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ovariectomized mice
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  去卵巢小鼠
     Objective To investigate the effects of different concentrations of estradiol on estrogen receptor expression and T-helper 1/ T-helper 2(Th1/Th2)balance of splenocytes of ovariectomized mice.
     目的研究不同浓度雌二醇(E_2)对去卵巢小鼠脾细胞雌激素受体(ER)及辅助性T细胞1(Th1)和辅助性T细胞2(Th2)之间平衡的影响。
短句来源
     The data were statistically analyzed with SPSS 12.0 software. Results The data showed that BMD of ovariectomized mice(0.151±0.008)g/cm~(2)was significantly lower than that of aged mice(0.160±0.007)g/cm~(2),P<0.01.The BMD in both groups was lower than that in normal adult mice(P<0.01).
     结果去卵巢小鼠的骨密度显著低于增龄小鼠〔分别为(0.151±0.008)和(0.160±0.007)g/cm2,P<0.01〕,两组骨密度值均较成年鼠低(P<0.01);
短句来源
     Conclusions Different levels of cstradiol have different effects on ERα,ERβgene expressions in splenocytes of ovariectomized mice:ERs expressions are up-regulated at physiological dose of estrogen and down-regulated at higher doses.
     结论不同浓度E_2对去卵巢小鼠脾细胞ERα、ERβ基因表达起不同的调节作用:在生理范围内为正向调节,超生理范围为负向调节。
短句来源
     The results showed: (1) the number of C cells in ovarietomized mice with no treatment increased dramatically as compared with the normal control group,while in ovariectomized mice treated with EB, HPC or EB+HPC it was similar to that of the normal control group;
     结果显示 :(1)去卵巢小鼠与正常对照组相比 ,甲状腺 C细胞数目剧增 ,给予 EB、HPC、EB+HPC治疗的各组小鼠甲状腺C细胞数目与正常对照组水平相近。
短句来源
     Effect of diethylstilbestrol on the ability of learning and memory of ovariectomized mice
     己烯雌酚对去卵巢小鼠学习记忆能力的改善作用
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  去势小鼠
     Results The effects of ZG administered by clyster or by oral perfusion, Diethylstilbestrol and Nüjindan were similar. They all increased cornification index(CI) of vaginal cell(P<0.01), uterus index(P<0.01), E2 level in blood(P<0.05) and the thickness of endometrium(P<0.05) in the ovariectomized mice.
     结果资冲颗粒灌肠组、资冲颗粒灌胃组、己烯雌酚组、女金丹组作用相似,均可增加去势小鼠阴道细胞角化指数(P<0.01)、子宫指数(P<0.01),提高小鼠血清E2水平(P<0.05),增加小鼠子宫内膜厚度(P<0.05)。
短句来源
     Methods:The ovariectomized mice were injected intraperitoneally with E_2, P and E_2+P respectively. The expressions of leukemia inhibitory factor (LIF), E-selectin and intercellular adhesion molecule-1 (ICAM-1) in endometria of mice were detected with RT-PCR.
     方法 应用去势小鼠模型 ,分别给予雌激素(E)、孕激素 (P)、雌激素 +孕激素 (E +P)腹腔注射 ,对照组 (C)注射助溶剂植物油 ,通过逆转录聚合酶链反应 (RT PCR)方法观察细胞间粘附分子 1(ICAM 1)、白血病抑制因子 (LIF)、E 选择素mRNA的变化。
短句来源
     The regulation of estradiol and progesterone on leukocyte and lymphocyte of peripheral blood in ovariectomized mice
     雌二醇和孕酮对去势小鼠外周血白细胞和淋巴细胞的调节
短句来源
     Objective: To investigate the regulation of estradiol and progesterone on leukocyte and lymphocyte of peripheral blood in ovariectomized mice.
     目的:探讨雌二醇、孕酮对去势小鼠外周血白细胞和淋巴细胞的调节。
短句来源
     Effect of Zichong Granules on estradiol level in ovariectomized mice administered by clyster and oral perfusion
     资冲颗粒灌肠和灌胃对去势小鼠雌激素水平的影响
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  卵巢切除小鼠
     Effect of 17β-estradiol on the expression of brain-derived neurotrophic factor and neurotrophin-3 in the hippocampus of ovariectomized mice
     17β-雌二醇对卵巢切除小鼠海马内脑源性神经营养因子及神经营养因子 3表达的影响(英文)
短句来源
     The distribution of estrogen receptors(ER) in the brain of ovariectomized mice was further examined by immunoflurescence method, in order to detect the possible role of ER in postmenopausal women.
     为检测雌激素受体在绝经后妇女可能的作用 ,采用免疫荧光法检测卵巢切除小鼠脑内雌激素受体 (ER)的分布。
短句来源
     Histologic Observation of the Effects of Exogenous Estrogen on Fracture Healing of Ovariectomized Mice
     外源性雌激素对卵巢切除小鼠骨折愈合影响的组织学观察
短句来源
     AN EXPERIMENTAL STUTY ON THE INFLUENCE OF ESTRIN ON FRACTURE HEALING OF OVARIECTOMIZED MICE
     雌激素对卵巢切除小鼠骨折愈合影响的实验研究
短句来源
     From the results it was found that little callus was formed in the mice not treated by estrin after ovariectomy, while the callus development was significantly delayed in the mice treated by a high dose of estrin, suggesting that the supplement of an ultra physiological dose of estrin was harmful to the early fracture healing in ovariectomized mice.
     结果发现卵巢切除后未用雌激素治疗者骨痂形成较小 ,而应用高剂量雌激素治疗者骨痂发育明显推迟 ,表明补充超生理剂量雌激素对卵巢切除小鼠骨折愈合 (早期 )不利。
短句来源
  “ovariectomized mice”译为未确定词的双语例句
     Stimulation of Brain Tubulin Synthesis by Estrogen in Ovariectomized Mice and Intact Female Mice
     Stimulation of Brain Tubulin Synthesis by Estrogen in Ovariectomized Mice and Intact Female Mice
短句来源
     In ovariectomized mice,the Th1/Th2 balance is destroyed,which suggests a Th1 polarization.
     小鼠去卵巢后影响脾细胞Th1和Th2的平衡,表现为Th1漂移。
短句来源
     Results: The CFU-GM and CFU-F from ovariectomized mice were obviously higher than those of the control group(P < 0.01);
     结果:实验组小鼠的CFU-GM、CFU-F均高于对照组小鼠(均P<0.01);
短句来源
     Effects of RGD-peptide(224) on bone metabolism and mechanical strength in ovariectomized mice
     RGD多肽(224)对卵巢切除小鼠骨代谢和骨生物力学的影响
短句来源
     Conclusion Significant changes in serum OPG and expression of OPG in bone occur in aged and ovariectomized mice.
     结论增龄以及去卵巢状态下.小鼠血清中OPG以及骨中OPG mRNA表达水平均有明显变化。
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  ovariectomized mice
In ovariectomized mice supplemented with estradiol but lacking measurable progesterone, PR-B-expressing tumors grow to twice the size of PR-A-expressing ones.
      
