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immature mice
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  未成年小鼠
     Effect of alcohol exposure on physical growth in immature mice
     酒精对未成年小鼠体格发育的影响
短句来源
     Objective To explore the effect of alcohol exposure on physical growth in immature mice.
     目的研究酒精对未成年小鼠体格发育的影响。
短句来源
     Conclusion Chronic drinking of high and middle dose alcohol will back the physical growth of immature mice.
     结论长期摄入高、中浓度酒精对未成年小鼠体格发育有抑制作用。
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     It was shown that only trace amount of tyrosine was seer in the ovaries of immature mice.
     结果表明:未成年小鼠卵巢内酪氨酸是痕迹量;
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     Objective:To investigate the toxic effect of acetic acid lead on haematopoietic stem/progenitor cells and peripheral blood in the immature mice of lead poisoning.
     目的:为防治铅中毒提供实验室研究资料,探讨铅染毒时铅对未成年小鼠骨髓造血干/祖细胞和外周血的毒性作用。
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  “immature mice”译为未确定词的双语例句
     Immunization of BALB/c Mice with hCGb-C3d3 Fusion Protein and Inhibiting Effect of Its Antiserum on hCG-induced Uterus Weight Increase of Immature Mice
     hCGβ-C3d3融合蛋白免疫BALB/c小鼠及其抗血清对hCG诱导鼠子宫增重的抑制效应
短句来源
     Experiment Study of Estrogen Receptor α and β Isoforms Expression in Ovary of Mature Mice and in Vitro Cultured Follicles of Immature Mice
     性成熟小鼠卵巢和性未成熟小鼠体外培养卵泡的雌激素受体α、β亚型表达的研究
短句来源
     The expression, tyrosine-phosphorylation and nuclear translocation of STAT3 were increased in the luminal and glandular epithelium of immature mice by PMSG treatments.
     用PMSG处理性未成熟的小鼠,可刺激子宫腔上皮和腺上皮中STAT3的表达,并促进子宫腔上皮和腺上皮中的STAT3发生酪氨酸磷酸化及核转位。
短句来源
     And also, the growth, that is increased weight of body, thymus, spleen and adrenal gland, was accelerated in immature mice with that.
     灌肠蕨粉糊状液还能促进幼年小鼠的生长发育,表现为体重增加以及胸腺、脾脏、肾上腺组织重量显著增加(P<005)。
短句来源
     Experiment on the Sexual Virility of Immature Mice Immunized with LHRH Fusion Protein Vaccine
     LHRH融合蛋白疫苗对性成熟前小鼠性腺轴系的影响
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  相似匹配句对
     Estrogenicity of trans-resveratrol in immature mice in vivo
     白藜芦醇的雌激素样作用研究
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     Conclusion Thymic function of immature mice is normal.
     结论 幼龄小鼠胸腺功能已成熟,并不随小鼠的发育而增强。
短句来源
     injected to mice.
     荧光分光光度计检测PLA纳粒能否进入小鼠脑部;
短句来源
     The Cat and the Mice
     猫和老鼠
短句来源
     APROACH TO THE STUDIES ON IMMATURE FLEAS
     对蚤类幼期研究中若干问题的探讨
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  immature mice
In ischemia, both K+ stimulation and NMDA potentiated the NO-induced release, particularly in the immature mice, probably without the involvement of the NO synthase or cGMP.
      
Ovulation was induced in immature mice by injections of pregnant mare serum gonadotropin (PMSG) and human chorionic gonadotropin (HCG) spaced 48 hours apart.
      
Group III metabotropic glutamate receptors were not at all involved in ischemic GABA release in the immature mice, but in adults their activation by O-phospho-l-serine potentiated the basal release and reduced the K+-stimulated release.
      
A histochemical account is presented of the changes that occur in the protein-carbohydrate composition of the cumulus-oocyte complex in immature mice after gonadotrophin treatment.
      
Arsenic tissue concentration of immature mice one hour after oral exposure to gold mine tailings
      
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Subcutaneous injection of lycorine at a dosage of 12 mg/kg once daily for 3 consecu- tive days induced marked involution of thymus in immature mice. Intravenous injection of a dose of 12 mg/kg of lycorine significantly depleted the adrenal ascorbic acid con- tent of the rabbit. Lycorine, at a dosage of 16 mg/kg, elicited eosinopenic response in the intact toad, but failed to induce similar response in the hypophysectomized animal. These results indicate that lycorine affected the function of the adrenal...

