rosiglitazone sodium 罗格列酮钠(18)   罗格列酮钠      To determine the content and its related substances of Rosiglitazone Sodium tablets by HPLC the Zorbax SB-C18 column(4.6 mm×250 mm, 5 μm)was used, 0.1 mol·L-1 sodium acetate solution (adjusted to pH 5.5 with acetate): methanol (30∶70) as the mobile phase, at a flow rate of 1 mL·min-1, at detection wavelength 245 nm.      建立高效液相色谱法测定罗格列酮钠片含量及有关物质。 该法采用ZorbaxSB-C18色谱柱(4.6mm×250mm,5μm),流动相为0.1mol/L乙酸钠溶液(用稀乙酸调节至pH5.5)-甲醇(30∶70),流速1mL·min-1,检测波长为245nm。 短句来源      Identification of Related Impurities in Rosiglitazone Sodium Substance by LC - MS/MS      LC-MS/MS联用技术分离鉴定罗格列酮钠原料药中有关物质 短句来源      Methods A 12-week randomized,rosiglitazone sodium 4 mg/d added to 47 type 2 diabetes patients with poor glycemic control by sulfonylureas and metformin.      方法对47例联合使用磺脲类、双胍类而血糖控制不好的患者每天早餐前加服4 mg罗格列酮钠,进行为期12周的临床观察。 短句来源      To determine the dissolution of Rosiglitazone Sodium Tablet, a UV-spectrophotometric method was used to study the dissolution with the detection wavelength at 234 nm.      采用紫外分光光度法测定罗格列酮钠片的溶出度。 检测波长234nm。 短句来源      Study on the Method for the Dissolution Test of Rosiglitazone Sodium Tablets      罗格列酮钠片溶出度测定方法的研究 短句来源 更多          “rosiglitazone sodium”译为未确定词的双语例句      Results A significant reduction was observed after 12 weeks by treatment with rosiglitazone sodium,in fasting plasma glucose(P<0.01),postprandial plasma glucose(P<0.01),plasma insulin(P<0.05),HbAlC(P<0.05) and HOMA-IR(P<0.05).      结果12周的HOMA-IR明显下降(P<0.05),空腹及餐后2小时血糖显著下降(P<0.01)、胰岛素水平显著下降(P<0.05),HbA lC显著下降(P<0.05)。 短句来源      The linearity of peak area was good when the injected quantity of Rosiglitazone sodium was in the range of (0.4～4.8) μg(r=0.999 9, n=7). The recovery of this method was 100.1%, the intra-day RSD and inter-day RSD were 0.56% and 0.63%(n=9) respectively.      在进样量(0.4～4.8)μg时,与峰面积呈良好线性,r=0.9999(n=7),平均回收率100.1%,日内和日间RSD分别为0.56%及0.63%(n=9)。 短句来源      Rosiglitazone sodium(5mg/kg.d-1)were applied each day among those animals of group C by intragastric administration.      结果(1)与B组相比,C组血清胰岛素水平逐渐上升,血糖水平逐渐下降。 短句来源   相似匹配句对      The Method for the Dissolution Test of Rosiglitazone Sodium Tablets      罗格列酮钠片溶出度的测定方法 短句来源      Chiral Separation of Rosiglitazone Sodium Using HPCE      毛细管电泳手性分离罗格列酮钠 短句来源      Sodium Nitroprusside      注射用硝普钠 短句来源      sodium citrate;      柠檬酸钠; 短句来源      Synthesis of Rosiglitazone      罗格列酮的合成 短句来源 查询“rosiglitazone sodium”译词为用户自定义的双语例句     我想查看译文中含有：的双语例句 为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法，我们为您准备了出自英文原文的大量英语例句，供您参考。          Objective: 2 - Hydroxypropyl - β- cyclodextrin ( HP -β- CD) was used as chiral separation reagent. By the optimization of the concentration of the HP - β- CD and the pH of buffer, the two kinds of enantiomers of rosiglitazone sodium were separated. At the same time, the effects of temperature on the separation have been studied. Methods: The buffer solution used in this method was 30 mmol· L-1 phosphate solution (containing 4% HP -bbbb - CD, pH 6. 5) , the detective wavelength was 248 nm. Result...             目的:以羟丙基-β-环糊精为手性分离剂,通过优化其浓度及缓冲液的pH来达到罗格列酮钠(外消旋体,具有2种异构体)的基线分离,并研究温度对分离的影响。方法:用30mmol·L~(-1)磷酸盐缓冲液(pH6.5,含4％羟丙基-β-环糊精)作为电泳液,检测波长248nm。结果:罗格列酮铀的2种异构体分离度为1.6,峰面积比值的精密度(RSD)为0.8％。结论:方法简单、精密度较高。可作为罗格列酮钠的手性分离方法。 文摘来源          HPCE methods for separating and determining the rosiglitazone sodium enantiomers were estabˉlished.The effects of buffer concentration,pH,and the type and concentrations of CDs in the chiral separaˉtion of rosiglitazone sodium were investigated.The buffer solution used in aqueous capillary electrophoresis(ACE)was150mmol/L Tris-H 3 PO 4 solution,pH=2.0,containing1mmol/Lβ-CD or DM-β-CD,and10%(φ)methanol.The voltage applied was25kV,and the detective wavelength was215nm.In addiˉtion,a si...             以环糊精及其衍生物为手性选择剂,通过优化缓冲液的浓度、酸度以及采用环糊精的种类和浓度等,建立了罗格列酮钠对映体的水介质和非水介质两种毛细管电泳拆分方法。最佳条件为:150 mmol/LTris-H3PO4缓冲液,pH=2.0,含有1 mmol/Lβ_CD或DM_β_CD,10%(φ)甲醇的运行液,分离电压为25 kV,检测波长215 nm。也可以使用含有9 mmol/L HDMS_β_CD,20 mmol/L磷酸和10 mmol/L NaOH的甲醇电泳液。两种拆分体系均实现了罗格列酮钠对映体的基线分离,而且拆分效率基本相当。方法简便、快速,可作为罗格列酮钠的手性分离方法。 文摘来源          To determine the dissolution of Rosiglitazone Sodium Tablet, a UV-spectrophotometric method was used to study the dissolution with the detection wavelength at 234 nm.The rotative velocity of 50r·min-1 and the 500 mL of water. The linear range of the standard curve was(4～20) μg·mL-1, r=0.999 9(n=7). The average recovery of this method was 99.95%(n=9), the within-day RSD and between-day RSD were 0.49% and 0.75% respectively. The drug dissolution rate for 20 min was over 95%. This method is conveni...             采用紫外分光光度法测定罗格列酮钠片的溶出度。检测波长234nm。转速50r·min-1,溶出介质为0.01mol/L盐酸500mL;罗格列酮钠在(4～20)μg·mL-1-范围内线性良好,r=0.9999(n=7),方法平均回收率99.95%(n=9),日内和日间RSD分别为0.49%及0.75%。20min定时取样测定,主药溶出95%以上。方法简便、准确,可有效地控制其质量。 文摘来源   << 更多相关文摘         相关查询: rosiglitazone sodium tablet rosiglitazone sodium tablets rosiglitazone sodium tablet a (sodium sodium rosiglitazone sodium triphosphate sodium valproic faropenem sodium sodium nitrate sodium monofluorophosphate loxoprofen sodium  对查询结果不满意

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