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cis retinoic acid     
相关语句
  顺维甲酸
     Objective:To study the anticancer mechanism of 9 cis retinoic acid(9 cis RA) and provide theoretical basis of clinical therapy of lung cancer.
     目的 :探讨 9 顺 维甲酸 ( 9 cis RA)的抗肿瘤机理 ,为临床治疗肺癌提供理论依据。
短句来源
     Objective To investigate the effect of 9 cis Retinoic Acid (9 cis RA) on cell cycle and differentiation in L 78 and A 2 Lung squamous carcinoma cell lines.
     目的 观察 9 顺维甲酸 (9 cis RA)对肺鳞癌细胞周期及分化作用的影响。
短句来源
     Objective To stud y effects of 9 cis retinoic acid(9 cis R A)on biological characteristics in lung squamous cancer cells.
     目的 探讨 9 顺维甲酸 ( 9 cis RA)对肺鳞癌细胞的生物学作用。
短句来源
     To study effects of 9 cis retinoic acid (9 cisRA) on biological characteristics of lung squamous cancer cells, cell growth, cell differentiation and apoptotic indexes were observed in 9 cisRA treated L 78 and A 2 lung squamous cancer cells with flow cytometry.
     为探讨 9 顺维甲酸(9 cisRA)对肺鳞癌细胞的生物学作用 ,应用流式细胞术等对 9 cisRA处理前后L78和A2 两肺鳞癌细胞株的生长、分化和凋亡等特性进行检测观察。 结果显示 ,9 cisRA对两肺癌细胞株的生长产生明显的抑制作用 ;
短句来源
  顺式维甲酸
     9 cis retinoic acid induces apoptosis in HL 60 cells
     9-顺式维甲酸诱导HL-60细胞凋亡
短句来源
     Objective To study the effects of vitamin D 3(VD 3), 9 cis retinoic acid (9 cis RA)and their receptors on the regulation of human hsp90β gene.
     目的 研究维生素 D3(VD3)、9-顺式维甲酸 (9- cis- RA)及其相应核受体对 hsp90 β基因表达的调控作用。
短句来源
     Secretion of VEGF by SW1990 cells, treated by 15 deoxy delta(12,14) prostaglandin J 2(15d PGJ 2), the ligand of PPAR γ and, 9 cis retinoic acid(9 cis RA) the ligand of retinoic X receptor(RXR)α, at different concentrations and durations, was detected by semi quantitative RT PCR.
     方法 体外培养胰腺癌细胞株SW 1990 ,给予PPAR γ配体 15 脱氧 前列腺素J2 (15d PGJ2 )及维甲类受体 (RXR)α配体 9 顺式 维甲酸 (9 cis RA) ,经不同浓度及不同时间作用后 ,用RT PCR方法检测其对SW 1990细胞VEGF表达的调节作用。
短句来源
     Objective:To investigate the apoptosis of HL 60 cells induced by 9 cis retinoic acid (9 cis RA),and illustrate the possible molecular mechanism.
     目的:检测9-顺式维甲酸(9-cisRA)诱导HL-60细胞凋亡的能力,并探讨其分子机制。
短句来源
     Objective: To investigate the effect of alltrans retinoic acid (ATRA) and 9cis retinoic acid (9cis RA) on the expression of Fas and the sensitivity to antiFas induced apotosis in HL-60 cells.
     目的:探讨全反式维甲酸(ATRA)和9顺式维甲酸(9cisRA)对HL60细胞Fas表达水平及维甲酸对抗Fas抗体诱导的细胞凋亡敏感性的影响。
短句来源
更多       
  9顺维甲酸
     Objective:To study the anticancer mechanism of 9 cis retinoic acid(9 cis RA) and provide theoretical basis of clinical therapy of lung cancer.
     目的 :探讨 9 顺 维甲酸 ( 9 cis RA)的抗肿瘤机理 ,为临床治疗肺癌提供理论依据。
短句来源
     Objective To investigate the effect of 9 cis Retinoic Acid (9 cis RA) on cell cycle and differentiation in L 78 and A 2 Lung squamous carcinoma cell lines.
     目的 观察 9 顺维甲酸 (9 cis RA)对肺鳞癌细胞周期及分化作用的影响。
短句来源
     Objective To stud y effects of 9 cis retinoic acid(9 cis R A)on biological characteristics in lung squamous cancer cells.
     目的 探讨 9 顺维甲酸 ( 9 cis RA)对肺鳞癌细胞的生物学作用。
短句来源
     To study effects of 9 cis retinoic acid (9 cisRA) on biological characteristics of lung squamous cancer cells, cell growth, cell differentiation and apoptotic indexes were observed in 9 cisRA treated L 78 and A 2 lung squamous cancer cells with flow cytometry.
     为探讨 9 顺维甲酸(9 cisRA)对肺鳞癌细胞的生物学作用 ,应用流式细胞术等对 9 cisRA处理前后L78和A2 两肺鳞癌细胞株的生长、分化和凋亡等特性进行检测观察。 结果显示 ,9 cisRA对两肺癌细胞株的生长产生明显的抑制作用 ;
短句来源
  “cis retinoic acid”译为未确定词的双语例句
     Either all trans retinoic acid (ATRA) or 9 cis retinoic acid (9cRA) potentiated As 2O 3 induced apoptosis, as measured by quantitative TdT fragment end labeling and flow cytometry assays in both HL-60S and HL-60R cells ( P< 0.05, for all RA+As 2O 3 combinations vs As 2O 3 alone in both sublines);
     结果 :As2 O3 (0 .5~ 4μmol·L 1)抑制HL 6 0R细胞生长 ,抑制能力与As2 O3 浓度及作用时间呈正相关 ;
短句来源
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  cis retinoic acid
The impact of pretransplant cytoreductive treatment, such as intensive chemotherapy, splenectomy, or 13-cis retinoic acid, is unclear.
      
