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target plasma concentration
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  血浆靶浓度
     The propofol was maintained at a target plasma concentration of 3 μg/ml.
     丙泊酚血浆靶浓度均为3μg/ml,与舒芬太尼同时靶控输注,直至气管插管后5min停止输注。
短句来源
     group B and C received TCI of midazolam (initial target plasma concentration 60 ng·ml-1).
     C组在BIS指导下咪达唑仑TCI镇静,初始血浆靶浓度为60 ng/ml。
短句来源
     The patients were randomized to receive fentanyl by TCI at a target plasma concentration of 1.0, 1.5, 2.25 or3.38 ng·ml-1 . The target plasma propofol concentration was set at 3 μg·ml-1 in all patients.
     麻醉诱导时通过TCI系统使所有病人异丙酚血浆靶浓度达到和维持3μg/ml,使各组芬太尼的血浆靶浓度分别达到1.00、1.50、2.25、3.38 ng/ml。
短句来源
     4 min later propofol was given by TCI system. The initial target plasma concentration was set at 1.0μg·ml-1 and was increased by 0.2μg·ml-1 every 3 min until OAA/S score reached 1 (5 = alert, 1 = does not respond to prodding) .
     4 min后以血浆靶浓度(Cp)1.0μg/ml TCI异丙酚,以后每3分钟递增0.2μg/ml,直至警觉/清醒评分(OAA/S评分)达到1分。
短句来源
     Anesthesia was induced with TCI of propofol at target plasma concentration of 3μg·ml-1 . TCI of remifentanil was started 5 min later.
     靶控输注异丙酚,血浆靶浓度为3μg/ml,5min后R2组、R4组、R6组分别靶控输注血浆靶浓度为2、4、6 ng/ml瑞芬太尼,R0组静脉注射3μg/kg芬太尼,3min后气管插管。
短句来源
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  靶浓度
     The propofol was maintained at a target plasma concentration of 3 μg/ml.
     丙泊酚血浆靶浓度均为3μg/ml,与舒芬太尼同时靶控输注,直至气管插管后5min停止输注。
短句来源
     group B and C received TCI of midazolam (initial target plasma concentration 60 ng·ml-1).
     C组在BIS指导下咪达唑仑TCI镇静,初始血浆靶浓度为60 ng/ml。
短句来源
     The patients were randomized to receive fentanyl by TCI at a target plasma concentration of 1.0, 1.5, 2.25 or3.38 ng·ml-1 . The target plasma propofol concentration was set at 3 μg·ml-1 in all patients.
     麻醉诱导时通过TCI系统使所有病人异丙酚血浆靶浓度达到和维持3μg/ml,使各组芬太尼的血浆靶浓度分别达到1.00、1.50、2.25、3.38 ng/ml。
短句来源
     4 min later propofol was given by TCI system. The initial target plasma concentration was set at 1.0μg·ml-1 and was increased by 0.2μg·ml-1 every 3 min until OAA/S score reached 1 (5 = alert, 1 = does not respond to prodding) .
     4 min后以血浆靶浓度(Cp)1.0μg/ml TCI异丙酚,以后每3分钟递增0.2μg/ml,直至警觉/清醒评分(OAA/S评分)达到1分。
短句来源
     Each target plasma concentration of propofol lasted for 12 min.
     每个靶浓度维持12min,双盲记录患者意识清醒.
短句来源
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  预期血药浓度
