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retinoic acid ra
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  retinoic acid ra
Biocompatibility studies of all-trans-retinoic acid (RA)-loaded microspheres were carried out after they were subcutaneously injected into rats.
      
We studied the effect of all-trans-retinoic acid (RA) on the expression of several surface lectin receptors and cell membrane fluidity of mouse forestomach carcinoma cell line (MFC)in vitro.
      
Objective: To detect which members in the connexin gene family are expressed in nasopharyngeal carcinoma (NPC) cell line HNE1, and the mechanism by which those genes are specifically switched on and off during retinoic acid (RA) induction.
      
80 timed pregnant Sprague-Dawley (SD) rats were randomly divided into 4 groups (n=20): group A (Control group), group B (Dexamethasone (DEX) 1 group), group C (DEX 2 group), group D (retinoic acid (RA) group).
      
The influence of platelet-derived growth factor (PDGF) on lung development in newborn rats and the effect of retinoic acid (RA) on PDGF in lung development were investigated.
      
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The effect of a retinoid (RA Ⅰ ) , synthesized by the Institute of Mate-ria Medica, CAMS was studied on Ecal09 cells in vitro and compared with that of f44-all-trans-retinoic acid (RA). Both RA and RAⅠ inhibited the proliferation of Ecal09CⅢ cells and colonization of Ecal09 cells in soft agar and on agar plate. On agar plate, the morphology of colonies of treated cells became flat (1-3 layers), while colonies of the control piled up to many layers. In Ecal09 spheroid culture...

The effect of a retinoid (RA Ⅰ ) , synthesized by the Institute of Mate-ria Medica, CAMS was studied on Ecal09 cells in vitro and compared with that of f44-all-trans-retinoic acid (RA). Both RA and RAⅠ inhibited the proliferation of Ecal09CⅢ cells and colonization of Ecal09 cells in soft agar and on agar plate. On agar plate, the morphology of colonies of treated cells became flat (1-3 layers), while colonies of the control piled up to many layers. In Ecal09 spheroid culture with human lung diploid fibroblasts as feeder layer, both RA and RA Ⅰ caused morphological changes with formation of ker-atinized epithelial pearls in some of the spheroids, but such changes did not occur in the absence of lung fibroblast. The pathological features of tumors after heterotransplantation of treated and untreated cells were similar, but the size of tumor grown from treated cells was much smaller. The effect of retin-oic acid and retinoid on proliferation and differentiation of epithelial neoplasm was discussed.

RAⅡ及RA在体外均抑制Eca109及Eca109-CⅢ细胞的群体增殖;抑制其在双层软琼脂及琼脂板上的集落生成率;减少其在琼脂上集落内的细胞层次;在有人胚肺二倍体成纤维细胞作饲养层的球体培养中,两种药均使部分细胞形成角化珠结构,受两种药作用的细胞,在动物体内生长的瘤体减小,RAⅡ还使其生瘤率降低,但细胞形态无显著改变。

Retinoids represent a new class of chemotherapeutic agents, It was found that retinoic acid (RA) and N-(4-carboxyphenyl)-retinamide (RII) exhibited inhibitory (cytotoxic, itnmune-potentiating)action on Ehrlich ascites carcinoma. It was shown that after ip injection of the drugs, the number of ascitic tumor cells was greatly diminished, survival time of tumor bearing mice significantly prolonged and ascitic fluid in a few totally disappeared. RA and RII also showed inhibitory action on...

Retinoids represent a new class of chemotherapeutic agents, It was found that retinoic acid (RA) and N-(4-carboxyphenyl)-retinamide (RII) exhibited inhibitory (cytotoxic, itnmune-potentiating)action on Ehrlich ascites carcinoma. It was shown that after ip injection of the drugs, the number of ascitic tumor cells was greatly diminished, survival time of tumor bearing mice significantly prolonged and ascitic fluid in a few totally disappeared. RA and RII also showed inhibitory action on Ehrlich ascites carcinoma cells in vitro. The inhibitory action of RA and RII on biosynthesis of DNA, RNA and protein was apparent, yet the RNA and protein contents remained unchanged, Besides, the cytotoxic action of RII was higher than that of RA.

腹腔给RA和RII使小鼠腹水中瘤细胞数明显减少;荷瘤鼠存活期延长;部分小鼠腹水消退。RA和RII可抑制体外培养的癌细胞DNA、RNA和蛋白质合成,细胞内RNA和蛋白质含量降低;RII的作用比RA强。

Two functional parameters evaluated by NBT dye reduction and YC rosette formation and a morphological change assessed by Wright-Giemsa stain of HL-60 cells were used to determine the extent of HL-60 cell differentiation induced by retinoids and DMSO. Studies revealed that under the action of retinoic acid(RA) and its two new synthetic analogs, 4-(ethoxycarbophenyl) retiamide(RI) and 4-(hydroxycarbophenyl) retiamide (RII), HL-60 cells could be induced to differentiate to more mature cells with...

Two functional parameters evaluated by NBT dye reduction and YC rosette formation and a morphological change assessed by Wright-Giemsa stain of HL-60 cells were used to determine the extent of HL-60 cell differentiation induced by retinoids and DMSO. Studies revealed that under the action of retinoic acid(RA) and its two new synthetic analogs, 4-(ethoxycarbophenyl) retiamide(RI) and 4-(hydroxycarbophenyl) retiamide (RII), HL-60 cells could be induced to differentiate to more mature cells with functional characteristics of granuloeytes. When HL-60 cells were incubated with 10~(-6)M of RⅠ and RⅡ for 6 days, 42.3% and 43.6% of the eells were capable of reducing NBT; 20.7% and 14.9% could form YC rosettes with yeast ceils covered by human C_3 complement. DMSO was also shown to be active in the induction of both functional differentiation phenotypes. However, the expression of C_3 complement receptor was much earlier than the emergence of NBT reduction capacity under its induction. It is resonable to speculate that the induction machanism of retinoids and DMSO is somewhat different. Both retinoids and DMSO could induce HL-60 cells into morphologically more mature myeloid cells including myeloeytes, metamyelocytes and banded neutrophils. However, only a few cells matured into fully segmented ones. The induction of differentiation of HL-60 cells by all of the drugs tested was found to be associated with a reduction of the number of viable ceils. Since this phenomenon appeared later than cell differentiation, it may be related with the change of growth characteristics of differentiated cells.

本文研究了新维甲酸衙生物——维胺酯(RⅠ)和维胺酸(RⅡ)对人早幼粒白血病细胞(HL-60)的分化诱导作用,并与维甲酸(RA)和二甲基亚砜(DMSO)进行了比较。HL-60细胞经RⅠ和RⅡ处理后,细胞对NBT染料还原能力增强,细胞表面出现C_3补体受体等中性粒细胞的分化特征,但作用比RA弱。DMSO诱导上述分化性状出现时间不同,提示维甲酸类药物与DMSO诱导分化的机制可能不同。上述药物均可使HL-60细胞形态按粒系途径向较成熟的方向发展,但变化出现较晚。

 
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