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hippocampus
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  海马
    Effects of Antidepressant Paroxetine on the Changes of Histology and Behavior in Rats Hippocampus Induced by Stress and Their Relationships with CREB-related Signal Cascades
    抗抑郁药帕罗西汀对应激所致大鼠海马组织学和行为学改变的影响及与CREB相关信号通路的关系
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    The Regulation of Respiration in Rat by Hippocampus and the Effects of Ca~(2+) on the Respiratory Inhibition Induced by Opioids
    大鼠海马对呼吸的调控及Ca~(2+)对阿片类物质呼吸抑制作用的影响
短句来源
    Decreasing in Somatostatin Level in Hippocampus of Rats Induced by Lead
    铅对大鼠海马生长抑素的影响
短句来源
    Effect of succinyl cholecystokinin heptapeptide on synaptosomal 45Ca uptake of mouse hippocampus
    琥珀酰缩胆囊素七肽对小鼠海马突触体摄取~(45)Ca的影响(英文)
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    Effects of ketamine on activity of Na~+, K~+-ATPase in rat cerebral cortex, brain stem,corpus striatum and hippocampus in vivo
    氯胺酮对大鼠大脑皮质、脑干、纹状体和海马Na~+,K~+-ATP酶活性的影响
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  海马组织
    3H- QNB and 3H- GABA were used as radioactive ligand for M- and GABA receptors respectively. M- and GABA receptors were assayed by radioligand binding assay (RBA) in cerebral cortex, hippocampus and cerebellum of analogue dementia rats.
    以~3H-QNB和~3H-GABA为放射性配基,用受体放射性配基结合分析法,测出拟痴呆模型大鼠大脑皮层和海马组织中的M受体和小脑组织中的GABA受体的R_t值明显降低;
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    The cAMP level was evaluated by the radioimmunoassay. RESULTS: Compared with sham-operated group, the learning abilities and memory of model group was worse (P<(0.05)) and the cAMP level in frontal cortex and hippocampus was lower (P<0.05);
    结果:与假手术组比较,模型组学习和记忆成绩均降低(P<0.05),且额叶皮层和海马组织cAMP水平也降低(P<0.05);
短句来源
    compared with model group, the learning abilities and memory of DHE group was better (P<0.05) and the cAMP level in frontal cortex and hippocampus was higher (P<0.05).
    而与模型组比较,双氢麦角碱组学习和记忆成绩均改善(P<0.05),且额叶皮层和海马组织cAMP水平也升高(P<0.05)。
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    RT-PCR results showed that in the PND7 group, intraperitoneal injection of ketamine resulted in an increased expression of NR2A, NR2B and NR2C subunit mRNAs in the hippocampus. No such change was observed in the expression of NR1 subunit mRNA.
    RT-PCR结果显示在PND7组,腹腔注射氯胺酮引起海马组织内NR2A,NR2B和NR2C亚型mRNA的表达上调,NR1受体亚型mRNA的表达无明显变化。
短句来源
    Conclusion ZD7288 could obviously inhibit synaptic transmission in the pathway from PP fibers to CA3 region in rat hippocampus, and this action of ZD7288 may be associated with altered contents of amino acids.
    结论 ZD7288可显著抑制大鼠穿通纤维—海马CA3区突触传递,并可降低海马组织氨基酸含量。
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  “hippocampus”译为未确定词的双语例句
    EFFECTS OF MORPHINE ON THE FORMALIN INDUCED IL-2RβmRNA EXPRESSION OF RAT HIPPOCAMPUS
    吗啡对福尔马林引起大鼠海马内IL-2RβmRNA表达的影响
短句来源
    Modification of GABAA receptor subunit expression in audiogenic seizure rat cortex and hippocampus following tolerance to flurazepam and reversal of tolerance by co-administration of Ro 15-4513
    用Ro 15-4513逆转氟西泮耐受性并观察GABA_A受体亚单位表达的影响
短句来源
    EFFECT OF MELATONIN ON CaM AND CaMKⅡ ACTIVITY IN HIPPOCAMPUS AND BRAINSTEM OF MORPHINE WITHDRAWAL RATS
    褪黑素对吗啡戒断大鼠脑内CaM和CaMKⅡ活性的影响
短句来源
    Relation between adenosine A_1 receptor and NMDA receptor on synaptic transmission in dentate gyrus of hippocampus
    腺苷A_1受体和NMDA受体在海马齿状回突触传递活动中的关系
短句来源
    Dose-effect dependence of ketamine in inducing the expression of heat shock protein 70 in the hippocampus of rats of different ages
    氯胺酮诱导不同年龄大鼠脑海马区热休克蛋白70表达的量效依赖性(英文)
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  hippocampus
The rCBF of the right frontal lobe and hippocampus was also detected by the PerifluxPF model laser Doppler flowmetry, and the expressions of c-fos or c-jun or Bcl-2 and Bax were also measured by immune histochemistry S-P method accordingly.
      
