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   orthotopic model 的翻译结果: 查询用时:0.183秒
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orthotopic model
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  原位模型
     Establishment of orthotopic model of hamster pancreatic cancer and its biologic characteristics
     仓鼠胰腺癌原位模型的建立及生物学特性
短句来源
     Establishment of Orthotopic Model of MG-63 Osteosarcoma
     MG-63骨肉瘤原位模型的建立
短句来源
     RESULTS: Orthotopic model of hamster pancreatic cancer had a high survival rate (95%) and grew rapidly.
     结果仓鼠胰腺癌原位模型成活率达95%,生长迅速.
短句来源
     AIM: To establish an orthotopic model of hamster pancreatic cancer and to analyze its biologic characteristics.
     目的建立仓鼠胰腺癌原位模型,并研究其生物学特性.
短句来源
  原位接种模型
     A simple and repeatable orthotopic model of the A549 cell line in nude mice
     一种简单可靠的A549裸小鼠原位接种模型的建立(英文)
短句来源
     RESULTS: The translantation tumors resemble the original human gastric adenocarcinomoa histologically. Tumor take rate of both tail vein model and direct orthotopic model were 60.0%. tumor take rates of both subcutaneous and peritoneal cavity model were 100%;
     结果 :肿瘤组织块保留了人胃腺癌的组织学特片 ,尾静脉注射与直接原位接种成瘤率均为6 0 % ,间接原位接种模型移植成瘤率为 80 % ,皮下与腹腔接种成瘤率均为 10 0 % .
短句来源
  “orthotopic model”译为未确定词的双语例句
     Then the orthotopic transplantation tumor model was established by injecting the subcutaneous transplanted tumor into liver(indirect orthotopic model).
     形成皮下移植瘤后再移植于裸鼠肝内,利用α-氰基丙烯酸烷基酯建立肝原位移植瘤模型(间接肝原位移植瘤模型)。
短句来源
     Results: The incidences of tumorigenicity and metastasis of orthotopic model were the highest,being at 73.3%(11/15)and 20%(3/15),respectively.
     结果:(1)组织块原位移植肾包膜下法成瘤率及转移率最高,分别为73.3%(11/15)、20%(3/15)。
短句来源
     Results Using α-cyanoacrylate to establish the indirect orthotopic model successfully and the survival rates of the transplantation tumor were 95.8 %.
     结果成功地利用α-氰基丙烯酸烷基酯建立了间接肝原位移植瘤模型。 移植瘤存活率达95.8%。
短句来源
     The model had higher survival rates (100%) than direct orthotopic model (35.6%, P <0.01).
     与直接肝原位移植瘤模型比较 ,该模型移植瘤存活率明显高于后者 (35 .6 % ,P<0 .0 1) ;
短句来源
     CONCLUSION: The establishment of orthotopic model of hamster pancreatic cancer cells pGHAM-1 is simple and easily copied, and maintains the biologic characteristics of pancreatic carcinoma, which is an ideal research model of pancreatic carcinoma.
     结论仓鼠胰腺癌细胞株pGHAM-1原位模型建立方法简便,易复制,而且肿瘤保持了胰腺癌的生物学特性,是理想的胰腺癌研究模型.
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  orthotopic model
An essential rule is to utilize an orthotopic model, since tumor-host interaction is organ specific.
      
Using an orthotopic model of bone metastasis, we observed that a combination of enzastaurin and localized radiation treatment reduced tumor blood vessel density, bone destruction and pain compared to single modality treatment.
      
In vivo, rPEDF dramatically suppressed primary osteosarcoma growth and the development of macroscopic pulmonary metastases in an orthotopic model of human osteosarcoma (SaOS-2).
      
Thus, this orthotopic model should be a valuable tool to investigate factors that promote or inhibit osteosarcoma growth and/or metastasis.
      
