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diclofenac lysine
相关语句
  双氯芬酸赖氨酸盐
     Preparation of diclofenac lysine extended release tablet and its drug release
     双氯芬酸赖氨酸盐缓释片的制备及体外释放度
短句来源
     Preparation of Diclofenac Lysine Sustained-release Tablets and Investigation of the Stability
     双氯芬酸赖氨酸盐缓释片的制备及初步稳定性研究
短句来源
     Pharmacokinetics study of Diclofenac lysine sustained-release tablet in dogs
     双氯芬酸赖氨酸盐缓释片家犬体内药物动力学研究
短句来源
     Diclofenac lysine salt (2)significantly inhibited acute inflammation induced by carrageenin etc. , proliferation of granuloma induced by cottonpellets and immune inflammation induced by adjuvant in rats and mice.
     双氯芬酸赖氨酸盐灌胃给药能明显抑制角叉菜胶等所致急性炎症、棉球肉芽肿慢性炎症及免疫性炎症佐剂关节炎。
短句来源
     OBJECTIVE:To prepare diclofenac lysine(DAL) extended release tablets and to investigate the release mechanism in vitro.
     目的:制备双氯芬酸赖氨酸盐缓释片,对其释放机制进行考察。
短句来源
  双氯芬酸赖氨酸
     METHODS 20 wister rats were divided into two groups randomizedly by oral administration of diclofenac sodium and diclofenac lysine,respectively and the same concentration of 1.0 mmol·L -1 and the same quantity of 1.4 ml.
     方法  2 0只Wister大鼠分成二组分别单次灌胃给予1.0mmol·L- 1 1.4ml双氯芬酸钠 (DS)和双氯芬酸赖氨酸 (DL) ,用高效液相色谱法测定血中DS及DL浓度。
短句来源
     Comparison of pharmacokinetic parameters between diclofenac sodium and diclofenac lysine in rats
     双氯芬酸钠及双氯芬酸赖氨酸在大鼠体内的药代动力学参数比较
短句来源
     ANTIINFLAMMATORY ACTION OF DICLOFENAC LYSINE SALT
     双氯芬酸赖氨酸盐的抗炎作用
短句来源
     OBJECTIVE To compare the pharmacokinetic parameters between diclofenac sodium and diclofenac lysine.
     目的 比较双氯芬酸钠及双氯芬酸赖氨酸体内药代动力学参数。
短句来源
     Pharmacokinetics study of Diclofenac lysine sustained-release tablet in dogs
     双氯芬酸赖氨酸盐缓释片家犬体内药物动力学研究
短句来源
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  “diclofenac lysine”译为未确定词的双语例句
     Preparation and determination of content of diclofenac lysine
     双氯灭痛赖氨酸盐的制备及其含量测定
短句来源
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Diclofenac lysine salt (2)significantly inhibited acute inflammation induced by carrageenin etc., proliferation of granuloma induced by cottonpellets and immune inflammation induced by adjuvant in rats and mice. The results suggested that the mechanism of 2 on inflammation are involved with (1)inhibiting synthesis or release of PGs and other inflammatory factors, (2)stabilizing the lysosome membrane, (3) inhibiting the mononuclear phagocyte system.

双氯芬酸赖氨酸盐灌胃给药能明显抑制角叉菜胶等所致急性炎症、棉球肉芽肿慢性炎症及免疫性炎症佐剂关节炎。其作用机理与抑制前列腺素等各种致炎介质的合成、释放,稳定溶酶体膜,抑制单核巨噬细胞系统吞噬功能有关。

OBJECTIVE To compare the pharmacokinetic parameters between diclofenac sodium and diclofenac lysine.METHODS 20 wister rats were divided into two groups randomizedly by oral administration of diclofenac sodium and diclofenac lysine,respectively and the same concentration of 1.0 mmol·L -1 and the same quantity of 1.4 ml.The blood sample were collected through rats neck vein with intubation.A HPLC method was used to determine the concentrations of diclofenac in plasma.RESULTS The plasma...

OBJECTIVE To compare the pharmacokinetic parameters between diclofenac sodium and diclofenac lysine.METHODS 20 wister rats were divided into two groups randomizedly by oral administration of diclofenac sodium and diclofenac lysine,respectively and the same concentration of 1.0 mmol·L -1 and the same quantity of 1.4 ml.The blood sample were collected through rats neck vein with intubation.A HPLC method was used to determine the concentrations of diclofenac in plasma.RESULTS The plasma concentration time curves were fitted to two compartment model.CONCLUSION The pharmacokinetic parameters between the two products had no significant difference ( P >0.05),except t 1/2β ( P <0.01).

目的 比较双氯芬酸钠及双氯芬酸赖氨酸体内药代动力学参数。方法  2 0只Wister大鼠分成二组分别单次灌胃给予1.0mmol·L- 1 1.4ml双氯芬酸钠 (DS)和双氯芬酸赖氨酸 (DL) ,用高效液相色谱法测定血中DS及DL浓度。用 3P87程序拟合计算药代动力学参数。结果与结论 经统计学方差分析 ,药 时曲线符合二室模型 ,两种双氯芬酸盐的AUC ,Vd ,tmax,cmax,CL无差异 (P >0 .0 5 ) ,两组t1 2 β有显著差异 (P <0 .0 1)

OBJECTIVE:To prepare diclofenac lysine(DAL) extended release tablets and to investigate the release mechanism in vitro.METHODS:The water-soluble matrix tablet was prepared by use of HPMC(K4M).The drug release was determined according to method of Chinese Pharmacopoeia(1995).The optimal formulation was obtained by orthogonal design and the imported diclofenac sodium extended release tablet was the controlled tablet.RESULTS:The release profile of the tablets in vitro was fitted well by zero-order...

OBJECTIVE:To prepare diclofenac lysine(DAL) extended release tablets and to investigate the release mechanism in vitro.METHODS:The water-soluble matrix tablet was prepared by use of HPMC(K4M).The drug release was determined according to method of Chinese Pharmacopoeia(1995).The optimal formulation was obtained by orthogonal design and the imported diclofenac sodium extended release tablet was the controlled tablet.RESULTS:The release profile of the tablets in vitro was fitted well by zero-order release.CONCLUSIONS:The formulation is reasonable and tablets release in vitro showed no obvious difference to the controlled tablet.

目的:制备双氯芬酸赖氨酸盐缓释片,对其释放机制进行考察。方法:以羟丙基甲基纤维素(HPMC K4M)为主要辅料,制备水溶性骨架片,通过正交设计优化出双氯芬酸赖氨酸盐缓释片的处方,以进口双氯芬酸钠缓释片为对照,根据中国药典1995年版所载的溶出方法测定其释放度。结果:所制备的缓释片在12 h内呈现良好的零级释药特征。结论:以正交法优选的双氯芬酸赖氨酸盐缓释片处方合理,体外释放与进口双氯芬酸钠缓释片相比差异无显著性。

 
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