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osteosarcoma
相关语句
  骨肉瘤
    ESTABLISHING AND APPLIED STUDY OF IN VITRO MODEL OF BONE RESORPTION BY OSTEOSARCOMA CELL
    大鼠骨肉瘤细胞吸收骨质实验模型的建立与应用初探
短句来源
    Methods: Total RNA was extracted from human osteosarcoma cell line SOSP-9607,and the whole length gene of COPS3 was obtained by RT-PCR.
    方法:从培养的人骨肉瘤细胞系SOSP-9607细胞中提取总RNA,经RT-PCR获得COPS3基因。
短句来源
    Ultrastructure changes of osteosarcoma cells inactivated by alcohol in different concentrations
    不同浓度酒精灭活后的国人成骨肉瘤细胞超微结构的变化
短句来源
    Identification of specificity of anti human osteosarcoma mAb 5D3
    抗人骨肉瘤单克隆抗体5D3的特异性鉴定
短句来源
    Establishment and Preliminary Evaluation of Rat Animal Model Bearing a Transplantable Osteosarcoma
    大鼠移植骨肉瘤动物模型的建立及初步评价
短句来源
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  成骨肉瘤
    Ultrastructure changes of osteosarcoma cells inactivated by alcohol in different concentrations
    不同浓度酒精灭活后的国人成骨肉瘤细胞超微结构的变化
短句来源
    Rat osteosarcoma clonal cell line (ROS 17/2.8) is a target cell of parathyroid hormone (PTH).
    大鼠成骨肉瘤细胞株(ROS17/2.8)系甲状旁腺素(PTH)的靶细胞。
短句来源
    Objective To observe the synergistic action of 17β estradiol(E 2) and L ascorbic acid on the activity of alkaline phosphatase (ALP), cell proliferation and gene expression in osteosarcoma MG 63 cell line, and to study the mechanism of E 2 in treating osteoporosis.
    目的 研究雌二醇 (17β estradiol,E2 )和抗坏血酸 (VitC)对成骨肉瘤样细胞株MG 6 3的协同作用 ,从而探讨E2 治疗骨质疏松的作用机制。
短句来源
    5. The nude mouse bearing human osteosarcoma SOSP-9607 and SOSP-9901 was made by injection of these two tumor cells into the mouse back and then the animal models were used in the in vivo tumor growth inhibition experiment.
    效地杀伤肿瘤细胞,对正常人体细胞无毒副作用。 5.用成骨肉瘤细胞系(SOSP-9607及 SOSP-9901)制作荷瘤裸
短句来源
  “osteosarcoma”译为未确定词的双语例句
    Forskolin augments the effects of glucocorticoids on proliferation and differentiation of a human osteosarcoma cell line by up-regulation of glucocorticoid receptor
    Forskolin augments the effects of glucocorticoids on proliferation and differentiation of a human osteosarcoma cell line by u
短句来源
    Expression of core binding factor alpha 1 gene and osteoblast markers in human osteoblast-like TE 85 osteosarcoma cell line
    Cbfal基因与成骨细胞标志物在HOS TE85中的表达
短句来源
    (2) To extract human bone morphogenetic protein 2 gene(hBMP-2) cDNA from human osteosarcoma tissue and construct an Eukaryotic Expression Vector recombinated with this gene (pIRES2-EGFP-hBMP2).
    (2) 提取hBMP-2 cDNA,构建其真核表达载体pIRES2-EGFP-hBMP2。 (3) 将pIRES2-EGFP-hBMP2转染兔MSCs,观察hBMP-2 cDNA在兔MSCs的表达情况及其诱导成骨情况,探讨其作用机制。
短句来源
    Results The expression of cellular BMP and PCNA in the transfected osteosarcoma cells decreased obviously (t=24.01, 26.09, respectively, P
    结果 转染后, OS-9901肿瘤细胞的内源性 BMP表达明显下降 (t=24.01,P
短句来源
    Results showed that purified sTRAIL could inhibit osteosarcoma by 61% and 63.3% respectively.
    瘤的生长,抑制率分别达到61%及63.3%。
短句来源
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  osteosarcoma
Measurement of bone alkaline phosphatase and relative study with osteosarcoma
      
The objective of this paper is to explore the value of bone alkaline phosphatase (BALP) for diagnosing osteosarcoma, evaluating the effect of the chemotherapy, judging the prognosis and supervising the relapse and metastasis.
      
