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osteosarcoma
相关语句
  骨肉瘤
    Paclitaxel-induced apoptsis in human osteosarcoma cell line and the apoptotic effect of Caspase-6 gene
    紫杉醇诱导成骨肉瘤细胞凋亡及Caspase-6基因对成骨肉瘤细胞的凋亡诱导作用
短句来源
    Preliminary Study on the Mechanisms of Arsenic Troxide-induced Apoptosis in Human Osteosarcoma MG-63 Cells
    三氧化二砷诱导骨肉瘤MG-63细胞凋亡分子机制的研究
短句来源
    Human Osteosarcoma Related Proteome Analysis and Study on Oncogene, Anti-oncogene, Apoptosis Related Gene Expression Differences with Gene Chips
    人骨肉瘤相关蛋白质组分析及癌基因、抑癌基因、凋亡相关基因表达差异的基因芯片研究
短句来源
    Experimental Studies on Induction of Apoptosis and Inhibition of Metastasis of Human Osteosarcoma Cells by Kappa-Selenocarrageenan
    硒酸酯多糖诱导人骨肉瘤细胞凋亡抑制转移及其机制的实验研究
短句来源
    Study on the Molecular Mechanisms of Osteosarcoma Cell Apoptosis Induced by Adriamycin in Combination with Microwave
    阿霉素联合微波诱导成骨肉瘤细胞凋亡分子机制的初步研究
短句来源
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  成骨肉瘤
    Paclitaxel-induced apoptsis in human osteosarcoma cell line and the apoptotic effect of Caspase-6 gene
    紫杉醇诱导成骨肉瘤细胞凋亡及Caspase-6基因对成骨肉瘤细胞的凋亡诱导作用
短句来源
    Study on the Molecular Mechanisms of Osteosarcoma Cell Apoptosis Induced by Adriamycin in Combination with Microwave
    阿霉素联合微波诱导成骨肉瘤细胞凋亡分子机制的初步研究
短句来源
    The Study of Cell Cycle of Human Osteosarcoma Cell Line OS-732
    人成骨肉瘤细胞系OS-732细胞周期的研究
短句来源
    Purification of Osteosarcoma Associated Antigen and its specificity analysis
    成骨肉瘤相关抗原的纯化及其特异性分析
短句来源
    Among them, there were 4 patients with osteosarcoma, 6 with malignant fibrous histocytoma, 1 with malignant giant cell tumor, 1 with synovial sarcoma, and 1 with Ewing's sarcoma.
    成骨肉瘤4例,骨恶性纤维组织细胞瘤6例,尤文瘤、滑膜肉瘤、恶性骨巨细胞瘤各1例,病程3~16个月。
短句来源
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  “osteosarcoma”译为未确定词的双语例句
    Histopathological and immunohistochemical studies of 120 cases of osteosarcoma
    Histopathological and immunohistochemical studies of 120 cases of osteosarcoma
短句来源
    Methods Different concentrations of ATRA were added into culture media system to induce apoptosis of human osteosarcoma cells. The apoptosis was detected by MTT assay,flow cytometry and TUNEL method.
    方法在培养液体系中加入不同浓度的全反式维甲酸(ATRA)进行不同时间长度的诱导,以MTT法,流式细胞术,TUNEL法检测细胞凋亡情况。
短句来源
    There was a significantly positive correlation between Survivin and cyclinD1,while negative correlation was observed between the Survivin and PTEN expression in osteosarcoma.
    Survivin和PTEN两者表达强度之间呈显著负相关(P<0.01),而Survivin与cyclinD1表达呈正相关(P<0.01)。
短句来源
    Skp2 protein expression in osteosarcoma was positively associated with the clinical stage and differentiation.
    Skp2蛋白表达与临床分期、肺转移及分化程度显著正相关(P<0.05)。
短句来源
    p27 protein expression in osteosarcoma was negatively associated with the clinical stage and differentiation.
    p27蛋白表达与临床分期、肺转移及分化程度呈负相关(P<0.05)。
短句来源
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  osteosarcoma
Measurement of bone alkaline phosphatase and relative study with osteosarcoma
      
The objective of this paper is to explore the value of bone alkaline phosphatase (BALP) for diagnosing osteosarcoma, evaluating the effect of the chemotherapy, judging the prognosis and supervising the relapse and metastasis.
      
