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hippocampus
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  海马
    The Study about Expression Changes of MAPK and NMDAR in the Hippocampus of Alzheimer's Rat
    阿尔茨海默病大鼠海马MAPK和NMDAR表达变化的研究
短句来源
    Experimental Study on Exacerbation of Hippocampus Neuronus Injury Caused by Diabetes in Vascular Dementia Rats
    糖尿病加重血管性痴呆大鼠海马神经元损伤的实验研究
短句来源
    A study of the relationship between hypomnesia and cholinergic neurons of hippocampus in vascular dementic rats
    血管性痴呆大鼠记忆障碍与海马胆碱能神经元关系的研究
短句来源
    Effects of norepinephrine and its antagonists,haloperidol on paired-pulse responses in rat hippocampus CA_3,region in vitro
    去甲肾上腺素及拮抗剂、氟哌啶醇对大鼠海马CA_3区双脉冲反应的影响
短句来源
    Methods The aggregated Aβ-42 was injected into the hippocampus of rats and the reverse peptide Aβ42-1 or phosphate buffer saline(PBS)was injected as controls.
    方法通过立体定位技术将Aβ_(1-42)注射至大鼠双侧海马,对照组注射反序列Aβ_(42-1)或PBS。
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  海马组织
    The hippocampus intracellular free calcium was determined with Fura-2/AM, free calmodulin (CaM) with flowcytometry, and the expressions of total CaM, Ca 2+ /CaM dependent kinase Ⅱα (CaMKⅡα) and Ⅳ (CaMKⅣ) with Western blotting.
    采用流式细胞仪、荧光标记术和免疫印迹法 ,检测捕食应激后 4 8h内大鼠海马细胞内游离Ca2 + 浓度与钙调素 (CaM )相对活性平均通道荧光 ,以及海马组织总CaM、Ca2 + /CaM依赖性蛋白激酶IIα (CaMKⅡα)与IV(CaMKⅣ )的表达变化。
短句来源
    RESULTS:Compared with the control group(0.50±0.92),the number of errors in the model group(6.50±7.76) increased( t=2.979,P< 0.05). Many neur cells had hydrodegeneration seahorse constitution of hippocampus and karyopyknosis, and necrosis of neur and phagocytosis cells were seen in screen mes.
    结果:与对照组(0.50±0.92)次相比,模型组小鼠跳台训练的错误次数(6.50±7.76)次明显增加(t=2.979,P<0.05),海马组织有大量的神经元细胞发生水变性,核固缩,并可见神经元的坏死和噬神经细胞现象,呈筛孔状。 与模型组(6.50±7.76)次比较;
短句来源
    the content of cytokines of IL-6 and TNF-αin hippocampus were reduced significantly.
    海马组织IL-6、TNF-α含量显著减少。
短句来源
    Methods: The OVX rats were used as a model. Hippocampus of OVX rats was removed from the rat brains on 1w, 2w, 3w, 4w and 8w after the ovariectomy, respectively, and the phosphorylation of tau protein was measured by Western blotting.
    方法建立大鼠双侧卵巢切除(OVX)模型,分别于术后1、2、3、4和8周取大鼠海马组织,WesternBlot检测Tau蛋白的磷酸化程度。
短句来源
    Objective:To investigate the changes of super microstructure of hippocampus and expression of caspase-3 in rats induced by amyloid β-peptide25-35(Aβ25-35).
    目的:探讨大鼠双侧海马注射Aβ25-35后海马组织形态、超微结构及caspase-3表达的改变。
短句来源
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  海马区
    Results c-jun mRNA expressed a little in cortex and hippocampus of normal rats,and increased a little in sham group than in normal rats(P>0.05).
    结果正常大鼠大脑皮层和海马区内即有少量的c-jun mRNA的表达,假手术组的表达略高于正常组(P>0.05)。
短句来源
    Objective To observe the effects of fetal rat NSCs transplantation on expression of GFAP and S-100β in hippocampus of rats with AD.
    目的探讨胎鼠神经干细胞移植对阿尔茨海默病(AD)大鼠海马区的GFAP与S-100β表达的影响。
短句来源
    The change of Alzheimer-like phosphorylation of Tau proteins in hippocampus of ovariectimized rats
    去势雌性大鼠海马区Tau蛋白Alzheimer样磷酸化的变化
短句来源
    Effect of molarless on the level of acetylcholine in rats hippocampus
    磨牙缺失后大鼠海马区乙酰胆碱含量改变的研究
短句来源
    Expression of presenilin-1 in hippocampus area of brain in rats during chronic cerebrovascular insufficiency
    慢性脑灌注不足大鼠海马区早老素-1的表达
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  “hippocampus”译为未确定词的双语例句
    Gene Expression Profile of Hippocampus and Cortex of Rat in Aβ_(1-40) -induced Rat Model for Alzheimer's Disease.
    Aβ_(1-40)诱导痴呆大鼠脑海马及皮质基因表达谱差异的实验研究
短句来源
    CONCLUSION Down-regulated anti-apoptotic PI3K/Akt/p70S6K signalingpathway induced by Aβ25-35 in rat hippocampus may contribute to the neuronal damage in AD.
    LY294002可明显减弱布洛芬上调磷酸化Akt/PKB和磷酸化p70S6K表达的作用。 结论 Aβ25-35引起抗凋亡通路PI3K/Akt/p70S6K下调可能参与AD的神经元损伤。
短句来源
    Objective: To evaluate the nitric oxide(NO) levels in rat brain cortex and hippocampus after chronic mild stress.
    目的:观察慢性应激(chronic mild stress,CMS)抑郁模型大鼠局部脑区一氧化氮(nitric oxide,NO)含量的变化,结合行为学改变,探讨抑郁的发病机理。
短句来源
    Objective To observe the survival, migration and effect of mouse embryonic neural stem cells (NSCs) after NSCs transplantation into the hippocampus of APP/PS1 double transgenic mice of Alzheimer disease (AD).
    目的在APP/PS1双转基因阿尔茨海默病(Alzheimer disease,AD)小鼠观察神经干细胞(nerual stem cells,NSCs)移植后细胞的存活、迁移以及对小鼠记忆功能的影响。
短句来源
    Objective To investigate the effects of intracerebroventricular(ICV) administration of streptozotocin(STZ) on expression of PSD-95 and Shank1 in rat hippocampus.
    目的观察侧脑室注射链脲佐菌素对大鼠脑PSD-95和Shank1表达的影响。
短句来源
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  hippocampus
The rCBF of the right frontal lobe and hippocampus was also detected by the PerifluxPF model laser Doppler flowmetry, and the expressions of c-fos or c-jun or Bcl-2 and Bax were also measured by immune histochemistry S-P method accordingly.
      