     Feasibility of application of propofol target plasma concentration and effect-site concentration to predict sedation level
     丙泊酚预期血药浓度和效应室浓度用于判断镇静深度的可行性研究
短句来源
     Methods Twelve ASA physical status of Ⅰ Ⅱ patients were anesthetized with target plasma concentration infusion of propofol,which increased in an increment of 0 5 1mg/L. After loss of consciousness,the propofol infusion rate was decreased in an increment of 0 5 1mg/L until the recovery of consciousness. Each target concentration was lasted for 12min.
     方法 选择ASAⅠ~Ⅱ级的择期手术患者 12例 ,以 0 5~ 1mg/L的预期血药浓度梯度 ,逐步上下调整靶控预期血药浓度给予术中镇静 ,每一预期浓度维持 12分钟。
短句来源
     Results Bispectral index (P k=0.817) and target plasma concentration (P k=0.841) differ significantly from propofol effect-site concentration (P k=0.908) in their ability to predict loss of consciousness.
     结果 预期血药浓度、效应室浓度和BIS等指标预测意识消失的Pk 平均值分别为 :0 841,0 90 8和 0 817。
短句来源
  “target plasma concentration”译为未确定词的双语例句
     those between BIS, AEPindex and the target plasma concentration of propofol were -0.932,-0.888 and -0.920,-0.923 (P<0.001).
     与异丙酚靶控浓度的相关系数分别为-0.932,-0.888和-0.920,-0.923(P<0.001)。
短句来源
     Tracheal intubation was performed with scopolamine 0.3 mg,midazolam 0.05 mg/kg,fentanyl 2 μg/kg,vecuronium 0.08 mg/kg bromide and propofol at a fixed target plasma concentration of 8 μg/ml.
     D组:为对照组,无任何表面麻醉。 诱导方法:东莨菪碱0.3mg、咪达唑仑(咪唑安定)0.05mg/kg,芬太尼2μg/kg、维库溴铵0.08mg/kg、丙泊酚采用血浆靶控8μg/ml输注。
短句来源
     The coefficient of correlation(r) between AAI and the target plasma concentration of propofol was-0.923(P<0.001).
     AAI与丙泊酚靶控浓度的相关系数为-0.923(P<0.001)。
短句来源
     Results The measured concentrations (Cm) of remifentanil were significantly lower than the target plasma concentration (Cp) at5, 10, 20 min of TCI in both groups ( P < 0.05) .
     结果在TCI 5、10、20 min时,两组瑞芬太尼Cm均低于Cp(P<0.05)。
短句来源
     Methods Twenty patients(ASA class Ⅰ-Ⅱ) scheduled for elective lower limb operations under epidural anesthesia were studied. TCI of propofol was initiated at target plasma concentration of 0.5 μg/ml,and increased by 0.3 to 0.5 μg/ml until loss of consciousness,and then decreased until consciousness recovery.
     方法随机选择20例美国麻醉医师协会(ASA)分级Ⅰ ̄Ⅱ级行择期下肢手术患者,硬膜外麻醉完善后,异丙酚TCI起始血药浓度为0.5μg/ml,然后以0.3 ̄0.5μg/ml的梯度递增直至意识消失,再递减至意识恢复。
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  target plasma concentration
The system employed a pharmacokinetic model working in real time to deliver any selected target plasma concentration of alfentanil.
      