Results showed that the rCBF of the right frontal lobe and hippocampus in the operation group was significantly lower than that in the false operation group (P >amp;lt; 0.05).
      
In conclusion, rCBF decrease can impair the learning and memory function in rats, which may be related to the increase of the expression ratio of c-fos or c-jun or Bcl-2 or Bax in the frontal cortex and hippocampus.
      
Proliferative Activity of Matrix Cells in the Lateral Ventricles and Granule Cells in the Dentate Gyrus of the Rat Hippocampus u
      
The stem and progenitor cells, as well as neuro- and gliogenesis, are most explored in the hippocampus and olfactory bulb.
      
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Scopolamine and anisodine are alike in chemical structure, except that anisodine possesses a hydroxyl group on the α-carbon atom of the tropic acid moiety. In this paper, the results of a comparative study on the physiological dispositions of scopolamine and anisodine, both labeled with ~3H by the Wilzbach technic, are reported.Biological materials were extracted with chloroform at an alkaline pH. The chloroform layer was separated and washed with phosphate buffer of pH 8. An aliquet of the extract was transferred...

Scopolamine and anisodine are alike in chemical structure, except that anisodine possesses a hydroxyl group on the α-carbon atom of the tropic acid moiety. In this paper, the results of a comparative study on the physiological dispositions of scopolamine and anisodine, both labeled with ~3H by the Wilzbach technic, are reported.Biological materials were extracted with chloroform at an alkaline pH. The chloroform layer was separated and washed with phosphate buffer of pH 8. An aliquet of the extract was transferred to a counting vial and evaporated to dryness. After addition of 5 ml of scientillation liquid (toluene containing ppo 0.5%, popop 0.03% or dioxane containing ppo 0.4%, popop 0.002%, naphthalene 6%) the samples were counted in a scientillation counter (Model F3-353, Hsi-an). The measured radioactivity was shown to be unchanged ~3H-scopolamine or ~3H-anisodine by specificity tests using thin layer chromatography.Both ~3H-scopolamine and ~3H-anisodine were found to be well absorbed from rat intestine in situ, but it seemed that ~3H-scopolamine was absorbed more rapidly and more completely than ~3H-anisodine. After a single intravenous injection of ~3H-scopolamine or ~3H-anisodine, a plot of the logarithm of drug concentration in plasma versus time yielded a curve with two distinct linear components. For ~3H-scopolamine and ~3H-anisodine, the T1/2 α were found to be 11 and 13 minutes, and the T1/2β were 95 and 70 minutes, respectively. When given intravenously, the highest levels of ~3H-scopolamine and ~3H-anisodine were found in the lungs and kidneys respectively. The content of both drugs in the brain was higher than that in the plasma. The distribution patterns of the two drugs over the various regions of the brain were similar: highest levels were found in the striatum, cerebral cortex and hippocampus, moderate levels were found in the septum and diencephalon, and very low levels were obtained in the lower brain stem and cerebellum. The contents of ~3H-scopolamine in the brain sections were signi-Ficantly higher than those of ~3H-anisodine, although their contents in plasma were similar.Following an intravenous dose of ~3H-scopolamine and ~3H-anisodine, the total radioactivity excreted in urine was 62% and 78% respectively within 48 hours, while those excreted in feces was 25% and 12.5% respectively. In rats with a biliary cannula, 40% and 20% respectively of an intravenous dose of ~3H-scopolamine and ~3H-anisodine could be recovered from the bile collected within 48 hours. In the urine, feces or bile, about 1/7 to 1/4 of the excreted total radioactivity was shown to be unchanged drug.~3H-scopolamine and ~3H-anisodine were shown to be metabolized by rat liver as well as by plasma. ~3H-anisodine was shown to be also metabolized by rat kidney slices. Both drugs were rapidly metabolized by liver, kidney and plasma of the rabbit. In this animal, it seemed that the metabolism of ~3H-scopolamine was more rapid than that of ~3H-anisodine.