Subcutaneous injection of lycorine at a dosage of 12 mg/kg once daily for 3 consecu- tive days induced marked involution of thymus in immature mice. Intravenous injection of a dose of 12 mg/kg of lycorine significantly depleted the adrenal ascorbic acid con- tent of the rabbit. Lycorine, at a dosage of 16 mg/kg, elicited eosinopenic response in the intact toad, but failed to induce similar response in the hypophysectomized animal. These results indicate that lycorine affected the function of the adrenal cortex presum- ably through stimulation of ACTH release. In addition, lycorine was found to possess anti-inflammatory activity on egg-white- induced oedema of the hind paw in intact rats, and on formalin-arthritis in rabbits (3mg/kg I.V.). However, lycorine failed to inhibit egg-white-induced oedema in ad- renalectomized rats. Thus, the anti-inflammatory action of lycorine is probably mediated by stimulating the pituitary-adrenal system.

作者用幼小鼠胸腺萎缩法、家兔肾上腺抗坏血酸含量降低及蟾蜍嗜酸性白血球减少等方法,证实石蒜碱具有刺激动物肾上腺皮质功能的作用;当用去除垂体蟾蜍作试验对象时,证明石蒜碱的这一作用系通过垂体而实现.此外,石蒜碱对家兔甲酸性关节炎及大鼠蛋白性关节炎显示明显的抗炎作用.

Trans-stilbene, a chemical reagent, was found to be effective in protecting the liver from GGl_4 injury. In the first series of experiments, mice were given orally two doses of stilbene (100 mg/kg for each dose) in the first day and a dose of GCl_4 (0.01 ml/kg) the next day. The SGPT and SGOT levels as well as BSP retention were significantly lower in stilbene pre-treated mice than in the GCl_4 controls determined 16 hrs after injection of the liver poison. Histological examination revealed that lesions of the...

Trans-stilbene, a chemical reagent, was found to be effective in protecting the liver from GGl_4 injury. In the first series of experiments, mice were given orally two doses of stilbene (100 mg/kg for each dose) in the first day and a dose of GCl_4 (0.01 ml/kg) the next day. The SGPT and SGOT levels as well as BSP retention were significantly lower in stilbene pre-treated mice than in the GCl_4 controls determined 16 hrs after injection of the liver poison. Histological examination revealed that lesions of the liver of stilbene pre-treated mice were less severe than those of GCl_4 controls. In the second series of experiments, a dose of GCl_4 was given to the mice and 40 hrs later the mice were given orally stilbene at dosages of 50 or 100 mg/kg twice a day for two days. The repair of injured liver tissue seemed to be accelerated since the liver weights and SGPT levels were statistically lower in the stilbene treated mice. These findings are parallel to the pathological observations.Since this compound did not show any effect in lowering either the SGPT levels or the GPT levels of liver tissue in normal mice at the dosage as high as 1000 mg/kg, the possibility of inhibition of the enzymes may be excluded.In the third series of experiments, mice fasted for 24 hrs were used. An hour after a dose of stilbene (100 or 200 mg/kg), mice were injected with 10% glucose (20ml/kg) and sacrificed 2 hours thereafter for the determination of liver glycogen. The results showed that glycogenesis was stimulated by the oral administration of stilbene. In adrenalectomized mice this action was even more significant: the liver glycogen in the stilbene (200 mg/kg) pre-treated mice was found to be twice as high as controls—a potency approximating 100 mg/kg of cortisone.No significant effect was found either on the pentobarbital sleeping time in mice (stilbene 200 mg/kg, p o) or on cotton pellet granuloma response in rats (stilbene 100 mg/kg/day p o for 7 days). However, the compound exhibited a very weak estrogenic activity as shown in the immature mice uterus assay.The toxicity of stilbene is low. When suspended in starch, the ip LD_(50) was found to be 6.50±0.76 g/kg in mice. No death was recorded in 10 mice given an oral dose of 8.0 g/kg. When dissolved in oil the toxicity of stilbene increased sharply, the po LD_(50) of its peanut oil solution was found tO he 0.92±0.14 g/kg. Four dogs (two males and two females) were fed stilbene 10~50 mg/kg for 30 days. No change in behavior, liver and kidney functions and blood counts was found.