Results: Of the 20 patients, 18 attained the target plasma concentration, and 16 of these achieved this initially or with just one dose adjustment.
      
The initial target plasma concentration for alfentanil after bypass was between 60 and 80 ng/mL.
      
The corresponding mean SC-57461 plasma concentration, taken to be the target plasma concentration for efficacy, was 0.4 g/ml.
      
Potential endpoints in phase I are dose limiting toxicity, target plasma concentration or inhibition of a relevant biomarker.
      
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Objective To evaluate the effects of fentanyl and lidocaine on hypnotic effect of propofol in total intravenous anesthesia(TIVA) Methods One hundred and sixty ASAI Ⅲ patients(86 male,74 female) aged (55 0±12 4)yr,weighing (58 0±9 8)kg,scheduled for elective surgery were randomly divided into propofol group(group P,n=30), propofol fentanyl group(group PF,n=52) and propofol lidocaine group (group PL,n=78) Patients with kidney and liver dysfunction, hypertension, neurological and mental disease...

Objective To evaluate the effects of fentanyl and lidocaine on hypnotic effect of propofol in total intravenous anesthesia(TIVA) Methods One hundred and sixty ASAI Ⅲ patients(86 male,74 female) aged (55 0±12 4)yr,weighing (58 0±9 8)kg,scheduled for elective surgery were randomly divided into propofol group(group P,n=30), propofol fentanyl group(group PF,n=52) and propofol lidocaine group (group PL,n=78) Patients with kidney and liver dysfunction, hypertension, neurological and mental disease were excluded All patients were premedicated with intramuscular phenobarbital 0 1g and atropine 0 5mg BP,HR,SpO 2 and BIS were continuously monitored The patients were anesthetized by TIVA with TCI The target plasma concentration for fentanyl was 2μg/L(group PF) and for lidocaine 4mg/L(group PL) The initial target plasma concentration of propofol was set at 1mg/L When pre set concentration was reached, target propofol plasma concentration was increased by increments of 0 5mg/L until loss of consciousness Blood samples were taken before anesthesia(T 0), loss of consciousness(T 1), immediately after intubation(T 2), at skin incision(T 3), 5 and 10 min after skin incision(T 4,T 5), when TIVA was ended (T 6) and when the patient waked up(T 7) for determination of plasma concentrations of propofol, fentanyl and lidocaine Results ED 90 and ED 50 of propofol for loss of consciousness were lower in group PF and PL than those in group P but the difference was of no statistical significance (P<0 05) Cp 50 and Cp 90 of propofol required for loss of consciousness in group PF and group PL were significantly lower than those in group P(P<0 05) The dose of propofol required for maintenance of anesthesia were reduced by 29 9% in group PF and 23 9% in group PL Systolic and diastolic blood pressure increased significantly after intubation and at skin incision in group P and group PL There was little difference in PE, MDAPE and MDPE of proplfol, fentanyl and lidocaine concentrations in the three groups Conclusions The dose response curve showed that fentanyl , lidocaine and propofol interact additively at loss of consciousness but plasma concentration response curve shows that they interact synergistically A possible explanation for this discrepancy may be related to the pharmacokinetic profile of the drug given Fentanyl and lidocaine reduce significantly the dose of propofol required for loss of conciousness, inhibit hemodynamic responses to tracheal intubation and skin incision

目的 比较芬太尼和利多卡因对异丙酚催眠作用的影响。方法  16 0例择期手术病人分为三组 ,分别采用靶控输注异丙酚 (P组 ,n =30 )、异丙酚 芬太尼 (PF组 ,n =5 2 )或异丙酚 利多卡因(PL组 ,n =78)全静脉麻醉。芬太尼和利多卡因目标血药浓度分别为 2 μg/L、4mg/L。术中行无创血液动力学监测和脑电监测 ,记录麻醉剂用量及麻醉恢复情况。应用高效液相色谱测定异丙酚、利多卡因血药浓度 ,放免法测定芬太尼血药浓度。结果 与P组相比 ,PF组、PL组麻醉诱导意识消失时异丙酚用量ED90 、ED50 无显著性差异 ,意识消失时异丙酚血药浓度Cp90 和Cp50 均明显降低 ,异丙酚麻醉维持用量分别降低 2 9 9%、2 3 9% (P <0 0 5 )。PF组气管插管、切皮前后收缩压 (SP)、舒张压 (DP)无明显改变 ,P组、PL组升高 ,以P组明显 (P <0 0 5 )。三组异丙酚、芬太尼和利多卡因预测误差 (PE)、预测误差绝对值的中位数 (MDAPE)和预测误差的中位数 (MDPE)无明显差异。结论 芬太尼、利多卡因对异丙酚催眠剂量 -反应曲线表现为相加作用 ,浓度 -...

