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hippocampus
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  海马
     Effect of Method for Replenishing Spleen and Stomach on the PKC Activities of Hippocampus Neuron and Bcl-2,Bax Protein Expression and Ultrastructure in Rats with Spleen Deficiency Syndromes
     补益脾胃法对脾虚老龄大鼠海马神经元PKC活性与bc1-2和bax蛋白表达及超微结构的影响
短句来源
     Influence and Its Mechanism of High Pressure on the Neurons and Glial Cells in the Hippocampus of Rats
     高气压对海马神经元和胶质细胞的影响及其机制
短句来源
     Prenatal Imprinting Effects of Glucocorticoid on 11β-hydroxysteroid Dehydrogenase Type Ⅰ in the Rat Hippocampus
     妊娠期糖皮质激素对大鼠海马11β-羟基类固醇脱氢酶Ⅰ型印迹作用的研究
短句来源
     Screening of the Differentially Expressed Genes and Cystatin C Expression in the Deafferented Hippocampus
     去传入海马的差异表达基因的筛选和Cystatin C表达
短句来源
     Study of the Role of GJB1、GAD、GIRK1 in Self-acceleration and Self-protection Mechanisms in the Hippocampus of Temporal Lobe Epilepsy Rat
     GJB1、GAD、GIRK1在颞叶癫痫大鼠海马内源性促痫与抗痫机制中作用的研究
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  海马组织
     Methods Wistar rats were exposed to EMP(6×10~4V·m~(-1)) and the expression of brain-derived neurotrophic factor(BDNF) and neural celladhesion molecule(NCAM) proteins in hippocampus were detected with Western blot analysis.
     方法以EMP 6×104V.m-1照射Wistar大鼠,用Western blot蛋白印迹法检测海马组织中脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)和神经细胞黏附分子(neural celladhesion molecule,NCAM)的表达。
短句来源
     After ischemia 2 h,the mRNA of Kv1.4,Kv2.1 and Kv4.2 in hippocampus increased by 50%,67% and 90%,respectively. And the mRNA of Kv1.4 and Kv4.2 maintained at a high level in hippocampus after ischemia 24 h.
     缺血2 h时,海马组织的Kv1.4,Kv2.1和Kv4.2 mRNA表达水平分别增加了50%,67%和90%,在缺血24 h时Kv1.4和Kv4.2mRNA仍保持高水平表达。
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     The content of NO or MDA in cerebral cortex and hippocampus of the experiment groups were lower than that of the control group (F=14.31~27.41,P=0.00).
     实验组大鼠大脑皮层和海马组织中NO和MDA含量明显低于对照组(F=14.31~27.41,P=0.00)。
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     The Expression and Effect of NR1,NR2A and NR2B in Hippocampus Tissue of Rats with Exercise Fatigue
     NR1、NR2A和NR2B在运动性疲劳大鼠海马组织中的表达及配方的调节作用
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     However, the protein expression levels of ERK1/2 decreased significantly (*P<0.05, n=6) both in cortex and hippocampus of delayed hypoxic preconditioned mice (H5-H6).
