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cis retinoic acid
相关语句
  顺维甲酸
    Objective:To study the anticancer mechanism of 9 cis retinoic acid(9 cis RA) and provide theoretical basis of clinical therapy of lung cancer.
    目的 :探讨 9 顺 维甲酸 ( 9 cis RA)的抗肿瘤机理 ,为临床治疗肺癌提供理论依据。
短句来源
    Objective To investigate the effect of 9 cis Retinoic Acid (9 cis RA) on cell cycle and differentiation in L 78 and A 2 Lung squamous carcinoma cell lines.
    目的 观察 9 顺维甲酸 (9 cis RA)对肺鳞癌细胞周期及分化作用的影响。
短句来源
    Objective To stud y effects of 9 cis retinoic acid(9 cis R A)on biological characteristics in lung squamous cancer cells.
    目的 探讨 9 顺维甲酸 ( 9 cis RA)对肺鳞癌细胞的生物学作用。
短句来源
    To study effects of 9 cis retinoic acid (9 cisRA) on biological characteristics of lung squamous cancer cells, cell growth, cell differentiation and apoptotic indexes were observed in 9 cisRA treated L 78 and A 2 lung squamous cancer cells with flow cytometry.
    为探讨 9 顺维甲酸(9 cisRA)对肺鳞癌细胞的生物学作用 ,应用流式细胞术等对 9 cisRA处理前后L78和A2 两肺鳞癌细胞株的生长、分化和凋亡等特性进行检测观察。 结果显示 ,9 cisRA对两肺癌细胞株的生长产生明显的抑制作用 ;
短句来源
  9顺维甲酸
    Objective:To study the anticancer mechanism of 9 cis retinoic acid(9 cis RA) and provide theoretical basis of clinical therapy of lung cancer.
    目的 :探讨 9 顺 维甲酸 ( 9 cis RA)的抗肿瘤机理 ,为临床治疗肺癌提供理论依据。
短句来源
    Objective To investigate the effect of 9 cis Retinoic Acid (9 cis RA) on cell cycle and differentiation in L 78 and A 2 Lung squamous carcinoma cell lines.
    目的 观察 9 顺维甲酸 (9 cis RA)对肺鳞癌细胞周期及分化作用的影响。
短句来源
    Objective To stud y effects of 9 cis retinoic acid(9 cis R A)on biological characteristics in lung squamous cancer cells.
    目的 探讨 9 顺维甲酸 ( 9 cis RA)对肺鳞癌细胞的生物学作用。
短句来源
    To study effects of 9 cis retinoic acid (9 cisRA) on biological characteristics of lung squamous cancer cells, cell growth, cell differentiation and apoptotic indexes were observed in 9 cisRA treated L 78 and A 2 lung squamous cancer cells with flow cytometry.
    为探讨 9 顺维甲酸(9 cisRA)对肺鳞癌细胞的生物学作用 ,应用流式细胞术等对 9 cisRA处理前后L78和A2 两肺鳞癌细胞株的生长、分化和凋亡等特性进行检测观察。 结果显示 ,9 cisRA对两肺癌细胞株的生长产生明显的抑制作用 ;
短句来源
  “cis retinoic acid”译为未确定词的双语例句
    Either all trans retinoic acid (ATRA) or 9 cis retinoic acid (9cRA) potentiated As 2O 3 induced apoptosis, as measured by quantitative TdT fragment end labeling and flow cytometry assays in both HL-60S and HL-60R cells ( P< 0.05, for all RA+As 2O 3 combinations vs As 2O 3 alone in both sublines);
    结果 :As2 O3 (0 .5~ 4μmol·L 1)抑制HL 6 0R细胞生长 ,抑制能力与As2 O3 浓度及作用时间呈正相关 ;
短句来源
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  cis retinoic acid
The impact of pretransplant cytoreductive treatment, such as intensive chemotherapy, splenectomy, or 13-cis retinoic acid, is unclear.
      
However, 13-cis retinoic acid (RA) and SAHA, a histone deacetylase inhibitor, have each been shown to induce apoptosis in medulloblastoma cultures and mouse models.
      
Response of preclinical medulloblastoma models to combination therapy with 13-cis retinoic acid and suberoylanilide hydroxamic a
      
According to in vitro and in vivo clinical studies, 13-cis retinoic acid (cRA) may be a promising agent for maintenance therapy in these patients.
      
In view of these results, 9-cis retinoic acid or stable analogues of this retinoid may have potential for the treatment of neuroblastoma.
      
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All trans retinoic acid(ATRA), 13-cis retinoic acid (CRA) and vitamin A (Vit A)were investigated in the plasma, leukocytes and erythrocytes from leukemia patients and healthy individuals by reverse phase high pressure liquid chromatography(HPLC). The following results were obtained. The ATRA, CRA and Vit A levels of plasma and erythrocytes from leukemia patients were within the range of control value, while ATRA(0.075±0.045 ng/106 cells) and CRA (0.13 ± 0.096 ng/106 cells) contents in leukemic cells were...

All trans retinoic acid(ATRA), 13-cis retinoic acid (CRA) and vitamin A (Vit A)were investigated in the plasma, leukocytes and erythrocytes from leukemia patients and healthy individuals by reverse phase high pressure liquid chromatography(HPLC). The following results were obtained. The ATRA, CRA and Vit A levels of plasma and erythrocytes from leukemia patients were within the range of control value, while ATRA(0.075±0.045 ng/106 cells) and CRA (0.13 ± 0.096 ng/106 cells) contents in leukemic cells were reduced when compared to control (ATRA 0.16 ± 0.06 ng/106 cells)(P < 0.05). These data suggested that there is probably abnormal retinoic acid metabolism in leukocytes from leukemic patients, and this abnormality may be responsible for the leukemogenesis.