目的 比较芬太尼和利多卡因对异丙酚催眠作用的影响。方法  16 0例择期手术病人分为三组 ,分别采用靶控输注异丙酚 (P组 ,n =30 )、异丙酚 芬太尼 (PF组 ,n =5 2 )或异丙酚 利多卡因(PL组 ,n =78)全静脉麻醉。芬太尼和利多卡因目标血药浓度分别为 2 μg/L、4mg/L。术中行无创血液动力学监测和脑电监测 ,记录麻醉剂用量及麻醉恢复情况。应用高效液相色谱测定异丙酚、利多卡因血药浓度 ,放免法测定芬太尼血药浓度。结果 与P组相比 ,PF组、PL组麻醉诱导意识消失时异丙酚用量ED90 、ED50 无显著性差异 ,意识消失时异丙酚血药浓度Cp90 和Cp50 均明显降低 ,异丙酚麻醉维持用量分别降低 2 9 9%、2 3 9% (P <0 0 5 )。PF组气管插管、切皮前后收缩压 (SP)、舒张压 (DP)无明显改变 ,P组、PL组升高 ,以P组明显 (P <0 0 5 )。三组异丙酚、芬太尼和利多卡因预测误差 (PE)、预测误差绝对值的中位数 (MDAPE)和预测误差的中位数 (MDPE)无明显差异。结论 芬太尼、利多卡因对异丙酚催眠剂量 -反应曲线表现为相加作用 ,浓度 -反应曲线表现为协同作用 ,此差异可能与药代动力学影响有关。芬太尼、利多卡因能减少异丙酚用量 ,抑制气管插管、切皮的血液动力学反应 ,以芬太尼作用明显。

Objective To investigate the influence of continuous infusion of tramadol on target plasma propofol concentration during maintenance of anesthesia with target-controlled infusion (TCI) system. Methods Fifty ASA Ⅰ - Ⅱ patients (22 male, 28 female) aged between 20-70 yr and weighing 42-85 kg, were randomly divided into two groups of 25 patients each: in group Ⅰ anesthesia was maintained with propofol given by TCI; in group Ⅱ anesthesia was maintained with propofol given by TCI and continuous...

Objective To investigate the influence of continuous infusion of tramadol on target plasma propofol concentration during maintenance of anesthesia with target-controlled infusion (TCI) system. Methods Fifty ASA Ⅰ - Ⅱ patients (22 male, 28 female) aged between 20-70 yr and weighing 42-85 kg, were randomly divided into two groups of 25 patients each: in group Ⅰ anesthesia was maintained with propofol given by TCI; in group Ⅱ anesthesia was maintained with propofol given by TCI and continuous tramadol infusion (loading dose 3 mg·kg and 0.5 mg·kg ·h for maintenance). The patients were premedicated with intramuscular scopolamine 0.3 mg. Anesthesia was induced with midazoiam 0.035 mg·kg-1, fentanyl 0.1 mg, target plasma propofol concentration 2.5-3.5 μg·ml-1 and vecuronium 0.1-0. 15mg·kg . After tracheal intubation the patients were mechanically ventilated. During maintenance of anesthesia BIS was maintained at 50 ± 10 by adjustment of target plasma propofol concentration. BIS, MAP, HR, HRV and LF/HF were continuously monitored. The total amount of propofol used during operation, the duration of surgery and time of recovery from anesthesia were recorded. Results There was no significant difference in BIS value between the two groups. Target plasma concentration of propofol was significantly higher at skin incision and extubation in group Ⅰ than that in group Ⅱ (P<0.05), hut there was no significant difference in the total amount of propofol used during operation, duration of operation and time of recovery from anesthesia between the two groups. HRV increased at the end of operation in group Ⅰ . HR was significantly faster at skin incision and during operation in group Ⅰ than that in group Ⅱ . LF/HF was significantly higher before skin incision and during operation in group Ⅰ than in group Ⅱ.Conclusion Continuous infusion of tramadol during anesthesia does not markedly influence the TCI plasma propofol concentration, but the analgesic effect of tramadol can decrease the autonomic nervous system activities and make recovery from anesthesia smoother.