Results showed that the rCBF of the right frontal lobe and hippocampus in the operation group was significantly lower than that in the false operation group (P >amp;lt; 0.05).
      
In conclusion, rCBF decrease can impair the learning and memory function in rats, which may be related to the increase of the expression ratio of c-fos or c-jun or Bcl-2 or Bax in the frontal cortex and hippocampus.
      
Proliferative Activity of Matrix Cells in the Lateral Ventricles and Granule Cells in the Dentate Gyrus of the Rat Hippocampus u
      
The stem and progenitor cells, as well as neuro- and gliogenesis, are most explored in the hippocampus and olfactory bulb.
      
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Nerve growth factor (NGF) was in-jected intraventricularly into the aged(24 months) rats with unilateral lesionsof the lateral fimbria. The activities ofcholine acetyltransferase (CHAT) weredetermined in the septum and hippocam-pus from the normal rats, the lesionedcytochrome C-treated rats (controls),and the lesioned and NGF-treated ratsat different times after the lesion. NGF-injection for 15 days after the lesionresulted in an increase of the CHATactivity in both the contralateral hippo-campus and the entire...

Nerve growth factor (NGF) was in-jected intraventricularly into the aged(24 months) rats with unilateral lesionsof the lateral fimbria. The activities ofcholine acetyltransferase (CHAT) weredetermined in the septum and hippocam-pus from the normal rats, the lesionedcytochrome C-treated rats (controls),and the lesioned and NGF-treated ratsat different times after the lesion. NGF-injection for 15 days after the lesionresulted in an increase of the CHATactivity in both the contralateral hippo-campus and the entire septum, to about130% of that in the normal animals,but resulted in a slight increase in theipsilateral lesioned hippocampus whencompared with the activity in the ipsi-lateral side of the cytochrome C-treatedcontrols. NGF-injection for 30 days afterthe lesion resulted in a 48% increase ofthe CHAT activity in the ipsilateralhippocampus as compared with the cyto-chrome C-treated controls, but failed toinduce a significant increase in the con-tralateral hippocampus. These findingsindicate that atrophic cholinergic neuronsin aged animals are similarly responsiveto NGF treatment, like those in theyoung animals. The action mechanism ofNGF was discussed.