However, 13-cis retinoic acid (RA) and SAHA, a histone deacetylase inhibitor, have each been shown to induce apoptosis in medulloblastoma cultures and mouse models.
      
Response of preclinical medulloblastoma models to combination therapy with 13-cis retinoic acid and suberoylanilide hydroxamic a
      
According to in vitro and in vivo clinical studies, 13-cis retinoic acid (cRA) may be a promising agent for maintenance therapy in these patients.
      
In view of these results, 9-cis retinoic acid or stable analogues of this retinoid may have potential for the treatment of neuroblastoma.
      
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The effect of inhibition of proliferation of a novel human megakaryoblastic leukemia cell line (HIMeg) by two physiological factors, 1.25-dihydroxyvitamin D3 [1,25(OH)2 D3] and 13-cis-retinoic acid (RA), was investigated. At the range of 10-9 - 10-6 mol/L, 1,25(OH)2 D3 and RA showed significant inhibition of proliferation of the megakaryoblastic leukemia cells,which was demonstrated by count of survival cells,incorporation of [3H]-TdR and [3H]-UR, and cloning efficiency. From above, it can...

The effect of inhibition of proliferation of a novel human megakaryoblastic leukemia cell line (HIMeg) by two physiological factors, 1.25-dihydroxyvitamin D3 [1,25(OH)2 D3] and 13-cis-retinoic acid (RA), was investigated. At the range of 10-9 - 10-6 mol/L, 1,25(OH)2 D3 and RA showed significant inhibition of proliferation of the megakaryoblastic leukemia cells,which was demonstrated by count of survival cells,incorporation of [3H]-TdR and [3H]-UR, and cloning efficiency. From above, it can further explain the m.echanism of differentiation-inducers and the effect of 1,25(OH)2D3 on myelofibrosis. It is possible for 1,25(OH)2D3 and RA to be used for a new -treatment.

本文报道了两种生理性诱导剂——活性维生素D_3[1,25(OH)_2D_3,简称D_3]和维甲酸(RA)对原始巨核白血病细胞的增殖抑制作用。采用活细胞计数、[~3H]-TdR和[~3H]-UR参入以及克隆形成率测定3项指标,对一株新建的人原始巨核白血病细胞系(HIMeg)进行实验,结果表明:10~(-9)~10~(-6)mol/LD_3和RA对巨核白血病细胞的生长抑制作用呈明显量效与时效关系,10~(-7) mol/L D_3可使其克隆形成率减少90%以上。从而进一步说明了诱导分化剂对白血病及D_3对骨髓纤维化的治疗机制,提示D_3和RA可能有新的治疗用途。

The action of 13-cis-retinoic acid(RA)in combination with 1,25-dihydroxyvitaminD_3(D_3)on two kinds of leukemia cell lines in vitro is reported.At the concentrationof 10~(-7) mol/L,RA and D_3 could inhibit the cell proliferation and they have additiveeffect on the human promyelocytic leukemia cell line(HL-60),and also have synergiceffect on the human megakaryoblastic leukemia cell line(HIMeg)in inducing celldifferentiation.The results suggest that RA in combination with D_3 may be used forthe...