目的 观察麻醉中持续泵注曲马多对靶控输注(TCI)异丙酚麻醉血药浓度的影响。方法 随机将ASAⅠ~Ⅱ级病人50例分为两组(各25例),Ⅰ组单纯TCI异丙酚麻醉,Ⅱ组TCI异丙酚麻醉复合曲马多3mg/kg后以0.5 mg·kg-1·h-1持续泵注。以BIS值50±10来调节TCI血药浓度。麻醉中连续观察BIS、MAP、HR、异丙酚血药浓度(CP)、心率变异性(HRV)、LF/HF等指标,以及术中异丙酚用量和麻醉苏醒时间。结果 两组间BIS差异无显著性。Ⅰ组CP仅在切皮和拔管时显著高于Ⅱ组(P<0.05),而异丙酚总用量,苏醒及手术时间两组间差异无统计学意义。Ⅰ组仅在术毕时HRV高于Ⅱ组;切皮时和术中Ⅰ组HR明显高于Ⅱ组;Ⅰ组LF/HF在切皮前及术中较Ⅱ组显著升高。结论 持续泵注曲马多对TCI异丙酚麻醉血药浓度无明显影响,但曲马多的镇痛作用使其较单纯TCI异丙酚麻醉术中自主神经反应性下降,术后恢复期更加平稳。

Objective To study the feasibility of application of target propofol plasma concentrations,effect siteconcentrations,hemodynamic,bispectral index (BIS) to predict sedation level.Methods Twelve ASA physical status of Ⅰ Ⅱ patients were anesthetized with target plasma concentration infusion of propofol,which increased in an increment of 0 5 1mg/L.After loss of consciousness,the propofol infusion rate was decreased in an increment...

Objective To study the feasibility of application of target propofol plasma concentrations,effect siteconcentrations,hemodynamic,bispectral index (BIS) to predict sedation level.Methods Twelve ASA physical status of Ⅰ Ⅱ patients were anesthetized with target plasma concentration infusion of propofol,which increased in an increment of 0 5 1mg/L.After loss of consciousness,the propofol infusion rate was decreased in an increment of 0 5 1mg/L until the recovery of consciousness.Each target concentration was lasted for 12min.This was repeated until patients "crossed over"from unconsciousness to consciousness several times.The electroencephalogram was monitored continuously.Measurements of blood pressure and heart rate were recorded just before and at 3min after each stimulation during induction and awakening.The relationship between target concentration and response to a verbal command,as well as that between response and BIS and hemodynamics,was determined.Results The propofol target concentration and effect site concetration correlated with BIS negatively ( r= -0 414,-0 470)( P< 0 001).Sedation level correlated with systolic blood pressure,target propofol plasma concentration,effect site concentration,and BIS except for heart rate.Conclusions Target propofol concentration,effect site concentration,blood pressure,and BIS could be used to predict sedation level.Effect site concentration would be better to predict the depth of sedation than the other indicators.

目的 研究丙泊酚预期血药浓度、效应室浓度用于判断镇静深度的可行性。方法 选择ASAⅠ~Ⅱ级的择期手术患者 12例 ,以 0 5~ 1mg/L的预期血药浓度梯度 ,逐步上下调整靶控预期血药浓度给予术中镇静 ,每一预期浓度维持 12分钟。双盲记录预期浓度、血液动力学、BIS并计算各指标与镇静评分的相关性、预期浓度、血液动力学与BIS的相关性。结果 预期血药浓度和效应室浓度与BIS的相关系数分别为 - 0 414和 - 0 470 (P <0 0 0 1)。收缩压、预期血药浓度、效应室浓度和BIS指标与镇静深度相关性好 ,r分别为 0 2 6 1、- 0 6 43、- 0 72 2、0 5 35 (P <0 0 0 1)。结论 预期血药浓度、效应室浓度、血压和BIS等指标均可用于预测镇静深度 ,其中效应室浓度预测价值最大。

 
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