An Orthotopic Model of Human Osteosarcoma Growth and Spontaneous Pulmonary Metastasis
      
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Objectives:To develop an animal model with similar course and characteris- tics of human gastric cancer. Methods:Orthotopic model of human stomach cancer was es- tablished in2 4BAL B/C- nu/nu nude mice by transplanted SGC- 790 1 human gastric cancer cell lines subcutaneously into nude mice.The animals were randomly divided into6 groups. Tumor- bearing nude mice were killed periodically(2 ,4,8,1 2 ,1 6 weeks respectively) after the operation,and the rest 4animals underwent autopsy. Results:Orthotopic...

Objectives:To develop an animal model with similar course and characteris- tics of human gastric cancer. Methods:Orthotopic model of human stomach cancer was es- tablished in2 4BAL B/C- nu/nu nude mice by transplanted SGC- 790 1 human gastric cancer cell lines subcutaneously into nude mice.The animals were randomly divided into6 groups. Tumor- bearing nude mice were killed periodically(2 ,4,8,1 2 ,1 6 weeks respectively) after the operation,and the rest 4animals underwent autopsy. Results:Orthotopic tumors devel- oped2~ 4weeks after the operation and grew grandually,liver metastases developed1 2 weeks after the operation,some animals suffered from pyloric obstruction and asites.The survival time was1 6~ 2 4weeks. Conclusions:This"patient- like"orthotopic model might be useful in the study of human stomach cancer.

目的 :建立与临床胃癌的生长过程和特点相似实验动物模型。  方法 :以 SGC- 790 1人胃癌细胞株裸鼠皮下移植瘤为材料 ,将瘤组织块种植到裸鼠胃壁 ,动态观察生长过程。  结果 :原位移植模型潜伏期 2~ 4周 ,第 4周以后原位肿瘤明显长出 ,第 12周以后出现肝转移 ,第 16周以后部分荷瘤鼠发生腹水 ,幽门梗阻 ,动物逐渐衰竭 ,出现恶病质等征象。  结论 :原位肿瘤模型与临床胃癌的生长过程和生物学特性非常相似 ,可作为胃癌实验研究的理想动物模型

AIM To establish an orthotopic model of human gastric carcinoma in the stomach wall of nude mice, and compare with its ectopic implantation counterpart in the subcutaneous tissues in oder to investigate whether the microenvironment of the host organ influenced the biological behavior such as invasion and metastasis of the carcinoma cells. METHODS The human gastric carcinoma cell line MGc 803 and its clonal line C11 were inoculated into the stomach wall and the subcutaneous tissues of nude mice respectively....

AIM To establish an orthotopic model of human gastric carcinoma in the stomach wall of nude mice, and compare with its ectopic implantation counterpart in the subcutaneous tissues in oder to investigate whether the microenvironment of the host organ influenced the biological behavior such as invasion and metastasis of the carcinoma cells. METHODS The human gastric carcinoma cell line MGc 803 and its clonal line C11 were inoculated into the stomach wall and the subcutaneous tissues of nude mice respectively. The tumor formation rate, the growth rate, the mode of growth, the invasion and metastatic behavior of the orthotopic and ectopic xenografts were investigated and compared. The specimens from the xenografts was cultured in vitro , and the cell proliferation ability was determined. RESULTS No significant differences were found between the orthotopic and ectopic xenografts in vitro and their cultured cells in vitro with respect to tumor formation rate, growth rate, morphologic characteristics, and the proliferation ability. However, tumor grew in subcutaneous tissue in lungs and few local lymph nodes. In contrast, tumors in the stomach wall invaded and destroyed the normal structure of the stomach wall, also infiltrated to the nearby organs. They metastasized to different organs, the lungs, the liver, spleen, and kidney. The lymph node (local and distant) metastasis incidence of the orthotopic xenografts was obviously frequent ( P <0 05) versus that of ectopic tumors, and the metastatic tumors could spread through the peritoneal and pelvic cavity. CONCLUSION The stomach wall of nude mice provided a more suitable microenvironment for the human gastric carcinoma MGc 803 and C11 xenografts to express their invasion and metastasis. The malignant biologic behavior of this orthotopic implantation model is similar to the metastasis of the gastric carcinoma in clinical patients.