将老年大白鼠(24个月)左侧海马繖部分切断,建立基底前脑胆碱能损害的老年痴呆动物模型。予侧脑室注射神经生长因子(NGF),分别在用药后15天和30天测隔区和海马胆碱乙酰转移酶(ChAT)活性。以正常鼠组和细胞色素C注射组作为对照。损害后隔区和同侧海马ChAT活性显著减少;NGF15天治疗组,隔区和损害对侧海马酶活性显著增加,是正常组的130%;30天治疗组,同侧海马酶活性比细胞色素C组增加48%。结果表时,NGF对老年鼠基底前脑胆碱能系统损害的治疗是有效的。本文还讨论了NGF在损害后急、慢性期的作用机制。

Abstract In a series of 300 brain autopsies, 18 cases were diagnosed as Alzheimer's disease(AD) with 10 male and 8 female average age 71.2 years(61 to 86) and courses of disease 0.5 to 6 years. All of them presented some degree of intellectual impairment. The clinical symptoms Progressed gradually. Pathologically, in all cases brain atrophy (mild degree in 6 cases, moderate degree in 8 cases and severe degree in 4 cases)was observed.Microscopically large amount of senile Plaques(SP) and neurofibrillary tangles(NFT)...

Abstract In a series of 300 brain autopsies, 18 cases were diagnosed as Alzheimer's disease(AD) with 10 male and 8 female average age 71.2 years(61 to 86) and courses of disease 0.5 to 6 years. All of them presented some degree of intellectual impairment. The clinical symptoms Progressed gradually. Pathologically, in all cases brain atrophy (mild degree in 6 cases, moderate degree in 8 cases and severe degree in 4 cases)was observed.Microscopically large amount of senile Plaques(SP) and neurofibrillary tangles(NFT) were found in brain cortex and hippocampus. In 8 cases, GVD were found in hippocampus. In all 18 cases cortical neurons were significantly decreased in comparison with control group(P<0.001). Eleven AD cases were accompanied by amyloid cerebral angiopathy.

在连续300例尸检脑标本中,筛选出60岁以上18例Alzheimer病(AD),占6%;病程6个月~6年,均表现不同程度的智能障碍。18例病理检查见重度脑萎缩4例,中度8例,轻度6例;镜下于脑叶皮质和海马区见大量老年斑及神经原纤维缠结,8例海马区有颗粒空泡变性。18例脑皮质神经元均明显减少,与对照组比较差异有非常显著性(P<0.0001)。11例AD并存有淀粉样脑血管病。

An unilateral transection of the fimbria-fornix of aged rat was made in order to establish an animal model of senile dementia. The fetal septal or mixed septal and locus ceruleus tissue suspension was implanted to bilateral hippocampi of the lesion aged rats. After 16 weeks, ChAT and TH immunocytochemistry were used to observe the survival,growth and connection with host hippocampus of the grafts. AChE histochemistry was applied to study the distribution of the cholinergic fibers in host hippocampus...

An unilateral transection of the fimbria-fornix of aged rat was made in order to establish an animal model of senile dementia. The fetal septal or mixed septal and locus ceruleus tissue suspension was implanted to bilateral hippocampi of the lesion aged rats. After 16 weeks, ChAT and TH immunocytochemistry were used to observe the survival,growth and connection with host hippocampus of the grafts. AChE histochemistry was applied to study the distribution of the cholinergic fibers in host hippocampus and to quantify the cholinergic fiber densities in CA1,CA3 and dentate gyrus. The results showed that both septal and combined grafts could survive,the graft septal mass was larger than the combined one.Inside the graft,the abundant ChAT positive neurons distributed more in the center or along the boundary with host hippocampus.A few TH positive neurons were dispersed.The quantitative study of AChE-positive fibers showed that the mean fiber densities of CA1,CA3 and dentate gyrus were all significantly decreased in lesion ipsilateral hippocampi compared to that in control rats. The septal grafts could mostly reinnervate the lesioned hippocampi in all three areas,but the combined grafts could only increase the fiber density in CA1, it had no effect on CA3 and dentate gyrus.The combined septal with locus ceruleus graft did not act as well as the septal graft.

以单侧横断老年大鼠穹窿伞的方法建立老年性痴呆模型,并将胚胎隔或隔与蓝斑联合移植物悬液注入模型鼠的双侧海马;16周后用胆碱乙酰转移酶(ChAT)及酪氨酸羟化酶(TH)免疫细胞化学法观察移植物的存活、生长及与宿主海马的关系;用乙酰胆碱酯酶组织化学染色法观察宿主海马内胆碱能纤维的分布并定量CA1、CA3及齿状回中的纤维密度。结果表明:隔及联合移植物均能存活,但隔移植物生长体积明显大于联合移植物,移植物中ChAT阳性神经元丰富,多分布于团块中央及与宿主海马交界处,偶见TH阳性神经元分散分布。损伤侧海马CA1、CA3及齿状回纤维密度较之老年对照组明显下降,隔移植物使损伤侧海马大部分重获胆碱能纤维支配,联合移植物只少量提高损伤鼠CA1区纤维密度,而对CA3及齿状回无影响。隔与蓝斑联合移植的效果不如单纯隔移植。

 
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