Higher levels of PR were observed in proestrous, estrous, and metestrous (p >amp;lt; 0.05) than in diestrous, and undetectable levels were found in ovariectomized mice.
      
Action of epidermal chalone on 17-β-estradiol-stimulated proliferation of vaginal epithelial cells of ovariectomized mice
      
Proliferative pool in the epithelium of reproductive organs of ovariectomized mice and mice receiving progesterone
      
The author studied the effect of ovarian hormones (folliculin and progesterone) on the mitotic activity of the terminal portions of the mammary glands in ovariectomized mice.
      
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The extract of Lu-jung(growing horns from Cervus xanthopygus,Milne-Edwards)given to castrated rats or mice could not promote the growth of their prostates and seminal vesicles.It showed no estrogenic activity in ovariectomized mice.While tested on gonadotropic activity,it could neither induce the formation of blood spots in ovaries of non-pregnant rabbits,nor cause toads to release spermatozoa into their urine.

1.马鹿鹿茸的浸液经去睾丸大白鼠和小白鼠前列腺精囊称重法和去卵巢小白鼠阴道涂片法试验,证明并无雄性素或雌性素样作用.2.马鹿鹿茸的浸液并不能使未孕家兔的卵巢出现血斑,也不能促使雄蟾蜍排精,因此亦不具有向性腺激素样作用.

In order to study the structure-activity relationships of oestradiol derivatives, the duration of oestrogenic activity after a single administration was tested in ovariectomized mice.Results showed that the duration of oral oestrogenic activity of quinestrol, a 3-cyclopentyl ether derivative of ethynyl oestradiol was significantly longer than that of its parent compound However, 3-etherification with other groups (such as CH_(3-), (CH_3)_2 CH_(2-), HC≡C-CH_(2-), H_2C≡CHCH_(2-), CH_3OCH_2CH_(2-)) didn't...