The action of 13-cis-retinoic acid(RA)in combination with 1,25-dihydroxyvitaminD_3(D_3)on two kinds of leukemia cell lines in vitro is reported.At the concentrationof 10~(-7) mol/L,RA and D_3 could inhibit the cell proliferation and they have additiveeffect on the human promyelocytic leukemia cell line(HL-60),and also have synergiceffect on the human megakaryoblastic leukemia cell line(HIMeg)in inducing celldifferentiation.The results suggest that RA in combination with D_3 may be used forthe treatment of acute megakaryoblastic leukemia and acute promyelocytic leukemia.It ispresumed that they had additive or synergic action in the differentiation of hemopoieticcells in vivo.

本文报道了13-顺式维甲酸(RA)和[1,25-二羟维生素 D_3 1,25(OH)_2D_3]合用对两种白血病细胞系的体外实验结果。在10~(-7)mol/L 浓度下,应用 ~3H-TdR 掺入、NBT 还原试验、流式细胞分析等技术,测得:RA 和1,25(OH)_2D_3合用后可进一步抑制细胞的增殖;在诱导分化作用方面,二者对人原始巨核白血病细胞株(HIMeg)有相加作用,而对人早幼粒细胞白血病细胞系(HL-60)则有一定协同作用。上述结果提示可将 RA 联合1,25(OH)_2D_3试用于治疗白血病;推测二者在体内巨核系和粒单系造血细胞分化中发挥着相加或协同的促进效应。

Changes of cell cycle kinetics of HL-60 cell line after ALL-trans retinoic acid(ATRA)and 9-cis retinoic acid(9-cis RA)induction were studied with BrdU/DNA bivariated flow cytometry. HL-60 cells were exposed to ATRA or 9-cis RA for 96 h. During the exposure, the RA-treated cells were obtained at 24,48,72 and 96 h and then the cell cycle kinetics was meas ured with BrdU/DNA bivariated flow cytometry.Data from 4 parameters of cell cycle showed that treatment with ATRA or 9-cis RA for 96...

Changes of cell cycle kinetics of HL-60 cell line after ALL-trans retinoic acid(ATRA)and 9-cis retinoic acid(9-cis RA)induction were studied with BrdU/DNA bivariated flow cytometry. HL-60 cells were exposed to ATRA or 9-cis RA for 96 h. During the exposure, the RA-treated cells were obtained at 24,48,72 and 96 h and then the cell cycle kinetics was meas ured with BrdU/DNA bivariated flow cytometry.Data from 4 parameters of cell cycle showed that treatment with ATRA or 9-cis RA for 96 h resulted in a decrease in the cell BrdU LI,production rate and an increase in Ts and Tpot. Mean while the ability of the cell to reduce NBT was enhanced by RA induction, and the percentage of matured cells was increased by cell morphology assessment.These results suggested that both ATRA and 9-cis-RA may induce HL-60 cell differentiation.

用Brdu/DNA双参数流式细胞仪技术研究了HL-60细胞经全反式维甲酸(ATRA)和9-顺式维甲酸(9-cisRA)诱导24,48和96h后,细胞周期动力学各参数,BrdULI,Ts,Tpot和PR的变化,同时测定细胞NBT还原试验和细胞形态学的变化,发现随着维甲酸诱导时间的延长,BrdULI逐渐降低,PR亦是逐渐减少,而Ts和Tpot则逐渐延长。NBT还原试验结果表明NBT阳性细胞百分比呈现上升趋势:细胞形态学观察显示稍成熟阶段细胞百分比上升,早幼粒阶段细胞所占百分比下降。本文观察了ATRA和9-cisRA在诱导HL-60细胞过程中以上各参数的变化,结果提示两类维甲酸对HL-60细胞均有诱导分化功能。

 
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