An UV method for determination of dissolution of loxoprofen sodium tablets was established according to ChP dissolution methodⅡ. The pharmacokinetics of loxoprofen sodium tablets in human was determined by HPLC.
Clinical observation: The 60 Rheumatoid arthritis patients that belongs to the damp-heat type divided into 2 groups randomly as follows: Experimental group(Re Bi Granule p.o 2g t.i.d ), comparative group(Loxoprofen Sodium Tablets, p.o 60mg t.i.d ).
METHODSAll 80 patients from the HuBei Provincial TCM Hospital conforming to the diagnostic standard, were randomly divided into two groups: therapeutic group of TongBi 2 (GroupA, n=40) and comparative group of Loxoprofen Sodium Tablets(GroupB, n=40), with MTX for both groups as basic treatment.
Objective: To establish an UV spectrophotometry method to determine the contents of loxoprofen sodium tablets. Methods: The water was used as solvent. The detection wavelength was set at 223nm. Results: The calibration curve was linear in the range from 4.016 to 16.064μg/mL, r=0.9997. The average recovery was 98.81% and the RSD was 1.29%(n=5). Conclusion: The method is accurate, rapid and simple for the quality control of loxoprofen sodium tablets.
An UV method for determination of dissolution of loxoprofen sodium tablets was established according to ChP dissolution methodⅡ.The pharmacokinetics of loxoprofen sodium tablets in human was determined by HPLC.The results showed that the relationship between dissolution in vitro and absorption in vivo was correlated,indicating the method for the dissolution test of loxoprofen sodium tablets was feasible.