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   double minutes 的翻译结果: 查询用时:0.224秒
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double minutes
相关语句
  双微体
     i(17q) and double minutes expression in peripheral blood of bladder transitional cell carcinoma patients
     i(17q)和双微体在膀胱癌患者外周血中的表达及意义
短句来源
     Conclusion : Esophageal carcinoma patients with double minutes in blood cell were resistant to radiotherapy , the course of progression was rapid.
     结论食管癌患者外周血发现双微体者多为晚期病人,这类病人对放射治疗者一定抗拒性,生存期短,病程发展快。
短句来源
     Objective To investigate the expression of double minutes (DM) in bladder transitional cell carcinoma (TCC) and its significance.
     目的 研究双微体(double minutes,DM)在膀胱移行上皮细胞癌中的表达及其意义。
短句来源
     Objective To determine the sizes of double minutes(DMs),one of the predominant am- plification structure found in primary tumors and drug-resistant cells.
     目的测定肿瘤细胞及耐药性细胞中双微体(double minutes,DMs)的大小。
短句来源
     Results , Double minutes were found in 7 cases(18.4%). The overall response rate of patients with DMs was 71.4%,that of patients without DMs was 96. 8%. The 1-year survival rates were 14. 3% in patients with DMs and 54. 8% in patients without DMs.
     结果38例患者中的7例患者发现双微体,占18.4%,含双微体患者放疗有效率71.4%,无双微体患者放疗有效率96.8%,1年生存率分别为14.3%和54.8%。
短句来源
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  “double minutes”译为未确定词的双语例句
     MDM2(murine double minute 2)was originally identified as an amplified gene carried on double minutes in a mouse tumor fibrous cell line 3T3. Over-expression of MDM2 produced a transformed phenotype.
     MDM2(murine double minute 2)最早发现于鼠3T3成纤维细胞系,它能导致此细胞系的自发转变。
短句来源
     The Sizes of Double Minutes in Human Ovarian Cancer Cells and Mouse MTX-resistant Cells Determined by Pulsed Field Gradient Gel Electrophoresis and Southern Blotting
     人卵巢癌细胞及小鼠MTX抗性细胞中DMs大小的测定
短句来源
     Chromosome banding analysis demonstrated gene amplification such as double minutes and homogeneously staining region in the short arm of chromosome 7 and heterozugous deletion of the long arm of chromosome 7, together with overexpression of P-glycoprotein, suggesting that this sub-line was classically multidrug resistant and could be an experimental model for study of resistant mechanism of stomach cancer and for new reversal method.
     染色体出现基因扩增改变如双小体,7号染色体短臂均染(HSR)和长臂不规则缺失。 细胞表面P糖蛋白明显增多,结果表明本文建立的胃癌细胞耐药亚系产生了典型的多药抗药性,为研究人胃癌耐药机制和寻找可能的逆转途径提供了较为理想的实验模型。
短句来源
  相似匹配句对
     Expression of double minutes in cases with leukemia
     白血病患者骨髓细胞双微体表达的细胞遗传学研究
短句来源
     double alkanes.
     双链烷技术。
短句来源
     It has the double functions.
     它具有双重功能:消极功能为限制原告滥诉,积极功能为通过司法生成权利。
短句来源
     C, 5 minutes.
     C左右,氧化处理时间为5min。
短句来源
     15 Minutes
     十五分钟
短句来源
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  double minutes
Pulsed-field gel electrophoresis of the DNA from cells containing radiation-induced double minutes showed that many copies of the dhfr gene were present on circular DNA molecules of 106, 2× 106, and 3×106 base pairs.
      
Metaphase spreads of chromosomes from EMT-6 cells that had been irradiated and subjected to stepwise increases in MTX concentration showed numerous double minutes.
      
Cytogenetic analysis revealed that double minutes (DMs) predominated in H2MTXResI, whereas homogeneously staining regions (HSRs) were the main feature of H2MTXResII cells.
      