芪(二苯乙烯)通常用于化学工业,对其药理活性的研究很少。通过动物实验我们发现芪能明显保护CCl_4引起的小鼠肝损害,表现在使高的SGPT及SGOT降低、BSP潴留减少、肝组织病变减轻等。芪明显促进肝糖元生成,此作用强度与可的松相近,但芪没有可的松那样的抗炎作用。在去肾上腺小鼠,芪仍能明显促进肝糖元生成,故此作用似乎不通过体内的垂体-肾上腺系统。芪对小鼠戊巴比妥睡眠时间影响不明显。根据实验资料分析,芪对CCl_4肝损害的保护机制大概不是通过酶诱导,也不象某些抗氧化剂那样直接对抗CCl_4的作用,但有可能与其促进肝糖元生成有某种关系。 芪有微弱的雌激素作用(约为己烯雌酚的数万分之一)。 芪的毒性很低,小鼠一次腹腔注射LD_(50)为6.5 g/kg,灌胃LD_(50)大于8 g/kg,但油溶液毒性较大(灌胃LD_(50)为0.92g/kg)。长期大量给予芪,对雄小鼠的生长及睾丸发育有抑制作用,给狗服芪50 mg/kg/天连续一个月以上未见明显异常反应。

The monopotassium salt of 14-Deoxy-11, 12-didehydroandrographolide-3,19-disuccinate (DAS) neutralized with equivalentamount of sodium bicarbonate is an aqueous soluble preparation derived from andrographolide which is the principal composition of Andrographis paniculata Ness. DAS was reported to have therapeutic effect on pneumonia and upper respiratory tract infection of virus origin. We investigated its anti-inflammatory activity in mice and rats. The experimental results showed that DAS significantly inhibited...

The monopotassium salt of 14-Deoxy-11, 12-didehydroandrographolide-3,19-disuccinate (DAS) neutralized with equivalentamount of sodium bicarbonate is an aqueous soluble preparation derived from andrographolide which is the principal composition of Andrographis paniculata Ness. DAS was reported to have therapeutic effect on pneumonia and upper respiratory tract infection of virus origin. We investigated its anti-inflammatory activity in mice and rats. The experimental results showed that DAS significantly inhibited the increase of capillary permeabilities induced by various phlogistic stimulations and exudation induced by croton oil, but had no effect on granuloma formation around cotton pellet or in granuloma pouch. DAS was found to inhibit egg-white induced edema of the hind paw in intact rats but not in adrenalectomized animals. DAS induced marked involution of the thymus in immature mice and significantly depleted the content of adrenal ascorbic acid of rats. However, this action of DAS was abolished by hypophysecton(?)y. After five consecutive daily injections of DAS the ACTH content of the pituitary gland some increased with significant depletion of adrenal ascorbic acid content in rats. These results indicate that the anti-inflammatory activity of DAS is presumably due to increasing synthesis and release of ACTH of the pituitary gland.

腹腔注射或皮下注射本品128~250 mg/kg,对二甲苯、组织胺、醋酸等所致小白鼠皮肤或腹腔毛细血管通透性增高、蛋清所致大鼠足肿胀及巴豆油所致炎性渗出均有明显的抑制作用,但对肉芽组织增生无明显影响。由于去除肾上腺后其抗炎作用消失,本品也不能延长去肾上腺幼年大白鼠的生存时间,但可引起幼年小白鼠胸腺萎缩、明显降低大白鼠肾上腺中维生素C的含量,多次给药并可增加垂体前叶中ACTH的含量,因此说明本品不具有肾上腺皮质激素样作用,但能兴奋垂体——肾上腺皮质系统功能,这一作用是在于促进了垂体前叶ACTH的合成和释放。继以大白鼠肾上腺中维生素C含量降低为指标,分析了本品作用的部位,结果表明,动物去除垂体后,此作用消失,戊巴比妥钠麻醉,作用仍然存在,但在戊巴比妥钠麻醉的基础上,吗啡、地塞米松、氯丙嗪等均能完全阻断本品降低肾上腺中维生素C含量的作用,上述结果提示本品兴奋垂体——肾上腺皮质系统功能的作用部位可能在皮层下中枢。

 
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