The immunoassay was used to check the BALP of the blood serum that was from 42 primary osteosarcoma patients.
      
BALP was more sensitive than ALP in diagnosing osteosarcoma (P = 0.015).
      
It has applied value in the diagnosis of osteosarcoma, reflection of the effect of chemotherapy and forecast the prognosis.
      
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Peroxidase-Antiperoxidase (PAP) soluble complex was prepared and used in immunoperoxidase visualization of microtubules and microtubular proteins in human esophageal carcinoma ECa109, stomach cancer SGC7901, breast cancer MCF7 and osteosarcoma OS732 cell lines with human foreskin fibroblast cells and stomach epithelial cells as normal control. In comparison with the well-developed CMTC (Cytoplasmic Microtubule Complex) of normal cells, the cytoplasmic microtubules of tumor cells largely decreased in number...

Peroxidase-Antiperoxidase (PAP) soluble complex was prepared and used in immunoperoxidase visualization of microtubules and microtubular proteins in human esophageal carcinoma ECa109, stomach cancer SGC7901, breast cancer MCF7 and osteosarcoma OS732 cell lines with human foreskin fibroblast cells and stomach epithelial cells as normal control. In comparison with the well-developed CMTC (Cytoplasmic Microtubule Complex) of normal cells, the cytoplasmic microtubules of tumor cells largely decreased in number and length or totally disappeared and replaced by brown precipitates of free non-microtubular tubulin components in the cytoplasm and more concentrated at the centrosomal region. The mitotic spindles of tumor cells were similar to those of normal cells. These results of PAP immunocytochemical method evidently confirmed our preliminary immunofluorescent observations on tumor cells which were considered to be microtubule-deficient during interphase. The CMTC pattern of stomach epithelial cells shown in this report be useful as a normal counterpart of tumor cells with epithelial origin is suggested. The cytoplasmic microtubules stained by PAP method were as sensitive to antimicrotubule factors such as low temperature or colcemid as were those stained by immunofluorescent method. Cytoplasmic microtubules underwent reversible depolymerization after low temperature or colcemid treatment and recovered again when released from the treatment. This is also a strong evidence for the efficiency and specificity of PAP method for microtubutes in our report Some modifications to De Mey's PAP-microtubule method in our work were described, using chloroform: methanol (2:1) as fixatives, using 0.3% Triton X100/PBS as anti-serum diluting solvent; using 1% Triton X-100/PBS in washing steps, all were proved to be advantageous not only in preserving cell shape and microtubule structures but also in simplifying the staining procedures and saving time with equally good staining results to those in other reports.

我们利用兔抗微管蛋白抗体和兔抗辣根过氧化物酶(HRP)抗血清制备的HRP—抗HRP(PAP)复合物,建立了微管的PAP免疫酶细胞化学方法。应用此法观察到人食管癌ECa 109、胃癌SGC 7901,乳腺癌MCF 7和成骨肉瘤OS 732细胞间期胞质微管减少或消失,只有大量弥散分布的微管蛋白棕色反应产物,在微管组织中心(MTOC)附近十分密集,而正常成纤维细胞和胎儿胃粘膜上皮细胞间期,都有发达的胞质微管结构(CMTC)。在分裂期,这些肿瘤细胞都显示纺锤体微管,与正常细胞比较无明显差异。本研究应用PAP方法进一步证明,以前用免疫荧光细胞化学方法观察到的人肿瘤细胞间期胞质微管缺陷的特征。除去低温(4℃)或秋水仙酰胺处理后,解聚的CMTC又可恢复,表明本方法与免疫荧光染色法,同样具有很高的特异性。本工作在细胞固定及免疫反应的某些步骤上有所改进。

Marked hypercalcemia would be caused by ectodermic solid tumor remote from the bone and Without any indication of bone invasion. It suggested that certain humoral factor secreted by the tumor may contribute to the pathogenesis.We partially purified and characterized bone resorption factor (BRF) from human transitional cell carcinoma (TCC) , rat Walker 256 carcinoma and mouse 7,12 dimethyl benz (a) anthracene (DMBA) induced squamous carcinoma. Gel filtration chromatography of tumor extract demonstrates a single...