The immunoassay was used to check the BALP of the blood serum that was from 42 primary osteosarcoma patients.
      
BALP was more sensitive than ALP in diagnosing osteosarcoma (P = 0.015).
      
It has applied value in the diagnosis of osteosarcoma, reflection of the effect of chemotherapy and forecast the prognosis.
      
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This article reports 27 cases of malignant tumors treated in our hospital from 1979 to 1981. These patients included 12 cases of osteosarcoma, 9 cases who underwent resection, 1 case with pulmonary metastasis after surgery, 2 cases who were not operated on, 5 cases of soft tissue sarcoma, 1 case of malignarit lymphoma, 2 cases of malignant melanoma and the remaining 7 cases of pulmonary metastatic tumor. In all patients, the diagnosis was confirmed by pathological examination. A total of 52 courses of...

This article reports 27 cases of malignant tumors treated in our hospital from 1979 to 1981. These patients included 12 cases of osteosarcoma, 9 cases who underwent resection, 1 case with pulmonary metastasis after surgery, 2 cases who were not operated on, 5 cases of soft tissue sarcoma, 1 case of malignarit lymphoma, 2 cases of malignant melanoma and the remaining 7 cases of pulmonary metastatic tumor. In all patients, the diagnosis was confirmed by pathological examination. A total of 52 courses of HD—MTX—CFR were administered to these 27 patients. The dosage of methotrexate (MTX) was given intravenously at 1—5g, 9—12mg citrovorum factor was injected intramuscularly every 6 hours for 3 days and 0.5—2mg VCP intravenously. The total accumulative dose of MTX (more than 5g) was given to 13 patients (48%) and 10g to 2 cases. The curative effect of osteosarcoma treated by the therapy was better than that of other tumors. In osteosarcoma, the objective signs were relieved partially in 2/3 of the patients and 4/5 of them survived for two years or more. Among the patients, 3/4 of patients survived without tumor. The common side-effects of HD—MTX—CFR were nausea, vomiting, slight fever, oral mucositis, skirt rashes and temporary elevation of GPT, but all of them were reversible. As we controlled strictly hydration and alkalization, there was no impaired function of the kidney.

本文报导从1979年4—1982年8对27例恶性肿瘤进行52次HD—MTX—CFR治疗观察,对骨肉瘤确能防止其肺转移、延长生存期、二年以上生存4/5(80%),其中3/4无瘤生存。对其他转移性肺癌疗效差,一年存活率仅为1/7。另外对该法的剂量、方法、毒付作用结合文献进行了讨论,体会该法符合细胞动力学,不仅具有大剂量冲击疗法的优点,且毒付作用为可逆性的。在严格掌握水化、碱化原则下,可完全避免致死性的肾功衰竭。

In this experiment,420 wistar rats were used to study thecomparative carcinogenetic effects of ~(241)Am,~(230)Pu and ~(237)Np.Thesenuclides were injected to animals intravenously,subcutaneously or directlyinto the lung(stansen's lung puncture method)in doses of 1.0,5.0 and8.5μCi/kg,respectively.As soluble nitrate,the nuclides were rapidlytransfered from the site of injection into the bone and the liver.Osteosarcomaswere found in some animals 8 months to one year after intoxication.Diagnosis of osteosarcoma...

In this experiment,420 wistar rats were used to study thecomparative carcinogenetic effects of ~(241)Am,~(230)Pu and ~(237)Np.Thesenuclides were injected to animals intravenously,subcutaneously or directlyinto the lung(stansen's lung puncture method)in doses of 1.0,5.0 and8.5μCi/kg,respectively.As soluble nitrate,the nuclides were rapidlytransfered from the site of injection into the bone and the liver.Osteosarcomaswere found in some animals 8 months to one year after intoxication.Diagnosis of osteosarcoma is based on the histopatological examinationand x-ray photography.In the Am-poisoned rats the incidence ofosteosarcoma is about 31—74%,varied with different doses and differentroutes of intoxication;in pu-poisoned rats,the incidence of osteosareomais about 55—66%.while in Np-poisoned rats,it is about 36—53%.Primarylung cancers were also found in those animals poisoned by means ofstansen's lung puncture method with the above three nuclides.The incidenceof primary lung cancers is about 6% in Am-and pu-poisoned rats and 13%in Np-poisoned rats.The incidence of metastasis of osteosareoma in lungis about 25—65% for Am-poisoned rats,45—55% for Pu-poisoned ratsand 41—80% for Np-poisoned rats.The life-span of above poisoned ratswas significantly shorter than that of the normal control animals.Thechemical weight for ~(241)Am,~(230)Pu and ~(237)Np in same unit of radioactivity(1.0μCi)equals to 0.308μg,15.9μg and 1418.7μg,respectively.For thisreason,we have to pay more attention to the chemical mass effect incaicinogenesis of the above three nuclides.