目的建立人胃癌裸鼠胃壁原位移植瘤模型,并与相应的皮下移植瘤作比较,以探讨宿主器官微环境对胃癌细胞浸润及转移等生物学行为的影响.方法将人胃癌细胞系MGc803及其克隆株C11癌细胞分别接种于裸鼠胃壁及背部皮下,比较原位和皮下移植瘤的成瘤率、生长率、生长方式及浸润、转移等生物学行为,以及体外回复培养后瘤细胞的增殖能力.结果胃壁原位及皮下移植瘤体内成瘤率、生长率及形态学上均无明显不同;其体外增殖能力也无显著性差异.但皮下移植瘤多呈局限性生长,无肝、脾、肾转移,其转移仅限于肺及个别局部淋巴结.胃壁原位移植瘤则浸润破坏胃壁各层组织结构,并直接蔓延到邻近各器官组织.其转移既有经血道至肝、肺、脾、肾等部位,也有经淋巴道至多数局部及远处淋巴结,其淋巴结的转移率较皮下移植瘤有显著增高(P<005);且多伴有腹、盆腔内广泛种植性转移.结论裸鼠胃壁微环境较皮下组织更适合于人胃癌MGc803及C11移植瘤的浸润及转移的表达,该原位移植瘤模型的恶性生物学行为更接近临床胃癌患者的体内侵袭及转移的实际.

Objective: To establish the orthotopic transplantation tumor model from the subcutaneous model of human hepatocellular carcinomas (HCC) in nude mice. Methods: Fresh specimens of HCC were transplanted to form subcutaneous transplantation tumor in nude mice using histologically intact tissue. Then the orthotopic transplantation tumor model was established by injecting the subcutaneous transplanted tumor into liver (indirect orthotopic model). It was compared with the direct orthotopic model, subcutaneous...

Objective: To establish the orthotopic transplantation tumor model from the subcutaneous model of human hepatocellular carcinomas (HCC) in nude mice. Methods: Fresh specimens of HCC were transplanted to form subcutaneous transplantation tumor in nude mice using histologically intact tissue. Then the orthotopic transplantation tumor model was established by injecting the subcutaneous transplanted tumor into liver (indirect orthotopic model). It was compared with the direct orthotopic model, subcutaneous model and peritoneal cavity model for HCC in nude mice. Results: The indirect orthotopic model propagated stably. The survival rates and spontaneous metastatic rates of the transplantation tumor were 100% and 57.8%, respectively. The model had higher survival rates (100%) than direct orthotopic model (35.6%, P <0.01). It also had higher local invasion rates (100%) and spontaneous metastatic rates (57.8%) than the subcutaneous model (14.5%, P <0.01; 37.1%, P <0.05) and the peritoneal cavity model (18.0%, P <0.01; 39.3%, P <0.05). Conclusion:The model is an ideal instrument for study of the metastatic mechanism and screen of anti metastatic drugs.

目的 :建立人肝癌裸鼠皮下 -肝原位移植瘤模型。方法 :先用组织学完整的新鲜人肝癌组织接种于裸鼠皮下 ,形成皮下移植瘤 ,然后用此移植瘤组织再接种于裸鼠肝内 ,建立肝原位移植瘤模型 (间接肝原位移植瘤模型 ) ,并将其与直接肝原位移植瘤模型、皮下移植瘤模型和腹腔内移植瘤模型作比较。 结果 :建立的间接肝原位移植瘤模型能稳定传代 ,移植瘤存活率达 10 0 % ,自发转移率达 5 7.8%。与直接肝原位移植瘤模型比较 ,该模型移植瘤存活率明显高于后者 (35 .6 % ,P<0 .0 1) ;与皮下移植瘤模型和腹腔内移植瘤模型比较 ,该模型局部侵袭率 (10 0 % )和自发远处转移率 (5 7.8% )明显高于皮下移植瘤模型 (14.5 % ,P<0 .0 1;37.1% ,P<0 .0 5 )和腹腔内移植瘤模型 (18.0 % ,P<0 .0 1;39.3% ,P<0 .0 5 )。 结论 :人肝癌裸鼠皮下 -肝原位移植瘤模型具有高存活率、高侵袭率和高转移率的优点 ,它的建立为研究人类肝癌的转移机制和筛选抗癌药物提供了理想的工具

 
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