     ②延迟性低氧预适应中(H5-H6),小鼠大脑皮层和海马组织内ERK1/2的蛋白表达量显著降低(P<0.05,n=6)。
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  海马区
     In hippocampus, α1, γ2L, and γ2S mRNA contents were significantly decreased (33%, 35%and 27% respectively).
     海马区的α1下降 33% ,γ2L下降 35 % ,γ2S下降 2 7% ,与对照组比较差异均有显著性。
短句来源
     GABA A receptor subunits α1, α3, α5, γ2L and γ2S were assayed using quantitative competitive RT PCR in rat frontparietal motor(FrPaM) and hippocampus.
     用竞争性定量RT PCR测定大鼠脑皮质运动区和海马区GABAA 受体α1、α3、α5、γ2L和γ2S亚单位mRNA的含量。
短句来源
     Results: Compared with ischemic group(24.88±2.88 and 2.95±0.34), the percentage of Bcl-2 immunoreaction positive cells in cortex and hippocampus CA1 in CGRP group increased significantly(70.83±8.95 and 4.17±0.34 respctively), (P<0.01);
     结果 :CGRP组大脑皮层及海马区 Bcl- 2免疫反应阳性百分率为分别 70 .83± 8.95和 4.17± 0 .34 ,较全脑缺血再灌注组 (2 4.88± 2 .88和 2 .95± 0 .34 )明显增加 (P<0 .0 1) ;
短句来源
     The distribution of cPLA_2 and caspase-3 in the rat hippocampus after MCAO
     大鼠脑缺血再灌注后海马区cPLA_2、Caspase-3的分布
短句来源
     Altered Expression of NR2B/PSD-95 Protein in the Hippocampus of Temporal Lobe Epilepsy Rats
     颞叶癫癎大鼠海马区NR2B/PSD-95的动态表达变化
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  “hippocampus”译为未确定词的双语例句
     Electrical Stimulation to the Hippocampus of Rats to Found Animal Models and Detection the Expression of Gst Gene with Gene Cmos Chip Technique in Intractable Epilepsy
     电刺激大鼠癫痫模型及基因芯片检测谷胱苷肽-巯-转移酶基因的表达
短句来源
     Gene Expression Profile of Hippocampus and Cortex of Rat in Aβ_(1-40) -induced Rat Model for Alzheimer's Disease.
     Aβ_(1-40)诱导痴呆大鼠脑海马及皮质基因表达谱差异的实验研究
短句来源
     Process and Analysis of Gene Expression Information in 150-day Human Fetal Hippocampus
     150天人胎脑海马基因表达信息的处理与分析
短句来源
     EFFECT OF EXCITATORY AMINO ACIDS. Ca ̄(2+) ON DELAYED NEURONAL DEATH IN HIPPOCAMPUS FOLLOWING TRANSIENT FOREBRAINISCHEMIA IN GERBILS
     EFFECT OF EXCITATORY AMINO ACIDS.Ca~(2+) ON DELAYED NEURONAL DEATH IN HIPPOCAMPUS FOLLOWING TRANSIENT FOREBRAINISCHEMIA IN GE
短句来源
     CHANGES OF GABA_A RECEPTOR γ_2 SUBUNIT IN HIPPOCAMPUS OF CHRONIC EPILEPTIC RATS──A STUDY OF IN SITU HIBRIDIZATION HISTOCHEMISTRY
     慢性癫痫大鼠海马内GABA_A受体γ_2亚单位的改变──原位杂交组织化学研究
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  hippocampus
The rCBF of the right frontal lobe and hippocampus was also detected by the PerifluxPF model laser Doppler flowmetry, and the expressions of c-fos or c-jun or Bcl-2 and Bax were also measured by immune histochemistry S-P method accordingly.
      