本实验用420只大鼠(维斯特种)研究~(241)Am、~(239)Pu 和~(237)Np(均为硝酸盐)的辐射致癌效应。中毒途径为肺内、静脉内和皮下。注入核素活度为1.0,5.0,8.5μCi/kg体重。中毒后八个月到一年左右,发现动物长出骨肉瘤。各核素组骨肉瘤发生率,因剂量和途径不同而异。在镅中毒各组中,肺内注入核素活度为1.0μCi/kg时,雄鼠骨肉瘤发生率为34%,雌鼠为31%;肺内5.0μCi/kg时为74%(雄鼠);皮下8.5μCi/kg时为69%(雄鼠)。在钚中毒组中,肺内注入核素活度为1.0,5.0μCi/kg 两个剂量组,骨肉瘤发生率分别为55%和66%(均为雄鼠)。在镎中毒组中,肺内1.0μCi/kg时,骨肉瘤发生率为37%;而经静脉注入相同活度时,为53%(均为雄鼠)。三种核素经肺中毒时,都发现一定数量的原发肺癌,发生率在2—13%之间。而皮下和静脉内中毒组未发现原发肺癌。三种核素诱发的骨肉瘤都有严重的向肺转移倾向,转移率在25%到80%之间。三种核素中毒动物寿命比对照组缩短29—58%,其中以钚中毒组为最短。

19 cases of osteosarcoma of maxilla were treated from 19661982. All were confirmed by pathological diagnosis. The clinical characteristics are as follows: (1). Occurance of age almost half of patients occur in 30 40 years, whichwasl5-20 years later than those of osteosarcoma of the trunk: (2). There was no hurt history:(3). Besides mass and pain, functional disabilities were common: (4). Ratio of maxilla and mandible was 1:2: (5). There were only about 20% of patients showed classical X-Ray feature,...

19 cases of osteosarcoma of maxilla were treated from 19661982. All were confirmed by pathological diagnosis. The clinical characteristics are as follows: (1). Occurance of age almost half of patients occur in 30 40 years, whichwasl5-20 years later than those of osteosarcoma of the trunk: (2). There was no hurt history:(3). Besides mass and pain, functional disabilities were common: (4). Ratio of maxilla and mandible was 1:2: (5). There were only about 20% of patients showed classical X-Ray feature, 80%of them showed some extent of bone destruction, which can't be diagnosedas osteosarcoma of maxilla: (6). Distant metastases were 16%. There was no metastasis of lymph modefound, but local recurrence was high up to 95%(it is the major cause ofdeath), so success or failure of treatment depends on dissection of locallesion: (7). After the local recurrence appear, radical excision can be done and 20%of patients can still live more than 5 years: (8). 5, lOyears survival rate was 21%(4/19) and 10.5%(2/19) respectively.

我院1966—1982年收治颌骨骨肉瘤19例,均经病理证实。分析其临床特点有:(1)发病年龄约半数在30~40岁,比躯干骨肉瘤好发年龄迟15~20年;(2)无外伤史;(3)除肿块及疼痛外,功能障碍常见;(4)上下颌骨发生比例为1:2;(5)约20%病人出现典型X线征,约80%病人仅表现为不同程度的骨质破坏,而不能诊断为骨肉瘤;(6)远处转移少(16%),无淋巴结转移,但局部复发(为死亡的主要原因)高达95%,故治疗的成败取决于局部;(7)复发后再行广泛切除,仍有20%病人可生存5年以上;(8)5、10年生存率分别为21%(4/9)、10.5%(2/19)。随诊率95%。

 
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