We are exploring the origin and function of amplified DNA sequences associated with double minutes (DMs) in a spontaneously transformed derivative of mouse 3T3 cells.
      
These variants exhibited high frequencies (40-100%) of tetraploidy or hypotetraploidy with loss of chromosomes and varying frequencies of double minutes (10-75% of metaphases).
      
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The capabilities of three components of PYM, A2, A5 and A6 for inducing chromosome aberrations and SCEs were studied. The results indicated that all three components of PYM could induce aberrations. For the 1st metaphase after treatment, over 60% of the aberrated were chromosome type aberrations. The chromosome disintegration, one third of which was accompanied with double minutes, was also observed. In the concentration range of 0.2-1.0μg/ml, the aberrated cell frequencies in every treatment increased...

The capabilities of three components of PYM, A2, A5 and A6 for inducing chromosome aberrations and SCEs were studied. The results indicated that all three components of PYM could induce aberrations. For the 1st metaphase after treatment, over 60% of the aberrated were chromosome type aberrations. The chromosome disintegration, one third of which was accompanied with double minutes, was also observed. In the concentration range of 0.2-1.0μg/ml, the aberrated cell frequencies in every treatment increased with the increase of concentration of the three components. For the 2nd metaphase after treatment, both aberrated chromosomal frequency and SCE frequency increased with the increase of the concentration. According to their capabilities for inducing chromosomal aberrations, in particular the double minutes, and enhancing SCEs, it was believed that A2, A5 and A6 are not only mutagens but also carcinogens.

本文报道平阳霉素(Pingyangmycin,PYM)的三种成分A_2、A_5和A_6诱发CHO-K1细胞染色体畸变和姐妹染色单体交换(SCEs)。处理后第一次分裂中期染色体型畸变占优势,其中有大量的染色体碎裂(Disintegration),在含染色体碎裂的细胞中三分之一伴随出现双微体(Double minutes,DMs)。细胞畸变的频率随处理浓度升高而增加。 处理后第二次分裂中期,细胞畸变的频率仍随处理试剂浓度增加而升高,SCEs频率随处理浓度升高而递增。 上述三种成分诱发染色休畸变的类型没有质的差异。

The gene amplification has been found in number of tumor cell lines and tumor cells. The amplification is related to chromosomal aberrations, including DMs and HSRs. Marinello reported that the shape of double minutes (DM) were usually ring-like.

用L615细胞的双微体(DM)转化A9细胞,得到了转化的A9t3细胞系。A9t3与A9细胞在细胞形态上有显著差异。A9t3细胞含有双微体,具有较高的抗氨甲喋呤能力,二氢叶酸还原酶活性增加,出现了A9细胞所没有的蛋白质电泳带。

Chromosomes of 41 bladder carcinomas were studied. The results showed that with the increase of histopathological grading of transitional cell carcinoma and decrease of cell differentiation, both the number and structure of chromosome, had markedly changed. The presence of four types of abnormal chromosome and some double minutes (DMS) may be of some significance in bladder carcinoma, and it is demonstrated that the chromosomal abnormalities and histopathological grading may have certain correlation in...

Chromosomes of 41 bladder carcinomas were studied. The results showed that with the increase of histopathological grading of transitional cell carcinoma and decrease of cell differentiation, both the number and structure of chromosome, had markedly changed. The presence of four types of abnormal chromosome and some double minutes (DMS) may be of some significance in bladder carcinoma, and it is demonstrated that the chromosomal abnormalities and histopathological grading may have certain correlation in bladder carcinoma.

作者应用染色体技术对41例膀胱癌染色体进行检查。结果表明,随着膀胱移行细胞癌病理分级的增高,癌细胞分化程度的降低,无论染色体数目抑或结构都有明显的变异;四种异常染色体的出现和双微体(DMS)的存在,提示它们在膀胱癌演化中有一定的意义;染色体改变与病理组织学分级间的关系也更一步得到肯定。

 
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