Marked hypercalcemia would be caused by ectodermic solid tumor remote from the bone and Without any indication of bone invasion. It suggested that certain humoral factor secreted by the tumor may contribute to the pathogenesis.We partially purified and characterized bone resorption factor (BRF) from human transitional cell carcinoma (TCC) , rat Walker 256 carcinoma and mouse 7,12 dimethyl benz (a) anthracene (DMBA) induced squamous carcinoma. Gel filtration chromatography of tumor extract demonstrates a single major peak of bone resorption activity (BRA, 45Ca release from calvarial bone) that elutes with an apparent MW of about 15,000 dalton. The BRA is associated with increased release of immunoreactive PGE 2 and both can be inhibited by indomethacin and boiling. In TCC and DMBA, the BRA were co-eluted with an activity of stimulating aden-ylate cyclase in rat osteosarcoma cells ROS 17/2.8. It appears that these factors are unique BRF, which are different from other known factors that can cause bone resorption.

某些源自外胚层的骨外实体瘤,它们并未浸润至骨组织,但可引起血钙显著增高,提示这些肿瘤可能分泌体液因子作用于骨导致溶骨。我们从人膀胱癌、大鼠乳腺癌(Walker 256)及7.12-Dimethyl Benz[α]anthracene诱发的小鼠鳞癌的提取液中初步分离鉴定了一种溶骨因子。肿瘤提取液经ultrogel层析,发观仅有一溶骨活性峰(~(45)Ca自乳鼠顶骨培养中的释出率),相当于表观分子量15,000道尔顿。此溶骨活性峰与PGE2生成的活性峰相平行,两者均能被Indomethacin及煮沸所抑制。在膀胱癌及鳞癌中,溶骨活性峰还与刺激大鼠成骨肉瘤细胞腺苷酸环化酶的活性相平行。实验结果表明此溶骨因子不同于其它已知能引起溶骨的因子。

The anti-invasive ability of cartilage was investigated in human hyaline cartilage co-cultured with OS-732 human osteosarcoma cell line. Invasive osteosarcoma cells were unable to invade normal hyaline cartilage after 7-day co-culture. Observation of TEM showed that the growth and metabolism of tumor cells were inhibited by co-cultured cartilage. However, cartilage extracted with 5M GuHCl was invaded by tumor cells. In this situation, tumor cells indicated a high growth and metabolic status and contained...

The anti-invasive ability of cartilage was investigated in human hyaline cartilage co-cultured with OS-732 human osteosarcoma cell line. Invasive osteosarcoma cells were unable to invade normal hyaline cartilage after 7-day co-culture. Observation of TEM showed that the growth and metabolism of tumor cells were inhibited by co-cultured cartilage. However, cartilage extracted with 5M GuHCl was invaded by tumor cells. In this situation, tumor cells indicated a high growth and metabolic status and contained abundant microtubules, microfilaments, rough endoplasmic reticulum, mitochondria and Golgi bodies. Cartilage matrix collagenous protein(CMCP), from extracted cartilage, was denatured and became more electron dense. In the control group, normal fibroblasts did not invade cartilage or extracted cartilage and its growth and metabolism did not inhibit by cartilage. Our report shows that resistance of hyaline cartilage to tumor invasion could be regulated in part by salt-derived materials which may inhibit the growth, metabolism and locomotion of tumor cells.

本文研究成骨肉瘤OS-732细胞系浸润软骨的机理,指出经盐酸胍处理后的软骨可被瘤细胞所浸润,这些浸润细胞在电镜下见其有生长、代谢旺盛的特点,提示正常软骨内含有抑制肿瘤细胞浸润的因子存在。

 
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