (CRMS) every 12 h or 10 mg immediate release morphine sulphate (IRMS) every 4 h for 7 days.
     方法:17例癌症病人,随机poCRMS或IRMS7d,用GCMS测定服药第5,6,7天吗啡血药浓度的峰谷水平。
短句来源
     Fifty four patients with sever cancer pain were treated with morphine sulphate controlled-release tablets 30~90 mg twice a day. The total response rate and complete remission rate were 96.3% (52/54) and 87% (47/54) respectively. The main clinical side-effects were constipation, nausea,vomiting, somnolence et al.
     本组54例重度癌痛晚期病人,给予口服美施康定30~90mg每12h一次治疗,有效率达963%(52/54),完全缓解率达87%(47/54),主要副作用为便秘、恶心、呕吐、嗜睡等
短句来源
  相似匹配句对
     Determination of morphine sulphate content in milk by HPLC
     高效液相色谱法测定乳汁中硫酸吗啡的含量
短句来源
     PHARMACOKINETICS OF MORPHINE SULPHATE TABLET IN CHINESE HEALTHY VOLUNTEERS
     中国健康志愿者一次口服硫酸吗啡普通片药代动力学研究
短句来源
     Morphine Immunoassay
     吗啡的免疫测定
短句来源
     Sulphate Investment Casting
     硫酸盐熔模铸造
短句来源
     Corrosion by sulphate and solution
     硫酸盐对水泥混凝土的侵蚀及其防治措施
短句来源
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  morphine sulphate
Guinea-pigs were treated with a single dose of morphine sulphate (15 mg/kg s.c.) or saline (control) and 2h later with naloxone hydrochloride (15 mg/kg s.c.) to precipitate withdrawal.
      
Tolerance to and physical dependence on morphine were produced and assessed in Swiss inbred albino mice by giving morphine sulphate (s.c.) three times a day for a period of 15 days in an increasing dose of 10 mg/kg every 24 hours.
      
Morphine sulphate reversed the effect of dopamine on prolactin secretion and on the proportion of prolactin in the gland that was in the dimeric form.
      
Two well resolved hydration steps were obtained on the sorption isotherm at water activities of 0.01 and 0.22 corresponding to the formation of dihydrate and pentahydrate of morphine sulphate.
      
Water vapor sorption on morphine sulphate was studied in a twin double sorption microcalorimeter at 25°C.
      
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A randomized and double-blind clinical trial of the analgesic effect of controlledrelease morphine sulphate(MS contin tablets.CRMS)against moderate and severe intensity of pain in cancer patients was carried out in several hospitals. Immediate-release morphine sulphate(IRMS)tablet was used as positive control.Total numbers of the patients were 262 cases.(101 cases for 30mg CRMS q12h,58 cases for 60mg CRMS q12h,103 cases for 10mg IRMS q4h).Duration of treatment was 6 days and drugs were administered...

A randomized and double-blind clinical trial of the analgesic effect of controlledrelease morphine sulphate(MS contin tablets.CRMS)against moderate and severe intensity of pain in cancer patients was carried out in several hospitals. Immediate-release morphine sulphate(IRMS)tablet was used as positive control.Total numbers of the patients were 262 cases.(101 cases for 30mg CRMS q12h,58 cases for 60mg CRMS q12h,103 cases for 10mg IRMS q4h).Duration of treatment was 6 days and drugs were administered orally. Pain intensity was assessed by visual analogue scale, Pain intensity difference(PID),sum of pain intensity difference(SPID), pain relief (PAR),total pain relief(TPAR),rate of PAR over grade 2 and total analgesic score(TANS) were parameters used for evaluating the analgesic effect. Clinical results showed that:there was no significant difference between the two treatment groups.