In order to study the structure-activity relationships of oestradiol derivatives, the duration of oestrogenic activity after a single administration was tested in ovariectomized mice.Results showed that the duration of oral oestrogenic activity of quinestrol, a 3-cyclopentyl ether derivative of ethynyl oestradiol was significantly longer than that of its parent compound However, 3-etherification with other groups (such as CH_(3-), (CH_3)_2 CH_(2-), HC≡C-CH_(2-), H_2C≡CHCH_(2-), CH_3OCH_2CH_(2-)) didn't prolong the oral activity of oestradiol and ethynyl oestradiol.The structural alterations at the G-17α position could significantly influence the oral oestrogenic activity. And if a cyclopentyl group was substituted for the ethynyl group of quinestrol to get the compound ⅩⅩⅨ, a more prolonged oestrogenic activity was observed.Although the ester derivatives of oestrodiol possessed a longlasting action after a single subcutaneous injection, such an action didn't appear on oral administration. The fact that the duration of oestrogenic activity of sublingual administration was longer than that of the oral route could be possibly explained by the lack of destruction in the gastrointestinal tract and liver. But the sublingual action was much shorter than that of subcutaneous administration.The duration of oestrogenic activity of 17β-esters of quinestrol was not different from that of its parent compound. However, 17 β-etherification could decrease the oestrogenic activity to varying degrees.

以去卵巢小鼠的雌激素作用维持时间为指标,探讨一系列雌二醇衍化物的构效关系。 结果表明,乙炔雌二醇的3-环戊醚衍化物(炔雌醚)的口服雌激素作用时间,显著较其母体化合物为长。但在雌二醇和乙炔雌二醇的3位碳上,以其它基团(如甲基、异丙基、丙炔基、丙烯基和乙基甲醚等)进行醚化,则均不能显著延长口服雌激素作用时间。 17α位的结构变化可明显影响雌激素的口服活性。炔雌醚17α位的乙炔基换成环戊基后,即17环戊雌二醇-3-环戊醚(ⅩⅩⅨ),雌激素作用时间更长。 雌二醇的酯类衍化物皮下注射有明显长效雌激素作用,但口服则不能显著延长作用时间。口腔(舌下)给药可能因避开胃肠道的水解和肝脏破坏,其作用时间较口服(灌胃)给药显著延长,但远不及皮下注射。 炔雌醚的17β位以脂肪酸酯化后,其作用时间与其母体相近;但如在17β位醚化后,则作用就有不同程度的降低。

In the present study Radix Trichosanthis was shown to terminate pregnancy in mice following subcutaneous administration on the 4 th and 5 th days of pregnancy. The ED_(50) of Radix Trichosanthis to terminate early pregnancy in mice was 1.78±0.28 mg/kg. Megestrol acetate or HCG could decrease the effect of Radix Trichosanthis, However, 15-methyl-PGF_(2α) could potentiate the effect of Radix Trichosanthis.Subcutaneous injection of Radix Trichosanthis at doses capable of terminating early pregnancy significantly...

In the present study Radix Trichosanthis was shown to terminate pregnancy in mice following subcutaneous administration on the 4 th and 5 th days of pregnancy. The ED_(50) of Radix Trichosanthis to terminate early pregnancy in mice was 1.78±0.28 mg/kg. Megestrol acetate or HCG could decrease the effect of Radix Trichosanthis, However, 15-methyl-PGF_(2α) could potentiate the effect of Radix Trichosanthis.Subcutaneous injection of Radix Trichosanthis at doses capable of terminating early pregnancy significantly inhibited the decidual reaction in pseudopregnant mice. This inhibitory effect, as well as the effect to terminate early pregnancy, increased with increasing dose. In addition to its partial antagonism to the interruption of early pregnancy by Radix Trichosanthis megestrol acetate also antagonized markedly the inhibitory effect of Radix Trichosanthis on deciduoma. From these results, it may be concluded that the effect of Radix Trichosanthis to terminate early pregnancy may be related to its inhibitory effect on deciduoma.After an intramuscular injection of Radix Trichosanthis on the 7 th day of pregnancy in rats the peripheral plasma level of progesterone was unchanged Within 48 hr after administration but decreased at 72 hr. The vaginal cornification test of ovariectomized mice and uterine weight assay of mice showed that Radix Trichosanthis possessed neither estrogenic nor antiestrogenic activity. It was suggested that the inhibitory effect of Radix TrichosanthiS on deciduoma was not the result of luteolysis. The precise mechanism of the antidecidual effect of Radix Trichosanthis remains to be clarified further.

小鼠妊娠第4、5日皮下注射天花粉,其抗早孕ED_(50)为1.78±0.28 mg/kg。天花粉的抗早孕作用可被甲地孕酮和HCG所部分拮抗,而为15-甲-PGF_(2α)所增强。抗早孕剂量天花粉对假孕小鼠的蜕膜有明显抑制作用。其抗早孕作用及抑制蜕膜作用均随剂量增加而增强。外源性甲地孕酮可对抗其抗早孕作用和抑制蜕膜作用。提示天花粉的抗早孕作用与其抑制蜕膜反应有关。外源性甲地孕酮有对抗天花粉抑制蜕膜反应的作用,提示天花粉有可能通过对抗假孕小鼠体内黄体激素作用而发挥抑制蜕膜反应的作用。本文初步探讨了这种对抗作用。

 
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