给大鼠灌胃~3H-东莨菪碱与~3H-樟柳碱后,吸收都好,但前者的吸收比后者更快更完全。静脉注射后,前者的T1/2α为11分钟,T1/2β为95分钟,后者的T1/2α为13分钟,T1/2β为70分钟。静脉注射后二者的组织浓度均以肺与肾最高,脑内的浓度都比血浆内者高。两药在脑的分布形式相似,以纹状体、大脑皮层及海马较多,膈区和间脑次之,低位脑干和小脑较低。虽然两药的血浆浓度相似,但在脑内各区的分布~3H-东莨菪碱明显高于~3H-樟柳碱。 两药静脉注射后,仅很小部分原形药从尿及粪排出,大部分以转化形式排出。两药都可被大鼠肝和血浆所转化,家兔的肝、肾和血浆也有这种活性,而且更强。~3H-东莨菪碱的转化速度明显地比~3H-樟柳碱快。 ~3H-东莨菪碱与~3H-樟柳碱在代谢上的差异可能与后者托品酸部分多一羟基因而极性较大有关。

1.In this work the technique of perfusion of cerebral ventricular system inconscious rabbits was applied to the study of 5-hydroxytrytamine(5-HT)releaseand the effect of Midaflur on it.Midaflur(4mg/kg i.v)could not directly modify5-HT release in brain in conscious rabbits,but the increase in the 5-HT releasewas observed in rabbit struggling with the procedure of injection of Midaflur.Therefore,the behavior of the conscious rabbits must be considered in studyingthe effect of drugs on the release of neurotransmitters...

1.In this work the technique of perfusion of cerebral ventricular system inconscious rabbits was applied to the study of 5-hydroxytrytamine(5-HT)releaseand the effect of Midaflur on it.Midaflur(4mg/kg i.v)could not directly modify5-HT release in brain in conscious rabbits,but the increase in the 5-HT releasewas observed in rabbit struggling with the procedure of injection of Midaflur.Therefore,the behavior of the conscious rabbits must be considered in studyingthe effect of drugs on the release of neurotransmitters in brain by perfusion of thecerebral ventricular system.2.Dopamine content was determined by the spectrophotofluorometric me-thod.The experimental results demonstrated that no significant change in dopa-mine content in caudate nucleus as well as in hippocampus was observed duringthe muscle relaxing.

1.用~3H-5-羟色胺脑室灌流清醒动物的方法,测定了脑内5-羟色胺的释放。实验结果表明,给兔静注咪达氟(4mg/kg)后,因动物挣扎引起5-羟色胺释放加强,可能咪达氟不直接加强兔脑5-羟色胺的释放。因此,必须指出,在用清醒动物脑室灌流的方法研究药物对神经递质释放是否有影响时,必须考虑到清醒动物的活动状态。2.用荧光方法测定了多巴胺含量。实验结果表明,给兔静注眯达氟(4或8mg/kg)以后10分钟,颈部和前肢产生明显肌松时海马中多巴胺含量虽有增加的趋势,但无统计学意义,尾核中多巴胺含量基本不变。因此,可以认为咪达氟所引起的肌肉松弛可能与脑内多巴胺含量关系不大。

By means of radioimmunoassay of enkephalin rats which have been exposed to 60Co γ-ray of 800 rad in 1,12,24,72, 144 hours and to be compared with those of 200, 400, 800 rad exposures for three days were studied. Contents of leu-enkephalin (Leu-enk) showed significant increase after 800 rad irradiation in seven regions of the brain (corpus striatum, nucleus accombens, hypothalamus, hippocampus, thalamus, brain stem and cerebral cortex) While the content of Met-enk was reducd in early and then increased....

By means of radioimmunoassay of enkephalin rats which have been exposed to 60Co γ-ray of 800 rad in 1,12,24,72, 144 hours and to be compared with those of 200, 400, 800 rad exposures for three days were studied. Contents of leu-enkephalin (Leu-enk) showed significant increase after 800 rad irradiation in seven regions of the brain (corpus striatum, nucleus accombens, hypothalamus, hippocampus, thalamus, brain stem and cerebral cortex) While the content of Met-enk was reducd in early and then increased. However, with a third day irradiation of 200, 400,and 800rad, Leu-enk in hypothalamus and nucleus accombens increased accordingly while Met-enk did not show similar changes.

应用脑啡肽放射免疫测定法,研究大鼠受~(60)Co-r射线800 rad照后第1、12、24、72和144小时,以及比较200、400和800rad照后第3天有关脑区脑啡肽含量的变化,发现800 rad照后大鼠的7个脑区(纹状体、伏隔核,下丘脑,海马,丘脑,脑干和皮层)亮氨酸脑啡肽(Leu-enk)含量均明显增加,而甲硫氨酸脑啡肽(Met-enk)先下降,尔后上升;200、400和800 rad照后第3天,下丘脑和伏隔核的LEK含量随照射剂量增加而增加,而MEK无类似的变化。

 
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