应用硫酸吗啡控释片(CRMS)对晚期癌症伴有中、重度疼痛患者进行镇痛效果观察。试验组硫酸吗啡控释片30mgq12hpo101例;60mgq12hpo58例。对照组硫酸吗啡普通片(IRMS)10mgq4hpo103例。均连续服用6d。采用疼痛强度差、总疼痛强度差、疼痛缓解度、总疼痛缓解度、中度以上疼痛缓解率、镇痛分和总镇痛分等项镇痛评价指标。结果表明硫酸吗啡控释片的镇痛效果与硫酸吗啡普通片无显著差异。

The pharmacokinetics of morphine sulphate was studied in 10 Chinese healthy volunteers after a single oral dose(20mg).Blood samples were collected at 0.25,0.5,1,1 .5,2,3,4,6,8 and 10 h after administration,and determined by GC MS method for morphine concentration in plasma. The pharmacokinetic parameters calculated according to 3P87 program were as following:Tmax=0.56±0.16h Cmax=21.27±6.21μg/L ,CL=220.4±34.7 L/h,T1/2β=3.03±0.74 h.The results showed that morphine was characterized by a rapid...

The pharmacokinetics of morphine sulphate was studied in 10 Chinese healthy volunteers after a single oral dose(20mg).Blood samples were collected at 0.25,0.5,1,1 .5,2,3,4,6,8 and 10 h after administration,and determined by GC MS method for morphine concentration in plasma. The pharmacokinetic parameters calculated according to 3P87 program were as following:Tmax=0.56±0.16h Cmax=21.27±6.21μg/L ,CL=220.4±34.7 L/h,T1/2β=3.03±0.74 h.The results showed that morphine was characterized by a rapid absorption and elimination. There was a lag time between the maximum analgesic effect and maximum plasrna concentration.

中国健康志愿者10名,一次口服硫酸吗啡普通片20mg,分别于服药后不同时间采取静脉血,用GC-MS测定血浆中吗啡含量。以3P87软件程序处理,求得其主要药代动力学参数:Cmax为21.27±6.21μg/L;Tmax为0.55±0.16h;曲线下面积AUC为93.08±16.65μg·h-1·L-1,T1/2β为3.03±0.74h。结果提示,硫酸吗啡普通片在人体内的吸收,消除均较快,并表明吗啡的最大血药浓度与临床的最强镇痛作用之间存在一个迟滞时间。

Morphine physical dependence was induced on day 10 in SD rats by daily administration of morphine sulphate(MS), but not morphine hydrochloride(MH), in their drinking water.With greater magnitude of naloxone induced withdrawal signs, the rats received daily twice subcutaneous injection of MS or MH for a week grew morphine dependence on day 7. The cardiovascular parameters during withdrawal syndrome in chronic morphine treatment rats showed variable changes according to the different experimental...

Morphine physical dependence was induced on day 10 in SD rats by daily administration of morphine sulphate(MS), but not morphine hydrochloride(MH), in their drinking water.With greater magnitude of naloxone induced withdrawal signs, the rats received daily twice subcutaneous injection of MS or MH for a week grew morphine dependence on day 7. The cardiovascular parameters during withdrawal syndrome in chronic morphine treatment rats showed variable changes according to the different experimental condition: In conscious rats intravenous administration of naloxone significantly increased the blood pressure and heart rate. In pentobarbital anaesthesia rats, however, it induced hypotension and bradycardia. Hypotension and bradycardia were more significant in morphinedrinking rats. Conclusion: Morphine sulphate is better than morphine hydrochloride in inducing morphine dependence in rats. The assessment of the severity of morphine dependence must use spectific parameter according to the methods by which physical dependence was induced.

在饮水中溶入硫酸吗啡,逐日提高吗啡浓度,SD大鼠在饮入吗啡后第10天产生明显的吗啡依赖。而同样方法饮入盐酸吗啡效果较差。每日皮下注射盐酸吗啡或硫酸吗啡1周后,纳洛酮催瘾下的戒断症状均明显强于口服饮入硫酸吗啡鼠。慢性吗啡处理大鼠戒断状态下心血管功能受麻醉、药物依赖性程度及吗啡给入途径的影响;清醒动物纳洛酮催瘾时血压升高、心率加快;戊巴比妥麻醉下血压降低、心率减慢,而且自饮吗啡成瘾鼠麻醉状态下的降压窦缓反应强于皮下注射吗啡成瘾鼠。结论:经自饮摄入法诱导吗啡依赖大鼠时,硫酸吗啡的效果优于盐酸吗啡。判断吗啡依赖的程度和指标必须结合动物模型的建立方法来确定。

 
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