Results showed that the rCBF of the right frontal lobe and hippocampus in the operation group was significantly lower than that in the false operation group (P >amp;lt; 0.05).
      
In conclusion, rCBF decrease can impair the learning and memory function in rats, which may be related to the increase of the expression ratio of c-fos or c-jun or Bcl-2 or Bax in the frontal cortex and hippocampus.
      
Proliferative Activity of Matrix Cells in the Lateral Ventricles and Granule Cells in the Dentate Gyrus of the Rat Hippocampus u
      
The stem and progenitor cells, as well as neuro- and gliogenesis, are most explored in the hippocampus and olfactory bulb.
      
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Two instrumental enzymes, Chymotrypsin (CT) and Trypsin (T), both are pro-teolytic enzymes capable of destroying some bonds of proteins and peptides, were usedin this experiment. A total of 26 young adu1t male albino rats served as the threenon-consolidation groups (NC) of DBA memory: normal saline solution (NS/NC),Trypsin (T/NC) and Chymotrypsin (CT/NC). After bilateral injection of CT and T into the Hippocampus (iH: AP_2L_2H_4 andAP_4L_3H_5), different effects were observed on the conditioned reflex...

Two instrumental enzymes, Chymotrypsin (CT) and Trypsin (T), both are pro-teolytic enzymes capable of destroying some bonds of proteins and peptides, were usedin this experiment. A total of 26 young adu1t male albino rats served as the threenon-consolidation groups (NC) of DBA memory: normal saline solution (NS/NC),Trypsin (T/NC) and Chymotrypsin (CT/NC). After bilateral injection of CT and T into the Hippocampus (iH: AP_2L_2H_4 andAP_4L_3H_5), different effects were observed on the conditioned reflex of DBA memorymodel (CR_(DBA)). 72 hours after iH. T, retention of CR_(DBA) clearly decreased, but afteriH. CT, memory remains consolidated. Differences in successive number of CR_(DBA)(SN_(CR)) and rate of CR_(DBA) (CR%) were statistically significant. The experimentaldoses of iH. T and CT approximately equal 1/3 of their LD_(50).

本实验选择了胰凝乳蛋白酶与胰蛋白酶,它们同属水解酶,能够内切蛋白质与肽类底物的某些键位。26只刚成年的雄性大鼠分作三组:生理盐水/不巩固组(NS/NC)、胰蛋白酶/不巩固组(T/NC)与胰凝乳蛋白酶/不巩固组(CT/NC)。 实验结果表明,双侧海马内注射(AP_2L_2H_4与AP_4L_3H_5)胰凝乳蛋白酶与胰蛋白酶后,对暗箱廻避(DBA)模式记忆有不同的影响。胰蛋白酶注射后,该记忆保持明显降低,而胰凝乳蛋白酶注射后仍可巩固。所用的实验剂量大致为半致死剂量的三分之一。

Scopolamine and anisodine are alike in chemical structure, except that anisodine possesses a hydroxyl group on the α-carbon atom of the tropic acid moiety. In this paper, the results of a comparative study on the physiological dispositions of scopolamine and anisodine, both labeled with ~3H by the Wilzbach technic, are reported.Biological materials were extracted with chloroform at an alkaline pH. The chloroform layer was separated and washed with phosphate buffer of pH 8. An aliquet of the extract was transferred...

Scopolamine and anisodine are alike in chemical structure, except that anisodine possesses a hydroxyl group on the α-carbon atom of the tropic acid moiety. In this paper, the results of a comparative study on the physiological dispositions of scopolamine and anisodine, both labeled with ~3H by the Wilzbach technic, are reported.Biological materials were extracted with chloroform at an alkaline pH. The chloroform layer was separated and washed with phosphate buffer of pH 8. An aliquet of the extract was transferred to a counting vial and evaporated to dryness. After addition of 5 ml of scientillation liquid (toluene containing ppo 0.5%, popop 0.03% or dioxane containing ppo 0.4%, popop 0.002%, naphthalene 6%) the samples were counted in a scientillation counter (Model F3-353, Hsi-an). The measured radioactivity was shown to be unchanged ~3H-scopolamine or ~3H-anisodine by specificity tests using thin layer chromatography.Both ~3H-scopolamine and ~3H-anisodine were found to be well absorbed from rat intestine in situ, but it seemed that ~3H-scopolamine was absorbed more rapidly and more completely than ~3H-anisodine. After a single intravenous injection of ~3H-scopolamine or ~3H-anisodine, a plot of the logarithm of drug concentration in plasma versus time yielded a curve with two distinct linear components. For ~3H-scopolamine and ~3H-anisodine, the T1/2 α were found to be 11 and 13 minutes, and the T1/2β were 95 and 70 minutes, respectively. When given intravenously, the highest levels of ~3H-scopolamine and ~3H-anisodine were found in the lungs and kidneys respectively. The content of both drugs in the brain was higher than that in the plasma. The distribution patterns of the two drugs over the various regions of the brain were similar: highest levels were found in the striatum, cerebral cortex and hippocampus, moderate levels were found in the septum and diencephalon, and very low levels were obtained in the lower brain stem and cerebellum. The contents of ~3H-scopolamine in the brain sections were signi-Ficantly higher than those of ~3H-anisodine, although their contents in plasma were similar.Following an intravenous dose of ~3H-scopolamine and ~3H-anisodine, the total radioactivity excreted in urine was 62% and 78% respectively within 48 hours, while those excreted in feces was 25% and 12.5% respectively. In rats with a biliary cannula, 40% and 20% respectively of an intravenous dose of ~3H-scopolamine and ~3H-anisodine could be recovered from the bile collected within 48 hours. In the urine, feces or bile, about 1/7 to 1/4 of the excreted total radioactivity was shown to be unchanged drug.~3H-scopolamine and ~3H-anisodine were shown to be metabolized by rat liver as well as by plasma. ~3H-anisodine was shown to be also metabolized by rat kidney slices. Both drugs were rapidly metabolized by liver, kidney and plasma of the rabbit. In this animal, it seemed that the metabolism of ~3H-scopolamine was more rapid than that of ~3H-anisodine.