应用反相高压液相色谱(HPLC)技术,检测了正常人和白血病病人血浆、白细胞及红细胞内生理性全反式维甲酸(ATRA)、13-顺式维甲酸(13-cis-RA,CRA)和维生素A(VitA)的含量。结果表明,急性早幼粒白血病患者及其它白血病患者血浆及红细胞中内源性ATRA、CRA和VitA均在正常范围内。白血病患者白细胞内ATRA(0.08±0.05ng/106细胞,单位下同)、CRA(0.13±0.10)水平均低于正常人(ATRA0.16±0.06,CRA0.33±0.16)(P<0.05)。提示白血病患者的白细胞内维甲酸代谢可能存在异常,并可能与白血病的发病有关。

Objective: In a human leukemic megakaryocytic cell line HIMeg, differentially expressed genes regulated by induced differentiation will be cloned, and from which the key genes in the process of induced differentiation will be identified. Methods: The human megakaryocytic leukemia cell line HIMeg was treated with 13 cis retinoic acid for 4 d, then total cellular RNA was extracted and reverse transcribed to first strand cDNA. The first strand cDNA was subjected to PCR based mRNA differential...

Objective: In a human leukemic megakaryocytic cell line HIMeg, differentially expressed genes regulated by induced differentiation will be cloned, and from which the key genes in the process of induced differentiation will be identified. Methods: The human megakaryocytic leukemia cell line HIMeg was treated with 13 cis retinoic acid for 4 d, then total cellular RNA was extracted and reverse transcribed to first strand cDNA. The first strand cDNA was subjected to PCR based mRNA differential display, cloning and sequence analysis. Results: From 5 cDNA fragment candidates obtained, RNA dot blot analysis demonstrated non regulation in 3 fragments, undetectable signals in one fragment, and altered gene expression in one cDNA fragment which was designated MDI 1 (mRNA downregulated after induced differentiation).The nucleotide sequence data reported here will appear in the GenBank under the accession number AF026526. Conclusion: A cDNA fragment encoded by a unknown gene was cloned. Further studies are required to determine its full length sequence, gene structure and biological function(s).

目的:克隆巨核白血病细胞诱导分化后表达变化的mRNA,从中寻找对诱导分化起关键作用的基因,最终揭示巨核白血病细胞诱导分化的分子机制。方法:人巨核白血病细胞HIMeg经13-顺式维甲酸处理4d后,收集细胞总RNA,进行mRNA差别显示、cDNA片段克隆和序列分析。结果:获得5个差示cDNA片段,经RNA点杂交分析后发现其中3个为假阳性,1个因没有杂交信号而无法确定,只有1个cDNA片段得到证实,其对应的mRNA在诱导分化后表达下降。该cDNA片段的核苷酸序列已在GenBank中登录,登录号为AF026526。结论:克隆到一个未知基因的cDNA片段,其全长cDNA序列、基因结构及生物功能有待进一步研究

In this paper,the effects of all-trans retinoic and 9-cis retinoic acid on the proliferation and apoptosis of HL-60 cell line were investigated.The expressions of Homeobox gene HOX A1 in human myeloid leukemia cell line HL-60 were determined by using semi-quantitative reverse transcription (RT-PCR) method.The results indicated that both all-trans retinoic acid and 9-cis retinoic acid showed an ability to suppress the proliferation of the HL-60 cells,and could promote apoptosis of the...

In this paper,the effects of all-trans retinoic and 9-cis retinoic acid on the proliferation and apoptosis of HL-60 cell line were investigated.The expressions of Homeobox gene HOX A1 in human myeloid leukemia cell line HL-60 were determined by using semi-quantitative reverse transcription (RT-PCR) method.The results indicated that both all-trans retinoic acid and 9-cis retinoic acid showed an ability to suppress the proliferation of the HL-60 cells,and could promote apoptosis of the cell line specifically,when combinative treatment of the two drugs were used,their efficacy was more obviously than used alone. On the basis of the data,we consider that one of mechanisms for the anti-cancer synergism of the two compounds might be influence on the network regulation system of HOXA1 gene expression,and the extent of the influence has some difference in different leukemias.Therefore,the anticancer regular pattern of the two drugs should further be explored,in order to make a more effective combinative chemotherapy scheme.

本文研究了全反式维甲酸和 9-顺维甲酸对HL - 6 0细胞增殖及凋亡的影响 ,并用半定量RT -PCR技术检测了人髓系白血病细胞株HL - 6 0细胞中同源盒HOXA1基因的表达。结果表明 ,全反式维甲酸及 9-顺维甲酸均能抑制HL - 6 0细胞增殖并能促进其凋亡 ,这种效应在两药联用时更为明显 ,根据上述结果 ,我们认为两药联用的抗癌机制之一可能是通过影响HOXA1基因表达的网络调节系统来实现的 ,但在不同的白血病中 ,其影响程度可能有所差异。因此 ,有必要更进一步探讨两种药物的抗癌调节模式 ,以便制定一个更有效的联合化疗方案

 
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