给大鼠灌胃~3H-东莨菪碱与~3H-樟柳碱后,吸收都好,但前者的吸收比后者更快更完全。静脉注射后,前者的T1/2α为11分钟,T1/2β为95分钟,后者的T1/2α为13分钟,T1/2β为70分钟。静脉注射后二者的组织浓度均以肺与肾最高,脑内的浓度都比血浆内者高。两药在脑的分布形式相似,以纹状体、大脑皮层及海马较多,膈区和间脑次之,低位脑干和小脑较低。虽然两药的血浆浓度相似,但在脑内各区的分布~3H-东莨菪碱明显高于~3H-樟柳碱。 两药静脉注射后,仅很小部分原形药从尿及粪排出,大部分以转化形式排出。两药都可被大鼠肝和血浆所转化,家兔的肝、肾和血浆也有这种活性,而且更强。~3H-东莨菪碱的转化速度明显地比~3H-樟柳碱快。 ~3H-东莨菪碱与~3H-樟柳碱在代谢上的差异可能与后者托品酸部分多一羟基因而极性较大有关。

1.In this work the technique of perfusion of cerebral ventricular system inconscious rabbits was applied to the study of 5-hydroxytrytamine(5-HT)releaseand the effect of Midaflur on it.Midaflur(4mg/kg i.v)could not directly modify5-HT release in brain in conscious rabbits,but the increase in the 5-HT releasewas observed in rabbit struggling with the procedure of injection of Midaflur.Therefore,the behavior of the conscious rabbits must be considered in studyingthe effect of drugs on the release of neurotransmitters...

1.In this work the technique of perfusion of cerebral ventricular system inconscious rabbits was applied to the study of 5-hydroxytrytamine(5-HT)releaseand the effect of Midaflur on it.Midaflur(4mg/kg i.v)could not directly modify5-HT release in brain in conscious rabbits,but the increase in the 5-HT releasewas observed in rabbit struggling with the procedure of injection of Midaflur.Therefore,the behavior of the conscious rabbits must be considered in studyingthe effect of drugs on the release of neurotransmitters in brain by perfusion of thecerebral ventricular system.2.Dopamine content was determined by the spectrophotofluorometric me-thod.The experimental results demonstrated that no significant change in dopa-mine content in caudate nucleus as well as in hippocampus was observed duringthe muscle relaxing.

1.用~3H-5-羟色胺脑室灌流清醒动物的方法,测定了脑内5-羟色胺的释放。实验结果表明,给兔静注咪达氟(4mg/kg)后,因动物挣扎引起5-羟色胺释放加强,可能咪达氟不直接加强兔脑5-羟色胺的释放。因此,必须指出,在用清醒动物脑室灌流的方法研究药物对神经递质释放是否有影响时,必须考虑到清醒动物的活动状态。2.用荧光方法测定了多巴胺含量。实验结果表明,给兔静注眯达氟(4或8mg/kg)以后10分钟,颈部和前肢产生明显肌松时海马中多巴胺含量虽有增加的趋势,但无统计学意义,尾核中多巴胺含量基本不变。因此,可以认为咪达氟所引起的肌肉松弛可能与脑内多巴胺含量关系不大。

 
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